Ronglin Xie

A Runx2 threshold for the cleidocranial dysplasia phenotype (2009)

Lou, Yang, Javed, Amjad, Hussain, Sadiq, Colby, Jennifer, Frederick, Dana, Pratap, Jitesh, ...

Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal disease that results from mutations in the bone-specific transcription factor RUNX2 (CBFA1/AML3). However, distinct RUNX2...

Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition (2007)

Xie, Ronglin, Liu, Lijun, Mitra, Partha, Stein, Janet L., Van Wijnen, Andre J., Stein, Gary S.

Histone nuclear factor P (HiNF-P) activates histone H4 gene transcription at the G1/S phase transition upon association with its cyclin E/CDK2 responsive co-factor p220NPAT. Here we characterize the...

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2 (2007)

Young, Daniel W., Hassan, Mohammad Q., Pratap, Jitesh, Galindo, Mario, Zaidi, Sayyed K., Lee, Suk Hee, ...

Regulation of ribosomal RNA genes is a fundamental process that supports the growth of cells and is tightly coupled with cell differentiation. Although rRNA transcriptional control by RNA polymerase...

HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription (2006)

Mitra, Partha, Xie, Ronglin, Harper, J. Wade, Stein, Janet L., Stein, Gary S., Van Wijnen, Andre J.

Cell cycle progression beyond the G1/S phase transition requires the activation of a transcription complex containing histone nuclear factor P (HiNF-P) and nuclear protein mapped to ataxia...

HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition (2005)

Miele, Angela, Braastad, Corey D., Holmes, William F., Mitra, Partha, Medina, Ricardo F., Xie, Ronglin, ...

Genome replication in eukaryotic cells necessitates the stringent coupling of histone biosynthesis with the onset of DNA replication at the G1/S phase transition. A fundamental question is the...

Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells (2004)

Lau, Andy T. Y., Li, Muyao, Xie, Ronglin, He, Qing-Yu, Chiu, Jen-Fu

Arsenic is a well-known carcinogen that possibly promotes tumors and the development of various types of cancer in individuals chronically exposed to arsenic in their work or living environment. Many...

Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase (2003)

Mitra, Partha, Xie, Ronglin, Medina, Ricardo F., Hovhannisyan, Hayk, Zaidi, Sayyed K., Wei, Yue, ...

At the G(1)/S phase cell cycle transition, multiple histone genes are expressed to ensure that newly synthesized DNA is immediately packaged as chromatin. Here we have purified and functionally...

The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter (2003)

Xie, Ronglin, Gupta, Sunita, Miele, Angela, Shiffman, Dov, Stein, Janet L., Stein, Gary S., ...

Cell growth control by interferons (IFNs) involves up-regulation of the tumor suppressor interferon regulatory factor 1 (IRF1). To exert its anti-proliferative effects, this factor must ultimately...

Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells (2003)

Lau, Andy T. Y., Li, Muyao, Xie, Ronglin, He, Qing-Yu, Chiu, Jen-Fu

Arsenic is a well-known carcinogen that possibly promotes tumors and the development of various types of cancer in individuals chronically exposed to arsenic in their work or living environment. Many...

Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells (2003)

Lau, Andy T. Y., Li, Muyao, Xie, Ronglin, He, Qing-Yu, Chiu, Jen-Fu

Arsenic is a well-known carcinogen that possibly promotes tumors and the development of various types of cancer in individuals chronically exposed to arsenic in their work or living environment. Many...

Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells (2002)

Xie, Ronglin, Van Wijnen, Andre J., Stein, Janet L., Stein, Gary S.

The IFN regulatory factor-2 (IRF-2) oncoprotein controls the cell cycle-dependent expression of histone H4 genes during S phase and may function as a component of an E2F-independent mechanism to...

The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7 (2001)

Xie, Ronglin, Van Wijnen, Andre J., Luong, Mai X., Stein, Janet L., Stein, Gary S.

Interferon regulatory factors (IRFs) are transcriptional mediators of interferon-responsive signaling pathways that are involved in antiviral defense, immune response, and cell growth regulation. To...

HiNF-P Directly Links the Cyclin E/CDK2/p220NPAT Pathway to Histone H4 Gene Regulation at the G1/S Phase Cell Cycle Transition

Miele, Angela, Braastad, Corey D., Holmes, William F., Mitra, Partha, Medina, Ricardo, Xie, Ronglin, ...

Genome replication in eukaryotic cells necessitates the stringent coupling of histone biosynthesis with the onset of DNA replication at the G1/S phase transition. A fundamental question is the...

HiNF-P Directly Links the Cyclin E/CDK2/p220NPAT Pathway to Histone H4 Gene Regulation at the G1/S Phase Cell Cycle Transition

Miele, Angela, Braastad, Corey D., Holmes, William F., Mitra, Partha, Medina, Ricardo, Xie, Ronglin, ...

Genome replication in eukaryotic cells necessitates the stringent coupling of histone biosynthesis with the onset of DNA replication at the G1/S phase transition. A fundamental question is the...