Zhu, Jingui, Sun, Yongqiao, Zhao, Fa-Qing, Yu, Jun, Craig, Roger, Hu, Songnian
Abstract Background Tarantula has been used as a model system for studying skeletal muscle structure and function, yet data on the genes expressed in tarantula muscle are lacking. Results We...
Victoria Hatch, Gang Zhi, Lula Smith, James T. Stull, Roger Craig, William Lehman
Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction 1 2
Designing antisense oligonucleotides with high efficacy is of great interest both for its usefulness to the study of gene regulation and for its potential therapeutic effects. The high cost...
Don Leclair, Sue Andersen, Jason Bryk, Roger Craig, Bill Donoghue, Justin Gagnon, ...
and management needs
ACKNOWLEDGEMENTS Principal Authors (2008)
Server Infrastructures, Don Leclair, Daniel Blanco, Roger Craig, Andrew Haigh, Lutz Holzbecher, ...
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Transductive Learning with EM Algorithm to Classify Proteins Based on Phylogenetic Profiles (2008)
Roger Craig, Li Liao, R. Craig, L. Liao
Abstract: Phylogenetic profiles of proteins � strings of ones and zeros encoding respectively the presence and absence of proteins in a group of genomes � have recently been used to identify...
Poole, Katrina J. V., Lorenz, Michael, Evans, Gwyndaf, Rosenbaum, Gerd, Pirani, Alnoor, Craig, Roger, ...
The regulation of striated muscle contraction involves changes in the interactions of troponin and tropomyosin with actin thin filaments. In resting muscle, myosin−binding sites on actin are...
Purification of Native Myosin Filaments from Muscle (2001)
Carlos Hidalgo, Raúl Padrón, Rachel Horowitz, Fa-qing Zhao, Roger Craig
ABSTRACT Analysis of the structure and function of native thick (myosin-containing) filaments of muscle has been hampered in the past by the difficulty of obtaining a pure preparation. We have...
The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va
Li, Xiang-dong, Jung, Hyun Suk, Wang, Qizhi, Ikebe, Reiko, Craig, Roger, Ikebe, Mitsuo
Myosin Va is a well known processive motor involved in transport of organelles. A tail-inhibition model is generally accepted for the regulation of myosin Va: inhibited myosin Va is in a folded...
Three-dimensional structure of vertebrate cardiac muscle myosin filaments
Zoghbi, Maria E., Woodhead, John L., Moss, Richard L., Craig, Roger
Contraction of the heart results from interaction of the myosin and actin filaments. Cardiac myosin filaments consist of the molecular motor myosin II, the sarcomeric template protein, titin, and the...
Jung, Hyun Suk, Komatsu, Satoshi, Ikebe, Mitsuo, Craig, Roger
Intramolecular interaction between myosin heads, blocking key sites involved in actin-binding and ATPase activity, appears to be a critical mechanism for switching off vertebrate smooth-muscle myosin...
Luther, Pradeep K., Bennett, Pauline M., Knupp, Carlo, Craig, Roger, Padrón, Raúl, Harris, Samantha P., ...
Myosin binding protein C (MyBP-C) is a component of the thick filament of striated muscle. The importance of this protein is revealed by recent evidence that mutations in the cardiac gene are a major...
Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State
Zhao, Fa-Qing, Padrón, Raúl, Craig, Roger
Blebbistatin is a small-molecule, high-affinity, noncompetitive inhibitor of myosin II. We have used negative staining electron microscopy to study the effects of blebbistatin on the organization of...
The tail binds to the head–neck domain, inhibiting ATPase activity of myosin VIIA
Umeki, Nobuhisa, Jung, Hyun Suk, Watanabe, Shinya, Sakai, Tsuyoshi, Li, Xiang-dong, Ikebe, Reiko, ...
Myosin VIIA is an unconventional myosin, responsible for human Usher syndrome type 1B, which causes hearing and visual loss. Here, we studied the molecular mechanism of regulation of myosin VIIA,...