De Ruijter, Wouter, Westendorp, Rudi G J, Gussekloo, Jacobijn
OBJECTIVES: To investigate whether plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) remains a specific marker of cardiac illness in very old age and can be used to identify very elderly...
Mooijaart, Simon P., Dallinga-Thie, Geesje M., Defesche, Joep C., Steyerberg, Ewout W., Westendorp, Rudi G.J., ...
Aims Activation of the complement system seems an important link between inflammation and atherogenesis. The Y402H polymorphism of complement factor H (CFH) has been associated with cardiovascular...
Adipocytokines and risk of stroke in older people: a nested case-control study (2009)
Stott, David J, Welsh, Paul, Rumley, Ann, Robertson, Michele, Ford, Ian, Sattar, Naveed, ...
Background Inflammation may play an important role in atherothrombosis and in promoting cerebral damage after stroke. We hypothesized that plasma adipocytokine concentrations would be associated with...
Reply: Increased reproductive success of women after prenatal undernutrition? (2009)
Painter, Rebecca C., Westendorp, Rudi G.J., De Rooij, Susanne R., Osmond, Clive, Barker, David J.P., Roseboom, Tessa J.
Increased reproductive success of women after prenatal undernutrition (2008)
Painter, Rebecca C., Westendorp, Rudi G.J., De Rooij, Susanne R., Osmond, Clive, Barker, David J.P., Roseboom, Tessa J.
BACKGROUND Prenatal exposure to the Dutch famine is associated with an increased risk of chronic degenerative disease. We now investigate whether prenatal famine exposure affected reproductive...
Association between apolipoprotein E4 and cognitive decline in elderly adults (2007)
Packard, Chris J., Westendorp, Rudi G.J., Stott, David J., Caslake, Muriel J., Murray, Heather M., Shepherd, James, ...
Kuningas, Maris, Gussekloo, Jacobijn, Mooijaart, Simon P., Vinkers, David J., Jolles, Jelle, Slagboom, P. Eline, ...
Meta-Analysis of Nonsteroidal Antiinflammatory Drug Use and Risk of Dementia (2005)
Gussekloo, Jacobijn, Vrijsen, Bram, Westendorp, Rudi G. J.
The authors performed a systematic review to summarize the epidemiologic evidence on the association between use of nonsteroidal antiinflammatory drugs (NSAIDs) and the risk of dementia. A total of...
Van Exel, Eric, Macfarlane, Peter W., Gussekloo, Jacobijn, Westendorp, Rudi G.J.
Background: Disability in activities of daily living (ADL) might be more prevalent among elderly with low income due to higher prevalence of chronic diseases and impairments, as well as stronger...
Decreased Mortality among Contemplative Monks in the Netherlands (1995)
Westendorp, Rudi G. J., Kunst, Anton E., Mackenbach, Johan P., Vandenbroucke, Jan P.
Although it is generally believed that a simple lifestyle may promote health, a recent study among Trappist and Benedictine monks in the Netherlands reported an increase in general morbidity (Am J...
Interleukin 10 secretion in relation to human IL-10 locus haplotypes
Eskdale, Joyce, Gallagher, Grant, Verweij, Cor L., Keijsers, Vivian, Westendorp, Rudi G. J., Huizinga, Tom W. J.
Stimulation of human blood cultures with bacterial lipopolysaccharide (LPS) shows large inter-individual variation in interleukin 10 (IL-10) secretion, which has been shown to have a genetic...
Sijbrands, Eric J G, Westendorp, Rudi G J, Defesche, Joep C, Smelt, Augustinus H M, Kastelein, John J P
Vinkers, David J, Gussekloo, Jacobijn, Stek, Max L, Westendorp, Rudi G J, Van Der Mast, Roos C
Objective To examine the temporal relation between depression and cognitive impairment in old age.
Bastiaens, Maarten T., Kielich, Christine, Gruis, Nelleke A., Westendorp, Rudi G. J., Vermeer, Bert Jan, ...
Melanocortin-1 receptor (MC1R) gene variants are associated with fair skin and red hair and, independently of these, with cutaneous malignant melanoma. The association of MC1R gene variants with...
Are we becoming less disposable?
Evolution has programmed us for early survival and reproduction but has left us vulnerable to disease in old age. In our present affluent environment, we are better adapting to these improved...
ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age
Mooijaart, Simon P, Berbée, Jimmy F. P, Van Heemst, Diana, Havekes, Louis M, Slagboom, P. Eline, ...
Among a cohort of people over 85 those with higher levels of apoE were more likely to die from cardiovascular disease. The observed association was independent of APOE genotype and plasma lipids.
Interleukin 10 secretion in relation to human IL-10 locus haplotypes
Eskdale, Joyce, Gallagher, Grant, Verweij, Cor L., Keijsers, Vivian, Westendorp, Rudi G. J., Huizinga, Tom W. J.
Stimulation of human blood cultures with bacterial lipopolysaccharide (LPS) shows large inter-individual variation in interleukin 10 (IL-10) secretion, which has been shown to have a genetic...
Sijbrands, Eric J G, Westendorp, Rudi G J, Defesche, Joep C, Smelt, Augustinus H M, Kastelein, John J P
Vinkers, David J, Gussekloo, Jacobijn, Stek, Max L, Westendorp, Rudi G J, Van Der Mast, Roos C
Objective To examine the temporal relation between depression and cognitive impairment in old age.
Bastiaens, Maarten T., Kielich, Christine, Gruis, Nelleke A., Westendorp, Rudi G. J., Vermeer, Bert Jan, ...
Melanocortin-1 receptor (MC1R) gene variants are associated with fair skin and red hair and, independently of these, with cutaneous malignant melanoma. The association of MC1R gene variants with...
Are we becoming less disposable?
Evolution has programmed us for early survival and reproduction but has left us vulnerable to disease in old age. In our present affluent environment, we are better adapting to these improved...
ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age
Mooijaart, Simon P, Berbée, Jimmy F. P, Van Heemst, Diana, Havekes, Louis M, Slagboom, P. Eline, ...
Among a cohort of people over 85 those with higher levels of apoE were more likely to die from cardiovascular disease. The observed association was independent of APOE genotype and plasma lipids.
Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity
Heijmans, Bastiaan T, Beekman, Marian, Houwing-Duistermaat, Jeanine J, Cobain, Mark R, Powell, Jonathan, Blauw, Gerard Jan, ...
Offspring of families from the Leiden Longevity Study had larger and fewer LDL particles than same-aged partners, suggesting that even in middle age LDL particle profiles are associated with...
Hormone replacement therapy: Authors' reply
Posthuma, Ward F M, Westendorp, Rudi G J, Vandenbroucke, Jan P
Cardioprotective effect of hormone replacement therapy: Authors' reply
Posthuma, Ward F M, Westendorp, Rudi G J, Vandenbroucke, Jan P
Increased reproductive success of women after prenatal undernutrition
Painter, Rebecca C., Westendorp, Rudi G.J., De Rooij, Susanne R., Osmond, Clive, Barker, David J.P., Roseboom, Tessa J.
De Ruijter, Wouter, Westendorp, Rudi G J, Assendelft, Willem J J, Le Cessie, Saskia, ...
Objectives To investigate the performance of classic risk factors, and of some new biomarkers, in predicting cardiovascular mortality in very old people from the general population with no history of...
Ford, Ian, Bezlyak, Vladimir, Stott, David J, Sattar, Naveed, Packard, Chris J, Perry, Ivan, ...
Using data from the PROSPER trial, Ian Ford and colleagues investigate whether reduced glomerular filtration rate is associated with cardiovascular and mortality risk among elderly people.
Sattar, Naveed, Murray, Heather M., Welsh, Paul, Blauw, Gerard J., Buckley, Brendan M., Cobbe, Stuart, ...
In a secondary analysis of a randomized trial comparing pravastatin versus placebo for the prevention of coronary and cerebral events in an elderly at-risk population, Naveed Sattar and colleagues...
Genome-wide Association Study of Smoking Initiation and Current Smoking
Vink, Jacqueline M., Smit, August B., Sullivan, Patrick, Willemsen, Gonneke, Hottenga, Jouke-Jan, ...
For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three...