Vila-Petroff, Martin, Salas, Margarita A., Said, Matilde, Valverde, Carlos A., Sapia, Luciana, Portiansky, Enrique, ...
Objectives: Ca2+/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the regulation of cardiac excitation–contraction coupling (ECC) as well as in apoptotic signaling and adverse...
In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts (2005)
Schmidt, Ulrich, Zhu, Xinsheng, Lebeche, Djamel, Huq, Fawzia, Guerrero, J. Luis, Hajjar, Roger J.
Objective: Diastolic dysfunction is a characteristic finding of the aged mammalian heart. Parvalbumin acts as a Ca2+ sink and enhances relaxation in skeletal muscle, and overexpression of parvalbumin...
Okafor, Chukwuka C, Perreault-Micale, Cynthia, Hajjar, Roger J, Lebeche, Djamel, Skiroman, Klara, Jabbour, George, ...
Abstract Background β-blocker treatment has emerged as an effective treatment modality for heart failure. Interestingly, β-blockers can activate both pro-apoptotic and anti-apoptotic pathways....
Type 1 phosphatase, a negative regulator of cardiac function. (2002)
Carr, Andrew N., Schmidt, Albrecht G., Suzuki, Yoichi, Del Monte, Federica, Sato, Yoji, Lanner, Carita, ...
Increases in type 1 phosphatase (PP1) activity have been observed in end stage human heart failure, but the role of this enzyme in cardiac function is unknown. To elucidate the functional...
Paige, John A., Liao, Ronligh, Hajjar, Roger J., Foisy, Rebecca L., Cory, C.Robert, O'Brien, Peter J., ...
Objective: Omega-3 fatty acids have been implicated in the amelioration of cardiovascular disease in humans. Since these fatty acids are found in salmonid fish and are known to be essential for all...
Hajjar, Roger J, Liao, Ronglih, Young, James B, Fuleihan, Farid, Glass, Mark G, Gwathmey, Judith K
Objective: With the recent availability of human myocardium, many animal models have been shown to be unsuitable as models of human heart failure. The aim of this study was to describe the...
Miyamoto, Michael I., Del Monte, Federica, Schmidt, Ulrich, DiSalvo, Thomas S., Kang, Zhao Bin, Matsui, Takashi, ...
In human and experimental models of heart failure, sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) activity is decreased, resulting in abnormal calcium handling. The disturbances in calcium metabolism...
Modulation of ventricular function through gene transfer in vivo
Hajjar, Roger J., Schmidt, Ulrich, Matsui, Takashi, Guerrero, J. Luis, Lee, Kyung-Han, Gwathmey, Judith K., ...
We used a catheter-based technique to achieve generalized cardiac gene transfer in vivo and to alter cardiac function by overexpressing phospholamban (PL) which regulates the activity of the...
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
De Windt, Leon J., Lim, Hae W., Bueno, Orlando F., Liang, Qiangrong, Delling, Ulrike, Braz, Julian C., ...
The Ca2+-calmodulin-activated Ser/Thr protein phosphatase calcineurin and the downstream transcriptional effectors of calcineurin, nuclear factor of activated T cells, have been implicated in the...
Functional consequences of caspase activation in cardiac myocytes
Communal, Catherine, Sumandea, Marius, De Tombe, Pieter, Narula, Jagat, Solaro, R. John, Hajjar, Roger J.
Cardiomyocyte apoptosis is present in many cardiac disease states, including heart failure and ischemic heart disease. Apoptosis is associated with the activation of caspases that mediate the...
Type 1 Phosphatase, a Negative Regulator of Cardiac Function
Carr, Andrew N., Schmidt, Albrecht G., Suzuki, Yoichi, Del Monte, Federica, Sato, Yoji, Lanner, Carita, ...
Increases in type 1 phosphatase (PP1) activity have been observed in end stage human heart failure, but the role of this enzyme in cardiac function is unknown. To elucidate the functional...
Okafor, Chukwuka C, Perreault-Micale, Cynthia, Hajjar, Roger J, Lebeche, Djamel, Skiroman, Klara, Jabbour, George, ...
Damped elastic recoil of the titin spring in myofibrils of human myocardium
Opitz, Christiane A., Kulke, Michael, Leake, Mark C., Neagoe, Ciprian, Hinssen, Horst, Hajjar, Roger J., ...
The giant protein titin functions as a molecular spring in muscle and is responsible for most of the passive tension of myocardium. Because the titin spring is extended during diastolic stretch, it...
Choukroun, Gabriel J., Marshansky, Vladimir, Gustafson, Corinne E., McKee, Mary, Hajjar, Roger J., Rosenzweig, Anthony, ...
The Golgi complex and the trans-Golgi network are critical cellular organelles involved in the endocytic and biosynthetic pathways of protein trafficking. Lipids have been implicated in the...
Del Monte, Federica, Lebeche, Djamel, Guerrero, J. Luis, Tsuji, Tsuyoshi, Doye, Angelia A., Gwathmey, Judith K., ...
Abnormal intracellular Ca2+ cycling plays an important role in cardiac dysfunction and ventricular arrhythmias in the setting of heart failure and transient cardiac ischemia followed by reperfusion...
A Pilot Study of a New Chicken Model of Alcohol-Induced Cardiomyopathy
Morris, Nancy, Kim, Catherine S., Doye, Angelia A., Hajjar, Roger J., Laste, Nancy, Gwathmey, Judith K.
Myofilament Calcium Regulation in Human Myocardium
Hajjar, Roger J., Schwinger, Robert H.G., Schmidt, Ulrich, Kim, Catherine S., Lebeche, Djamel, Doye, Angelia A., ...
Del Monte, Federica, Harding, Sian E., Schmidt, Ulrich, Matsui, Takashi, Kang, Zhao Bin, William Dec, G., ...
Del Monte, Federica, Williams, Eric, Lebeche, Djemal, Schmidt, Ulrich, Rosenzweig, Anthony, Gwathmey, Judith K., ...
Decreased Efficiency of Adenovirus-Mediated Gene Transfer in Aging Cardiomyocytes
Communal, Catherine, Huq, Fawzia, Lebeche, Djamel, Mestel, Celine, Gwathmey, Judith K, Hajjar, Roger J.
Targeting Phospholamban by Gene Transfer in Human Heart Failure
Del Monte, Federica, Harding, Sian E., William Dec, G., Gwathmey, Judith K., Hajjar, Roger J.
Catheter-based antegrade intracoronary viral gene delivery with coronary venous blockade
Hayase, Motoya, Monte, Federica Del, Kawase, Yoshiaki, MacNeill, Briain D., McGregor, Jennifer, Yoneyama, Ryuichi, ...
Hayase, Motoya, Federica del Monte, Yoshiaki Kawase, Brian D. MacNeill, Jennifer McGregor, Ryuichi Yoneyama, Kozo Hoshino, Tsuyoshi Tsuji, Alec M. De Grand, Judith K. Gwathmey, John V. Frangioni, and...
Miyamoto, Michael I., Del Monte, Federica, Schmidt, Ulrich, DiSalvo, Thomas S., Kang, Zhao Bin, Matsui, Takashi, ...
In human and experimental models of heart failure, sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) activity is decreased, resulting in abnormal calcium handling. The disturbances in calcium metabolism...
Modulation of ventricular function through gene transfer in vivo
Hajjar, Roger J., Schmidt, Ulrich, Matsui, Takashi, Guerrero, J. Luis, Lee, Kyung-Han, Gwathmey, Judith K., ...
We used a catheter-based technique to achieve generalized cardiac gene transfer in vivo and to alter cardiac function by overexpressing phospholamban (PL) which regulates the activity of the...
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
De Windt, Leon J., Lim, Hae W., Bueno, Orlando F., Liang, Qiangrong, Delling, Ulrike, Braz, Julian C., ...
The Ca2+-calmodulin-activated Ser/Thr protein phosphatase calcineurin and the downstream transcriptional effectors of calcineurin, nuclear factor of activated T cells, have been implicated in the...
Functional consequences of caspase activation in cardiac myocytes
Communal, Catherine, Sumandea, Marius, De Tombe, Pieter, Narula, Jagat, Solaro, R. John, Hajjar, Roger J.
Cardiomyocyte apoptosis is present in many cardiac disease states, including heart failure and ischemic heart disease. Apoptosis is associated with the activation of caspases that mediate the...
Type 1 Phosphatase, a Negative Regulator of Cardiac Function
Carr, Andrew N., Schmidt, Albrecht G., Suzuki, Yoichi, Del Monte, Federica, Sato, Yoji, Lanner, Carita, ...
Increases in type 1 phosphatase (PP1) activity have been observed in end stage human heart failure, but the role of this enzyme in cardiac function is unknown. To elucidate the functional...
Okafor, Chukwuka C, Perreault-Micale, Cynthia, Hajjar, Roger J, Lebeche, Djamel, Skiroman, Klara, Jabbour, George, ...
Damped elastic recoil of the titin spring in myofibrils of human myocardium
Opitz, Christiane A., Kulke, Michael, Leake, Mark C., Neagoe, Ciprian, Hinssen, Horst, Hajjar, Roger J., ...
The giant protein titin functions as a molecular spring in muscle and is responsible for most of the passive tension of myocardium. Because the titin spring is extended during diastolic stretch, it...
Choukroun, Gabriel J., Marshansky, Vladimir, Gustafson, Corinne E., McKee, Mary, Hajjar, Roger J., Rosenzweig, Anthony, ...
The Golgi complex and the trans-Golgi network are critical cellular organelles involved in the endocytic and biosynthetic pathways of protein trafficking. Lipids have been implicated in the...
Del Monte, Federica, Lebeche, Djamel, Guerrero, J. Luis, Tsuji, Tsuyoshi, Doye, Angelia A., Gwathmey, Judith K., ...
Abnormal intracellular Ca2+ cycling plays an important role in cardiac dysfunction and ventricular arrhythmias in the setting of heart failure and transient cardiac ischemia followed by reperfusion...
Targeting calcium cycling proteins in heart failure through gene transfer
Del Monte, Federica, Hajjar, Roger J
Our understanding of cardiac excitation-contraction coupling has improved significantly over the last 10 years. Furthermore, defects in the various steps of excitation-contraction coupling that...
Lim, Chee Chew, Yang, Haijun, Yang, Mingfeng, Wang, Chien-Kao, Shi, Jianru, Berg, Eric A., ...
Troponin C (TnC) belongs to the superfamily of EF-hand (helix–loop–helix) Ca2+-binding proteins and is an essential component of the regulatory thin filament complex. In a patient diagnosed with...