Scientific Commons: Roman K. Thomas

Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools...

PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR (2009)

Sos, Martin L., Koker, Mirjam, Weir, Barbara A., Heynck, Stefanie, Rabinovsky, Rosalia, Zander, Thomas, ...

A flexible rank-based framework for detecting copy number aberrations from array data (2009)

LaFramboise, Thomas, Winckler, Wendy, Thomas, Roman K.

Motivation: DNA copy number aberration—both inherited and sporadic—is a significant contributor to a variety of human diseases. Copy number characterization is therefore an area of intense...

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 (2009)

Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., ...

High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications (2009)

Ocak, S., Sos, Martin L., Thomas, Roman K., Massion, P. P.

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer (2009)

Sos, Martin L., Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M., Koker, Mirjam, ...

Chemical genomics of RAD001 in non-small cell lung cancer (2009)

Seidel, Daniela, Ansen, Sascha, Thomas, Roman K., Wolf, Jürgen

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 (2009)

Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., ...

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer (2009)

Sos, Martin L., Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M., Koker, Mirjam, ...

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer (2009)

Sos, Martin L., Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M., Koker, Mirjam, ...

Standardized high-throughput evaluation of cell-based compound screens (2008)

Frommolt, Peter, Thomas, Roman K

Abstract Background High-throughput screening of pharmaceutical compound activity in tissue culture experiments requires time-consuming repeated analysis of the large amounts of data generated....

Somatic mutations affect key pathways in lung adenocarcinoma (2008)

Ding, Li, Getz, Gad, Wheeler, David A., Mardis, Elaine R., McLellan, Michael D., Cibulskis, Kristian, ...

Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well- classified primary tumours. Here we report the results of a collaborative...

2 Molecular Tumor Biology and Tumor (2008)

Primary Effusion, Lymphoma Cell Lines, Jeanette R. Doerr, Cindy S. Malone, Francesca M. Fike, Melinda S. Gordon, ...

*Corresponding authors 0022-2836/ $- see front matter q 2005 Published by Elsevier Ltd. Hodgkin and Reed–Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) and primary effusion lymphoma...

Genomic Approaches to Lung Cancer (2008)

Roman K. Thomas, Matthew Meyerson

Abstract The last decade has seen remarkable success in clinical targeting of activated oncogenes in cancer.We have applied gene expression profiling, high-density single-nucleotide polymorphism...

Modeling genomic diversity and tumor dependency in malignant melanoma (2008)

Lin, William M., Baker, Alissa C., Beroukhim, Rameen, Winckler, Wendy, Feng, Whei, Marmion, Jennifer M., ...

Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma (2008)

Marks, Jennifer L., Gong, Yixuan X., Chitale, Dhananjay, Golas, Ben, McLellan, Michael D., Kasai, Yumi, ...

Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway (2008)

Sos, Martin L., Zander, Thomas, Thomas, Roman K., Staratschek-Jox, Andrea, Claasen, Julia, Wolf, Jürgen

Somatic mutations affect key pathways in lung adenocarcinoma (2008)

Ding, Li, Getz, Gad, Wheeler, David A., Mardis, Elaine R., McLellan, Michael D., Cibulskis, Kristian, ...

Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance (2008)

Shimamura, Takeshi, Li, Danan, Ji, Hongbin, Haringsma, Henry J., Liniker, Elizabeth, Borgman, Christa L., ...

Early detection of erlotinib treatment response in NSCLC by 3'-Deoxy-3'-[18F]-fluoro-L-thymidine ([18F]FLT) positron emission tomography (PET) (2008)

Ullrich, Roland T., Zander, Thomas, Neumaier, Bernd, Koker, Mirjam, Shimamura, Takeshi, Waerzeggers, Yannic, ...

Early detection of erlotinib treatment response in NSCLC by 3'-Deoxy-3'-[18F]-fluoro-L-thymidine ([18F]FLT) positron emission tomography (PET) (2008)

Ullrich, Roland T., Zander, Thomas, Neumaier, Bernd, Koker, Mirjam, Shimamura, Takeshi, Waerzeggers, Yannic, ...

Early detection of erlotinib treatment response in NSCLC by 3'-Deoxy-3'-[18F]-fluoro-L-thymidine ([18F]FLT) positron emission tomography (PET) (2008)

Ullrich, Roland T., Zander, Thomas, Neumaier, Bernd, Koker, Mirjam, Shimamura, Takeshi, Waerzeggers, Yannic, ...

Early detection of erlotinib treatment response in NSCLC by 3'-Deoxy-3'-[18F]-fluoro-L-thymidine ([18F]FLT) positron emission tomography (PET) (2008)

Ullrich, Roland T., Zander, Thomas, Neumaier, Bernd, Koker, Mirjam, Shimamura, Takeshi, Waerzeggers, Yannic, ...

Standardized high-throughput evaluation of cell-based compound screens (2008)

Frommolt, Peter, Thomas, Roman K.

Standardized high-throughput evaluation of cell-based compound screens (2008)

Frommolt, Peter, Thomas, Roman K.

BioMed Central (2008)

Bmc Bioinformatics, Peter Frommolt, Roman K Thomas

Software Standardized high-throughput evaluation of cell-based compound screens

Characterizing the cancer genome in lung adenocarcinoma (2007)

Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...

Somatic alterations in cellular DNA underlie almost all human cancers(1). The prospect of targeted therapies(2) and the development of high-resolution, genome-wide approaches(3-8) are now spurring...

Corrigendum: High-throughput oncogene mutation profiling in human cancer. (2007)

Thomas, Roman K, Baker, Alissa C, Debiasi, Ralph M, Winckler, Wendy, Laframboise, Thomas, Lin, William M, ...

Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression1, 2. However, widespread clinical application of this information is hampered by an...

Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy (2007)

Li, Danan, Shimamura, Takeshi, Ji, Hong Bin, Chen, Liang, Haringsma, Henry J., McNamara, Kate, ...

The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ ERBB2 inhibitor HKI-272. (2007)

Minami, Y., Shimamura, T., Shah, Kinjal, Laframboise, Thomas, Glatt, Karen A., Liniker, E., ...

High-throughput oncogene mutation profiling in human cancer (2007)

Thomas, Roman K., Baker, Alissa C., Debiasi, Ralph M., Winckler, Wendy, Laframboise, Thomas, Lin, William M., ...

Translational lung cancer genomics (2007)

Thomas, Roman K., Meyerson, Matthew

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma (2007)

Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, ...

Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models (2007)

Ji, Hongbin, Wang, Zhenxiong, Perera, Samanthi A., Li, Danan, Liang, Mei-Chih, Zaghlul, Sara, ...

Efficient activation of autologous tumor-specific T cells: a simple coculture technique of autologous dendritic cells compared to established cell fusion strategies in primary human colorectal carcinoma (2007)

Draube, Andreas, Beyer, Marc, Schumer, Stephan, Thomas, Roman K., Von Tresckow, Bastian, Koslowsky, Thomas C., ...

Characterizing the cancer genome in lung adenocarcinoma (2007)

Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain. (2006)

Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...

BACKGROUND: Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain (2006)

Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...

Background Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain (2006)

Jeffrey C. Lee, Igor Vivanco, Rameen Beroukhim, Whei L. Feng, Ralph M. DeBiasi, ...

BackgroundProtein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...

Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272 (2006)

Shimamura, Takeshi, Ji, Hongbin, Minami, Yuko, Thomas, Roman K., Lowell, April M., Shah, Kinjal, ...

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing (2006)

Thomas, Roman K., Nickerson, Elizabeth, Simons, Jan F., Jänne, Pasi A., Tengs, Torstein, Yuza, Yuki, ...

EGFR activation in glioblastoma through novel missense mutations in the extracellular domain (2006)

Lee, Jeffrey C., Huang, Julie H.Y., Beroukhim, Rameen, Feng, Whei L., DeBiasi, R.M., King, J.C., ...

The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD (2006)

Schmitz, Roland, Thomas, Roman K., Harttrampf, Anne C., Wickenhauser, Claudia, Schultze, Joachim L., Hansmann, Martin-Leo, ...

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase Iinhibitors (2006)

Ji, Hongbin, Zhao, Xiaojun, Yuza, Yuki, Shimamura, Takeshi, Li, Danan, Protopopov, Alexei, ...

Genomic approaches to lung cancer (2006)

Thomas, Roman K., Weir, Barbara A., Meyerson, Matthew

A transforming MET mutation discovered in non-small cell lung cancer using microarray-based resequencing (2006)

Tengs, Torstein, Lee, Jeff C., Paez, J. Guillermo, Zhao, Xiaojun, LaFramboise, Thomas, Giannoukos, Georgia, ...

Inhibition of nuclear translocation of nuclear factor-kappa B despite lack of functional I kappa B alpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies (2005)

Thomas, Roman K., Sos, Martin L., Zander, Thomas, Mani, O., Popov, A., Berenbrinker, D., ...

Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors (2005)

Thomas, Roman K., Greulich, Heidi, Yuza, Yuki, Lee, Jeff C., Tengs, Torstein, Feng, Wei, ...

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

Ji, Hongbin, Zhao, Xiaojun, Yuza, Yuki, Shimamura, Takeshi, Li, Danan, Protopopov, Alexei, ...

The tyrosine kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva) have shown anti-tumor activity in the treatment of non-small cell lung cancer (NSCLC). Dramatic and durable responses have...

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

Ji, Hongbin, Zhao, Xiaojun, Yuza, Yuki, Shimamura, Takeshi, Li, Danan, Protopopov, Alexei, ...

The tyrosine kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva) have shown anti-tumor activity in the treatment of non-small cell lung cancer (NSCLC). Dramatic and durable responses have...

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain

Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H. Y, Feng, Whei L, DeBiasi, Ralph M, ...

Ingo Mellinghoff and colleagues sequenced theEGFR gene in glioblastoma samples and cell lines and identified missense mutations in the extracellular domain that suggest a new mechanism for EGFR...

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, ...

Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze cancer genomes...

Early Detection of Erlotinib Treatment Response in NSCLC by 3′-Deoxy-3′-[18F]-Fluoro-L-Thymidine ([18F]FLT) Positron Emission Tomography (PET)

Ullrich, Roland T., Zander, Thomas, Neumaier, Bernd, Koker, Mirjam, Shimamura, Takeshi, Waerzeggers, Yannic, ...

Standardized high-throughput evaluation of cell-based compound screens

Frommolt, Peter, Thomas, Roman K

Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

Sos, Martin L., Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, ...

Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools...

High Expression Levels of Total IGF-1R and Sensitivity of NSCLC Cells In Vitro to an Anti-IGF-1R Antibody (R1507)

Gong, Yixuan, Yao, Evelyn, Shen, Ronglai, Goel, Aviva, Arcila, Maria, Teruya-Feldstein, Julie, ...

Systematically linking drug susceptibility to cancer genome aberrations

Sos, Martin L., Thomas, Roman K.

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

Sos, Martin L., Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M., Koker, Mirjam, ...

In cancer, genetically activated proto-oncogenes often induce “upstream” dependency on the activity of the mutant oncoprotein. Therapeutic inhibition of these activated oncoproteins can induce...

Roman K. Thomas

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