Woditschka, Stephan, Haag, Jill D, Mau, Bob, Lubet, Ronald A, Gould, Michael N
Abstract Introduction While current breast cancer chemoprevention strategies using selective estrogen response modulators and aromatase inhibitors are quite successful, their effects are limited to...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Horn, Thomas L., Torres, Karen E. O., Naylor, Jennifer M., Cwik, Michael J., Detrisac, Carol J., Kapetanovic, Izet M., ...
Tamoxifen (TAM) is a nonsteroidal antiestrogen that prevents estrogen receptor–positive breast cancer in rodents and humans. Bexarotene (BEX), a selective agonist for retinoid X receptors, inhibits...
Modulation by budesonide of a CpG endonuclease in mouse lung tumors (2007)
Li, Long, Tao, Lianhui, Lubet, Ronald A., Steele, Vernon E., Pereira, Michael A.
CpG endonuclease activity was identified in nuclear extracts obtained from mouse lung tumors. Enzyme activity was determined using a 333 bp polymerase chain reaction product of the estrogen...
McCormick, David L., Johnson, William D., Kozub, Nicole M., Rao, K.V.N., Lubet, Ronald A., Steele, Vernon E., ...
Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or combinations of them were evaluated for prevention of lung tumors and for...
Modulation by Budesonide of a CpG Endonuclease in Mouse Lung Tumors (2007)
Li, Long, Tao, Lianhui, Lubet, Ronald A., Steele, Vernon E., Pereira, Michael A.
CpG endonuclease activity was identified in nuclear extracts obtained from mouse lung tumors. Enzyme activity was determined using a 333bp PCR-Product of the estrogen receptor-α gene that contained...
Grubbs, Clinton J., Lubet, Ronald A., Atigadda, Venkatram R., Christov, Konstantin, Deshpande, Anil M., Tirmal, Vivek, ...
A number of retinoid X receptor (RXR) agonists have proven to be highly effective in preventing methylnitrosourea (MNU) induced mammary cancers. However, these agonists have side effects;...
Yao, Ruisheng, Wang, Yian, Lu, Yan, Lemon, William J., End, David W., Grubbs, Clinton J., ...
Rats treated with the alkylating agent methylnitrosourea (MNU) develop multiple, hormonally dependent mammary tumors. Roughly 50% of the tumors have Ha-ras mutation, whereas 50% do not. The...
Yao, Ruisheng, Wang, Yian, Lu, Yan, Lemon, William J., End, David W., Grubbs, Clinton J., ...
Rats treated with the alkylating agent MNU develop multiple hormonally dependent tumors. Roughly 50% of the tumors have Ha-ras mutation while 50% do not. The MNU induced rat mammary tumor model was...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib), or combinations of them were evaluated for prevention of lung tumors and for...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib), or combinations of them were evaluated for prevention of lung tumors and for...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib), or combinations of them were evaluated for prevention of lung tumors and for...
McCormick, David L., Johnson, William D., Kozub, Nicole M., Rao, K. V. N., Lubet, Ronald A., Steele, Vernon E., ...
Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or combinations of them were evaluated for prevention of lung tumors and for...
Lubet, Ronald A., Huebner, Kay, Fong, Louise Y.Y., Altieri, Dario C., Steele, Vernon E., Kopelovich, Levy, ...
The administration of 4-hydroxybutyl(butyl)nitrosamine (OH-BBN) to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers. Since prior studies demonstrated...
Lubet, Ronald A., Christov, Konstantin, Nunez, Nomeli P., Hursting, Steven D., Steele, Vernon E., Juliana, M.Margaret, ...
Various aspects of the chemopreventive and chemotherapeutic properties of the RXR receptor agonist Targretin (LGD 1069) were examined in the methylnitrosourea (MNU)-induced model of mammary cancer....
Crist, Keith A., Zhang, Zhongqiu, You, Ming, Gunning, William T., Conran, Phillip B., Steele, Vernon E., ...
Human ovarian cancer is predominantly of epithelial cell origin (>90% of malignant tumors) and most often presents at advanced stage with poor prognosis. Most animal models of ovarian carcinoma yield...
Grubbs, Clinton J., Lubet, Ronald A., Atigadda, Venkatram R., Christov, Konstantin, Deshpande, Anil M., Tirmal, Vivek, ...
A number of retinoid X receptor (RXR) agonists have proven to be highly effective in preventing methylnitrosourea (MNU) induced mammary cancers. However, these agonists have side effects;...
Crist, Keith A., Zhang, Zhongqiu, You, Ming, Gunning, William T., Conran, Phillip B., Steele, Vernon E., ...
Human ovarian cancer is predominantly of epithelial cell origin (>90% of malignant tumors) and most often presents at an advanced stage with poor prognosis. Most animal models of ovarian carcinoma...
Pereira, Michael A., Tao, Lianhui, Wang, Wei, Li, Yingzhe, Umar, Asad, Steele, Vernon E., ...
The ability of celecoxib and α-difluoromethylornithine (DFMO) to modulate the DNA hypomethylation and the hypermethylation of the estrogen receptor (ER)-α gene in colon tumors was evaluated as...
Pereira, Michael A., Tao, Lianhui, Wang, Wei, Li, Yingzhe, Umar, Asad, Steele, Vernon E., ...
The ability of celecoxib and α-difluoromethylornithine (DFMO) to modulate the DNA hypomethylation and the hypermethylation of the estrogen receptor-α gene in colon tumors was evaluated as potential...
Lubet, Ronald A., Christov, Konstantin, Nunez, Naomoli, Hursting, Stephen D., Steele, Vernon E., Juliana, M. Margaret, ...
Various aspects of the chemopreventive and chemotherapeutic properties of the RXR receptor agonist targretin (LCD 1069) were examined in the methylnitrosourea (MNU)-induced model of mammary cancer....
Lubet, Ronald A., Huebner, Kay, Fong, Louise Y. Y., Altieri, Dario C., Steele, Vernon E., Kopelovich, Levy, ...
The administration of OH-BBN to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers that were characterized for expression of certain cancer related genes (FHIT,...
Fischer, Susan M., Conti, Claudio J., Lubet, Ronald A., Aldaz, C. Marcelo, Viner, Jaye
The cyclooxygenase-2 (COX-2) inhibitor celecoxib and the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) were each previously shown to prevent skin tumor development when...
Balansky, Roumen M., Izzotti, Alberto, D'Agostini, Francesco, Camoirano, Anna, Bagnasco, Maria, Lubet, Ronald A., ...
No information is available on the interaction between cigarette smoke, the most important man-made carcinogen, and light, the most widespread natural carcinogen. In order to clarify this issue,...
Fischer, Susan M., Conti, Claudio J., Viner, Jaye, Aldaz, C.Marcelo, Lubet, Ronald A.
The cyclooxygenase-2 (COX-2) inhibitor celecoxib and the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) were each previously shown to prevent skin tumor development when...
Balansky, Roumen M., Izzotti, Alberto, D'Agostini, Francesco, Camoirano, Anna, Bagnasco, Maria, Lubet, Ronald A., ...
No information is available on the interaction between cigarette smoke, the most important man-made carcinogen, and light, the most widespread natural carcinogen. In order to clarify this issue,...
Fischer, Susan M., Conti, Claudio J., Lubet, Ronald A., Aldaz, C. Marcelo, Viner, Jaye
The cyclooxygenase-2 (COX-2) inhibitor celecoxib and the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) were each previously shown to prevent skin tumor development when...
Balansky, Roumen M., Izzotti, Alberto, D'Agostini, Francesco, Camoirano, Anna, Bagnasco, Maria, Lubet, Ronald A., ...
No information is available on the interaction between cigarette smoke, the most important man-made carcinogen, and light, the most widespread natural carcinogen. In order to clarify this issue,...
Tao, Lianhui, Kramer, Paula M., Wang, Wei, Yang, Siming, Lubet, Ronald A., Steele, Vernon E., ...
Modulation of gene expression in tumors has the potential of being a surrogate end-point biomarker for chemoprevention. Thus, we determined the modulation by chemopreventive agents of the protein and...
Prevention of mouse lung tumors by budesonide and its modulation of biomarkers (2002)
Pereira, Michael A., Li, Yingzhe, Gunning, William T., Kramer, Paula M., Al-Yaqoub, Fadel, Lubet, Ronald A., ...
Chemopreventive drugs have the potential to decrease the morbidity and mortality of lung cancer. The development of these drugs could be expedited by the application of surrogate end-point biomarkers...
Fischer, Susan M., Lee, Marilyn, Lubet, Ronald A.
Targeting specific events associated with tumor development represents a rational approach to chemoprevention as well as therapeutic intervention. In this study the ability of difluoromethylornithine...
D'Agostini, Francesco, Balansky, Roumen M., Izzotti, Alberto, Lubet, Ronald A., Kelloff, Gary J., De Flora, Silvio
Preclinical studies may elucidate the meaning of biomarkers applicable to epidemiologic studies and to clinical trials for cancer prevention. No study has explored so far the effect of cigarette...
Zujewski, JoAnne, Vaughn-Cooke, Anika, Flanders, Kathleen C, Eckhaus, Michael A, Lubet, Ronald A, Wakefield, Lalage M
Abstract Using a carcinogen-initiated rat model of mammary tumorigenesis, we tested the hypothesis that transforming growth factor (TGF)-βs are useful biomarkers of chemopreventive efficacy in the...
Lantry, Laura E., Zhang, Zhongqiu, Yao, Rusheng, Crist, Keith A., Wang, Yian, Ohkanda, Junko, ...
The Ras protein undergoes a series of post-translational modifications at the C-terminal CAAX motif, which culminates with the anchoring of p21 Ras to the plasma membrane where it relays growth...
Li, Hong, Schut, Herman A.J., Conran, Philip, Kramer, Paula M., Lubet, Ronald A., Steele, Vernon E., ...
The dose–response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF)...
Shao, Jinyi, Sheng, Hongmiao, Aramandla, Radhika, Pereira, Michael A., Lubet, Ronald A., Hawk, Ernest, ...
Evidence is accumulating which indicates that cyclooxygenase-2 (COX-2) is involved in the pathogenesis of colorectal cancer. We evaluated the expression of COX-2 in replication error-positive (RER)...
Zheng, Ye, Kramer, Paula M., Lubet, Ronald A., Steele, Vernon E., Kelloff, Gary J., Pereira, Michael A.
We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with...
Lantry, Laura E., Zhang, Zhongqiu, Crist, Keith A., Wang, Yian, Kelloff, Gary J., Lubet, Ronald A., ...
Carcinogenesis is a multistep process in which many alterations in both genetic and epigenetic controls lead to a growth advantage for neoplastic cells. Hypermethylation has been established as the...
Rodríguez-Burford, Cristina, Lubet, Ronald A., Eto, Isao, Juliana, M. Margaret, Kelloff, Gary J., Grubbs, Clinton J., ...
These studies examined whether the small to moderate reductions in body weight gain (⩽15%) affect mammary carcinogenesis. Beginning 1 week prior to methylnitrosourea (MNU) administration...
Izzotti, Alberto, Bagnasco, Maria, D'Agostini, Francesco, Cartiglia, Cristina, Lubet, Ronald A., Kelloff, Gary J, ...
The assessment of pathological effects produced by environmental tobacco smoke in humans is controversial in epidemiological studies. On the other hand, animal models are poorly sensitive to smoke...
Pereira, Michael A., Barnes, Leta H., Steele, Vernon E., Kelloff, Gary V., Lubet, Ronald A.
Piroxicam has been shown to prevent azoxymethane (AOM)-induced aberrant crypt foci and colon cancer in rats. In this communication we evaluate whether piroxicam can also cause regression of...
Pereira, Michael A., Grubbs, Clinton J., Barnes, Leta H., Li, Hong, Olson, Greg R., Eto, Isao, ...
Curcumin and quercetin were evaluated in rats for their ability to modulate the carcinogenic activity of azoxy-methane (AOM) in the colon and 7, 12-dimethyl-benz[a]anthracene (DMBA) in the mammary...
Matzinger, Steven A., Crist, Keith A., Stoner, Gary D., Anderson, Marshall W., Pereira, Michael A., Steele, Vernon E., ...
The purpose of this study was to evaluate the effects of the loss of a p53 allele and phenethyl isothiocyanate (PEITC) pre-treatment on the tumorigenicity of...
Ice, Jerry M., Diwan, Bhalchandra A., Hu, Henry, Ward, Jerrold M., Nims, Raymond W., Lubet, Ronald A.
To test predictions that barbiturates which are long-acting sedatives and/or strong inducers of CYP2B-mediated monooxygenase activities would be effective promoters of hepato-carcinogenesis, a...
Diwan, Bhalchandra A., Lubet, Ronald A., Ward, Jerrold M., Hrabie, Joseph A., Rice, Jerry M.
The tumor-promoting and carcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in the liver and in other organs were quantified and compared to those of phenobarbital (PB) in...
McLemore, Theodore L., Adelberg, Steven, Liu, Mark C., McMahon, Noreen A., Yu, Sha Jin, Hubbard, Walter C., ...
The major polycyclic aromatic hydrocarbon inducible-cy-tochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome...
Nims, Raymond W., Devor, Deborah E., Henneman, John R., Lubet, Ronald A.
The effects of a series of barbiturates, of known and varying liver tumor-promoting ability, on several short-term endpoints including liver weight and liver-to-body weight ratio increases and...
Kasid, Usha N., Stefanik, David F., Lubet, Ronald A., Dritschilo, Anatoly, Smulson, Mark E.
Inhibition of poly(ADP-Rib) by benzamide (BA) or 3-aminobenzamide (3AB) for a limited period (i.e., when ADP-ribosylation is elevated) during and shortly following X-ray or MNNG-induced DNA damage of...
Lubet, Ronald A., McCarvill, John T., Putman, Donald L., Schwartz, Jeffery L., Schechtman, Leonard M.
3-Aminobenzamide, a potent inhibitor of nuclear poly ADP-ribosyl synthetase, was tested for its ability to alter the toxic and/or transforming effects of ethyl methanesulfonate, methyl...
Lubet, Ronald A., Connolly, Geralynn M., Nebert, Daniel W., Kouri, Richard E.
Four inbred strains of mice (C3H/HeJ, C57BL/6J, AKR/J, and DBA/2J) were injected s.c. with 150 μg of dibenz[a,h]-anthracene and followed for 9 months. Strains C3H/HeJ and...
Zujewski, JoAnne, Vaughn-Cooke, Anika, Flanders, Kathleen C, Eckhaus, Michael A, Lubet, Ronald A, Wakefield, Lalage M
Using a carcinogen-initiated rat model of mammary tumorigenesis, we tested the hypothesis that transforming growth factor (TGF)-βs are useful biomarkers of chemopreventive efficacy in the breast....
Halberg, Richard B., Katzung, Darren S., Hoff, Peter D., Moser, Amy R., Cole, Carolyn E., Lubet, Ronald A., ...
The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness...
Balansky, Roumen, D'Agostini, Francesco, Ganchev, Gancho, Izzotti, Alberto, Di Marco, Barbara, Lubet, Ronald A., ...
The FHIT gene has many hallmarks of a tumor-suppressor gene and is involved in a large variety of cancers. We treated A/J mice and (C57BL/6J × 129/SvJ)F1 (B6/129 F1) mice, either wild-type or...
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice1
Yan, Ying, Wang, Yian, Tan, Qing, Lubet, Ronald A, You, Ming
We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were...
Differential Gene Expression in Chemically Induced Mouse Lung Adenomas1
Yao, Ruisheng, Wang, Yian, Lubet, Ronald A, You, Ming
Because of similarities in histopathology and tumor progression stages between mouse and human lung adenocarcinomas, the mouse lung tumor model with lung adenomas as the endpoint has been used...
Altered Gene Expression Profile in Mouse Bladder Cancers Induced by Hydroxybutyl(butyl)nitrosamine
Yao, Ruisheng, Lemon, William J, Wang, Yian, Grubbs, Clinton J, Lubet, Ronald A, You, Ming
A variety of genetic alterations and gene expression changes are involved in the pathogenesis of bladder tumor. To explore these changes, oligonucleotide array analysis was performed on RNA obtained...
McDoniels-Silvers, Amy L, Stoner, Gary D, Lubet, Ronald A, You, Ming
The Atlas human cDNA expression array was used to evaluate gene expression profile changes in the genesis of human lung adenocarcinomas and squamous cell carcinomas. Gene expression changes between...
Yan, Ying, Wang, Yian, Tan, Qing, Hara, Yukihiko, Yun, Taik-Koo, Lubet, Ronald A, ...
The objective of this investigation was to determine the efficacy of several novel agents in preventing lung tumorigenesis in mice. We evaluated polyphenon E, red ginseng, and rapamycin in A/J mice...
Zujewski, JoAnne, Vaughn-Cooke, Anika, Flanders, Kathleen C, Eckhaus, Michael A, Lubet, Ronald A, Wakefield, Lalage M
Using a carcinogen-initiated rat model of mammary tumorigenesis, we tested the hypothesis that transforming growth factor (TGF)-βs are useful biomarkers of chemopreventive efficacy in the breast....
Halberg, Richard B., Katzung, Darren S., Hoff, Peter D., Moser, Amy R., Cole, Carolyn E., Lubet, Ronald A., ...
The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness...
Balansky, Roumen, D'Agostini, Francesco, Ganchev, Gancho, Izzotti, Alberto, Di Marco, Barbara, Lubet, Ronald A., ...
The FHIT gene has many hallmarks of a tumor-suppressor gene and is involved in a large variety of cancers. We treated A/J mice and (C57BL/6J × 129/SvJ)F1 (B6/129 F1) mice, either wild-type or...
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice1
Yan, Ying, Wang, Yian, Tan, Qing, Lubet, Ronald A, You, Ming
We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were...
Differential Gene Expression in Chemically Induced Mouse Lung Adenomas1
Yao, Ruisheng, Wang, Yian, Lubet, Ronald A, You, Ming
Because of similarities in histopathology and tumor progression stages between mouse and human lung adenocarcinomas, the mouse lung tumor model with lung adenomas as the endpoint has been used...
Altered Gene Expression Profile in Mouse Bladder Cancers Induced by Hydroxybutyl(butyl)nitrosamine
Yao, Ruisheng, Lemon, William J, Wang, Yian, Grubbs, Clinton J, Lubet, Ronald A, You, Ming
A variety of genetic alterations and gene expression changes are involved in the pathogenesis of bladder tumor. To explore these changes, oligonucleotide array analysis was performed on RNA obtained...
McDoniels-Silvers, Amy L, Stoner, Gary D, Lubet, Ronald A, You, Ming
The Atlas human cDNA expression array was used to evaluate gene expression profile changes in the genesis of human lung adenocarcinomas and squamous cell carcinomas. Gene expression changes between...
Yan, Ying, Wang, Yian, Tan, Qing, Hara, Yukihiko, Yun, Taik-Koo, Lubet, Ronald A, ...
The objective of this investigation was to determine the efficacy of several novel agents in preventing lung tumorigenesis in mice. We evaluated polyphenon E, red ginseng, and rapamycin in A/J mice...
Gene Expression Profiling of Chemically Induced Rat Bladder Tumors
Yao, Ruisheng, Yi, Yijun, Grubbs, Clinton J, Lubet, Ronald A, You, Ming
A variety of genetic alterations and gene expression changes are involved in the pathogenesis of bladder tumors. To explore expression changes in 4-hydroxybutyl(butyl)nitrosamine-induced rat bladder...