Ross L. Coppel

Hot, sweet and sticky: the glycobiology of Plasmodium falciparum (2008)

Von Itzstein, Mark, Plebanksi, Magdalena, Cook, Brian M., Coppel, Ross L.

Yes

Hot, sweet and sticky: the glycobiology of Plasmodium falciparum (2008)

Von Itzstein, Mark, Plebanksi, Magdalena, Cook, Brian M., Coppel, Ross L.

Hot, sweet and sticky: the glycobiology of Plasmodium falciparum (2008)

Von Itzstein, Mark, Plebanksi, Magdalena, Cook, Brian M., Coppel, Ross L.

Antibodies elicited in adults by a primary Plasmodium falciparumblood-stage infection recognize different epitopes compared with immune individuals (2007)

Eisen, Damon P, Wang, Lina, Jouin, Helene, Murhandarwati, E Elsa H, Black, Casilda G, Mercereau-Puijalon, Odile, ...

Abstract Background Asexual stage antibody responses following initial Plasmodium falciparum infections in previously healthy adults may inform vaccine development, yet these have not been as...

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents (2007)

Owen, David James, Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Thomson, Robin Joy, Chong, Andrew, ...

Yes

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents (2007)

Owen, David James, Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Thomson, Robin Joy, Chong, Andrew, ...

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents (2007)

Owen, David James, Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Thomson, Robin Joy, Chong, Andrew, ...

The recent emergence of clinically oppressive superbugs, some with resistance to nearly all frontline drug therapies, has challenged our ability to combat such infectious organisms as Mycobacterium...

Fusion of FNA-cytology and Gene-expression Data Using Dempster-Shafer Theory of Evidence to Predict Breast Cancer Tumors (2006)

Mansoor Raza, Iqbal Gondal, David Green, Ross L. Coppel

Decision-in decision-out fusion architecture can be used to fuse the outputs of multiple classifiers from different diagnostic sources. In this paper, Dempster-Shafer Theory (DST) has been used to...

Associations Between Responses to the Rhoptry-Associated Membrane Antigen of Plasmodium falciparum and Immunity to Malaria Infection (2006)

Topolska, Agnieszka E., Richie, Thomas L., Nhan, Doan H., Coppel, Ross L.

Rhoptry proteins participate in the invasion of red blood cells by merozoites during the malaria parasite's asexual-stage cycle. Interference with the rhoptry protein function has been shown to...

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Yes

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Yes

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Herein, we analyze in general the current vaccine market and identify potential factors driving and modulating supply and demand for vaccines. An emphasis is placed on changes in regulation in the...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Yes

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Yes

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Saturation transfer difference (STD) 1H NMR experiments were used to probe the epitope binding characteristics of the sialidase [EC 3.2.1.18] from the bacterium Vibrio cholerae, the causative agent...

Is there a Relation between Chlamydia Infection and Primary Biliary Cirrhosis? (2003)

Ogyi Park, Shuji Matsumura, Aftab A. Ansari, Ross L. Coppel, M. Eric Gershwin

Over the past two decades, a number of studies have failed to provide direct evidence of specific microbial chronic infection in primary biliary cirrhosis (PBC). However, a recent report suggests...

Is there a Relation between Chlamydia Infection and Primary Biliary Cirrhosis? (2003)

Ogyi Park, Shuji Matsumura, Aftab A. Ansari, Ross L. Coppel, M. Eric Gershwin

Over the past two decades, a number of studies have failed to provide direct evidence of specific microbial chronic infection in primary biliary cirrhosis (PBC). However, a recent report suggests...

PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished) (2002)

Bahl, Amit, Brunk, Brian, Coppel, Ross L., Crabtree, Jonathan, Diskin, Sharon J., Fraunholz, Martin J., ...

PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates finished and draft genome sequence data and...

Intracellular structures of normal and aberrant Plasmodium falciparum malaria parasites imaged by soft x-ray microscopy

Magowan, Cathleen, Brown, John T., Liang, Joy, Heck, John, Coppel, Ross L., Mohandas, Narla, ...

Soft x-ray microscopy is a novel approach for investigation of intracellular organisms and subcellular structures with high spatial resolution. We used x-ray microscopy to investigate structural...

Characterization of a Mycobacterium smegmatis Mutant Lacking Penicillin Binding Protein 1

Billman-Jacobe, Helen, Haites, Ruth E., Coppel, Ross L.

The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of...

Antibody Responses to Infections with Strains of Plasmodium falciparum Expressing Diverse Forms of Merozoite Surface Protein 2

Weisman, Simon, Wang, Lina, Billman-Jacobe, Helen, Nhan, Doan Hanh, Richie, Thomas L., Coppel, Ross L.

Individuals living in areas where Plasmodium falciparum is endemic experience numerous episodes of infection. These episodes may or may not be symptomatic, with the outcome depending on a combination...

Naturally Acquired Antibody Responses to Plasmodium falciparum Merozoite Surface Protein 4 in a Population Living in an Area of Endemicity in Vietnam

Wang, Lina, Richie, Thomas L., Stowers, Anthony, Nhan, Doan Hanh, Coppel, Ross L.

Merozoite surface protein 4 (MSP4) of Plasmodium falciparum is a glycosylphosphatidylinositol-anchored integral membrane protein that is being developed as a component of a subunit vaccine against...

PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished)

Bahl, Amit, Brunk, Brian, Coppel, Ross L., Crabtree, Jonathan, Diskin, Sharon J., Fraunholz, Martin J., ...

PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates finished and draft genome sequence data and annotation...

Immunization with Recombinant Plasmodium yoelii Merozoite Surface Protein 4/5 Protects Mice against Lethal Challenge

Kedzierski, Lukasz, Black, Casilda G., Coppel, Ross L.

Plasmodium yoelii merozoite surface protein 4/5 (PyMSP4/5), expressed as a recombinant protein, was highly effective at protecting mice against lethal challenge with P. yoelii. There was a...

Temporal Variation of the Merozoite Surface Protein-2 Gene of Plasmodium falciparum

Eisen, Damon, Billman-Jacobe, Helen, Marshall, Vikki F., Fryauff, Dave, Coppel, Ross L.

Extensive polymorphism of key parasite antigens is likely to hamper the effectiveness of subunit vaccines against Plasmodium falciparum infection. However, little is known about the extent of the...

Identification of the Plasmodium chabaudi Homologue of Merozoite Surface Proteins 4 and 5 of Plasmodium falciparum

Black, Casilda G., Wang, Lina, Hibbs, Alan R., Werner, Ekkehard, Coppel, Ross L.

Previous studies of Plasmodium falciparum have identified a region of chromosome 2 in which are clustered three genes for glycosylphosphatidylinositol (GPI)-anchored merozoite surface proteins, MSP2,...

Structural and Antigenic Properties of Merozoite Surface Protein 4 of Plasmodium falciparum

Wang, Lina, Black, Casilda G., Marshall, Vikki M., Coppel, Ross L.

Merozoite surface protein 4 (MSP4) of Plasmodium falciparum is a glycosylphosphatidylinositol-anchored integral membrane protein of 272 residues that possesses a single epidermal growth factor...

Immunization with a Combination of Merozoite Surface Proteins 4/5 and 1 Enhances Protection against Lethal Challenge with Plasmodium yoelii

Kedzierski, Lukasz, Black, Casilda G., Goschnick, Matthew W., Stowers, Anthony W., Coppel, Ross L.

It is widely believed that subunit vaccines composed of multiple components will offer greater protection against challenge by malaria, and yet there is little experimental evidence to support this...

Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

Kita, Hiroto, Matsumura, Shuji, He, Xiao-Song, Ansari, Aftab A., Lian, Zhe-Xiong, Van De Water, Judy, ...

While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma, it has been suggested that the pathology is mediated by autoreactive...

Immunogenetics and the design of Plasmodium falciparum vaccines for use in malaria-endemic populations

Plebanski, Magdalena, Proudfoot, Owen, Pouniotis, Dodie, Coppel, Ross L., Apostolopoulos, Vasso, Flannery, Graham

Oral Immunization with a Recombinant Malaria Protein Induces Conformational Antibodies and Protects Mice against Lethal Malaria

Wang, Lina, Kedzierski, Lukasz, Wesselingh, Steven L., Coppel, Ross L.

The increasing death toll from malaria, due to the decreasing effectiveness of current prophylactic and therapeutic regimens, has sparked a search for alternative methods of control, such as...

Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells

Waterkeyn, Jacqueline G., Wickham, Mark E., Davern, Kathleen M., Cooke, Brian M., Coppel, Ross L., Reeder, John C., ...

Adhesion of parasite-infected red blood cells to the vascular endothelium is a critical event in the pathogenesis of malaria caused by Plasmodium falciparum. Adherence is mediated by the variant...

Associations between Responses to the Rhoptry-Associated Membrane Antigen of Plasmodium falciparum and Immunity to Malaria Infection

Topolska, Agnieszka E., Richie, Thomas L., Nhan, Doan Hanh, Coppel, Ross L.

Rhoptry proteins participate in the invasion of red blood cells by merozoites during the malaria parasite's asexual-stage cycle. Interference with the rhoptry protein function has been shown to...

Oral Immunization with a Combination of Plasmodium yoelii Merozoite Surface Proteins 1 and 4/5 Enhances Protection against Lethal Malaria Challenge

Wang, Lina, Goschnick, Matthew W., Coppel, Ross L.

Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody...

Function of the Cytochrome bc1-aa3 Branch of the Respiratory Network in Mycobacteria and Network Adaptation Occurring in Response to Its Disruption†

Matsoso, Limenako G., Kana, Bavesh D., Crellin, Paul K., Lea-Smith, David J., Pelosi, Assunta, Powell, David, ...

The aerobic electron transport chain in Mycobacterium smegmatis can terminate in one of three possible terminal oxidase complexes. The structure and function of the electron transport pathway leading...

A Set of Glycosylphosphatidyl Inositol-Anchored Membrane Proteins of Plasmodium falciparum Is Refractory to Genetic Deletion

Sanders, Paul R., Kats, Lev M., Drew, Damien R., O'Donnell, Rebecca A., O'Neill, Matthew, Maier, Alexander G., ...

Targeted gene disruption has proved to be a powerful approach for studying the function of important ligands involved in erythrocyte invasion by the extracellular merozoite form of the human malaria...

Intracellular structures of normal and aberrant Plasmodium falciparum malaria parasites imaged by soft x-ray microscopy

Magowan, Cathleen, Brown, John T., Liang, Joy, Heck, John, Coppel, Ross L., Mohandas, Narla, ...

Soft x-ray microscopy is a novel approach for investigation of intracellular organisms and subcellular structures with high spatial resolution. We used x-ray microscopy to investigate structural...

Characterization of a Mycobacterium smegmatis Mutant Lacking Penicillin Binding Protein 1

Billman-Jacobe, Helen, Haites, Ruth E., Coppel, Ross L.

The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of...

Antibody Responses to Infections with Strains of Plasmodium falciparum Expressing Diverse Forms of Merozoite Surface Protein 2

Weisman, Simon, Wang, Lina, Billman-Jacobe, Helen, Nhan, Doan Hanh, Richie, Thomas L., Coppel, Ross L.

Individuals living in areas where Plasmodium falciparum is endemic experience numerous episodes of infection. These episodes may or may not be symptomatic, with the outcome depending on a combination...

Naturally Acquired Antibody Responses to Plasmodium falciparum Merozoite Surface Protein 4 in a Population Living in an Area of Endemicity in Vietnam

Wang, Lina, Richie, Thomas L., Stowers, Anthony, Nhan, Doan Hanh, Coppel, Ross L.

Merozoite surface protein 4 (MSP4) of Plasmodium falciparum is a glycosylphosphatidylinositol-anchored integral membrane protein that is being developed as a component of a subunit vaccine against...

PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished)

Bahl, Amit, Brunk, Brian, Coppel, Ross L., Crabtree, Jonathan, Diskin, Sharon J., Fraunholz, Martin J., ...

PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates finished and draft genome sequence data and annotation...

Immunization with Recombinant Plasmodium yoelii Merozoite Surface Protein 4/5 Protects Mice against Lethal Challenge

Kedzierski, Lukasz, Black, Casilda G., Coppel, Ross L.

Plasmodium yoelii merozoite surface protein 4/5 (PyMSP4/5), expressed as a recombinant protein, was highly effective at protecting mice against lethal challenge with P. yoelii. There was a...

Temporal Variation of the Merozoite Surface Protein-2 Gene of Plasmodium falciparum

Eisen, Damon, Billman-Jacobe, Helen, Marshall, Vikki F., Fryauff, Dave, Coppel, Ross L.

Extensive polymorphism of key parasite antigens is likely to hamper the effectiveness of subunit vaccines against Plasmodium falciparum infection. However, little is known about the extent of the...

Identification of the Plasmodium chabaudi Homologue of Merozoite Surface Proteins 4 and 5 of Plasmodium falciparum

Black, Casilda G., Wang, Lina, Hibbs, Alan R., Werner, Ekkehard, Coppel, Ross L.

Previous studies of Plasmodium falciparum have identified a region of chromosome 2 in which are clustered three genes for glycosylphosphatidylinositol (GPI)-anchored merozoite surface proteins, MSP2,...

Structural and Antigenic Properties of Merozoite Surface Protein 4 of Plasmodium falciparum

Wang, Lina, Black, Casilda G., Marshall, Vikki M., Coppel, Ross L.

Merozoite surface protein 4 (MSP4) of Plasmodium falciparum is a glycosylphosphatidylinositol-anchored integral membrane protein of 272 residues that possesses a single epidermal growth factor...

Immunization with a Combination of Merozoite Surface Proteins 4/5 and 1 Enhances Protection against Lethal Challenge with Plasmodium yoelii

Kedzierski, Lukasz, Black, Casilda G., Goschnick, Matthew W., Stowers, Anthony W., Coppel, Ross L.

It is widely believed that subunit vaccines composed of multiple components will offer greater protection against challenge by malaria, and yet there is little experimental evidence to support this...

Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

Kita, Hiroto, Matsumura, Shuji, He, Xiao-Song, Ansari, Aftab A., Lian, Zhe-Xiong, Van De Water, Judy, ...

While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma, it has been suggested that the pathology is mediated by autoreactive...

Immunogenetics and the design of Plasmodium falciparum vaccines for use in malaria-endemic populations

Plebanski, Magdalena, Proudfoot, Owen, Pouniotis, Dodie, Coppel, Ross L., Apostolopoulos, Vasso, Flannery, Graham

Oral Immunization with a Recombinant Malaria Protein Induces Conformational Antibodies and Protects Mice against Lethal Malaria

Wang, Lina, Kedzierski, Lukasz, Wesselingh, Steven L., Coppel, Ross L.

The increasing death toll from malaria, due to the decreasing effectiveness of current prophylactic and therapeutic regimens, has sparked a search for alternative methods of control, such as...

Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells

Waterkeyn, Jacqueline G., Wickham, Mark E., Davern, Kathleen M., Cooke, Brian M., Coppel, Ross L., Reeder, John C., ...

Adhesion of parasite-infected red blood cells to the vascular endothelium is a critical event in the pathogenesis of malaria caused by Plasmodium falciparum. Adherence is mediated by the variant...

Associations between Responses to the Rhoptry-Associated Membrane Antigen of Plasmodium falciparum and Immunity to Malaria Infection

Topolska, Agnieszka E., Richie, Thomas L., Nhan, Doan Hanh, Coppel, Ross L.

Rhoptry proteins participate in the invasion of red blood cells by merozoites during the malaria parasite's asexual-stage cycle. Interference with the rhoptry protein function has been shown to...

Oral Immunization with a Combination of Plasmodium yoelii Merozoite Surface Proteins 1 and 4/5 Enhances Protection against Lethal Malaria Challenge

Wang, Lina, Goschnick, Matthew W., Coppel, Ross L.

Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody...

Function of the Cytochrome bc1-aa3 Branch of the Respiratory Network in Mycobacteria and Network Adaptation Occurring in Response to Its Disruption†

Matsoso, Limenako G., Kana, Bavesh D., Crellin, Paul K., Lea-Smith, David J., Pelosi, Assunta, Powell, David, ...

The aerobic electron transport chain in Mycobacterium smegmatis can terminate in one of three possible terminal oxidase complexes. The structure and function of the electron transport pathway leading...

A Set of Glycosylphosphatidyl Inositol-Anchored Membrane Proteins of Plasmodium falciparum Is Refractory to Genetic Deletion

Sanders, Paul R., Kats, Lev M., Drew, Damien R., O'Donnell, Rebecca A., O'Neill, Matthew, Maier, Alexander G., ...

Targeted gene disruption has proved to be a powerful approach for studying the function of important ligands involved in erythrocyte invasion by the extracellular merozoite form of the human malaria...

Genome reduction in Leptospira borgpetersenii reflects limited transmission potential

Bulach, Dieter M., Zuerner, Richard L., Wilson, Peter, Seemann, Torsten, McGrath, Annette, Cullen, Paul A., ...

Leptospirosis is one of the most common zoonotic diseases in the world, resulting in high morbidity and mortality in humans and affecting global livestock production. Most infections are caused by...

Fusion of FNA-cytology and Gene-expression Data Using Dempster-Shafer Theory of Evidence to Predict Breast Cancer Tumors

Raza, Mansoor, Gondal, Iqbal, Green, David, Coppel, Ross L

Decision-in decision-out fusion architecture can be used to fuse the outputs of multiple classifiers from different diagnostic sources. In this paper, Dempster-Shafer Theory (DST) has been used to...

Antibodies elicited in adults by a primary Plasmodium falciparum blood-stage infection recognize different epitopes compared with immune individuals

Eisen, Damon P, Wang, Lina, Jouin, Helene, Murhandarwati, E Elsa H, Black, Casilda G, Mercereau-Puijalon, Odile, ...

Expression, purification, crystallization and preliminary X-ray diffraction analysis of an essential lipoprotein implicated in cell-wall biosynthesis in Mycobacteria

Marland, Zara, Beddoe, Travis, Zaker-Tabrizi, Leyla, Coppel, Ross L., Crellin, Paul K., Rossjohn, Jamie

A lipoprotein implicated in mycobacterial cell-wall biosynthesis, LpqW, was expressed in E. coli. Crystals were obtained that diffracted to 2.4 Å resolution.

A Maurer's cleft–associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells

Cooke, Brian M., Buckingham, Donna W., Glenister, Fiona K., Fernandez, Kate M., Bannister, Lawrence H., Marti, Matthias, ...

The high mortality of Plasmodium falciparum malaria is the result of a parasite ligand, PfEMP1 (P. falciparum) erythrocyte membrane protein 1), on the surface of infected red blood cells (IRBCs),...

Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis

Picardeau, Mathieu, Bulach, Dieter M., Bouchier, Christiane, Zuerner, Richard L., Zidane, Nora, Wilson, Peter J., ...

Leptospira biflexa is a free-living saprophytic spirochete present in aquatic environments. We determined the genome sequence of L. biflexa, making it the first saprophytic Leptospira to be...

Is there a Relation between Chlamydia Infection and Primary Biliary Cirrhosis?

Leung, Patrick S. C., Park, Ogyi, Matsumura, Shuji, Ansari, Aftab A., Coppel, Ross L., Gershwin, M. Eric

Over the past two decades, a number of studies have failed to provide direct evidence of specific microbial chronic infection in primary biliary cirrhosis (PBC). However, a recent report suggests...

Identification of HLA-A2–restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis: T Cell Activation Is Augmented by Immune Complexes Cross-Presented by Dendritic Cells

Kita, Hiroto, Lian, Zhe-Xiong, Van De Water, Judy, He, Xiao-Song, Matsumura, Shuji, Kaplan, Marshall, ...

Primary biliary cirrhosis (PBC) is characterized by an intense biliary inflammatory CD4+ and CD8+ T cell response. Very limited information on autoantigen-specific cytotoxic T lymphocyte (CTL)...

Is there a Relation between Chlamydia Infection and Primary Biliary Cirrhosis?

Leung, Patrick S. C., Park, Ogyi, Matsumura, Shuji, Ansari, Aftab A., Coppel, Ross L., Gershwin, M. Eric

Over the past two decades, a number of studies have failed to provide direct evidence of specific microbial chronic infection in primary biliary cirrhosis (PBC). However, a recent report suggests...

Mutations in pimE Restore Lipoarabinomannan Synthesis and Growth in a Mycobacterium smegmatis lpqW Mutant▿ ‡

Crellin, Paul K., Kovacevic, Svetozar, Martin, Kirstee L., Brammananth, Rajini, Morita, Yasu S., Billman-Jacobe, Helen, ...

Lipoarabinomannans (LAMs) and phosphatidylinositol mannosides (PIMs) are abundant glycolipids in the cell walls of all corynebacteria and mycobacteria, including the devastating human pathogen...

Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes

Maier, Alexander G., Rug, Melanie, O'Neill, Matthew T., Brown, Monica, Chakravorty, Srabasti, Szestak, Tadge, ...

A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These...

Identification of Rhoptry Trafficking Determinants and Evidence for a Novel Sorting Mechanism in the Malaria Parasite Plasmodium falciparum

Richard, Dave, Kats, Lev M., Langer, Christine, Black, Casilda G., Mitri, Khosse, Boddey, Justin A., ...

The rhoptry of the malaria parasite Plasmodium falciparum is an unusual secretory organelle that is thought to be related to secretory lysosomes in higher eukaryotes. Rhoptries contain an extensive...