Toyoda, Hiroki, Zhao, Ming-Gao, Ulzhöfer, Bettina, Wu, Long-Jun, Xu, Hui, Seeburg, Peter H, ...
Abstract Cortical areas including the anterior cingulate cortex (ACC) are important for pain and pleasure. Recent studies using genetic and physiological approaches have demonstrated that the...
Split-Cre complementation indicates coincident activity of different genes In Vivo (2009)
Hirrlinger, Johannes, Scheller, Anja, Hirrlinger, Petra G., Kellert, Beate, Tang, Wannan, Wehr, Michael C., ...
Sanderson, David J., Good, Mark A., Skelton, Kathryn, Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., ...
The GluA1 AMPA receptor subunit is a key mediator of hippocampal synaptic plasticity and is especially important for a rapidly-induced, short-lasting form of potentiation. GluA1 gene deletion impairs...
Of Spatiotemporal Discontiguity, Wolfram B. Schmitt, Roozbeh Arianpour, Peter H. Seeburg, Rolf Sprengel, ...
Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluR-A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild-type and sham-operated controls,...
Single−spike detection in vitro and in vivo with a genetic Ca2+ sensor (2008)
Haydon−Wallace, Damian J., Astori, Simone, Yang, Ying, Bausen, Melanie, Kügler, Sebastian, ...
Measurement of population activity with single−action−potential, single−neuron resolution is pivotal for understanding information representation and processing in the brain and how the...
Suitability of tamoxifen−induced mutagenesis for behavioral phenotyping (2008)
Vogt, M. A., Chourbaji, S., Brandwein, C., Dormann, C., Sprengel, Rolf, Gass, P.
Tamoxifen−induced mutagenesis via the so−called CreERT2 fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient...
Bockamp, Ernesto, Sprengel, Rolf, Eshkind, Leonid, Lehmann, Thomas, Braun, Jan M., Emmrich, Frank, ...
Many mouse models are currently available, providing avenues to elucidate gene function and to recapitulate specific pathological conditions. To a large extent, successful translation of clinical...
Glutamate mediates platelet activation through the AMPA receptor (2008)
Morrell, C. N., Sun, H., Ikeda, M., Beique, J. C., Swaim, A. M., Mason, E., ...
Glutamate is an excitatory neurotransmitter that binds to the kainate receptor, the N−methyl−D−aspartate (NMDA) receptor, and the...
Bannerman, David M., Niewoehner, Burkhard, Lyon, Louisa, Romberg, Carola, Schmitt, Wolfram B., Taylor, Amy, ...
NMDA receptors (NMDARs) containing NR2A ({varepsilon}1) subunits are key contributors to hippocampal long−term potentiation (LTP) induction in adult animals and have therefore been widely...
The role of the GluR−A (GluR1) AMPA receptor subunit in learning and memory (2008)
Sanderson, D. J., Good, M. A., Seeburg, Peter H., Sprengel, Rolf, Rawlins, J. N. P., Bannerman, D. M.
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certain kinds of learning and memory in the mammalian brain. The expression of long−term potentiation...
AMPA receptor subunit 1 (GluR−A) knockout mice model the glutamate hypothesis of depression (2008)
Chourbaji, S., Vogt, M. A., Fumagalli, F., Sohr, R., Frasca, A., Brandwein, C., ...
Recent evidence indicates that glutamate homeostasis and neurotransmission are altered in major depressive disorder, but the nature of the disruption and the mechanisms by which it contributes to the...
Developmental impact of a familial GABAA receptor epilepsy mutation (2008)
Chiu, Cindy, Reid, Christopher A., Heneu, O. Tan, Davies, Philip J., Single, Frank Nicolai, Koukoulas, Irene, ...
Epilepsy, with a lifetime prevalence rate of 3%, is a common and serious neurological disorder. It is characterized by recurrent paroxysms resulting from hypersynchronous discharges in the brain....
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking (2008)
Engblom, David, Bilbao, Ainhoa, Sanchis−Segura, Carles, Dahan, Lionel, Perreau−Lenz, Stéphanie, Balland, Bénédicte, ...
Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1−containing AMPA receptors. This cocaine−evoked plasticity depends on NMDA receptor...
Luo, Ceng, Seeburg, Peter H., Sprengel, Rolf, Kuner, Rohini
The second messenger calcium is a key mediator of activity−dependent neural plasticity. How persistent nociceptive activity alters calcium influx and release in the spinal cord is not...
Role of GluR1 in activity−dependent motor system development (2008)
Zhang, Lujia, Schessl, Joachim, Werner, Markus, Bonnemann, Carsten, Xiong, Guoxiang, Mojsilovic−Petrovic, Jelena, ...
Activity−dependent specification of neuronal architecture during early postnatal life is essential for refining the precision of communication between neurons. In the spinal cord under normal...
Single−spike detection in vitro and in vivo with a genetic Ca2+ sensor (2008)
Haydon−Wallace, Damian J., Astori, Simone, Yang, Ying, Bausen, Melanie, Kügler, Sebastian, ...
Measurement of population activity with single−action−potential, single−neuron resolution is pivotal for understanding information representation and processing in the brain and how the...
Single−spike detection in vitro and in vivo with a genetic Ca2+ sensor (2008)
Haydon−Wallace, Damian J., Astori, Simone, Yang, Ying, Bausen, Melanie, Kügler, Sebastian, ...
Measurement of population activity with single−action−potential, single−neuron resolution is pivotal for understanding information representation and processing in the brain and how the...
Silencing and un−silencing of tetracycline−controlled genes in neurons (2007)
Zhu, P. H., Aller, M. I., Baron, U., Cambridge, S., Bausen, Melanie, Herb, Jan, ...
Wiedholz, L. M., Owens, W. A., Horton, R. E., Feyder, M., Karlsson, R.−M., Hefner, K., ...
There is growing evidence implicating dysfunctional glutamatergic neurotransmission and abnormal interactions between the glutamate and dopamine (DA) systems in the pathophysiology of various...
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy (2007)
Tan, Heneu, Reid, Christopher, Single, Frank Nicolai, Davies, Philip, Chiu, Cindy, Murphy, Susan, ...
Mutations in the GABAA receptor {gamma}2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed...
Silencing and un−silencing of tetracycline−controlled genes in neurons (2007)
Zhu, P. H., Aller, M. I., Baron, U., Cambridge, S., Bausen, Melanie, Herb, Jan, ...
Wiedholz, L. M., Owens, W. A., Horton, R. E., Feyder, M., Karlsson, R.−M., Hefner, K., ...
There is growing evidence implicating dysfunctional glutamatergic neurotransmission and abnormal interactions between the glutamate and dopamine (DA) systems in the pathophysiology of various...
Remembering the subtle differences (2007)
Bannerman, David M., Sprengel, Rolf
A good taxi driver in a cosmopolitan city has to find an arbitrary destination from any starting point, efficiently and with high precision, relying on recollection of the city's layout and...
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy (2007)
Tan, Heneu, Reid, Christopher, Single, Frank Nicolai, Davies, Philip, Chiu, Cindy, Murphy, Susan, ...
Mutations in the GABAA receptor {gamma}2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed...
Humeau, Yann, Reisel, Daniel, Johnson, Alexander W., Borchardt, Thilo, Jensen, Vidar, Gebhardt, Christine, ...
The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR−A) contributes to amygdala−dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways...
Niewoehner, B., Single, Frank Nicolai, Hvalby, Ø., Jensen, V., Seeburg, Peter H., ...
Novel spatially restricted genetic manipulations can be used to assess contributions made by synaptic plasticity to learning and memory, not just selectively within the hippocampus, but even within...
Shimshek, Derya R., Jensen, Vidar, Celikel, Tansu, Geng, Yu, Schupp, Bettina, Bus, Thorsten, ...
We demonstrate the fundamental importance of glutamate receptor B (GluR−B) containing AMPA receptors in hippocampal function by analyzing mice with conditional GluR−B deficiency in postnatal...
Shimshek, Derya R., Jensen, Vidar, Celikel, Tansu, Geng, Yu, Schupp, Bettina, Bus, Thorsten, ...
We demonstrate the fundamental importance of glutamate receptor B (GluR−B) containing AMPA receptors in hippocampal function by analyzing mice with conditional GluR−B deficiency in postnatal...
Shimshek, Derya R., Bus, Thorsten, Grinevich, Valery, Single, Frank Nicolai, Mack, Volker, Sprengel, Rolf, ...
The roles of ionotropic glutamate receptors in mammalian reproduction are unknown. We therefore generated mice lacking a major subtype of...
Role of AMPA receptors in synaptic plasticity (2006)
The a (alpha−)−amino−3−hydroxy−5−methyl−4−isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous...
Yang, Ying, Marcello, Marco, Endris, Volker, Saffrich, Rainer, Fischer, Roger, Trendelenburg, Michael, ...
Over the past several years, it has become clear that the Rho family of GTPases plays an important role in various aspects of neuronal development including cytoskeleton dynamics and cell adhesion...
Bockamp, Ernesto, Antunes, Cecilia, Maringer, Marko, Heck, Rosario, Presser, Katrin, Beilke, Sven, ...
The stem cell leukemia gene SCL, also known as TAL−1, encodes a basic helix−loop−helix transcription factor expressed in erythroid, myeloid, megakaryocytic, and hematopoietic stem cells. To be...
Involvement of the AMPA receptor GluR−C subunit in alcohol−seeking behavior and relapse (2006)
Sanchis−Segura, Carles, Borchardt, Thilo, Vengeliene, Valentina, Zghoul, Tarek, Bachteler, Daniel, Gass, Peter, ...
Craving and relapse are core symptoms of drug addiction and alcoholism. It is suggested that, after chronic drug consumption, long−lasting neuroplastic changes within the glutamatergic system are...
Binshtok, Alexander, Fleidervish, Ilya, Sprengel, Rolf, Gutnick, Michael
In layer 4 of the somatosensory cortex, the glutamatergic synapses that interconnect spiny stellate (SpS) neurons, which are the major targets of thalamocortical input, differ from most other...
Derya R. Shimshek, Thorsten Bus, Jinhyun Kim, Andre Mihaljevic, Volker Mack, Peter H. Seeburg, ...
Genetic manipulation of AMPA receptors in mouse forebrain dissects specific contributions of AMPA receptor expression variation in piriform cortex and hippocampus to olfactory learning and memory,...
Derya R. Shimshek, Thorsten Bus, Jinhyun Kim, Andre Mihaljevic, Volker Mack, Peter H. Seeburg, ...
Genetic perturbations of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study,...
Shimshek, Derya R., Bus, Thorsten, Kim, Jinhyun, Mihaljevic, André, Mack, Volker, Seeburg, Peter H., ...
Genetic perturbations of á−amino−3−hydroxy−5−methyl−4−isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In...
Restoration of spatial working memory by genetic rescue of GluR−A−deficient mice (2005)
Schmitt, W., Sprengel, Rolf, Mack, Volker, Draft, Ryan, Seeburg, Peter H., Deacon, Robert M. J., ...
Gene−targeted mice lacking the AMPA receptor subunit GluR−A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3−CA1 long−term potentiation (LTP) and have...
Shimshek, Derya R., Bus, Thorsten, Kim, Jinhyun, Mihaljevic, André, Mack, Volker, Seeburg, Peter H., ...
Genetic perturbations of á−amino−3−hydroxy−5−methyl−4−isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In...
A genetic switch for epilepsy in adult mice (2004)
Krestel,Heinz Eric, Shimshek,Derya R., Jensen,Vidar, Nevian,Thomas, Kim,Jin−Hyun, Geng,Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
A genetic switch for epilepsy in adult mice (2004)
Krestel,Heinz Eric, Shimshek,Derya R., Jensen,Vidar, Nevian,Thomas, Kim,Jin−Hyun, Geng,Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
Hartmann,Bettina, Ahmadi,Seifollah, Heppenstall,Paul, Lewin,Gary, Schott,Claus, Borchardt,Thilo, ...
Ca2+−permeable AMPA receptors are densely expressed in the spinal dorsal horn, but their functional significance in pain processing is not understood. By disrupting the genes encoding GluR−A or...
Gass,Peter, Fleischmann,Alexander, Hvalby,Øivind, Jensen,Vidar, Zacher,Christiane, Strekalova,Tatyana, ...
The immediate early gene c−fos is part of the AP−1 transcription factor complex, which is involved in molecular mechanisms underlying learning and memory. Mice that lack c−Fos in the brain show...
Reduced aggression in AMPA−type glutamate receptor GluR−A subunit−deficient mice (2004)
Vekovischeva,Olga Y., Aitta−Aho,T., Echenko,O., Kankaanpaa,A., Seppala,T., Honkanen,A., ...
The importance of AMPA−type glutamate receptors has been demonstrated in neuronal plasticity and in adaptation to drugs of abuse. We studied the involvement of AMPA receptors in social interaction...
Aronoff,Rachel, Mellem,Jerry E., Maricq,Andres Villu, Sprengel,Rolf, Seeburg,Peter H.
Ionotropic glutamate receptors (iGluRs) in Caenorhabditis elegans are predicted to have high permeability for Ca2+ because of glutamine (Q) residues in the pore loop. This contrasts to the low Ca2+...
Schmitt,Wolfram B., Arianpour,Roozbeh, Deacon,Robert M. J., Seeburg,Peter H., Sprengel,Rolf, Rawlins,J. Nicholas P., ...
Gene−targeted mice lacking the AMPA receptor subunit glutamate receptor−A (GluR−A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild−type and sham−operated...
Bannerman,David M., Deacon,Robert M. J., Brady,S., Bruce,A., Sprengel,Rolf, Seeburg,Peter H., ...
Previous studies have demonstrated a spatial working memory deficit in glutamate receptor (GluR)−A (GluR1) AMPA receptor subunit knockout mice. The present study evaluated male and female...
Schmitt,Wolfram B., Deacon,Robert M. J., Reisel,D., Sprengel,Rolf, Seeburg,Peter H., Rawlins,J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
Schmitt,Wolfram B., Deacon,Robert M. J., Reisel,D., Sprengel,Rolf, Seeburg,Peter H., Rawlins,J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
Schmitt, Wolfram B., Deacon, Robert M. J., Reisel, D., Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
A genetic switch for epilepsy in adult mice (2004)
Krestel, Heinz Eric, Shimshek, Derya R., Jensen, Vidar, Nevian, Thomas, Kim, Jin−Hyun, Geng, Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
A genetic switch for epilepsy in adult mice (2004)
Krestel, Heinz Eric, Shimshek, Derya R., Jensen, Vidar, Nevian, Thomas, Kim, Jin−Hyun, Geng, Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
Bannerman, David M., Deacon, Robert M. J., Brady, S., Bruce, A., Sprengel, Rolf, Seeburg, Peter H., ...
Previous studies have demonstrated a spatial working memory deficit in glutamate receptor (GluR)−A (GluR1) AMPA receptor subunit knockout mice. The present study evaluated male and female...
Gass, Peter, Fleischmann, Alexander, Hvalby, Øivind, Jensen, Vidar, Zacher, Christiane, Strekalova, Tatyana, ...
The immediate early gene c−fos is part of the AP−1 transcription factor complex, which is involved in molecular mechanisms underlying learning and memory. Mice that lack c−Fos in the brain show...
Reduced aggression in AMPA−type glutamate receptor GluR−A subunit−deficient mice (2004)
Vekovischeva, Olga Y., Aitta−Aho, T., Echenko, O., Kankaanpaa, A., Seppala, T., Honkanen, A., ...
The importance of AMPA−type glutamate receptors has been demonstrated in neuronal plasticity and in adaptation to drugs of abuse. We studied the involvement of AMPA receptors in social interaction...
Hartmann, Bettina, Ahmadi, Seifollah, Heppenstall, Paul, Lewin, Gary, Schott, Claus, Borchardt, Thilo, ...
Ca2+−permeable AMPA receptors are densely expressed in the spinal dorsal horn, but their functional significance in pain processing is not understood. By disrupting the genes encoding GluR−A or...
Aronoff, Rachel, Mellem, Jerry E., Maricq, Andres Villu, Sprengel, Rolf, Seeburg, Peter H.
Ionotropic glutamate receptors (iGluRs) in Caenorhabditis elegans are predicted to have high permeability for Ca2+ because of glutamine (Q) residues in the pore loop. This contrasts to the low Ca2+...
Schmitt, Wolfram B., Arianpour, Roozbeh, Deacon, Robert M. J., Seeburg, Peter H., Sprengel, Rolf, Rawlins, J. Nicholas P., ...
Gene−targeted mice lacking the AMPA receptor subunit glutamate receptor−A (GluR−A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild−type and sham−operated...
Schmitt, Wolfram B., Deacon, Robert M. J., Reisel, D., Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
Jensen,Vidar, Kaiser,Katharina M. M., Borchardt,Thilo, Adelmann,Giselind, Rozov,Andrei, Burnashev,Nail, ...
In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)...
Köhr,Georg, Jensen,Vidar, Koester,Helmut J., Mihaljevic,Andre L. A., Utvik,Jo Kristian, Kvello,Ane, ...
NMDA receptors (NMDARs) are essential for modulating synaptic strength at central synapses. At hippocampal CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality...
Fleischmann,Alexander, Hvalby,Øyvind, Jensen,Vidar, Strekalova,Tatyana, Zacher,Christiane, Layer,Liliana, ...
Long-term learning and memory require long-lasting changes in the strength of specific synaptic connections between neurons (Martin et al., 2000; Kandel, 2001). These adaptive changes in synaptic...
Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice (2003)
Andrásfalvy,Bertalan K., Smith,Mark A., Borchardt,Thilo, Sprengel,Rolf, Magee,Jeffrey C.
Neurons of the central nervous system (CNS) exhibit a variety of forms of synaptic plasticity, including associative long-term potentiation and depression (LTP/D), homeostatic activity-dependent...
Sprengel, Rolf, Spanagel, Rainer, Kvello, Ane, Layer, Liliana, Zacher, Christiane, Strekalova, Tatyana, ...
The immediate early gene c-fos is part of the activator protein-1 transcription factor and has been postulated to participate in the molecular mechanisms of learning and memory. To test this...
Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice (2003)
Andrásfalvy, Bertalan K., Smith, Mark A., Borchardt, Thilo, Sprengel, Rolf, Magee, Jeffrey C.
Neurons of the central nervous system (CNS) exhibit a variety of forms of synaptic plasticity, including associative long-term potentiation and depression (LTP/D), homeostatic activity-dependent...
Fleischmann, Alexander, Hvalby, Øyvind, Jensen, Vidar, Strekalova, Tatyana, Zacher, Christiane, Layer, Liliana, ...
Long-term learning and memory require long-lasting changes in the strength of specific synaptic connections between neurons (Martin et al., 2000; Kandel, 2001). These adaptive changes in synaptic...
Jensen, Vidar, Kaiser, Katharina M. M., Borchardt, Thilo, Adelmann, Giselind, Rozov, Andrei, Burnashev, Nail, ...
In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)...
Köhr, Georg, Jensen, Vidar, Koester, Helmut J., Mihaljevic, Andre L. A., Utvik, Jo Kristian, Kvello, Ane, ...
NMDA receptors (NMDARs) are essential for modulating synaptic strength at central synapses. At hippocampal CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality...
ER-based double iCRE fusion protein allows partial recombination in forebrain (2002)
Casanova,James E., Fehsenfeld,Sandra, Lemberger,Thomas, Shimshek,Derya R., Sprengel,Rolf, Mantamadiotis,Theo
Here we describe the generation of a new tamoxifen-inducible double Cre fusion protein generated by fusing two ERT2 domains onto both ends of the iCre recombinase (a codon improved Cre recombinase)....
Anastassiadis,Konstantinos, Kim,Jin-Hyun, Daigle,Nathalie, Sprengel,Rolf, Schöler,Hans R., Stewart,A. Francis
Several strategies for regulated stable transgene expression in mammalian cells have been described. These strategies have different strengths and weaknesses, however they all share a common problem,...
Molecular dissection of hippocampal theta-burst pairing potentiation (2002)
Hoffman,Dax A., Sprengel,Rolf, Sakmann,Bert
Long-term potentiation (LTP) of synaptic efficacy in the hippocampus is frequently induced by tetanic stimulation of presynaptic afferents or by pairing low frequency stimulation with postsynaptic...
Codon-improved Cre recombinase (iCre) expression in the mouse (2002)
Shimshek,Derya R., Kim,Jin-Hyun, Hübner,Michael R., Spergel,Daniel J., Buchholz,Frank, Casanova,James E., ...
By applying the mammalian codon usage to Cre recombinase, we improved Cre expression, as determined by immunoblot and functional analysis, in three different mammalian cell lines. The improved Cre...
Mohrmann,Ralf, Köhr,Georg, Sprengel,Rolf, Hatt,Hanns, Gottmann,Kurt
Channel properties and synaptic targeting of N-methyl-D-aspartate (NMDA) receptors determine their importance in synaptic transmission, long-term synaptic plasticity, and developmental reorganization...
Anastassiadis, Konstantinos, Kim, Jin-Hyun, Daigle, Nathalie, Sprengel, Rolf, Schöler, Hans R., Stewart, A. Francis
Several strategies for regulated stable transgene expression in mammalian cells have been described. These strategies have different strengths and weaknesses, however they all share a common problem,...
ER-based double iCRE fusion protein allows partial recombination in forebrain (2002)
Casanova, James E., Fehsenfeld, Sandra, Lemberger, Thomas, Shimshek, Derya R., Sprengel, Rolf, Mantamadiotis, Theo
Here we describe the generation of a new tamoxifen-inducible double Cre fusion protein generated by fusing two ERT2 domains onto both ends of the iCre recombinase (a codon improved Cre recombinase)....
Molecular dissection of hippocampal theta-burst pairing potentiation (2002)
Hoffman, Dax A., Sprengel, Rolf, Sakmann, Bert
Long-term potentiation (LTP) of synaptic efficacy in the hippocampus is frequently induced by tetanic stimulation of presynaptic afferents or by pairing low frequency stimulation with postsynaptic...
Mohrmann, Ralf, Köhr, Georg, Sprengel, Rolf, Hatt, Hanns, Gottmann, Kurt
Channel properties and synaptic targeting of N-methyl-D-aspartate (NMDA) receptors determine their importance in synaptic transmission, long-term synaptic plasticity, and developmental reorganization...
Codon-improved Cre recombinase (iCre) expression in the mouse (2002)
Shimshek, Derya R., Kim, Jin-Hyun, Hübner, Michael R., Spergel, Daniel J., Buchholz, Frank, Casanova, James E., ...
By applying the mammalian codon usage to Cre recombinase, we improved Cre expression, as determined by immunoblot and functional analysis, in three different mammalian cell lines. The improved Cre...
Jerecic,Jasna, Schulze, Christian H., Seeburg,Peter H., Jonas,Peter, Sprengel,Rolf, Bischofsberger,Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Jerecic,Jasna, Schulze, Christian H., Seeburg,Peter H., Jonas,Peter, Sprengel,Rolf, Bischofsberger,Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Seeburg,Peter H., Single,Frank N., Kuner,Thomas, Higuchi,Miyoko, Sprengel,Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Seeburg,Peter H., Single,Frank N., Kuner,Thomas, Higuchi,Miyoko, Sprengel,Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack,Volker, Burnashev,Nail, Kaiser,Katharina M. M., Rozov,Andrej, Jensen,Vidar, Hvalby,Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack,Volker, Burnashev,Nail, Kaiser,Katharina M. M., Rozov,Andrej, Jensen,Vidar, Hvalby,Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Vekovischeva,Olga Y., Zamanillo,Daniel, Echenko,Oxana, Seppälä,Timo, Uusi-Oukari,Mikko, Honkanen,Aapo, ...
AMPA-type glutamate receptors have been suggested to be involved in the neurobiological mechanisms of drug addiction. We have made use of two mouse lines, which both have modulated AMPA receptor...
Spergel,Daniel J., Krüth,Ulrich, Shimshek,Derya R., Sprengel,Rolf, Seeburg,Peter H.
This review summarizes recent work on the use of reporter genes to label selected neuronal populations in transgenic mice, with particular emphasis on gonadotropin-releasing hormone (GnRH) neurons....
Krestel,Heinz Eric, Mayford,Mark, Seeburg,Peter H., Sprengel,Rolf
Doxycycline (Dox)-sensitive co-regulation of two transcriptionally coupled transgenes was investigated in the mouse. For this, we generated four independent mouse lines carrying coding regions for...
Glutamate receptor channel signatures (2001)
Sprengel,Rolf, Aronoff,Rachel, Völkner,Michaela, Schmitt,Bertram, Mosbach,Raphael, Kuner,Thomas
Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...
Glutamate receptor channel signatures (2001)
Sprengel,Rolf, Aronoff,Rachel, Völkner,Michaela, Schmitt,Bertram, Mosbach,Raphael, Kuner,Thomas
Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...
Jerecic, Jasna, Schulze, Christian H., Seeburg, Peter H., Jonas, Peter, Sprengel, Rolf, Bischofsberger, Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Krestel, Heinz Eric, Mayford, Mark, Seeburg, Peter H., Sprengel, Rolf
Doxycycline (Dox)-sensitive co-regulation of two transcriptionally coupled transgenes was investigated in the mouse. For this, we generated four independent mouse lines carrying coding regions for...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack, Volker, Burnashev, Nail, Kaiser, Katharina M. M., Rozov, Andrej, Jensen, Vidar, Hvalby, Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Seeburg, Peter H., Single, Frank N., Kuner, Thomas, Higuchi, Miyoko, Sprengel, Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Spergel, Daniel J., Krüth, Ulrich, Shimshek, Derya R., Sprengel, Rolf, Seeburg, Peter H.
This review summarizes recent work on the use of reporter genes to label selected neuronal populations in transgenic mice, with particular emphasis on gonadotropin-releasing hormone (GnRH) neurons....
Glutamate receptor channel signatures (2001)
Sprengel, Rolf, Aronoff, Rachel, Völkner, Michaela, Schmitt, Bertram, Mosbach, Raphael, Kuner, Thomas
Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...
Vekovischeva, Olga Y., Zamanillo, Daniel, Echenko, Oxana, Seppälä, Timo, Uusi-Oukari, Mikko, Honkanen, Aapo, ...
AMPA-type glutamate receptors have been suggested to be involved in the neurobiological mechanisms of drug addiction. We have made use of two mouse lines, which both have modulated AMPA receptor...
Jerecic, Jasna, Schulze, Christian H., Seeburg, Peter H., Jonas, Peter, Sprengel, Rolf, Bischofsberger, Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack, Volker, Burnashev, Nail, Kaiser, Katharina M. M., Rozov, Andrej, Jensen, Vidar, Hvalby, Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Seeburg, Peter H., Single, Frank N., Kuner, Thomas, Higuchi, Miyoko, Sprengel, Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Glutamate receptor channel signatures (2001)
Sprengel, Rolf, Aronoff, Rachel, Völkner, Michaela, Schmitt, Bertram, Mosbach, Raphael, Kuner, Thomas
Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...
Bond,Chris T., Sprengel,Rolf, Bissonnette,John M., Kaufmann,Walter A., Pribnow,David, Neelands,Torben, ...
In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel...
Higuchi,Miyoko, Maas,Stefan, Single,Frank N., Hartner,Jochen C., Rozov,Andrej, Burnashev,Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Higuchi,Miyoko, Maas,Stefan, Single,Frank N., Hartner,Jochen C., Rozov,Andrej, Burnashev,Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single,Frank N., Rozov,Andrej, Burnashev,Nail, Zimmermann,Frank, Hanley,Daniel F., Forrest,Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single,Frank N., Rozov,Andrej, Burnashev,Nail, Zimmermann,Frank, Hanley,Daniel F., Forrest,Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Bond, Chris T., Sprengel, Rolf, Bissonnette, John M., Kaufmann, Walter A., Pribnow, David, Neelands, Torben, ...
In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel...
Higuchi, Miyoko, Maas, Stefan, Single, Frank N., Hartner, Jochen C., Rozov, Andrej, Burnashev, Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Kask, Kalev, Jerecic, Jasna, Zamanillo, Daniel, Wilbertz, Johannes, Sprengel, Rolf, Seeburg, Peter H.
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single, Frank N., Rozov, Andrej, Burnashev, Nail, Zimmermann, Frank, Hanley, Daniel F., Forrest, Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Higuchi, Miyoko, Maas, Stefan, Single, Frank N., Hartner, Jochen C., Rozov, Andrej, Burnashev, Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Kask, Kalev, Jerecic, Jasna, Zamanillo, Daniel, Wilbertz, Johannes, Sprengel, Rolf, Seeburg, Peter H.
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single, Frank N., Rozov, Andrej, Burnashev, Nail, Zimmermann, Frank, Hanley, Daniel F., Forrest, Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Feldmeyer,Dirk, Kask,Kalev, Brusa,Rossella, Kornau,Hans Christian, Kolhekar,Rohini, Rozov,Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
GABA- and glutamate-activated channels in GFP-tagged GnRH neurons in transgenic mice (1999)
Spergel,Daniel J., Krüth,Ulrich, Hanley,Daniel F., Sprengel,Rolf, Seeburg,Peter H.
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1999)
Sprengel,Rolf, Higuchi,Miyoko, Monyer,Hannah, Seeburg,Peter H.
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo,Daniel, Sprengel,Rolf, Hvalby,Øivind, Jensen,Vidar, Burnashev,Nail, Rozov,Andrej, ...
Studies on conditional gene expression in the brain (1999)
Jerecic,Jasna, Single,Frank N., Krüth,Ulrich, Krestel,Heinz Eric, Kolhekar,Rohini, Storck,Thorsten, ...
Feldmeyer,Dirk, Kask,Kalev, Brusa,Rossella, Kornau,Hans Christian, Kolhekar,Rohini, Rozov,Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo,Daniel, Sprengel,Rolf, Hvalby,Øivind, Jensen,Vidar, Burnashev,Nail, Rozov,Andrej, ...
Feldmeyer, Dirk, Kask, Kalev, Brusa, Rossella, Kornau, Hans Christian, Kolhekar, Rohini, Rozov, Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
GABA- and glutamate-activated channels in GFP-tagged GnRH neurons in transgenic mice (1999)
Spergel, Daniel J., Krüth, Ulrich, Hanley, Daniel F., Sprengel, Rolf, Seeburg, Peter H.
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1999)
Sprengel, Rolf, Higuchi, Miyoko, Monyer, Hannah, Seeburg, Peter H.
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo, Daniel, Sprengel, Rolf, Hvalby, Øivind, Jensen, Vidar, Burnashev, Nail, Rozov, Andrej, ...
Studies on conditional gene expression in the brain (1999)
Jerecic, Jasna, Single, Frank N., Krüth, Ulrich, Krestel, Heinz Eric, Kolhekar, Rohini, Storck, Thorsten, ...
Feldmeyer, Dirk, Kask, Kalev, Brusa, Rossella, Kornau, Hans Christian, Kolhekar, Rohini, Rozov, Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo, Daniel, Sprengel, Rolf, Hvalby, Øivind, Jensen, Vidar, Burnashev, Nail, Rozov, Andrej, ...
Kask,Kalev, Zamanillo,Daniel, Rozov,Andrej, Burnashev,Nail, Sprengel,Rolf, Seeburg,Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Kask,Kalev, Zamanillo,Daniel, Rozov,Andrej, Burnashev,Nail, Sprengel,Rolf, Seeburg,Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel,Rolf, Suchanek,Bettina, Amico,Carla, Brusa,Rossella, Burnashev,Nail, Rozov,Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel,Rolf, Suchanek,Bettina, Amico,Carla, Brusa,Rossella, Burnashev,Nail, Rozov,Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Kask, Kalev, Zamanillo, Daniel, Rozov, Andrej, Burnashev, Nail, Sprengel, Rolf, Seeburg, Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel, Rolf, Suchanek, Bettina, Amico, Carla, Brusa, Rossella, Burnashev, Nail, Rozov, Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Kask, Kalev, Zamanillo, Daniel, Rozov, Andrej, Burnashev, Nail, Sprengel, Rolf, Seeburg, Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel, Rolf, Suchanek, Bettina, Amico, Carla, Brusa, Rossella, Burnashev, Nail, Rozov, Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1997)
Sprengel,Rolf, Higuchi,Miyoko, Monyer,Hannah, Seeburg,Peter H.
Glutamate receptor channels, RNA editing and epilepsy (1997)
Seeburg,Peter H., Brusa,Rossella, Higuchi,Miyoko, Sprengel,Rolf
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1997)
Sprengel, Rolf, Higuchi, Miyoko, Monyer, Hannah, Seeburg, Peter H.
Glutamate receptor channels, RNA editing and epilepsy (1997)
Seeburg, Peter H., Brusa, Rossella, Higuchi, Miyoko, Sprengel, Rolf
RED2, a brain specific member of the RNA specific adenosine deaminase family (1996)
Melcher,Thorsten, Maas,Stefan, Herb,Anne, Sprengel,Rolf, Higuchi,Miyoko, Seeburg,Peter H.
The mammalian RNA-specific adenosine deaminases DRADA/dsRAD (alias ADAR) and RED1 (alias ADARB1) have been implicated in the site-selective editing of brain-expressed pre-mRNAs for glutamate receptor...
Herb,Anne, Higuchi,Miyoko, Sprengel,Rolf, Seeburg,Peter H.
RNA editing by adenosine deamination in brain-expressed pre-mRNAs for glutamate receptor (GluR) subunits alters gene-specified codons for functionally critical positions, such as the channels Q/R...
A candidate enzyme for RNA editing at the Q/R site in GluR-B pre-mRNA (1996)
Melcher,Thorsten, Maas,Stefan, Herb,Anne, Sprengel,Rolf, Seeburg,Peter H., Higuchi,Miyoko
Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse (1996)
Storck,Thorsten, Storck,U., Kolhekar,Rohini, Sprengel,Rolf, Seeburg,Peter H.
Targeting vectors for embryonic stem (ES) cells typically contain a mouse gene segment of >7 kb with the neo gene inserted for positive selection of the targeting event. More complex targeting...
Herb, Anne, Higuchi, Miyoko, Sprengel, Rolf, Seeburg, Peter H.
RNA editing by adenosine deamination in brain-expressed pre-mRNAs for glutamate receptor (GluR) subunits alters gene-specified codons for functionally critical positions, such as the channels Q/R...
RED2, a brain specific member of the RNA specific adenosine deaminase family (1996)
Melcher, Thorsten, Maas, Stefan, Herb, Anne, Sprengel, Rolf, Higuchi, Miyoko, Seeburg, Peter H.
The mammalian RNA-specific adenosine deaminases DRADA/dsRAD (alias ADAR) and RED1 (alias ADARB1) have been implicated in the site-selective editing of brain-expressed pre-mRNAs for glutamate receptor...
A candidate enzyme for RNA editing at the Q/R site in GluR-B pre-mRNA (1996)
Melcher, Thorsten, Maas, Stefan, Herb, Anne, Sprengel, Rolf, Seeburg, Peter H., Higuchi, Miyoko
Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse (1996)
Storck, Thorsten, Storck, U., Kolhekar, Rohini, Sprengel, Rolf, Seeburg, Peter H.
Targeting vectors for embryonic stem (ES) cells typically contain a mouse gene segment of >7 kb with the neo gene inserted for positive selection of the targeting event. More complex targeting...
Brusa,Rossella, Zimmermann,Frank, Feldmeyer,Dirk, Gass,Peter, Seeburg,Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
Brusa,Rossella, Zimmermann,Frank, Feldmeyer,Dirk, Gass,Peter, Seeburg,Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
Gene Structure of the Murine N-MethylD-Aspartate Receptor Subunit NR2C (1995)
Suchanek,Bettina, Seeburg,Peter H., Sprengel,Rolf
The murine N-methyl D-aspartate receptor subunit NR2C (-3) is encoded by a unique gene composed of 12 translated and three 5`-untranslated exons that spread over 20 kilobases of genomic sequence....
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg,Peter H., Sprengel,Rolf, Monyer,Hannah, Higuchi,Miyoko, Kuner,Thomas, Köhr,Georg, ...
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg,Peter H., Sprengel,Rolf, Monyer,Hannah, Higuchi,Miyoko, Kuner,Thomas, Köhr,Georg, ...
Brusa, Rossella, Zimmermann, Frank, Feldmeyer, Dirk, Gass, Peter, Seeburg, Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
Gene Structure of the Murine N-MethylD-Aspartate Receptor Subunit NR2C (1995)
Suchanek, Bettina, Seeburg, Peter H., Sprengel, Rolf
The murine N-methyl D-aspartate receptor subunit NR2C (-3) is encoded by a unique gene composed of 12 translated and three 5`-untranslated exons that spread over 20 kilobases of genomic sequence....
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg, Peter H., Sprengel, Rolf, Monyer, Hannah, Higuchi, Miyoko, Kuner, Thomas, Köhr, Georg, ...
Brusa, Rossella, Zimmermann, Frank, Feldmeyer, Dirk, Gass, Peter, Seeburg, Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg, Peter H., Sprengel, Rolf, Monyer, Hannah, Higuchi, Miyoko, Kuner, Thomas, Köhr, Georg, ...
Molecular biology of glutamate receptors (1994)
Schoepfer,Ralf, Monyer,Hannah, Sommer,B., Wisden,William, Sprengel,Rolf, Kuner,Thomas, ...
Molecular biology of glutamate receptors (1994)
Schoepfer,Ralf, Monyer,Hannah, Sommer,B., Wisden,William, Sprengel,Rolf, Kuner,Thomas, ...
Molecular biology of NMDA receptors (1994)
Seeburg,Peter H., Monyer,Hannah, Sprengel,Rolf, Burnashev,Nail
Molecular biology of NMDA receptors (1994)
Seeburg,Peter H., Monyer,Hannah, Sprengel,Rolf, Burnashev,Nail
Molecular biology of glutamate receptors (1994)
Schoepfer, Ralf, Monyer, Hannah, Sommer, B., Wisden, William, Sprengel, Rolf, Kuner, Thomas, ...
Molecular biology of glutamate receptors (1994)
Schoepfer, Ralf, Monyer, Hannah, Sommer, B., Wisden, William, Sprengel, Rolf, Kuner, Thomas, ...
Molecular biology of NMDA receptors (1994)
Seeburg, Peter H., Monyer, Hannah, Sprengel, Rolf, Burnashev, Nail
Molecular biology of NMDA receptors (1994)
Seeburg, Peter H., Monyer, Hannah, Sprengel, Rolf, Burnashev, Nail
Higuchi,Miyoko, Single,Frank N., Köhler,Martin, Sommer,B., Sprengel,Rolf, Seeburg,Peter H.
A functionally critical position (Q/R site) of the AMPA receptor subunit GluR-B is controlled by RNA editing that operates in the nucleus, since in brain and clonal cell lines of neural origin,...
The unique properties of glutamate receptor channels (1993)
Sprengel,Rolf, Seeburg,Peter H.
Rapid excitatory neurotransmission in the central nervous system (CNS) is mediated predominantly by synaptically released -glutamate which activates cation selective channels with different kinetic...
The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family (1993)
Lomeli,H., Sprengel,Rolf, Laurie,David J., Köhr,Georg, Herb,Anne, Seeburg,Peter H., ...
We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25%...
Bach,A. W. J., Unger,L., Sprengel,Rolf, Mengod,G., Palacios,J., Seeburg,Peter H., ...
Using polymerase chain reaction (PCR) a complementary DNA (cDNA) encoding a 5-hydroxytryptamine (5-HT) receptor was isolated from rat forebrain. The amplified cDNA specifies an open reading frame of...
Bach, A. W. J., Unger, L., Sprengel, Rolf, Mengod, G., Palacios, J., Seeburg, Peter H., ...
Using polymerase chain reaction (PCR) a complementary DNA (cDNA) encoding a 5-hydroxytryptamine (5-HT) receptor was isolated from rat forebrain. The amplified cDNA specifies an open reading frame of...
Higuchi, Miyoko, Single, Frank N., Köhler, Martin, Sommer, B., Sprengel, Rolf, Seeburg, Peter H.
A functionally critical position (Q/R site) of the AMPA receptor subunit GluR-B is controlled by RNA editing that operates in the nucleus, since in brain and clonal cell lines of neural origin,...
The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family (1993)
Lomeli, H., Sprengel, Rolf, Laurie, David J., Köhr, Georg, Herb, Anne, Seeburg, Peter H., ...
We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25%...
The unique properties of glutamate receptor channels (1993)
Sprengel, Rolf, Seeburg, Peter H.
Rapid excitatory neurotransmission in the central nervous system (CNS) is mediated predominantly by synaptically released -glutamate which activates cation selective channels with different kinetic...
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer,Hannah, Sprengel,Rolf, Schoepfer,Ralf, Herb,Anne, Higuchi,Miyoko, Lomeli,H., ...
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer,Hannah, Sprengel,Rolf, Schoepfer,Ralf, Herb,Anne, Higuchi,Miyoko, Lomeli,H., ...
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer, Hannah, Sprengel, Rolf, Schoepfer, Ralf, Herb, Anne, Higuchi, Miyoko, Lomeli, H., ...
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer, Hannah, Sprengel, Rolf, Schoepfer, Ralf, Herb, Anne, Higuchi, Miyoko, Lomeli, H., ...
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels (1991)
Sommer, B., Köhler, Martin, Sprengel, Rolf, Seeburg, Peter H.
A cerebellar GABAA receptor selective for a behavioural alcohol antagonist (1990)
Lüddens,H., Pritchett,D. B., Köhler,Martin, Killisch,I., Keinänen,Kari, Monyer,Hannah, ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg,Peter H., Wisden,William, Verdoorn,Todd A., Pritchett,D. B., Werner,Pia, Herb,Anne, ...
Purification, cloning and expression of a peripheral-type benzodiazepine receptor (1990)
Krueger,K. E., Mukhin,A. G., Antkiewicz-Michaluk,L., Santi,M. R., Grayson,D. R., Guidotti,A., ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg,Peter H., Wisden,William, Verdoorn,Todd A., Pritchett,D. B., Werner,Pia, Herb,Anne, ...
A cerebellar GABAA receptor selective for a behavioural alcohol antagonist (1990)
Lüddens, H., Pritchett, D. B., Köhler, Martin, Killisch, I., Keinänen, Kari, Monyer, Hannah, ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg, Peter H., Wisden, William, Verdoorn, Todd A., Pritchett, D. B., Werner, Pia, Herb, Anne, ...
Purification, cloning and expression of a peripheral-type benzodiazepine receptor (1990)
Krueger, K. E., Mukhin, A. G., Antkiewicz-Michaluk, L., Santi, M. R., Grayson, D. R., Guidotti, A., ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg, Peter H., Wisden, William, Verdoorn, Todd A., Pritchett, D. B., Werner, Pia, Herb, Anne, ...
The lutropin receptor: An unusual member of the G protein-coupled receptor family (1989)
McFarland,K. C., Sprengel,Rolf, Phillips,H. S., Köhler,Martin, Rosenblit,N., Nikolics,K., ...
Two novel GABAA receptor subunits exist in distinct neuronal subpopulations (1989)
Shivers,B. D., Killisch,I., Sprengel,Rolf, Sontheimer,H., Köhler,Martin, Schofield,P. R., ...
Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor (1989)
Sprengel,Rolf, Werner,Pia, Seeburg,Peter H., Mukhin,A. G., Sonti,M. R., Grayson,D. R., ...
The lutropin receptor: An unusual member of the G protein-coupled receptor family (1989)
McFarland, K. C., Sprengel, Rolf, Phillips, H. S., Köhler, Martin, Rosenblit, N., Nikolics, K., ...
Two novel GABAA receptor subunits exist in distinct neuronal subpopulations (1989)
Shivers, B. D., Killisch, I., Sprengel, Rolf, Sontheimer, H., Köhler, Martin, Schofield, P. R., ...
Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor (1989)
Sprengel, Rolf, Werner, Pia, Seeburg, Peter H., Mukhin, A. G., Sonti, M. R., Grayson, D. R., ...
Translationally coupled initiation of protein synthesis in Bacillus subtilis (1985)
Sprengel, Rolf, Reiss, Bernd, Schaller, Heinz
The neomycin phosphotransferase gene (neo) from Transposon Tn5 is active in Gram-negative bacteria but silent in B.subtilis since it lacks an appropriate ribosome binding site for Gram-positive...
Besteht aus 2 Mikrofiches
Neugebauer, Kristina, Sprengel, Rolf, Schaller, Heinz
The gene for the penicillinase from B. licheniformis has been cloned in a functional state on a 1.5 kb DNA fragment and its nucleotide sequence has been determined. A sequence of 307 amino acid...
A juvenile form of hippocampal LTP in GluR-A-deficient mice
Jensen,Vidar, Kaiser,Katharina M. M., Borchardt,Thilo, Adelmann,G., Rozov,Andrej, Burnashev,Nail, ...
Impaired regulation of synaptic strength in hippocampal neurons from GluR-1-deficient mice
Andrásfalvy,B., Smith,M. A., Borchardt,Thilo, Sprengel,Rolf, Magee,Jeffrey C.
The intracellular domains of the NMDA receptor subtypes determine LTP induction
Köhr,Georg, Jensen,Vidar, Köster,Helmut J., Mihaljevic,A. L. A., Utvik,Jo Kristian, Kvello,Øyvind, ...
Homer binds TRPC family channels and is srequired for gating of TRPC1 by IP 3 receptors
Seeburg,Peter H., Dehoff,M. H., Schwarz,Martin K., Chen,J., Kang,S. H., Kiselyov,K., ...
The intracellular domains of the NMDA receptor subtypes determine LTP induction
Köhr,Georg, Jensen,Vidar, Köster,Helmut J., Mihaljevic,A. L. A., Utvik,Jo Kristian, Kvello,Øyvind, ...
A juvenile form of hippocampal LTP in GluR-A-deficient mice
Jensen,Vidar, Kaiser,Katharina M. M., Borchardt,Thilo, Adelmann,G., Rozov,Andrej, Burnashev,Nail, ...
Kask, Kalev, Zamanillo, Daniel, Rozov, Andrei, Burnashev, Nail, Sprengel, Rolf, Seeburg, Peter H.
Calcium permeability of l-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Shimshek, Derya R, Bus, Thorsten, Kim, Jinhyun, Mihaljevic, Andre, Mack, Volker, Seeburg, Peter H, ...
Genetic perturbations of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study,...
Kask, Kalev, Zamanillo, Daniel, Rozov, Andrei, Burnashev, Nail, Sprengel, Rolf, Seeburg, Peter H.
Calcium permeability of l-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Shimshek, Derya R, Bus, Thorsten, Kim, Jinhyun, Mihaljevic, Andre, Mack, Volker, Seeburg, Peter H, ...
Genetic perturbations of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study,...
A juvenile form of hippocampal LTP in GluR-A-deficient mice
Jensen, Vidar, Kaiser, Katharina M. M., Borchardt, Thilo, Adelmann, G., Rozov, Andrej, Burnashev, Nail, ...
Impaired regulation of synaptic strength in hippocampal neurons from GluR-1-deficient mice
Andrásfalvy, B., Smith, M. A., Borchardt, Thilo, Sprengel, Rolf, Magee, Jeffrey C.
The intracellular domains of the NMDA receptor subtypes determine LTP induction
Köhr, Georg, Jensen, Vidar, Köster, Helmut J., Mihaljevic, A. L. A., Utvik, Jo Kristian, Kvello, Øyvind, ...
An inducible genetic mouse model for epilepsy
Krestel, Heinz Eric, Nevian, Thomas, Shimshek, Derya R., Kim, Jin-Hyun, Bast, T., Rating, D., ...
Homer binds TRPC family channels and is srequired for gating of TRPC1 by IP 3 receptors
Seeburg, Peter H., Dehoff, M. H., Schwarz, Martin K., Chen, J., Kang, S. H., Kiselyov, K., ...
The intracellular domains of the NMDA receptor subtypes determine LTP induction
Köhr, Georg, Jensen, Vidar, Köster, Helmut J., Mihaljevic, A. L. A., Utvik, Jo Kristian, Kvello, Øyvind, ...
A juvenile form of hippocampal LTP in GluR-A-deficient mice
Jensen, Vidar, Kaiser, Katharina M. M., Borchardt, Thilo, Adelmann, G., Rozov, Andrej, Burnashev, Nail, ...
Silencing and Un-silencing of Tetracycline-Controlled Genes in Neurons
Zhu, Peixin, Aller, M. Isabel, Baron, Udo, Cambridge, Sidney, Bausen, Melanie, Herb, Jan, ...
To identify the underlying reason for the controversial performance of tetracycline (Tet)-controlled regulated gene expression in mammalian neurons, we investigated each of the three components that...
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy
Tan, Heneu O., Reid, Christopher A., Single, Frank N., Davies, Philip J., Chiu, Cindy, Murphy, Susan, ...
Mutations in the GABAA receptor γ2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed a...
Impaired Regulation of Synaptic Strength in Hippocampal Neurons from GluR1-Deficient Mice
Andrásfalvy, Bertalan K, Smith, Mark A, Borchardt, Thilo, Sprengel, Rolf, Magee, Jeffrey C
Neurons of the central nervous system (CNS) exhibit a variety of forms of synaptic plasticity, including associative long-term potentiation and depression (LTP/D), homeostatic activity-dependent...
Jensen, Vidar, Kaiser, Katharina M M, Borchardt, Thilo, Adelmann, Giselind, Rozov, Andrei, Burnashev, Nail, ...
In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires l-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)...
Glutamate mediates platelet activation through the AMPA receptor
Morrell, Craig N., Sun, Henry, Ikeda, Masahiro, Beique, Jean-Claude, Swaim, Anne Marie, Mason, Emily, ...
Glutamate is an excitatory neurotransmitter that binds to the kainate receptor, the N-methyl-D-aspartate (NMDA) receptor, and the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor...
Feyder, Michael, Wiedholz, Lisa, Sprengel, Rolf, Holmes, Andrew
There is compelling evidence that l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) glutamate receptors containing the GluR1 subunit contribute to the molecular mechanisms associated with...
Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo
Hirrlinger, Johannes, Scheller, Anja, Hirrlinger, Petra G., Kellert, Beate, Tang, Wannan, Wehr, Michael C., ...
Cre/LoxP recombination is the gold standard for conditional gene regulation in mice in vivo. However, promoters driving the expression of Cre recombinase are often active in a wide range of cell...
Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus
Romberg, Carola, Raffel, Joel, Martin, Lucy, Sprengel, Rolf, Seeburg, Peter H, Rawlins, J Nicholas P, ...
Long-term potentiation (LTP) at hippocampal CA3–CA1 synapses is thought to be mediated, at least in part, by an increase in the postsynaptic surface expression of...
Sanderson, David J., Good, Mark A., Skelton, Kathryn, Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., ...
The GluA1 AMPA receptor subunit is a key mediator of hippocampal synaptic plasticity and is especially important for a rapidly-induced, short-lasting form of potentiation. GluA1 gene deletion impairs...
Toyoda, Hiroki, Zhao, Ming-Gao, Ulzhöfer, Bettina, Wu, Long-Jun, Xu, Hui, Seeburg, Peter H, ...
Cortical areas including the anterior cingulate cortex (ACC) are important for pain and pleasure. Recent studies using genetic and physiological approaches have demonstrated that the investigation of...