Hirasawa, Ryutaro, Chiba, Hatsune, Kaneda, Masahiro, Tajima, Shoji, Li, En, Jaenisch, Rudolf, ...
Parental origin-specific DNA methylation regulates the monoallelic expression of the mammalian imprinted genes. The methylation marks or imprints are established in the parental germline and...
Linhart, Heinz G., Lin, Haijiang, Yamada, Yasuhiro, Moran, Eva, Steine, Eveline J., Gokhale, Sumita, ...
Increased methylation of CpG islands and silencing of affected target genes is frequently found in human cancer; however, in vivo the question of causality has only been addressed by loss-of-function...
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis (2007)
Shaw, Alice T., Meissner, Alexander, Dowdle, James A., Crowley, Denise, Magendantz, Margaret, Ouyang, Chensi, ...
Somatic activation of Ras occurs frequently in human cancers, including one-third of lung cancers. Activating Ras mutations also occur in the germline, leading to complex developmental syndromes. The...
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis (2006)
Shimazu, Kazuhiro, Zhao, Mingrui, Sakata, Kazuko, Akbarian, Schahram, Bates, Brian, Jaenisch, Rudolf, ...
In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in which the NT-3...
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis (2006)
Shimazu, Kazuhiro, Zhao, Mingrui, Sakata, Kazuko, Akbarian, Schahram, Bates, Brian, Jaenisch, Rudolf, ...
In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in which the NT-3...
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis (2006)
Shimazu, Kazuhiro, Zhao, Mingrui, Sakata, Kazuko, Akbarian, Schahram, Bates, Brian, Jaenisch, Rudolf, ...
In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in which the NT-3...
Characterization of a highly variable eutherian microRNA gene (2005)
HOUBAVIY, HRISTO B., DENNIS, LUCAS, JAENISCH, RUDOLF, SHARP, PHILLIP A.
Mouse microRNAs (miRNAs) miR-290–miR295 are encoded by a cluster of partially homologous pre-miRNA hairpins and are likely to be functionally important in embryonic stem (ES) cells and...
Characterization of a highly variable eutherian microRNA gene (2005)
HOUBAVIY, HRISTO B., DENNIS, LUCAS, JAENISCH, RUDOLF, SHARP, PHILLIP A.
Mouse microRNAs (miRNAs) miR-290–miR295 are encoded by a cluster of partially homologous pre-miRNA hairpins and are likely to be functionally important in embryonic stem (ES) cells and...
Meissner, Alexander, Gnirke, Andreas, Bell, George W., Ramsahoye, Bernard, Lander, Eric S., Jaenisch, Rudolf
We describe a large-scale random approach termed reduced representation bisulfite sequencing (RRBS) for analyzing and comparing genomic methylation patterns. BglII restriction fragments were...
Reprogramming of a melanoma genome by nuclear transplantation (2004)
Hochedlinger, Konrad, Blelloch, Robert, Brennan, Cameron, Yamada, Yasuhiro, Kim, Minjung, Chin, Lynda, ...
We have used nuclear transplantation to test whether the reprogramming activity of oocytes can reestablish developmental pluripotency of malignant cancer cells. We show here that the nuclei of...
Rapid generation of inducible mouse mutants (2003)
Seibler, Jost, Zevnik, Branko, Küter-Luks, Birgit, Andreas, Susanne, Kern, Heidrun, Hennek, Thomas, ...
We have generated an optimized inducible recombination system for conditional gene targeting based on a Cre recombinase–steroid receptor fusion. This configuration allows efficient...
Simplified mammalian DNA isolation procedure (1991)
Laird, Peter W., Zijderveld, Alice, Linders, Koert, Rudnicki, Michael A., Jaenisch, Rudolf, Berns, Anton
Breindl, Michael, Kalthoff, Holger, Jaenisch, Rudolf
We have microinjected genomic DNA clones containing the Moloney murine leukemia virus (M-MuLV) proviral genome and flanking mouse sequences from Mov-3, Mov-7 and Mov-10 mice into Xenopus laevis...
Harbers, Klaus, Schnieke, Angelika, Stuhlmann, Heidi, Jaenisch, Rudolf
The Mov-2 and Mov-10 substrains of mice, each carrying Moloney leukemia virus (= M-MuLV) in their germ line at the Mov-2 and Mov-10 locus, respectively, do occasionally at a later age (Mov-2) or not...
Reprogramming of murine and human somatic cells using a single polycistronic vector
Carey, Bryce W., Markoulaki, Styliani, Hanna, Jacob, Saha, Kris, Gao, Qing, Mitalipova, Maisam, ...
Directed reprogramming of somatic cells by defined factors provides a novel method for the generation of patient-specific stem cells with the potential to bypass both the practical and ethical...
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
Tropea, Daniela, Giacometti, Emanuela, Wilson, Nathan R., Beard, Caroline, McCurry, Cortina, Fu, Dong Dong, ...
Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a range of...
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Tao, Jifang, Hu, Keping, Chang, Qiang, Wu, Hao, Sherman, Nicholas E., Martinowich, Keri, ...
Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain...