Stone, Jeremy G., Rolston, Raj K., Ueda, Masumi, Lee, Hyoung-Gon, Richardson, Sandy L., Castellani, Rudy J., ...
Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases. With...
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches (2009)
Rudy J. Castellani, Xiongwei Zhu, Hyoung-Gon Lee, Mark A. Smith, George Perry
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Molecular Pathogenesis of Alzheimer's Disease: Reductionist versus Expansionist Approaches. (2009)
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer's disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
ABSTRACT: Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas alpha-synuclein has been found to be...
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease (2008)
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
Abstract Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of...
Pathology's New Role: Defining Disease Process and Protective Responses. (2008)
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease (2008)
Rudy J. Castellani, Akihiko Nunomura, Raj K. Rolston, Paula I. Moreira, Atsushi Takeda, George Perry, ...
Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological...
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease. (2008)
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
ABSTRACT: Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of...
Teresa A. Evans, Sandra L. Siedlak, Liang Lu, Xiaoming Fu, Zeneng Wang, Woody R. McGinnis, ...
Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and...
Involvement of complex carbohydrate chemistry in Alzheimerâs disease (2005)
Dewitt, David A., Castellani, Rudy J., Perry, George, Smith, Mark A.
The cardinal feature of Alzheimer disease is the extracellular deposition of proteinaceous amyloid-β fibrils as senile plaques. Amyloid-β plays an essential role in disease diagnosis and is...
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Hibernation, a model of neuroprotection. (2001)
Zhou, Fang, Zhu, Xiongwei, Castellani, Rudy J., Stimmelmayr, Raphaela, Perry, George, Smith, Mark A., ...
Hibernation, a natural model of tolerance to cerebral ischemia, represents a state of pronounced fluctuation in cerebral blood flow where no brain damage occurs. Numerous neuroprotective aspects may...
Molecular Genetic Alterations in Radiation-Induced Astrocytomas
Brat, Daniel J., James, C. David, Jedlicka, Anne E., Connolly, Denise C., Chang, Ed, Castellani, Rudy J., ...
Astrocytic tumors occasionally arise in the central nervous system following radiotherapy. It is not clear if these gliomas represent a unique molecular genetic subset. We identified nine cases in...
Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated τ, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Hibernation, a Model of Neuroprotection
Zhou, Fang, Zhu, Xiongwei, Castellani, Rudy J., Stimmelmayr, Raphaela, Perry, George, Smith, Mark A., ...
Hibernation, a natural model of tolerance to cerebral ischemia, represents a state of pronounced fluctuation in cerebral blood flow where no brain damage occurs. Numerous neuroprotective aspects may...
Smith, Mark A., Zhu, Xiongwei, Lee, Hyoung-gon, Harris, Peggy L.R., Fortino, Anne E., Perry, George, ...
A number of recent studies have suggested that cardiac myocytes, previously considered post-mitotic, re-enter the cell cycle and possess the ability to proliferate with certain pathogenic stimuli. To...
Pathology's New Role: Defining Disease Process and Protective Responses
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of amyloid-β...
Stone, Jeremy G., Rolston, Raj K., Ueda, Masumi, Lee, Hyoung-Gon, Richardson, Sandy L., Castellani, Rudy J., ...
Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases. With...
Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
Castellani, Rudy J., Nunomura, Akihiko, Rolston, Raj K., Moreira, Paula I., Takeda, Atsushi, Perry, George, ...
Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological...
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major...
The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse
Lee, Hyoung-gon, Casadesus, Gemma, Nunomura, Akihiko, Zhu, Xiongwei, Castellani, Rudy J., Richardson, Sandy L., ...
Many different proteins associated with the cell cycle, including cyclins, cyclin-dependent kinases, and proto-oncogenes such as c-MYC (MYC), are increased in degenerating neurons. Consequently, an...
Lee, Hyoung-gon, Chen, Qun, Wolfram, Julie A., Richardson, Sandy L., Liner, Anna, Siedlak, Sandra L., ...
While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a “fetal re-expression” pattern, the functional role of Myc in...