Anu Santhanagopal, Peter Chidiac, William C. Horne, Roland Baron, S. Jeffrey Dixon
Two isoforms of the calcitonin receptor are expressed in rabbit: the common C1a isoform and the calcitonin receptor �e13 isoform, which has a deletion in the seventh transmembrane domain. Using...
Essential role for ADAM19 in cardiovascular morphogenesis (2004)
Zhou,Hong-Ming, Weskamp,Gisela, Chesneau,Valérie, Sahin,Umut, Vortkamp,Andrea, Horiuchi,Keisuke, ...
Congenital heart disease is the most common form of human birth defects, yet much remains to be learned about its underlying causes. Here we report that mice lacking functional ADAM19 (mnemonic for a...
Essential role for ADAM19 in cardiovascular morphogenesis (2004)
Zhou, Hong-Ming, Weskamp, Gisela, Chesneau, Valérie, Sahin, Umut, Vortkamp, Andrea, Horiuchi, Keisuke, ...
Congenital heart disease is the most common form of human birth defects, yet much remains to be learned about its underlying causes. Here we report that mice lacking functional ADAM19 (mnemonic for a...
Theilhaber, Joachim, Connolly, Timothy, Roman-Roman, Sergio, Bushnell, Steven, Jackson, Amanda, Call, Kathy, ...
Spred is a Sprouty-related suppressor of Ras signalling (2001)
Toru Wakioka, Atsuo Sasaki, Reiko Kato, Takanori Shouda, Akira Matsumoto, Kanta Miyoshi, ...
Li, Yan Chun, Pirro, Alison E., Amling, Michael, Delling, Gunter, Baron, Roland, Bronson, Roderick, ...
Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR). The VDR is expressed in many tissues, including several tissues...
Dissociation between bone resorption and bone formation in osteopenic transgenic mice
Corral, David A., Amling, Michael, Priemel, Matthias, Loyer, Evelyn, Fuchs, Sebastien, Ducy, Patricia, ...
Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts....
Sims, Natalie A., Clément-Lacroix, Philippe, Minet, Dominique, Fraslon-Vanhulle, Caroline, Gaillard-Kelly, Martine, Resche-Rigon, Michèle, ...
Although the role of estradiol in maintaining bone mass is well established, the relative contributions of the estradiol receptors ERα and ERβ and of the androgen receptor (AR) remain...
Potential Role for ADAM15 in Pathological Neovascularization in Mice
Horiuchi, Keisuke, Weskamp, Gisela, Lum, Lawrence, Hammes, Hans-Peter, Cai, Hui, Brodie, Thomas A., ...
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of...
Akiyama, Toru, Bouillet, Phillippe, Miyazaki, Tsuyoshi, Kadono, Yuho, Chikuda, Hirotaka, Chung, Ung-il, ...
Osteoclasts (OCs) undergo rapid apoptosis without trophic factors, such as macrophage colony-stimulating factor (M-CSF). Their apoptosis was associated with a rapid and sustained increase in the...
Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5
Sims, Natalie A., Clément-Lacroix, Philippe, Da Ponte, Francesca, Bouali, Yasmina, Binart, Nadine, Moriggl, Richard, ...
Growth hormone (GH) regulates both bone growth and remodeling, but it is unclear whether these actions are mediated directly by the GH receptor (GHR) and/or IGF-I signaling. The actions of GH are...
Essential Role for ADAM19 in Cardiovascular Morphogenesis
Zhou, Hong-Ming, Weskamp, Gisela, Chesneau, Valérie, Sahin, Umut, Vortkamp, Andrea, Horiuchi, Keisuke, ...
Congenital heart disease is the most common form of human birth defects, yet much remains to be learned about its underlying causes. Here we report that mice lacking functional ADAM19 (mnemonic for a...
Tyrosine Phosphatase Epsilon Is a Positive Regulator of Osteoclast Function in Vitro and In Vivo
Chiusaroli, Riccardo, Knobler, Hilla, Luxenburg, Chen, Sanjay, Archana, Granot-Attas, Shira, Tiran, Zohar, ...
Protein tyrosine phosphorylation is a major regulator of bone metabolism. Tyrosine phosphatases participate in regulating phosphorylation, but roles of specific phosphatases in bone metabolism are...
Kveiborg, Marie, Sabatakos, George, Chiusaroli, Riccardo, Wu, Meilin, Philbrick, William M., Horne, William C., ...
Osteoblasts and adipocytes may develop from common bone marrow mesenchymal precursors. Transgenic mice overexpressing ΔFosB, an AP-1 transcription factor, under the control of the neuron-specific...
Lanske, Beate, Amling, Michael, Neff, Lynn, Guiducci, Jennifer, Baron, Roland, Kronenberg, Henry M.
Parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP) bind to and activate the same PTH/PTHrP receptor. Deletion of either the PTHrP gene or the PTH/PTHrP receptor gene leads to...
Bruzzaniti, Angela, Neff, Lynn, Sanjay, Archana, Horne, William C., De Camilli, Pietro, Baron, Roland
Podosomes are highly dynamic actin-containing adhesion structures found in osteoclasts, macrophages, and Rous sarcoma virus (RSV)-transformed fibroblasts. After integrin engagement, Pyk2 recruits Src...
Seck, Thomas, Pellegrini, Maria, Florea, Ana Maria, Grignoux, Veronique, Baron, Roland, Mierke, Dale F., ...
The CTRΔe13 splice variant of the rabbit calcitonin receptor, which lacks the 14 amino acids of the seventh transmembrane domain (TMD) that are encoded by exon 13, is poorly expressed on the cell...
Theilhaber, Joachim, Connolly, Timothy, Roman-Roman, Sergio, Bushnell, Steven, Jackson, Amanda, Call, Kathy, ...
A supervised classification scheme for analyzing microarray expression data, based on the k-nearest-neighbor method coupled to noise-reduction filters, has been used to find genes involved in the...
Clément-Lacroix, Philippe, Ai, Minrong, Morvan, Frederic, Roman-Roman, Sergio, Vayssière, Béatrice, Belleville, Cecille, ...
One of the well characterized cell biologic actions of lithium is the inhibition of glycogen synthase kinase-3β and the consequent activation of canonical Wnt signaling. Because deficient Wnt...
Aoki, Kazuhiro, Saito, Hiroaki, Itzstein, Cecile, Ishiguro, Masaji, Shibata, Tatsuya, Blanque, Roland, ...
Activating receptor activator of NF-κB (RANK) and TNF receptor (TNFR) promote osteoclast differentiation. A critical ligand contact site on the TNFR is partly conserved in RANK. Surface plasmon...
Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
Windahl, Sara H., Galien, René, Chiusaroli, Riccardo, Clément-Lacroix, Philippe, Morvan, Frederic, Lepescheux, Liên, ...
The use of estrogens and androgens to prevent bone loss is limited by their unwanted side effects, especially in reproductive organs and breast. Selective estrogen receptor modulators (SERMs)...
Li, Yan Chun, Pirro, Alison E., Amling, Michael, Delling, Gunter, Baron, Roland, Bronson, Roderick, ...
Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR). The VDR is expressed in many tissues, including several tissues...
Dissociation between bone resorption and bone formation in osteopenic transgenic mice
Corral, David A., Amling, Michael, Priemel, Matthias, Loyer, Evelyn, Fuchs, Sebastien, Ducy, Patricia, ...
Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts....
Sims, Natalie A., Clément-Lacroix, Philippe, Minet, Dominique, Fraslon-Vanhulle, Caroline, Gaillard-Kelly, Martine, Resche-Rigon, Michèle, ...
Although the role of estradiol in maintaining bone mass is well established, the relative contributions of the estradiol receptors ERα and ERβ and of the androgen receptor (AR) remain...
Theilhaber, Joachim, Connolly, Timothy, Roman-Roman, Sergio, Bushnell, Steven, Jackson, Amanda, Call, Kathy, ...
A supervised classification scheme for analyzing microarray expression data, based on the k-nearest-neighbor method coupled to noise-reduction filters, has been used to find genes involved in the...
Potential Role for ADAM15 in Pathological Neovascularization in Mice
Horiuchi, Keisuke, Weskamp, Gisela, Lum, Lawrence, Hammes, Hans-Peter, Cai, Hui, Brodie, Thomas A., ...
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of...
Akiyama, Toru, Bouillet, Phillippe, Miyazaki, Tsuyoshi, Kadono, Yuho, Chikuda, Hirotaka, Chung, Ung-il, ...
Osteoclasts (OCs) undergo rapid apoptosis without trophic factors, such as macrophage colony-stimulating factor (M-CSF). Their apoptosis was associated with a rapid and sustained increase in the...
Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5
Sims, Natalie A., Clément-Lacroix, Philippe, Da Ponte, Francesca, Bouali, Yasmina, Binart, Nadine, Moriggl, Richard, ...
Growth hormone (GH) regulates both bone growth and remodeling, but it is unclear whether these actions are mediated directly by the GH receptor (GHR) and/or IGF-I signaling. The actions of GH are...
Essential Role for ADAM19 in Cardiovascular Morphogenesis
Zhou, Hong-Ming, Weskamp, Gisela, Chesneau, Valérie, Sahin, Umut, Vortkamp, Andrea, Horiuchi, Keisuke, ...
Congenital heart disease is the most common form of human birth defects, yet much remains to be learned about its underlying causes. Here we report that mice lacking functional ADAM19 (mnemonic for a...
Tyrosine Phosphatase Epsilon Is a Positive Regulator of Osteoclast Function in Vitro and In Vivo
Chiusaroli, Riccardo, Knobler, Hilla, Luxenburg, Chen, Sanjay, Archana, Granot-Attas, Shira, Tiran, Zohar, ...
Protein tyrosine phosphorylation is a major regulator of bone metabolism. Tyrosine phosphatases participate in regulating phosphorylation, but roles of specific phosphatases in bone metabolism are...
Kveiborg, Marie, Sabatakos, George, Chiusaroli, Riccardo, Wu, Meilin, Philbrick, William M., Horne, William C., ...
Osteoblasts and adipocytes may develop from common bone marrow mesenchymal precursors. Transgenic mice overexpressing ΔFosB, an AP-1 transcription factor, under the control of the neuron-specific...
Lanske, Beate, Amling, Michael, Neff, Lynn, Guiducci, Jennifer, Baron, Roland, Kronenberg, Henry M.
Parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP) bind to and activate the same PTH/PTHrP receptor. Deletion of either the PTHrP gene or the PTH/PTHrP receptor gene leads to...
Bruzzaniti, Angela, Neff, Lynn, Sanjay, Archana, Horne, William C., De Camilli, Pietro, Baron, Roland
Podosomes are highly dynamic actin-containing adhesion structures found in osteoclasts, macrophages, and Rous sarcoma virus (RSV)-transformed fibroblasts. After integrin engagement, Pyk2 recruits Src...
Clément-Lacroix, Philippe, Ai, Minrong, Morvan, Frederic, Roman-Roman, Sergio, Vayssière, Béatrice, Belleville, Cecille, ...
One of the well characterized cell biologic actions of lithium is the inhibition of glycogen synthase kinase-3β and the consequent activation of canonical Wnt signaling. Because deficient Wnt...
Aoki, Kazuhiro, Saito, Hiroaki, Itzstein, Cecile, Ishiguro, Masaji, Shibata, Tatsuya, Blanque, Roland, ...
Activating receptor activator of NF-κB (RANK) and TNF receptor (TNFR) promote osteoclast differentiation. A critical ligand contact site on the TNFR is partly conserved in RANK. Surface plasmon...
Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
Windahl, Sara H., Galien, René, Chiusaroli, Riccardo, Clément-Lacroix, Philippe, Morvan, Frederic, Lepescheux, Liên, ...
The use of estrogens and androgens to prevent bone loss is limited by their unwanted side effects, especially in reproductive organs and breast. Selective estrogen receptor modulators (SERMs)...
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation
Koga, Fumitaka, Xu, Wanping, Karpova, Tatiana S., McNally, James G., Baron, Roland, Neckers, Len
Hsp90 plays an essential role in maintaining stability and activity of its clients, including oncogenic signaling proteins that regulate key signal transduction nodes. Hsp90 inhibitors interfere with...
Destaing, Olivier, Sanjay, Archana, Itzstein, Cecile, Horne, William C., Toomre, Derek, De Camilli, Pietro, ...
Podosomes are dynamic actin-rich structures composed of a dense F-actin core surrounded by a cloud of more diffuse F-actin. Src performs one or more unique functions in osteoclasts (OCLs), and...
Gil-Henn, Hava, Destaing, Olivier, Sims, Natalie A., Aoki, Kazuhiro, Alles, Neil, Neff, Lynn, ...
The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast...
Li, Lei, Hisamoto, Koji, Kim, Kyung Hee, Haynes, M. Page, Bauer, Philip M., Sanjay, Archana, ...
Little is known about the tyrosine kinase c-Src's function in the systemic circulation, in particular its role in arterial responses to hormonal stimuli. In human aortic and venous endothelial cells,...
Amling, Michael, Neff, Lynn, Tanaka, Sakae, Inoue, Daisuke, Kuida, Keisuke, Weir, Eleanor, ...
Parathyroid hormone–related peptide (PTHrP) appears to play a major role in skeletal development. Targeted disruption of the PTHrP gene in mice causes skeletal dysplasia with accelerated...
Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
Miyazaki, Tsuyoshi, Neff, Lynn, Tanaka, Sakae, Horne, William C., Baron, Roland
The function of the nonreceptor tyrosine kinase c-Src as a plasma membrane–associated molecular effector of a variety of extracellular stimuli is well known. Here, we show that c-Src is also...
A Functional Link between Dynamin and the Actin Cytoskeleton at Podosomes
Ochoa, Gian-Carlo, Slepnev, Vladimir I., Neff, Lynn, Ringstad, Niels, Takei, Kohji, Daniell, Laurie, ...
Cell transformation by Rous sarcoma virus results in a dramatic change of adhesion structures with the substratum. Adhesion plaques are replaced by dot-like attachment sites called podosomes....
Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation
Marzia, Marilena, Sims, Natalie A., Voit, Susanne, Migliaccio, Silvia, Taranta, Anna, Bernardini, Silvia, ...
c-src deletion in mice leads to osteopetrosis as a result of reduced bone resorption due to an alteration of the osteoclast. We report that deletion/reduction of Src expression enhances osteoblast...
Sanjay, Archana, Houghton, Adam, Neff, Lynn, DiDomenico, Emilia, Bardelay, Chantal, Antoine, Evelyne, ...
The signaling events downstream of integrins that regulate cell attachment and motility are only partially understood. Using osteoclasts and transfected 293 cells, we find that a molecular complex...
Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density▿ †
Ellwanger, Kristina, Saito, Hiroaki, Clément-Lacroix, Philippe, Maltry, Nicole, Niedermeyer, Joachim, Lee, Woon Kyu, ...
Kremen1 and Kremen2 (Krm1 and Krm2) are transmembrane coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/β-catenin signaling. The physiological relevance of Kremen proteins in mammals as Wnt...
Sabatakos, George, Rowe, Glenn C, Kveiborg, Marie, Wu, Meilin, Neff, Lynn, Chiusaroli, Riccardo, ...
Purev, Enkhtsetseg, Neff, Lynn, Horne, William C., Baron, Roland
c-Cbl and Cbl-b are highly conserved adaptor proteins that participate in integrin signaling, regulating cytoskeletal organization, motility, and bone resorption. Deletion of both c-Cbl and Cbl-b in...
Increased Energy Expenditure and Insulin Sensitivity in the High Bone Mass ΔFosB Transgenic Mice
Rowe, Glenn C., Choi, Cheol Soo, Neff, Lynn, Horne, William C., Shulman, Gerald I., Baron, Roland
Obesity and osteoporosis are major health issues affecting millions of individuals. Transgenic mice overexpressing ΔFosB, an activator protein-1 transcription factor, under the control of the...
Dynamin Reduces Pyk2 Y402 Phosphorylation and Src Binding in Osteoclasts ▿ †
Bruzzaniti, Angela, Neff, Lynn, Sandoval, Amanda, Du, Liping, Horne, William C., Baron, Roland
Signaling via the Pyk2-Src-Cbl complex downstream of integrins contributes to the assembly, organization, and dynamics of podosomes, which are the transient adhesion complexes of highly motile cells...