Eslamboli, Andisheh, Romero-Ramos, Marina, Burger, Corinna, Bjorklund, Tomas, Muzyczka, Nicholas, Mandel, Ronald J, ...
Abstract is not available
Eslamboli, Andisheh, Romero-Ramos, Marina, Burger, Corinna, Bjorklund, Tomas, Muzyczka, Nicholas, Mandel, Ronald J., ...
Overexpression of human α-synuclein (α-syn) using recombinant adeno-associated viral (rAAV) vectors provides a novel tool to study neurodegenerative processes seen in Parkinson's disease and other...
Carlsson, Thomas, Winkler, Christian, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J, Cenci, Angela, ...
Abstract is not available
Carlsson, Thomas, Winkler, Christian, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Cenci, Angela, ...
Dyskinesias are a major complication of long-term l-3,4-dihydroxyphenylalanine (l-DOPA) treatment in Parkinson's disease, and are believed to result from the intermittent and pulsatile supply of...
Carlsson, Thomas, Winkler, Christian, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Cenci, Angela, ...
Summary Dyskinesias are a major complication of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) treatment in Parkinson's disease, and are believed to result from the intermittent and pulsatile supply...
Carlsson, Thomas, Winkler, Christian, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Cenci, Angela, ...
Summary Dyskinesias are a major complication of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) treatment in Parkinson's disease, and are believed to result from the intermittent and pulsatile supply...
Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Bjorklund, Anders
Abstract is not available
Gustafsson, Elin, Andsberg, Gunnar, Darsalia, Vladimer, Mohapel, Paul, Mandel, Ronald J., Kirik, Deniz, ...
Abstract is not available
Arvidsson, Andreas, Kirik, Deniz, Lundberg, Cecilia, Mandel, Ronald J, Andsberg, Gunnar, Kokaia, Zaal, ...
Abstract is not available
Andsberg, Gunnar, Kokaia, Zaal, Klein, Ronald L, Muzyczka, Nicholas, Lindvall, Olle, Mandel, Ronald J
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were continuously delivered to the striatum at biologically active levels via recombinant adeno-associated viral (rAAV) gene...
Kirik, Deniz, Rosenblad, Carl, Burger, Corinna, Lundberg, Cecilia, Johansen, Teit E, Muzyczka, Nicholas, ...
Recombinant adeno-associated viral vectors display efficient tropism for transduction of the dopamine neurons of the substantia nigra. Taking advantage of this unique property of recombinant...
Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J, ...
Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of L-dopa in animals with lesions of the nigrostriatal pathway. The functional...
Larsson, Elin, Mandel, Ronald J, Klein, Ronald L, Muzyczka, Nicholas, Lindvall, Olle, Kokaia, Zaal
Abstract is not available
Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery
Zufferey, Romain, Dull, Thomas, Mandel, Ronald J., Bukovsky, Anatoly, Quiroz, Dulce, Naldini, Luigi, ...
In vivo transduction of nondividing cells by human immunodeficiency virus type 1 (HIV-1)-based vectors results in transgene expression that is stable over several months. However, the use of HIV-1...
Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...
Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...
Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders
We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets. The α-synuclein protein was expressed in...
Peden, Carmen S., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J.
Epidemiological studies report that 80% of the population maintains antibodies (Ab) to wild-type (wt) adeno-associated virus type 2 (AAV2), with 30% expressing neutralizing Ab (NAb). The blood-brain...
Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery
Zufferey, Romain, Dull, Thomas, Mandel, Ronald J., Bukovsky, Anatoly, Quiroz, Dulce, Naldini, Luigi, ...
In vivo transduction of nondividing cells by human immunodeficiency virus type 1 (HIV-1)-based vectors results in transgene expression that is stable over several months. However, the use of HIV-1...
Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...
Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...
Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders
We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets. The α-synuclein protein was expressed in...
Peden, Carmen S., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J.
Epidemiological studies report that 80% of the population maintains antibodies (Ab) to wild-type (wt) adeno-associated virus type 2 (AAV2), with 30% expressing neutralizing Ab (NAb). The blood-brain...
Gorbatyuk, Oleg S., Li, Shoudong, Sullivan, Layla F., Chen, Weijun, Kondrikova, Galina, Manfredsson, Fredric P., ...
Studies have shown that α-synuclein (α-syn) deposited in Lewy bodies in brain tissue from patients with Parkinson disease (PD) is extensively phosphorylated at Ser-129. We used recombinant...