Scientific Commons: Rudi Beyaert

The mammalian protein-protein interaction trap (MAPPIT) is a two-hybrid technique founded on type I cytokine signal transduction. Thereby, bait and prey proteins are linked to signalling deficient...

Cellular expression of A20 and ABIN-3 in response to Toll-like Receptor-4 stimulation (2009)

Verhelst, Kelly, Verstrepen, Lynn, Coornaert, Beatrice, Carpentier, Isabelle, Beyaert, Rudi

Although Toll-like receptor (TLR)-induced expression of several proinflammatory genes is required to provoke an efficient immune response, excessive or prolonged activation of TLR signaling can...

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling (2009)

Verstrepen, Lynn, Carpentier, Isabelle, Verhelst, Kelly, Beyaert, Rudi

ABINs have been described as three different proteins (ABIN-1, ABIN-2, ABIN-3) that bind the ubiquitin-editing nuclear factor-kappa B (NF-kappa B) inhibitor protein A20 and which show limited...

Translational control of eukaryotic gene expression (2009)

Van Der Kelen, Katrien, Beyaert, Rudi, Inzé, Dirk, De Veylder, Lieven

Translational control mechanisms are, besides transcriptional control and mRNA stability, the most deter mining for final protein levels. A large number of accessory factors that assist the ribosome...

The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation (2009)

Mueller, Andreas J., Hoffmann, Claudia, Galle, Marlies, Van Den Broeke, Aeke, Heikenwalder, Mathias, Falter, Laura, ...

In the healthy intestinal mucosa, homeostasis between the immune system and commensal micro-flora prevents detrimental inflammatory responses. Infection with acute enteropathogens such as Salmonella...

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology (2009)

Vereecke, Lars, Beyaert, Rudi, Van Loo, Geert

Nuclear factor (NF)-kappa B has an important role in immunity and inappropriate NF-kappa B activity has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms normally ensure...

TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme (2008)

Verstrepen, L, Bekaert, T, Chau, Tieu-Lan, Tavernier, J, Chariot, Alain, Beyaert, Rudi

Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and interleukin-1 (IL-1R) play an important role in innate immunity by regulating the activity of distinct...

Are the IKKs and IKK-related kinases TBK1/IKKe similarly activated ? (2008)

Chau, Tieu-Lan, Gioia, Romain, Gatot, Jean-Stéphane, Patrascu, Felicia Alina, Carpentier, Isabelle, Chapelle, Jean-Paul, ...

The IKKs, IKKa and IKKb, and the IKK-related kinases TBK1 and IKKe, play essential roles in innate immunity through signal-induced activation of NF-κB and IRF3/7, respectively. Although the...

The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens (2008)

De Boever, Sandra, Beyaert, Rudi, VANDEMAELE, F, Baert, Kris, Duchateau, Luc, Goddeeris, Bruno, ...

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappa B activation (2008)

IHA, H, PELOPONESE, JM, Verstrepen, Lynn, ZAPART, G, IKEDA, F, SMITH, CD, ...

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20 (2008)

Coornaert, Beatrice, BAENS, M, Heyninck, Karen, Bekaert, Tine, Haegman, Mira, Staal, Jens, ...

Sensing of viral infection and activation of innate immunity by toll-like receptor 3 (2008)

Vercammen, Elisabeth, Staal, Jens, Beyaert, Rudi

Expression of the NF-kappa B inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappa B (2008)

Verstrepen, Lynn, ADIB-CONQUY, M, Kreike, Marja, Carpentier, Isabelle, ADRIE, C, CAVAILLON, JM, ...

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? (2008)

CHAU, TL, GIOIA, R, GATOT, JS, PATRASCU, F, Carpentier, Isabelle, CHAPELLE, JP, ...

Ubiquitin binding mediates the NF-kappa B inhibitory potential of ABIN proteins (2008)

WAGNER, S, Carpentier, Isabelle, ROGOV, V, Kreike, Marja, IKEDA, F, LOHR, F, ...

Prolonged exposure to IL-1 beta and IFN gamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappa B/NO-dependent mechanism (2008)

Vercammen, Elisabeth, Staal, Jens, Van Den Broeke, Aeke, Haegman, Mira, Vereecke, Lars, Schotte, Peter, ...

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1 beta maturation by caspase-8 (2008)

Maelfait, Jonathan, Vercammen, Elisabeth, Janssens, Sophie, Schotte, Peter, Haegman, Mira, MAGEZ, S, ...

TLR-4, IL-1R and TNF-R signaling to NF-kappa B: variations on a common theme (2008)

Verstrepen, Lynn, Bekaert, Tine, CHAU, TL, Tavernier, Jan, CHARIOT, A, Beyaert, Rudi

ABINs inhibit EGF receptor-mediated NF-kappa B activation and growth of EGF receptor-overexpressing tumour cells (2008)

Huang, Lieven, Verstrepen, Lynn, Heyninck, Karen, Wullaert, Andy, REVETS, H, DE BAETSELIER, P, ...

The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1 beta maturation (2008)

Galle, Marlies, Schotte, Peter, Haegman, Mira, Wullaert, Andy, YANG, HJ, JIN, S, ...

Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation (2008)

Carpentier, Isabelle, Coornaert, Beatrice, Beyaert, Rudi

Non-apoptotic functions of caspase-8 (2008)

Maelfait, Jonathan, Beyaert, Rudi

A Novel TRAF6 Binding Site in MALT1 Defines Distinct Mechanisms of NF-{kappa}B Activation by API2{middle dot}MALT1 Fusions (2007)

Van Loo, Geert, Hagens, Sofie, Broeckx, Vicky, Beyaert, Rudi, ...

The recurrent translocation t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue (MALT) lymphoma results in the expression of an API2.MALT1 fusion protein that constitutively activates...

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappa B activation (2007)

Wullaert, Andy, Verstrepen, Lynn, Van Huffel, Sofie, ADIB-CONQUY, M, Cornelis, Sigrid, Kreike, Marja, ...

A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis (2007)

Schepens, Bert, Tinton, Sandrine, Bruynooghe, Yanik, Parthoens, Eef, Haegman, Mira, Beyaert, Rudi, ...

MAPPIT analysis of TLR adaptor complexes (2007)

Ulrichts, Peter, Peelman, Frank, Beyaert, Rudi, Tavernier, Jan

A novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappa B activation by API2 center dot MALT1 fusions (2007)

NOELS, H, Van Loo, Geert, HAGENS, S, BROECKX, V, Beyaert, Rudi, MARYNEN, P, ...

Hepatic tumor necrosis factor signaling and nuclear factor-kappa B: Effects on liver homeostasis and beyond (2007)

Wullaert, Andy, Van Loo, Geert, Heyninck, Karen, Beyaert, Rudi

Pellino proteins: novel players in TLR and IL-1R signalling (2007)

SCHAUVILEGE, R, Janssens, Sophie, Beyaert, Rudi

Inhibition of NF-kappa B activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G(1) cell cycle arrest in primary hepatocytes (2007)

PAPELEU, P, Wullaert, Andy, ELAUT, G, HENKENS, T, VINKEN, M, LAUS, G, ...

Immune modulation by the pseudomonas type III secretion system (2007)

Beyaert, Rudi, Galle, Marlies, Haegman, Mira, SCHOTT, P

Study of the role of FAS-associated death domain protein FADD in brain pathology by conditional gene inactivation (2007)

Van Loo, Geert, Beyaert, Rudi, WAISMAN, A, PRINZ, M, PASPARAKIS, M

Identification and evaluation of protein-protein interactions involved in NF-kB signaling using MAPPIT technology (2007)

Vereecke, Lars, Lievens, Sam, Tavernier, Jan, Van Loo, Geert, Sze, Mozes, Beyaert, Rudi

TNFa and IKKb-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKg and NF-kB activation (2006)

Bonif, Marianne, Meuwis, Marie-Alice, Close, Pierre, Benoit, Valérie, Heyninck, Karen, Chapelle, Jean-Paul, ...

Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent...

TNF alpha- and IKK beta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKK gamma and NF-kappa B activation (2006)

BONIF, M, MEUWIS, MA, CLOSE, P, BENOIT, V, Heyninck, Karen, CHAPELLE, JP, ...

A novel link between Lck, Bak expression and chemosensitivity (2006)

Heyninck, Karen, Beyaert, Rudi

Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients (2006)

ADIB-CONQUY, M, ADRIE, C, FITTING, C, GATTOLLIAT, O, Beyaert, Rudi, CAVAILLON, JM

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: A role as novel RING E3-ubiquitin-ligases (2006)

Schauvliege, Reinout, Janssens, Sophie, Beyaert, Rudi

Mechanisms of crosstalk between TNF-induced NF-kappa B and JNK activation in hepatocytes (2006)

Wullaert, Andy, Heyninck, Karen, Beyaert, Rudi

Ubiquitin: tool and target for intracellular NF-kappa B inhibitors (2006)

Wullaert, Andy, Heyninck, Karen, Janssens, Sophie, Beyaert, Rudi

Charaterisation of an LPS inflammation model in chickens (2006)

De Boever, Sandra, Beyaert, Rudi, VANDEMAELE, F, Goddeeris, Bruno, De Backer, Patrick, Croubels, Siska

Abin1 (2006)

Heyninck, Karen, Beyaert, Rudi

Abin2 (2006)

Heyninck, Karen, Beyaert, Rudi

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality (2005)

Wielockx, Ben, Van Huffel, Sofie, Bogaert, Veerle, Papeleu, Peggy, ...

Tumor necrosis factor (TNF) is a proinflammatory cytokine that plays a central role in acute and chronic hepatitis B and C infection and alcoholic liver disease as well as fulminant liver failure....

Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2 alpha (2005)

Tinton, Sandrine, Schepens, Bert, Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid

A20 inhibits NF-kappa B activation by dual ubiquitin-editing functions (2005)

Heyninck, Karen, Beyaert, Rudi

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1 (2005)

Cornelis, Sigrid, Bruynooghe, Yanik, Van Loo, Geert, Saelens, Xavier, Vandenabeele, Peter, Beyaert, Rudi

Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model (2005)

El Bakkouri, Karim, Wullaert, Andy, Haegman, Mira, Heyninck, Karen, Beyaert, Rudi

UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein (2005)

Cornelis, Sigrid, Tinton, Sandrine, Schepens, Bert, Bruynooghe, Yanik, Beyaert, Rudi

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality (2005)

Wullaert, Andy, Wielockx, Ben, Van Huffel, Sofie, Bogaert, Veerle, DE GEEST, B, PAPELEU, P, ...

The polypyrimidine tract-binding protein stimulates HIF-1 alpha IRES-mediated translation during hypoxia (2005)

Schepens, Bert, Tinton, Sandrine, Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid

Role of the adaptor protein Trif in Toll-like receptor signaling to caspase-1 (2005)

Vercammen, Elisabeth, Beyaert, Rudi

Role of the adaptor protein Trif in Toll-like receptor signaling to caspase-1 (2005)

Vercammen, Elisabeth, Beyaert, Rudi

The polypyrimidine tract-binding protein stimulates HIF-1{alpha} IRES-mediated translation during hypoxia (2005)

Schepens, Bert, Tinton, Sandrine A., Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid

When oxygen supply is restricted, protein synthesis is rapidly abrogated owing to inhibition of global translation. However, HIF-1α protein expression can persist during hypoxia, owing to an...

UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein (2005)

Cornelis, Sigrid, Tinton, Sandrine A., Schepens, Bert, Bruynooghe, Yanik, Beyaert, Rudi

Upstream of N-ras (Unr) has been described as an internal initiation trans-acting factor (ITAF) in the cap-independent translation of some particular viral and cellular mRNAs. Two factors led us to...

Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis (2004)

Carpentier, Isabelle, Habraken, Yvette, Piette, Jacques, ...

Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b+ myeloblasts. Both disease manifestations are more pronounced in...

Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+myelopoiesis (2004)

De Klerck, Bert, Carpentier, Isabelle, Lories, Rik J, Habraken, Yvette, Piette, Jacques, Carmeliet, Geert, ...

Abstract Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b + myeloblasts. Both disease manifestations are more pronounced in...

Function and regulation of tumor necrosis factor receptor type 2 (2004)

Carpentier, Isabelle, Coornaert, Beatrice, Beyaert, Rudi

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1 beta (2004)

Schotte, Peter, Denecker, Geertrui, Van Den Broeke, Aeke, Vandenabeele, Peter, CORNELIS, GR, Beyaert, Rudi

Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20 (2004)

Heyninck, Karen, Van Huffel, Sofie, Kreike, Marja, Beyaert, Rudi

The yeast three-hybrid system as a tool to study caspases (2004)

Van Criekinge, Wim, Schotte, Peter, Heyninck, Karen, Beyaert, Rudi

Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b(+) myelopoiesis (2004)

DE KLERCK, B, Carpentier, Isabelle, LORIES, RJ, HABRAKEN, Y, PIETTE, J, CARMELIET, G, ...

Inhibition of interleukin 1 receptor/toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4 (2003)

BURNS, K, Janssens, Sophie, BRISSONI, B, OLIVOS, N, Beyaert, Rudi, TSCHOPP, J

A novel type of deubiquitinating enzyme* (2003)

EVANS, PC, SMITH, TS, LAI, MJ, WILLIAMS, MG, BURKE, DF, Heyninck, Karen, ...

Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1 (2003)

Heyninck, Karen, Kreike, Marja, Beyaert, Rudi

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members (2003)

Janssens, Sophie, Beyaert, Rudi

MyD88(S), a splice variant of MyD88, differentially modulates NF-kappa B- and AP-1-dependent gene expression (2003)

Janssens, Sophie, BURNS, K, Vercammen, Elisabeth, TSCHOPP, J, Beyaert, Rudi

Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease (2003)

Heyninck, Karen, Wullaert, Andy, Beyaert, Rudi

Role of toll-like receptors in pathogen recognition (2003)

Janssens, Sophie, Beyaert, Rudi

Nuclear factor kB: Regulation and role in disease (2003)

Beyaert, Rudi

NF-kB activation by Tumor Necrosis Factor and Interleukin-1 (2003)

Carpentier, Isabelle, Janssens, Sophie, Heyninck, Karen, Beyaert, Rudi

Cytotoxicity of gamma versus alpha radiation in lymphoid cell lines with defects in the TNF receptor family mediated and NF-kappa B related apoptotic and anti-apoptotic pathways (2003)

VANDENBULCKE, KJ, VANDENBULCKE, K, Beyaert, Rudi, APOSTOLIDES, C, NIKULA, T, JANSSENS, W, ...

Regulation of IL-1 receptor- and TLR-induced NF-kB activation by alternative splicing of MyD88 (2003)

Beyaert, Rudi, Burns, Kimberley, Sophie, Janssens, Tschopp, Jurg, Vercammen, Elisabeth

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas. (2002)

Beyaert, Rudi, Van Loo, Geert, Heyninck, Karen, Vandenabeele, Peter

Regulation of interleukin-1-and lipopolysaccharide-induced NF-kappa B activation by alternative splicing of MyD88. (2002)

Janssens, Sophie, BURNS, K, TSCHOPP, J, Beyaert, Rudi

A universal role for MyD88 in TLR/IL-1R-mediated signaling. (2002)

Janssens, Sophie, Beyaert, Rudi

Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1. (2002)

Schauvliege, Reinout, VANROBAEYS, J, Schotte, Peter, Beyaert, Rudi

Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations. (2002)

TEN BOSCH, JV, Schotte, Peter, FERSTER, A, AZZI, N, BOEHLER, T, Laureys, Genevieve, ...

A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid. (2002)

Van Loo, Geert, Demol, Hans, Van Gurp, Maria, HOORELBEKE, B, Schotte, Peter, Beyaert, Rudi, ...

Caspases are not localized in mitochondria during life or death (2002)

Van Loo, Geert, Saelens, Xavier, Matthijssens, Filip, Schotte, Peter, Beyaert, Rudi, Declercq, Wim, ...

Isolation and characterization of two novel A20-like proteins. (2001)

EVANS, PC, TAYLOR, ER, COADWELL, J, Heyninck, Karen, Beyaert, Rudi, KILSHAW, PJ

Crosstalk between NF-êB-activating and apoptosis-inducing proteins of the TNF-receptor complex. (2001)

Heyninck, Karen, Beyaert, Rudi

Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappa B activation and protein-protein interactions. (2001)

Klinkenberg, Marco, Van Huffel, Sofie, Heyninck, Karen, Beyaert, Rudi

The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide. (2001)

Schotte, Peter, Schauvliege, Reinout, Janssens, Sophie, Beyaert, Rudi

Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells. (2001)

VANDERMEEREN, M, Janssens, Sophie, WOUTERS, H, BORGHMANS, I, BORGERS, M, Beyaert, Rudi, ...

Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. (2001)

Van Huffel, Sofie, Delaei, Filip, Heyninck, Karen, De Valck, Dirk, Beyaert, Rudi

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3. (2001)

WIEDER, T, ESSMANN, F, PROKOP, A, SCHMELZ, K, SCHULZE-OSTHOFF, K, Beyaert, Rudi, ...

Endonuclease G : a mitochondrial protein released in apoptosis and involved in caspaseindependent DNA degradation (2001)

Van Loo, Geert, Schotte, Peter, Van Gurp, Maria, Demol, Hans, HOORELBEKE, B, Gevaert, Kris, ...

Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF) - Evidence for a role of the TNF receptor-associated death domain protein. (2001)

Schotte, Peter, Van Loo, Geert, Carpentier, Isabelle, Vandenabeele, Peter, Beyaert, Rudi

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis. (2000)

Beyaert, Rudi, Heyninck, Karen, Van Huffel, Sofie

Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (2000)

Cornelis, Sigrid, BRUYNOOGHE, Y, Denecker, Geertrui, Van Huffel, Sofie, Tinton, Sandrine, Beyaert, Rudi

Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity. (2000)

D'Herde, Katharina, DE PREST, B, Mussche, Sylvie, Schotte, Peter, Beyaert, Rudi, Van Coster, Rudy, ...

A sensitizing function for lithium ions in tumor necrosis factor and interleukin-1 signalling. (1999)

Beyaert, Rudi

NF-KB as an emerging target in atopy. (1999)

Beyaert, Rudi

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. (1999)

De Valck, Dirk, JIN, DY, Heyninck, Karen, Van De Craen, Marc, Contreras, Roland, Fiers, Walther, ...

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappa B activation at the level of TRAF6. (1999)

Heyninck, Karen, Beyaert, Rudi

Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20. (1999)

Heyninck, Karen, Denecker, Geertrui, De Valck, Dirk, Fiers, Walther, Beyaert, Rudi

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN. (1999)

Heyninck, Karen, De Valck, Dirk, Vanden Berghe, Wim, Van Criekinge, Wim, Contreras, Roland, Fiers, Walther, ...

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. (1999)

RICKERS, A, PETERS, N, BADOCK, V, Beyaert, Rudi, Vandenabeele, Peter, DORKEN, B, ...

Non-specific effects of methyl ketone peptide inhibitors of caspases. (1999)

Schotte, Peter, Declercq, Wim, Van Huffel, Sofie, Vandenabeele, Peter, Beyaert, Rudi

Yeast two-hybrid : State of the art (1999)

VAN CRIEKINGE, W, Beyaert, Rudi

GAL4 is a substrate for caspases : Implications for two-hybrid screening and other GAL4-based assays. (1999)

VAN CRIEKINGE, W, Cornelis, Sigrid, Van De Craen, Marc, Vandenabeele, Peter, Fiers, Walther, Beyaert, Rudi

Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome. (1999)

VAN GASSEN, G, DE JONGHE, C, PYPE, S, Van Criekinge, Wim, JULLIAMS, A, VANDERHOEVEN, I, ...

TRAF1 is a TNF inducible regulator of NF-kappa B activation. (1999)

Carpentier, Isabelle, Beyaert, Rudi

More than one way to die: apoptosis, necrosis and reactive oxygen damage. (1999)

Fiers, Walther, Beyaert, Rudi, Declercq, Wim, Vandenabeele, Peter

A sensitizing function for lithium ions in tumor necrosis factor apoptosis (1999)

Schotte, Peter, Beyaert, Rudi

Apoptosis induced by gamma irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases (1999)

Louagie, Henk, Schotte, Peter, Vral, Anne, Cornelissen, Maria, Thierens, Hubert, Beyaert, Rudi, ...

TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways. (1998)

Carpentier, Isabelle, Declercq, Wim, MALININ, NL, WALLACH, D, Fiers, Walther, Beyaert, Rudi

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. (1998)

Vercammen, Dominique, Beyaert, Rudi, Denecker, Geertrui, Goossens, Vera, Van Loo, Geert, Declercq, Wim, ...

Sensitization of TNF-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. (1998)

PENNING, LC, SCHIPPER, RG, Vercammen, Dominique, VERHOFSTAD, AAJ, DENECKER, T, Beyaert, Rudi, ...

Use of the yeast three-hybrid system as a tool to study caspases. (1998)

Van Criekinge, Wim, Van Gurp, Maria, Decoster, Els, Schotte, Peter, Van De Craen, Marc, Fiers, Walther, ...

Cathepsin B-mediated activation of the proinflammatory caspase-11. (1998)

Schotte, Peter, Van Criekinge, Wim, Van De Craen, Marc, Van Loo, Geert, Desmedt, Marjory, Grooten, Johan, ...

Differential activation of phospholipases during necrosis or apoptosis: A comparative study using tumor necrosis factor and anti-Fas antibodies. (1998)

De Valck, Dirk, Vercammen, Dominique, Fiers, Walther, Beyaert, Rudi

Tumor necrosis factor and lymphotoxin (1998)

Beyaert, Rudi, Fiers, Walther

Is er leven na de (cel)dood? (1998)

VAN CRIEKTNGE, W, Smits, Elke, Burvenich, Christian, Beyaert, Rudi

Characterization of seven murine caspase family members. (1997)

VANDECRAEN, M, Vandenabeele, Peter, Declercq, Wim, VANDENBRANDE, I, VANLOO, G, MOLEMANS, F, ...

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor. (1997)

Beyaert, Rudi, KIDD, VJ, Cornelis, Sigrid, VANDECRAEN, M, Denecker, Geertrui, LAHTI, JM, ...

Cleavage of caspase family members by granzyme B: A comparative study in vitro. (1997)

VANDECRAEN, M, VANDENBRANDE, I, Declercq, Wim, IRMLER, M, Beyaert, Rudi, TSCHOPP, J, ...

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. (1997)

BARGE, RMY, WILLEMZE, R, Vandenabeele, Peter, Fiers, Walther, Beyaert, Rudi

Cell death induction by receptors of the TNF family: Towards a molecular understanding. (1997)

WALLACH, D, BOLDIN, M, VARFOLOMEEV, E, Beyaert, Rudi, Vandenabeele, Peter, Fiers, Walther

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. (1997)

Denecker, Geertrui, Vandenabeele, Peter, Grooten, Johan, PENNING, LC, Declercq, Wim, Beyaert, Rudi, ...

A20 inhibits NF-kappa B activation independently of binding to 14-3-3 proteins. (1997)

DEVALCK, D, Heyninck, Karen, Van Criekinge, Wim, Vandenabeele, Peter, Fiers, Walther, Beyaert, Rudi

Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways. (1997)

Decoster, Els, Vandevoorde, Veronique, Beyaert, Rudi, Haegeman, Guy, Fiers, Walther

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells. (1997)

Vercammen, Dominique, Vandenabeele, Peter, Beyaert, Rudi, Declercq, Wim, Fiers, Walther

A20, an inhibitor of cell death, self-associates by its zinc finger domain. (1996)

DEVALCK, D, Heyninck, Karen, Van Criekinge, Wim, Contreras, Roland, Beyaert, Rudi, Fiers, Walther

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor. (1996)

Beyaert, Rudi, CUENDA, A, VANDENBERGHE, W, PLAISANCE, S, LEE, JC, Haegeman, Guy, ...

Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells. (1996)

NIKI, T, SCHUPPAN, D, DEBLESER, PJ, VRIJSEN, R, PIPELEERSMARICHAL, M, Beyaert, Rudi, ...

Functional characterization of the prodomain of interleukin-1 beta-converting enzyme. (1996)

Van Criekinge, Wim, Beyaert, Rudi, VANDECRAEN, M, Vandenabeele, Peter, Schotte, Peter, DEVALCK, D, ...

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis. (1996)

Fiers, Walther, Beyaert, Rudi, Boone, Elke, Cornelis, Sigrid, Declercq, Wim, Decoster, Els, ...

2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION. (1995)

Vandenabeele, Peter, Declercq, Wim, Beyaert, Rudi, Fiers, Walther

Casein kinase-1 phosphorylates the p75 tumor-necrosis-factor receptor and negatively regulates tumor-necrosis-factor signaling for apoptosis. (1995)

Beyaert, Rudi, Vanhaesebroeck, Bart, Declercq, Wim, VANLINT, J, Vandenabeele, Peter, AGOSTINIS, P, ...

Two tumour necrosis factor receptors: Structure and function (1995)

Vandenabeele, Peter, Declercq, Wim, Beyaert, Rudi, Fiers, Walther

FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY. (1994)

Vandenabeele, Peter, GOOSSENS, V, Beyaert, Rudi, Declercq, Wim, Grooten, Johan, VANHAESEBROECK, B, ...

Molecular mechanisms of tumor necrosis factor-induced cytotoxicity - What we do understand and what we do not. (1994)

Beyaert, Rudi, Fiers, Walther

TUMOR-NECROSIS-FACTOR CYTOTOXICITY IS ASSOCIATED WITH PHOSPHOLIPASE-D ACTIVATION. (1993)

DEVALCK, D, Beyaert, Rudi, Van Roy, Frans, Fiers, Walther

Effect of bcl-2-proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. (1993)

Vanhaesebroeck, Bart, REED, JC, DEVALCK, D, Grooten, Johan, MIYASHITA, T, TANAKA, S, ...

SENSITIZATION OF TUMOR-CELLS TO TUMOR-NECROSIS-FACTOR ACTION BY THE PROTEIN-KINASE INHIBITOR STAUROSPORINE. (1993)

Beyaert, Rudi, Vanhaesebroeck, Bart, HEYNINCK, K, Boone, Elke, DEVALCK, D, SCHULZEOSTHOFF, K, ...

ENHANCEMENT OF TUMOR-NECROSIS-FACTOR CYTOTOXICITY BY LITHIUM-CHLORIDE IS ASSOCIATED WITH INCREASED INOSITOL PHOSPHATE ACCUMULATION. (1993)

Beyaert, Rudi, HEYNINCK, K, DEVALCK, D, BOEYKENS, F, Van Roy, Frans, Fiers, Walther

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. (1993)

SCHULZEOSTHOFF, K, Beyaert, Rudi, Vandevoorde, Veronique, Haegeman, Guy, Fiers, Walther

Tumor necrosis factor cytotoxicity is associated with activation of cellular phospholipases (1993)

De Valck, Dirk, Beyaert, Rudi, Van Roy, Frans, HERS, W

Two pathways of tumor necrosis factor signal transduction: In vitro and in vivo implications (1993)

Fiers, Walther, Beyaert, Rudi, Brouckaert, Peter, Cauwels, Anje, Declercq, Wim, De Valck, Dirk, ...

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. (1992)

SCHULZEOSTHOFF, K, BAKKER, AC, Vanhaesebroeck, Bart, Beyaert, Rudi, JACOB, WA, Fiers, Walther

Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice : Possible role in the triggering and exacerbation of psoriasis by lithium treatment. (1992)

Beyaert, Rudi, SCHULZEOSTHOFF, K, Van Roy, Frans, Fiers, Walther

Yeast Two-Hybrid: State of the Art

Van Criekinge, Wim, Beyaert, Rudi

Genome projects are approaching completion and are saturating sequence databases. This paper discusses the role of the two-hybrid system as a generator of hypotheses. Apart from this rather...

Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis

De Klerck, Bert, Carpentier, Isabelle, Lories, Rik J, Habraken, Yvette, Piette, Jacques, Carmeliet, Geert, ...

Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b+ myeloblasts. Both disease manifestations are more pronounced in interferon-γ...

Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2α

Tinton, Sandrine A., Schepens, Bert, Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid

The PITSLRE kinases belong to the large family of cyclin-dependent protein kinases. Their function has been related to cell-cycle regulation, splicing and apoptosis. We have previously shown that the...

UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein

Cornelis, Sigrid, Tinton, Sandrine A., Schepens, Bert, Bruynooghe, Yanik, Beyaert, Rudi

Upstream of N-ras (Unr) has been described as an internal initiation trans-acting factor (ITAF) in the cap-independent translation of some particular viral and cellular mRNAs. Two factors led us to...

The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia

Schepens, Bert, Tinton, Sandrine A., Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid

When oxygen supply is restricted, protein synthesis is rapidly abrogated owing to inhibition of global translation. However, HIF-1α protein expression can persist during hypoxia, owing to an...

TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation

Bonif, Marianne, Meuwis, Marie-Alice, Close, Pierre, Benoit, Valérie, Heyninck, Karen, Chapelle, Jean-Paul, ...

Pro-inflammatory cytokines trigger signalling cascades leading to NF-κB (nuclear factor-κB)-dependent gene expression through IKK [IκB (inhibitory κB) kinase]-dependent phosphorylation and...

Yeast Two-Hybrid: State of the Art

Van Criekinge, Wim, Beyaert, Rudi

Genome projects are approaching completion and are saturating sequence databases. This paper discusses the role of the two-hybrid system as a generator of hypotheses. Apart from this rather...

Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis

De Klerck, Bert, Carpentier, Isabelle, Lories, Rik J, Habraken, Yvette, Piette, Jacques, Carmeliet, Geert, ...

Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b+ myeloblasts. Both disease manifestations are more pronounced in interferon-γ...

Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2α

Tinton, Sandrine A., Schepens, Bert, Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid

The PITSLRE kinases belong to the large family of cyclin-dependent protein kinases. Their function has been related to cell-cycle regulation, splicing and apoptosis. We have previously shown that the...

UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein

Cornelis, Sigrid, Tinton, Sandrine A., Schepens, Bert, Bruynooghe, Yanik, Beyaert, Rudi

Upstream of N-ras (Unr) has been described as an internal initiation trans-acting factor (ITAF) in the cap-independent translation of some particular viral and cellular mRNAs. Two factors led us to...

The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia

Schepens, Bert, Tinton, Sandrine A., Bruynooghe, Yanik, Beyaert, Rudi, Cornelis, Sigrid

When oxygen supply is restricted, protein synthesis is rapidly abrogated owing to inhibition of global translation. However, HIF-1α protein expression can persist during hypoxia, owing to an...

TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation

Bonif, Marianne, Meuwis, Marie-Alice, Close, Pierre, Benoit, Valérie, Heyninck, Karen, Chapelle, Jean-Paul, ...

Pro-inflammatory cytokines trigger signalling cascades leading to NF-κB (nuclear factor-κB)-dependent gene expression through IKK [IκB (inhibitory κB) kinase]-dependent phosphorylation and...

A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis

Schepens, Bert, Tinton, Sandrine A, Bruynooghe, Yanik, Parthoens, Eef, Haegman, Mira, Beyaert, Rudi, ...

The upstream of N-Ras (Unr) protein is involved in translational regulation of specific genes. For example, the Unr protein contributes to translation mediated by several viral and cellular internal...

Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4

Burns, Kimberly, Janssens, Sophie, Brissoni, Brian, Olivos, Natalia, Beyaert, Rudi, Tschopp, Jürg

Toll-like receptors (TLRs) and members of the proinflammatory interleukin 1 receptor (IL-1R) family are dependent on the presence of MyD88 for efficient signal transduction. The bipartite nature of...

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

Vercammen, Dominique, Beyaert, Rudi, Denecker, Geertrui, Goossens, Vera, Van Loo, Geert, Declercq, Wim, ...

Murine L929 fibrosarcoma cells treated with tumor necrosis factor (TNF) rapidly die in a necrotic way, due to excessive formation of reactive oxygen intermediates. We investigated the role of...

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

Heyninck, Karen, De Valck, Dirk, Berghe, Wim Vanden, Van Criekinge, Wim, Contreras, Roland, Fiers, Walter, ...

The zinc finger protein A20 is a tumor necrosis factor (TNF)– and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-κB)–dependent gene expression....

Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3

Vercammen, Elisabeth, Staal, Jens, Beyaert, Rudi

Toll-like receptors (TLRs) form a major group of transmembrane receptors that are involved in the detection of invading pathogens. Double-stranded RNA is a marker for viral infection that is...

Potentiation of tumour necrosis factor-mediated activities by lithium salts : A review. Lithium, 1992, 3, 181-189.

Beyaert, Rudi, Fiers, Walther

Tumor necrosis factor : Mechanism of action and its potential for anticancer therapy. In Shugar, D., Rode, W. & Borowski, E. (eds.), 'Molecular Aspects of Chemotherapy', Polish Scientific Publishers PWN/Springer-Verlag, Warszawa/Berlin, 1992, pp. 116' -125.

HERS, W, Beyaert, Rudi, Brouckaert, Peter, Decoster, Els, De Valck, Dirk, EVERAERDT, B, ...

Tumor necrosis factor : Mechanism of action at the molecular, cellular and in vivo level. 3rd Intern. Conference on Tumor Necrosis Factor and Related Cytokines. Makuhari (Chiba, Japan), november 21-25, 1990. In Osawa, T. & Bonavida, B. (eds.), 'TumorNecrosis Factor : Structure-function Relationship and Clinical Application', Karger, Basel, 1992, pp. 66-73.

Fiers, Walther, Beyaert, Rudi, Brouckaert, Peter, Decoster, Els, De Valck, Dirk, EVERAERDT, B, ...

Tumour necrosis factor: Intracellular mechanism of action. In Guenounou, M. (ed.), 'HIV and Cytokines', INSERM, Paris, pp. 33-41, 1997.

Fiers, Walther, Beyaert, Rudi, Boone, Elke, Declercq, Wim, Decoster, Els, De Valck, Dirk, ...

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation

Iha, Hidekatsu, Peloponese, Jean-Marie, Verstrepen, Lynn, Zapart, Grzegorz, Ikeda, Fumiyo, Smith, C Dahlem, ...

Nuclear factor kappa B (NF-κB) is a key mediator of inflammation. Unchecked NF-κB signalling can engender autoimmune pathologies and cancers. Here, we show that Tax1-binding protein 1 (TAX1BP1) is...

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

Maelfait, Jonathan, Vercammen, Elisabeth, Janssens, Sophie, Schotte, Peter, Haegman, Mira, Magez, Stefan, ...

The cytokine interleukin (IL)-1β is a key mediator of the inflammatory response and has been implicated in the pathophysiology of acute and chronic inflammation. IL-1β is synthesized in response to...

Rudi Beyaert

Publication List Details