Umgelter, Andreas, Wagner, Katrin, Reindl, Wolfgang, Nurtsch, Nils, Huber, Wolfgang, Schmid, Roland M
Abstract Background Patients with advanced cirrhosis of the liver typically display circulatory disturbance. Haemodynamic management may be critical for avoiding and treating functional renal failure...
Apoptotic pathways in pancreatic ductal adenocarcinoma (2008)
Hamacher, Rainer, Schmid, Roland M, Saur, Dieter, Schneider, Günter
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer...
Umgelter, Andreas, Reindl, Wolfgang, Wagner, Katrin S, Franzen, Michael, Stock, Konrad, Schmid, Roland M, ...
Abstract Introduction Circulatory dysfunction in cirrhotic patients may cause a specific kind of functional renal failure termed hepato-renal syndrome (HRS). It contributes to the high incidence of...
Conditional ablation of Notch signaling in pancreatic development (2008)
Nakhai, Hassan, Siveke, Jens T, Klein, Bettina, Mendoza-Torres, Lidia, Mazur, Pawel K, Algul, Hana, ...
The role of the Notch signaling members Notch1, Notch2 and Rbpj in exocrine pancreatic development is not well defined. We therefore analyzed conditional pancreas-specific Rbpj and combined...
Geisler, Fabian, Nagl, Florian, Mazur, Pawel K., Lee, Marcel, Zimber-Strobl, Ursula, Strobl, Lothar J., ...
The Notch pathway is an evolutionary conserved, intercellular signaling pathway that plays an important role in cell fate specification and the embryonic development of many organs, including the...
Aichler, Michaela, Algül, Hana, Behne, Dietrich, Hölzlwimmer, Gabriele, Michalke, Bernhard, Quintanilla-Martinez, Leticia, ...
Genetic predisposition and environmental factors act in concert in the pathogenesis of multi-factorial diseases. Selenoproteins represent fundamental antioxidative systems for the maintenance of...
Is supra-ventricular arrhythmia a reason for the bad performance of the FlowTrac device? (2007)
Umgelter, Andreas, Reindl, Wolfgang, Schmid, Roland M, Huber, Wolfgang
No abstract available.
Von Delius, Stefan, Lersch, Christian, Schulte-Frohlinde, Ewert, Mayr, Martina, Schmid, Roland M, Eckel, Florian
Abstract Background Patients with advanced gallbladder and biliary tract carcinoma face a dismal prognosis, as no effective palliative chemotherapy exists. The antitumor effect of gemcitabine is...
Genetic alterations in pancreatic carcinoma (2003)
Schneider, Gunter, Schmid, Roland M
Abstract Cancer of the exocrine pancreas represents the fifth leading cause of cancer death in the Western population with an average survival after diagnosis of 3 to 6 months and a five-year...
Wagner, Martin, Greten, Florian R., Weber, Christoph K., Koschnick, Stefan, Mattfeldt, Torsten, Deppert, Wolfgang, ...
Reinigung, Klonierung und Charakterisierung des Transkriptionsfaktors NF-kB [NF-kappaB] / (1995)
Ulm, Univ., Habil.-Schr., 1995.
Liptay, Susanne, Schmid, Roland M., Perkins, Neil D., Meltzer, Paul S., Altherr, Michael R., McPherson, John D., ...
The chromosomal locations of the human genes NFKB1 and NFKB2, which encode two alternative DNA binding subunits of the NF-[kappa]B complex, p105 and p49/p100, respectively, have been determined. p105...
Strohscheer, I., Kleinert, R., Westphal, C., Schüller, J., Werner, K., Anders, O., ...
Peer Reviewed
Samuelson, Linda C., Wiebauer, Karin, Howard, Georgette, Schmid, Roland M., Koeplin, David, Meisler, Miriam H.
The mouse pancreatic ribonuclease gene Rib-1 was isolated from a library of mouse genomic DNA and sequenced. This small gene contains a nontranslated exon of 52 base pairs, an intron of 791 base...
p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1
Oswald, Franz, Täuber, Birgitt, Dobner, Thomas, Bourteele, Soizic, Kostezka, Ulrike, Adler, Guido, ...
Notch-1 belongs to a family of transmembrane receptor proteins that direct the decisions as to various cell fates. After ligand binding, a proteolytic cleavage step occurs and the intracellular part...
NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ
Oswald, Franz, Liptay, Susanne, Adler, Guido, Schmid, Roland M.
NF-κB2 (p100/p52), a member of the NF-κB/Rel family of transcription factors, is involved in the regulation of a variety of genes important for immune function. Previously, we have shown that the...
SHARP is a novel component of the Notch/RBP-Jκ signalling pathway
Oswald, Franz, Kostezka, Ulrike, Astrahantseff, Kathy, Bourteele, Soizic, Dillinger, Karin, Zechner, Ulrich, ...
Notch proteins are the receptors for an evolutionarily highly conserved signalling pathway that regulates numerous cell fate decisions during development. Signal transduction involves the...
Genetic alterations in pancreatic carcinoma
Schneider, Gunter, Schmid, Roland M
Cancer of the exocrine pancreas represents the fifth leading cause of cancer death in the Western population with an average survival after diagnosis of 3 to 6 months and a five-year survival rate...
Saur, Dieter, Vanderwinden, Jean-Marie, Seidler, Barbara, Schmid, Roland M., De Laet, Marc-Henri, Allescher, Hans-Dieter
Infantile hypertrophic pyloric stenosis (IHPS), characterized by enlarged pyloric musculature and gastric-outlet obstruction, is associated with altered expression of neuronal nitric oxide synthase...
Von Delius, Stefan, Lersch, Christian, Schulte-Frohlinde, Ewert, Mayr, Martina, Schmid, Roland M, Eckel, Florian
Wagner, Martin, Greten, Florian R., Weber, Christoph K., Koschnick, Stefan, Mattfeldt, Torsten, Deppert, Wolfgang, ...
This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-α. Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or...
p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1
Oswald, Franz, Täuber, Birgitt, Dobner, Thomas, Bourteele, Soizic, Kostezka, Ulrike, Adler, Guido, ...
Notch-1 belongs to a family of transmembrane receptor proteins that direct the decisions as to various cell fates. After ligand binding, a proteolytic cleavage step occurs and the intracellular part...
NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ
Oswald, Franz, Liptay, Susanne, Adler, Guido, Schmid, Roland M.
NF-κB2 (p100/p52), a member of the NF-κB/Rel family of transcription factors, is involved in the regulation of a variety of genes important for immune function. Previously, we have shown that the...
SHARP is a novel component of the Notch/RBP-Jκ signalling pathway
Oswald, Franz, Kostezka, Ulrike, Astrahantseff, Kathy, Bourteele, Soizic, Dillinger, Karin, Zechner, Ulrich, ...
Notch proteins are the receptors for an evolutionarily highly conserved signalling pathway that regulates numerous cell fate decisions during development. Signal transduction involves the...
Genetic alterations in pancreatic carcinoma
Schneider, Gunter, Schmid, Roland M
Cancer of the exocrine pancreas represents the fifth leading cause of cancer death in the Western population with an average survival after diagnosis of 3 to 6 months and a five-year survival rate...
Wagner, Martin, Greten, Florian R., Weber, Christoph K., Koschnick, Stefan, Mattfeldt, Torsten, Deppert, Wolfgang, ...
This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-α. Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or...
Saur, Dieter, Vanderwinden, Jean-Marie, Seidler, Barbara, Schmid, Roland M., De Laet, Marc-Henri, Allescher, Hans-Dieter
Infantile hypertrophic pyloric stenosis (IHPS), characterized by enlarged pyloric musculature and gastric-outlet obstruction, is associated with altered expression of neuronal nitric oxide synthase...
Von Delius, Stefan, Lersch, Christian, Schulte-Frohlinde, Ewert, Mayr, Martina, Schmid, Roland M, Eckel, Florian
Bauer, Anette, Villunger, Andreas, Labi, Verena, Fischer, Silke F., Strasser, Andreas, Wagner, Hermann, ...
Apoptosis of activated T cells is critical for the termination of immune responses. Here we show that adjuvant-stimulated dendritic cells secrete cytokines that prime activated T cells for survival...
Algül, Hana, Treiber, Matthias, Lesina, Marina, Nakhai, Hassan, Saur, Dieter, Geisler, Fabian, ...
Activation of the transcription factor NF-κB/Rel has been shown to be involved in inflammatory disease. Here we studied the role of RelA/p65, the main transactivating subunit, during acute...
IKKα controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression
Schneider, Günter, Saur, Dieter, Siveke, Jens T, Fritsch, Ralph, Greten, Florian R, Schmid, Roland M
The IκB-inducing kinase (IKK) is composed of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ. IKK-regulated signaling pathways are believed to promote the proliferation of...
Bourteele, Soizic, Oesterle, Katja, Weinzierl, Andreas O, Paxian, Stephan, Riemann, Marc, Schmid, Roland M, ...
Nuclear factor kappa B (NF-κB) is a key regulator of the immune response, but in almost the same manner it is involved in induction of inflammation, proliferation and regulation of apoptosis. In the...
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine
Liptay, Susanne, Bachem, Max, Häcker, Georg, Adler, Guido, Debatin, Klaus M, Schmid, Roland M
Chronic inflammatory diseases have been shown to be associated with NF-κB activation and impaired apoptosis of immune cells. The aim of the present study was to investigate if sulfasalazine and its...
Molecular mechanisms of sulfasalazine-induced T-cell apoptosis
Liptay, Susanne, Fulda, Simone, Schanbacher, Marta, Bourteele, Soizic, Ferri, Karine F, Kroemer, Guido, ...
Impaired apoptosis of T-lymphocytes is involved in the development of chronic inflammatory disorders. Previously we have shown that the anti-inflammatory drug sulfasalazine induces apoptosis in a...
Is supra-ventricular arrhythmia a reason for the bad performance of the FlowTrac device?
Umgelter, Andreas, Reindl, Wolfgang, Schmid, Roland M, Huber, Wolfgang
Umgelter, Andreas, Reindl, Wolfgang, Wagner, Katrin S, Franzen, Michael, Stock, Konrad, Schmid, Roland M, ...
Frequent Loss of TIMP-3 Expression in Progression of Esophageal and Gastric Adenocarcinomas1
Gu, Ping, Xing, Xiangbin, Tänzer, Marc, Röcken, Christoph, Weichert, Wilko, Ivanauskas, Audrius, ...
Tissue inhibitor of metalloproteinase 3 (TIMP-3) promoter methylation has been linked to loss of TIMP-3 expression in various cancers. In this study, we analyzed TIMP-3 gene methylation using...
Apoptotic pathways in pancreatic ductal adenocarcinoma
Hamacher, Rainer, Schmid, Roland M, Saur, Dieter, Schneider, Günter
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a...
Umgelter, Andreas, Wagner, Katrin, Reindl, Wolfgang, Nurtsch, Nils, Huber, Wolfgang, Schmid, Roland M
Seidler, Barbara, Schmidt, Annegret, Mayr, Ulrich, Nakhai, Hassan, Schmid, Roland M., Schneider, Günter, ...
Site- and time-specific somatic gene transfer by using the avian sarcoma-leukosis retrovirus RCAS (replication-competent avian sarcoma-leukosis virus long terminal repeat with splice acceptor) has...
Opposing functions of IKKβ during acute and chronic intestinal inflammation
Eckmann, Lars, Nebelsiek, Tim, Fingerle, Alexander A., Dann, Sara M., Mages, Jörg, Lang, Roland, ...
NF-κB is a key transcriptional regulator of inflammatory responses, but also controls expression of prosurvival genes, whose products protect tissues from damage and may thus act indirectly in an...
Weber, Andreas, Von Weyhern, Claus, Fend, Falko, Schneider, Jochen, Neu, Bruno, Meining, Alexander, ...
AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.
In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis
Weber, Andreas, Huber, Wolfgang, Kamereck, Klaus, Winkle, Philipp, Voland, Petra, Weidenbach, Hans, ...
AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis.
Diagnostic approaches for cholangiocarcinoma
Weber, Andreas, Schmid, Roland M, Prinz, Christian
Cholangiocarcinomas arise from the epithelial cells of the bile ducts and are associated with poor prognosis. Despite new diagnostic approaches, the definite diagnosis of this malignancy continues to...