Roy M. Anderson

Density-dependent effects on the weight of female Ascaris lumbricoidesinfections of humans and its impact on patterns of egg production (2009)

Walker, Martin, Hall, Andrew, Anderson, Roy M, Basáñez, María-Gloria

Abstract Background Ascaris lumbricoides exhibits density-dependent egg production, a process which has a marked impact on both the transmission dynamics and the stability of the parasite population....

Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: A Cluster-Randomised Trial in Eastern Zimbabwe (2007)

Simon Gregson, Saina Adamson, Spiwe Papaya, Jephias Mundondo, Constance A. Nyamukapa, Peter R. Mason, ...

BackgroundHIV-1 control in sub-Saharan Africa requires cost-effective and sustainable programmes that promote behaviour change and reduce cofactor sexually transmitted infections (STIs) at the...

ผลกระทบทางประชากรของโรคเอดส์ในประเทศไทย (2006)

เกื้อ วงศ์บุญสิน, สุชาดา กีระนันทน์, สุวาณี สุรเสียงสังข์, Garnett, Geoffrey P., Anderson, Roy M., ...

การวิจัยนี้ใช้ตัวแบบเชิงคณิตศาสตร์ซึ่งเป็นตัวแบบเชิงกำหนดที่แบ่งกล...

Updated projections of future vCJD deaths in the UK (2003)

Ghani, Azra C, Donnelly, Christl A, Ferguson, Neil M, Anderson, Roy M

Abstract Background Past projections of the future course of the vCJD epidemic in the UK have shown considerable uncertainty, with wide confidence bounds. However, recent vCJD case data have...

HIV and fertility change in rural Zimbabwe (1997)

Gregson, Simon, Zhuwau, Tom, Anderson, Roy M., Chandiwana, Stephen K.

Fertility transition and HIV epidemics are currently running parallel in some sub-Saharan African populations. Interactions between the two at the individual and population levels could accentuate or...

HIV and fertility change in rural Zimbabwe (1997)

Gregson, Simon, Zhuwau, Tom, Anderson, Roy M., Chandiwana, Stephen K.

Fertility transition and HIV epidemics are currently running parallel in some sub-Saharan African populations. Interactions between the two at the individual and population levels could accentuate or...

HIV and fertility change in rural Zimbabwe (1997)

Gregson, Simon, Zhuwau, Tom, Anderson, Roy M., Chandiwana, Stephen K., Awusabo-Asare, Kofi, Pisani, Elisabeth, ...

Fertility transition and HIV epidemics are currently running parallel in some sub-Saharan African populations. Interactions between the two at the individual and population levels could accentuate or...

HIV and fertility change in rural Zimbabwe (1997)

Gregson, Simon, Zhuwau, Tom, Anderson, Roy M., Chandiwana, Stephen K.

Fertility transition and HIV epidemics are currently running parallel in some sub-Saharan African populations. Interactions between the two at the individual and population levels could accentuate or...

HIV and fertility change in rural Zimbabwe (1997)

Gregson, Simon, Zhuwau, Tom, Anderson, Roy M., Chandiwana, Stephen K.

Fertility transition and HIV epidemics are currently running parallel in some sub-Saharan African populations. Interactions between the two at the individual and population levels could accentuate or...

Mixing matrices: Necessary constraints in populations of finite size (1996)

UCHE, CHINMA O., ANDERSON, ROY M.

This paper analyses the constraints used to define the elements of mixing matrices employed in deterministic models of the transmission dynamics of sexually transmitted infections. These matrices...

Antiviral therapy and the transmission dynamics of HIV-1 (1996)

Garnett, Geoff P., Anderson, Roy M.

The factors influencing the transmission dynamics of HIV are discussed in the context of the community wide use of antiviral therapy. A mathematical framework is constructed to examine the impact of...

Balancing sexual partnership in an age and activity stratified model of HIV transmission in heterosexual populations (1994)

GARNETT, GEOFFREY P., ANDERSON, ROY M.

A mathematical model of the transmission dynamics of HIV-1 in a heterosexual population stratified by age, sex, and sexual activity (defined by rates of sexual partner acquisition) is presented. The...

Gonococcal infection, infertility, and population growth: I. Endemic states in behaviourally homogeneous growing populations (1992)

SWINTON, JONATHAN, GARNETT, GEOFFREY P., BRUNHAM, ROBERT C., ANDERSON, ROY M.

Sexually transmitted diseases such as gonorrhoea are a significant cause of infertility in women when the infection is untreated. They have the potential to alter human population growth rates in...

Gonococcal infection, infertility, and population growth: II. The influence of heterogeneity in sexual behaviour (1992)

GARNETT, GEOFFREY P., SWINTON, JONATHAN, BRUNHAM, ROBERT C., ANDERSON, ROY M.

Heterogeneity in sexual behaviour has an important influence on the transmission dynamics of sexually transmitted diseases (STDs). The authors describe the development of a simple mathematical model,...

Sexual Contact Patterns between Men and Women and the Spread of HIV-1 in Urban Centres in Africa (1991)

BOILY, MARIE-CLAUDE, ANDERSON, ROY M.

A simple model of the transmission of HIV-1 by heterosexual contact and from mother to unborn infant is developed to assess the influence of patterns of mixing between low and high sexual activity...

Spatial, Temporal, and Genetic Heterogeneity in Host Populations And the Design of Immunization Programmes (1984)

ANDERSON, ROY M., MAY, ROBERT M.

The relevance of heterogeneity in infectious disease transmission to the design of immunization programmes is examined by the use of simple deterministic models of recurrent epidemic behaviour. In...

Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs

Austin, Daren J., Bonten, Marc J. M., Weinstein, Robert A., Slaughter, Sarah, Anderson, Roy M.

Vancomycin-resistant enterococci (VRE) recently have emerged as a nosocomial pathogen especially in intensive-care units (ICUs) worldwide. Transmission via the hands of health-care workers is an...

Antigen-driven CD4+ T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy

Ferguson, Neil M., DeWolf, Frank, Ghani, Azra C., Fraser, Christophe, Donnelly, Christl A., Reiss, Peter, ...

Antigen-induced stimulation of the immune system can generate heterogeneity in CD4+ T cell division rates capable of explaining the temporal patterns seen in the decay of HIV-1 plasma RNA levels...

Quantification of intrinsic residual viral replication in treated HIV-infected patients

Fraser, Christophe, Ferguson, Neil M., Anderson, Roy M.

The intrinsic rate of viral replication in HIV-infected patients treated with antiretroviral combination therapy is estimated by using a mathematical model of viral dynamics. This intrinsic...

Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses

Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...

The speed of virus replication has typically been seen as an advantage for a virus in overcoming the ability of the immune system to control its population growth. Under some circumstances, the...

Factors that make an infectious disease outbreak controllable

Fraser, Christophe, Riley, Steven, Anderson, Roy M., Ferguson, Neil M.

The aim of this study is to identify general properties of emerging infectious agents that determine the likely success of two simple public health measures in controlling outbreaks, namely (i)...

Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs

Austin, Daren J., Bonten, Marc J. M., Weinstein, Robert A., Slaughter, Sarah, Anderson, Roy M.

Vancomycin-resistant enterococci (VRE) recently have emerged as a nosocomial pathogen especially in intensive-care units (ICUs) worldwide. Transmission via the hands of health-care workers is an...

Antigen-driven CD4+ T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy

Ferguson, Neil M., DeWolf, Frank, Ghani, Azra C., Fraser, Christophe, Donnelly, Christl A., Reiss, Peter, ...

Antigen-induced stimulation of the immune system can generate heterogeneity in CD4+ T cell division rates capable of explaining the temporal patterns seen in the decay of HIV-1 plasma RNA levels...

Quantification of intrinsic residual viral replication in treated HIV-infected patients

Fraser, Christophe, Ferguson, Neil M., Anderson, Roy M.

The intrinsic rate of viral replication in HIV-infected patients treated with antiretroviral combination therapy is estimated by using a mathematical model of viral dynamics. This intrinsic...

Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses

Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...

The speed of virus replication has typically been seen as an advantage for a virus in overcoming the ability of the immune system to control its population growth. Under some circumstances, the...

Factors that make an infectious disease outbreak controllable

Fraser, Christophe, Riley, Steven, Anderson, Roy M., Ferguson, Neil M.

The aim of this study is to identify general properties of emerging infectious agents that determine the likely success of two simple public health measures in controlling outbreaks, namely (i)...

Implications of BSE infection screening data for the scale of the British BSE epidemic and current European infection levels.

Donnelly, Christl A, Ferguson, Neil M, Ghani, Azra C, Anderson, Roy M

The incidence of confirmed clinical cases of bovine spongiform encephalopathy (BSE) in Great Britain continues to decline, but the recent discovery of cases in previously unaffected countries...

Factors determining the pattern of the variant Creutzfeldt-Jakob disease (vCJD) epidemic in the UK.

Ghani, Azra C, Ferguson, Neil M, Donnelly, Christl A, Anderson, Roy M

Following the emergence of a new variant of Creutzfeldt-Jakob disease (vCJD) 6 years ago, and the gradual rise in clinical cases, there has been increased speculation regarding the overall magnitude...

Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic.

Anderson, Roy M, Fraser, Christophe, Ghani, Azra C, Donnelly, Christl A, Riley, Steven, Ferguson, Neil M, ...

This paper reviews current understanding of the epidemiology, transmission dynamics and control of the aetiological agent of severe acute respiratory syndrome (SARS). We present analyses of data on...

Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: A Cluster-Randomised Trial in Eastern Zimbabwe

Gregson, Simon, Adamson, Saina, Papaya, Spiwe, Mundondo, Jephias, Nyamukapa, Constance A, Mason, Peter R, ...

In cluster-randomised trial in Zimbabwe integrated peer education, condom distribution, and management of sexually transmitted infections did not reduce incidence of population-level HIV-1.

Critique of early models of the demographic impact of HIV/AIDS in sub-Saharan Africa based on contemporary empirical data from Zimbabwe

Gregson, Simon, Nyamukapa, Constance, Lopman, Ben, Mushati, Phyllis, Garnett, Geoffrey P., Chandiwana, Stephen K., ...

Early mathematical models varied in their predictions of the impact of HIV/AIDS on population growth from minimal impact to reductions in growth, in pessimistic scenarios, from positive to negative...