Visualising disease progression on multiple variables with vector plots and path plots (2009)
Lazic, Stanley E, Mason, Sarah L, Michell, Andrew W, Barker, Roger A
Abstract Background It is often desirable to observe how a disease progresses over time in individual patients, rather than graphing group averages; and since multiple outcomes are typically recorded...
Williams-Gray, Caroline H., Evans, Jonathan R., Goris, An, Foltynie, Thomas, Ban, Maria, Robbins, Trevor W., ...
Cognitive abnormalities are common in Parkinson's disease, with important social and economic implications. Factors influencing their evolution remain unclear but are crucial to the development of...
Adam Hampshire, Trevor W. Robbins, Adrian M. Owen, Roger A. Barker
Cognitive dysfunction commonly occurs even in the early stages of Parkinson’s disease (PD). Impairment on frontostriatally based executive tasks is particularly well described but affects only a...
Attentional control in Parkinson's disease is dependent on COMT val158met genotype (2008)
Williams-Gray, Caroline H., Hampshire, Adam, Barker, Roger A., Owen, Adrian M.
Cognitive deficits occur even in the earliest stages of Parkinson's disease. Some such deficits are known to relate to dysfunction in dopaminergic frontostriatal networks, and may be influenced by a...
Hypothalamic involvement in Huntington's disease: an in vivo PET study (2008)
Politis, Marios, Pavese, Nicola, Tai, Yen F., Tabrizi, Sarah J., Barker, Roger A., Piccini, Paola
Recent studies have shown alterations in metabolism, sleep and circadian rhythms as well as in several neuropeptides derived from the hypothalamic–pituitary axis in Huntington's disease patients;...
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease (2007)
Clark, Graeme R, Foltynie, Thomas, Lewis, Simon J. G, Brown, Joanne, ...
Objective: Parkinson's disease (PD) is a neurodegenerative condition that typically presents as a movement disorder but is known to be associated with variable degrees of cognitive impairment...
Microglial activation in presymptomatic Huntington's disease gene carriers (2007)
Tai, Yen F., Pavese, Nicola, Gerhard, Alexander, Tabrizi, Sarah J., Barker, Roger A., Brooks, David J., ...
Microglial activation may play a role in the pathogenesis of Huntington's disease (HD). Using 11C-(R)-PK11195 (PK) positron emission tomography (PET), we investigated microglial activation in HD...
No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease (2006)
Foltynie, Thomas, Brown, Joanne, Maranian, Melanie, Walton, Amie, ...
Underwood, Benjamin R., Broadhurst, David, Dunn, Warwick B., Ellis, David I., Michell, Andrew W., Vacher, Coralie, ...
There has been considerable progress recently towards developing therapeutic strategies for Huntington's disease (HD), with several compounds showing beneficial effects in transgenic mouse models....
Underwood, Benjamin R., Broadhurst, David, Dunn, Warwick B., Ellis, David I., Michell, Andrew W., Vacher, Coralie, ...
There has been considerable progress recently towards developing therapeutic strategies for Huntington's disease (HD), with several compounds showing beneficial effects in transgenic mouse models....
Foltynie, Thomas, Brayne, Carol E. G., Robbins, Trevor W., Barker, Roger A.
We have used multiple sources to identify a population‐representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2‐year period. All...
Foltynie, Thomas, Brayne, Carol E. G., Robbins, Trevor W., Barker, Roger A.
We have used multiple sources to identify a population-representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2-year period. All patients have...
Pavese, Nicola, Andrews, Thomasin C., Brooks, David J., Ho, Aileen K., Rosser, Anne E., Barker, Roger A., ...
We have studied the progression of striatal and extrastriatal post‐synaptic dopaminergic changes in a group of 12 patients with Huntington’s disease using serial 11C‐raclopride PET, a...
Foltynie, Thomas, Brayne, Carol E. G., Robbins, Trevor W., Barker, Roger A.
We have used multiple sources to identify a population-representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2-year period. All patients have...
Rosser, Anne Elizabeth, Barker, Roger A., Harrower, T., Watts, C., Farrington, M., Ho, A. K., ...
Objectives: Huntington’s disease (HD) is an inherited autosomal dominant condition in which there is a CAG repeat expansion in the huntingtin gene of 36 or more. Patients display progressive motor,...
Rosser, Anne Elizabeth, Barker, Roger A., Harrower, T., Watts, C., Farrington, M., Ho , A. K., ...
Objectives: Huntington’s disease (HD) is an inherited autosomal dominant condition in which there is a CAG repeat expansion in the huntingtin gene of 36 or more. Patients display progressive motor,...
Rosser, Anne Elizabeth, Barker, Roger A., Harrower, T., Watts, C., Farrington, M., Ho, A. K., ...
Objectives: Huntington’s disease (HD) is an inherited autosomal dominant condition in which there is a CAG repeat expansion in the huntingtin gene of 36 or more. Patients display progressive motor,...
Rosser, Anne Elizabeth, Barker, Roger A., Harrower, T., Watts, C., Farrington, M., Ho , A. K., ...
Objectives: Huntington’s disease (HD) is an inherited autosomal dominant condition in which there is a CAG repeat expansion in the huntingtin gene of 36 or more. Patients display progressive motor,...
Armstrong, Richard J. E., Hurelbrink, Carrie B., Tyers, Pam, Ratcliffe, Emma L., Richards, Andrew, Dunnett, Stephen Bruce, ...
Neural precursors with the properties of neural stem cells can be isolated from the developing brain, can be expanded in culture, and have been suggested as a potential source of cells for neuronal...
Armstrong, Richard J. E., Hurelbrink, Carrie B., Tyers, Pam, Ratcliffe, Emma L., Richards, Andrew, Dunnett, Stephen Bruce, ...
Neural precursors with the properties of neural stem cells can be isolated from the developing brain, can be expanded in culture, and have been suggested as a potential source of cells for neuronal...
Cools, Roshan, Stefanova, Elka, Barker, Roger A., Robbins, Trevor W., Owen, Adrian M.
This study examined the effects of l‐dopa medication in patients with Parkinson’s disease on cortical and subcortical blood flow changes during two tasks known to involve frontostriatal...
Cools, Roshan, Barker, Roger A., Sahakian, Barbara J., Robbins, Trevor W.
We investigated how dopamine (DA) systems contribute to cognitive performance in the domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic medication in patients...
Mechanisms of cognitive set flexibility in Parkinson's disease (2001)
Cools, Roshan, Barker, Roger A., Sahakian, Barbara J., Robbins, Trevor W.
Previous research on cognitive set shifting in patients with Parkinson's disease has often been confounded by concept formation, rule learning, working memory and/or general slowing of cognitive...
Immune Problems in Central Nervous System Cell Therapy
Barker, Roger A., Widner, Håkan
Summary: Transplantation of cells and tissues to the mammalian brain and CNS has revived the interest in the immunological status of brain and its response to grafted tissue. The previously held view...
Immune Problems in Central Nervous System Cell Therapy
Barker, Roger A., Widner, Håkan
Summary: Transplantation of cells and tissues to the mammalian brain and CNS has revived the interest in the immunological status of brain and its response to grafted tissue. The previously held view...