Lina Chen, George Davey Smith, Roger M. Harbord, Sarah J. Lewis
BackgroundAlcohol has been reported to be a common and modifiable risk factor for hypertension. However, observational studies are subject to confounding by other behavioural and sociodemographic...
Debbie A. Lawlor, Nicholas J. Timpson, Roger M. Harbord, Sam Leary, Andy Ness, Mark I. McCarthy, ...
BackgroundThe developmental overnutrition hypothesis suggests that greater maternal obesity during pregnancy results in increased offspring adiposity in later life. If true, this would result in the...
Bekkering, Geertruida E., Harris, Ross J., Thomas, Steve, Mayer, Anne-Marie B., Beynon, Rebecca, Ness, Andrew R., ...
Epidemiologic investigations often report dose-response associations, which may be combined in meta-analyses. The authors examined how often the log odds, risk, or hazard ratio per unit increase in...
A unification of models for meta-analysis of diagnostic accuracy studies (2007)
Harbord, Roger M., Deeks, Jonathan J., Egger, Matthias, Whiting, Penny, Sterne, Jonathan A. C.
Studies of diagnostic accuracy require more sophisticated methods for their meta-analysis than studies of therapeutic interventions. A number of different, and apparently divergent, methods for...
A unification of models for meta-analysis of diagnostic accuracy studies (2007)
Harbord, Roger M., Deeks, Jonathan J., Egger, Matthias, Whiting, Penny, Sterne, Jonathan A. C.
Studies of diagnostic accuracy require more sophisticated methods for their meta-analysis than studies of therapeutic interventions. A number of different, and apparently divergent, methods for...
Lewis, Sarah J., Harbord, Roger M., Harris, Ross, Smith, George Davey
Background: Evidence from case–control studies suggests that increasing dietary folate intake is associated with a reduced risk of breast cancer. However, large cohort studies have found no such...
A unification of models for meta-analysis of diagnostic accuracy studies (2006)
Harbord, Roger M., Deeks, Jonathan J., Egger, Matthias, Whiting, Penny, Sterne, Jonathan A.C.
Studies of diagnostic accuracy require more sophisticated methods for their meta-analysis than studies of therapeutic interventions. A number of different, and apparently divergent, methods for...
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study (2005)
Timpson, Nicholas J., Lawlor, Debbie A., Harbord, Roger M., Gaunt, Tom R., Day, Proflan N.M., Palmer, Lyle J., ...
BACKGROUND: Circulating C-reactive protein (CRP) is associated with the metabolic syndrome and might be causally linked to it. Our aim was to generate estimates of the association between plasma CRP...
Likelihood-based estimation of microsatellite mutation rates.
Whittaker, John C, Harbord, Roger M, Boxall, Nicola, Mackay, Ian, Dawson, Gary, Sibly, Richard M
Microsatellites are widely used in genetic analyses, many of which require reliable estimates of microsatellite mutation rates, yet the factors determining mutation rates are uncertain. The most...
Likelihood-based estimation of microsatellite mutation rates.
Whittaker, John C, Harbord, Roger M, Boxall, Nicola, Mackay, Ian, Dawson, Gary, Sibly, Richard M
Microsatellites are widely used in genetic analyses, many of which require reliable estimates of microsatellite mutation rates, yet the factors determining mutation rates are uncertain. The most...
Chen, Lina, Davey Smith, George, Harbord, Roger M, Lewis, Sarah J
Using a mendelian randomization approach Sarah Lewis and colleagues find strong support for the hypothesis that alcohol intake has a marked effect on blood pressure and the risk of hypertension.
Lawlor, Debbie A, Timpson, Nicholas J, Harbord, Roger M, Leary, Sam, Ness, Andy, McCarthy, Mark I, ...
Using parental-offspring associations and theFTO gene as an instrumental variable for maternal adiposity, Debbie Lawlor and colleagues found that greater maternal BMI during offspring development...
Funnel plots are a visual tool for investigating publication and other bias in meta-analysis. They are simple scatterplots of the treatment effects estimated from individual studies (horizontal axis)...
metan: fixed- and random-effects meta-analysis
Ross J. Harris, Michael J. Bradburn, Jonathan J. Deeks, Roger M. Harbord, Douglas G. Altman
This article describes updates of the meta-analysis command metan and options that have been added since the command’s original publication (Bradburn, Deeks, and Altman, metan - an alternative...
Lawlor, Debbie A., Harbord, Roger M., Timpson, Nic J., Lowe, Gordon D. O., Rumley, Ann, Gaunt, Tom R., ...
We present a revised version of the metareg command, which performs meta-analysis regression (meta-regression) on study-level summary data. The major revisions involve improvements to the estimation...