Roger F. Castilho

High susceptibility of activated lymphocytes to oxidative stress-induced cell death (2008)

Degasperi,Giovanna R., Castilho,Roger F., Vercesi,Anibal E.

The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to tert-butyl hydroperoxide (t-BOOH)-induced necrotic cell...

Overexpression of heat shock protein 70 in R6 / 2 Huntington’s disease mice has only modest effects on disease progression (2003)

Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F., Leist, Marcel, Jäätela, Marja, Brundin, Patrik

Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract in a protein called huntingtin. The inducible form of heat shock protein 70 (Hsp70) has been...

Transgenic mice expressing a Huntington’s disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity (1999)

Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik

Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...

Transgenic mice expressing a Huntington’s disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik

Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...

Transgenic mice expressing a Huntington’s disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik

Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...