Thye, Thorsten, Nejentsev, Sergey, Intemann, Christopher D., Browne, Edmund N., Chinbuah, Margaret Amanua, Gyapong, John, ...
Current endeavour focuses on human genetic factors that contribute to susceptibility to or protection from tuberculosis (TB). Monocytes are crucial in containing Mycobacterium tuberculosis infection,...
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis (2008)
Herb, Florian, Thye, Thorsten, Niemann, Stefan, Browne, Edmund N.L., Chinbuah, Margaret A., Gyapong, John, ...
The 5-lipoxygenase (ALOX5)-derived lipid mediators leukotrienes and lipoxins have regulatory functions in inflammation by modulating activities of immune cells and cytokine production. Recently, it...
Genome-Wide Linkage Analysis of Malaria Infection Intensity and Mild Disease (2007)
Christian Timmann, Jennifer A. Evans, Inke R. König, André Kleensang, Franz Rüschendorf, Julia Lenzen, ...
Although balancing selection with the sickle-cell trait and other red blood cell disorders has emphasized the interaction between malaria and human genetics, no systematic approach has so far been...
Marks, Florian, Meyer, Christian G., Sievertsen, Jürgen, Timmann, Christian, Evans, Jennifer, Horstmann, Rolf D., ...
Increasing resistance, recrudescences, and treatment failure have led to the replacement of chloroquine with the combination of pyrimethamine (PYR) and sulfadoxine (SDX) as the first-line...
Marks, Florian, Evans, Jennifer, Meyer, Christian G., Browne, Edmund N., Flessner, Christa, Von Kalckreuth, Vera, ...
Markers of Plasmodium falciparum resistance to chloroquine (CQ) and pyrimethamine-sulfadoxine (PYR-SDX) are widespread in areas where malaria is endemic. In an area where the use PYR-SDX is...
Marks, Florian, Meyer, Christian G., Sievertsen, Jürgen, Timmann, Christian, Evans, Jennifer, Horstmann, Rolf D., ...
Increasing resistance, recrudescences, and treatment failure have led to the replacement of chloroquine with the combination of pyrimethamine (PYR) and sulfadoxine (SDX) as the first-line...
Thye, Thorsten, Burchard, Gerd D., Nilius, Manfred, Müller-Myhsok, Bertram, Horstmann, Rolf D.
Helicobacter pylori is considered the most prevalent infectious agent among humans, and it causes gastric inflammation, gastroduodenal ulcers, and a risk of gastric cancer. We performed a genomewide...
Marks, Florian, Evans, Jennifer, Meyer, Christian G., Browne, Edmund N., Flessner, Christa, Von Kalckreuth, Vera, ...
Markers of Plasmodium falciparum resistance to chloroquine (CQ) and pyrimethamine-sulfadoxine (PYR-SDX) are widespread in areas where malaria is endemic. In an area where the use PYR-SDX is...
Genome-Wide Linkage Analysis of Malaria Infection Intensity and Mild Disease
Timmann, Christian, Evans, Jennifer A, König, Inke R, Kleensang, André, Rüschendorf, Franz, Lenzen, Julia, ...
Although balancing selection with the sickle-cell trait and other red blood cell disorders has emphasized the interaction between malaria and human genetics, no systematic approach has so far been...
IL10 Haplotype Associated with Tuberculin Skin Test Response but Not with Pulmonary TB
Thye, Thorsten, Browne, Edmund N., Chinbuah, Margaret A., Gyapong, John, Osei, Ivy, Owusu-Dabo, Ellis, ...
Evidence from genetic association and twin studies indicates that susceptibility to tuberculosis (TB) is under genetic control. One gene implicated in susceptibility to TB is that encoding...
Thye, Thorsten, Scarisbrick, Genevieve, Browne, Edmund N. L., Chinbuah, Margaret Amanua, Gyapong, John, Osei, Ivy, ...
The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has...
Intemann, Christopher D., Thye, Thorsten, Niemann, Stefan, Browne, Edmund N. L., Amanua Chinbuah, Margaret, Enimil, Anthony, ...
The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of disposing cytosolic cellular structures and of reducing the growth of...