Ruben Smith

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion (2009)

Smith, Ruben, Bacos, Karl, Fedele, Valentina, Soulet, Denis, Walz, Helena A., Obermüller, Stefanie, ...

Huntington's disease is a severe progressive neurodegenerative disorder caused by a CAG expansion in the IT15 gene, which encodes huntingtin. The disease primarily affects the neostriatum and...

Communication breakdown - synaptic dysfunction in Huntington's disease. (2007)

Smith, Ruben

Huntington's disease (HD) is a neurodegenerative disease caused by a CAG-triplet expansion in the gene encoding the protein huntingtin. The disease typically starts in mid-life and progresses for...

Cholinergic neuronal defect without cell loss in Huntington's disease (2006)

Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG-repeat expansion in the huntingtin (IT15) gene. The striatum is one of the regions most affected by neurodegeneration,...

Cholinergic neuronal defect without cell loss in Huntington's disease (2006)

Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...

Huntington's Disease (HD) is a neurodegenerative disorder caused by a CAG-repeat expansion in the huntingtin (IT15) gene. The striatum is one of the regions most affected by neurodegeneration,...

Orexin loss in Huntington's disease (2004)

Petersén, Åsa, Gil, Joana, Maat-Schieman, Marion LC, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...

Huntington's disease is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms intracellular...

Orexin loss in Huntington's disease (2004)

Petersén, Åsa, Gil, Joana, Maat-Schieman, Marion LC, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...

Huntington's disease is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms intracellular...