Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis (2008)
Abstract Ras small GTPases are activated in many hematopoietic growth factor signaling and in hematological malignancies, but their role in hematopoiesis and leukemogenesis is not completely known....
Development and characterization of a transgenic mouse model for poliomyelitis / (1992)
Thesis (Ph. D.)--Columbia University, 1992.
Development and characterization of a transgenic mouse model for poliomyelitis [microform] / (1992)
Thesis (Ph. D.)--Columbia University, 1992.
Cuenco, Grace M., Nucifora, Giuseppina, Ren, Ruibao
The human t(3;21)(q26;q22) translocation is found as a secondary mutation in some cases of chronic myelogenous leukemia during the blast phase and in therapy-related myelodysplasia and acute...
Gross, Alec W., Zhang, Xiaowu, Ren, Ruibao
The bcr-abl oncogene plays a critical role in the pathogenesis of chronic myelogenous leukemia (CML). The fusion of Bcr sequences to Abl constitutively activates the Abl protein tyrosine kinase. We...
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of a hematopoietic stem cell. The majority of cases of CML are associated with...
Zhang, Xiaowu, Subrahmanyam, Ramesh, Wong, Ray, Gross, Alec W., Ren, Ruibao
Bcr-Abl, a fusion protein generated by t(9;22)(q34;q11) translocation, plays a critical role in the pathogenesis of chronic myelogenous leukemia (CML). It has been shown that Bcr-Abl contains...
Cuenco, Grace M., Nucifora, Giuseppina, Ren, Ruibao
The human t(3;21)(q26;q22) translocation is found as a secondary mutation in some cases of chronic myelogenous leukemia during the blast phase and in therapy-related myelodysplasia and acute...
Gross, Alec W., Zhang, Xiaowu, Ren, Ruibao
The bcr-abl oncogene plays a critical role in the pathogenesis of chronic myelogenous leukemia (CML). The fusion of Bcr sequences to Abl constitutively activates the Abl protein tyrosine kinase. We...
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of a hematopoietic stem cell. The majority of cases of CML are associated with...
Zhang, Xiaowu, Subrahmanyam, Ramesh, Wong, Ray, Gross, Alec W., Ren, Ruibao
Bcr-Abl, a fusion protein generated by t(9;22)(q34;q11) translocation, plays a critical role in the pathogenesis of chronic myelogenous leukemia (CML). It has been shown that Bcr-Abl contains...
Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice
Parikh, Chaitali, Subrahmanyam, Ramesh, Ren, Ruibao
Activating mutations in RAS, predominantly NRAS, are common in myeloid malignancies. Previous studies in animal models have shown that oncogenic NRAS is unable to induce myeloid malignancies...
Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling
Yan, Ming, Luo, Jiann-Kae, Ritchie, Kenneth J., Sakai, Ikuya, Takeuchi, Kasuto, Ren, Ruibao, ...
Interferon (IFN) signaling induces the expression of interferon-responsive genes and leads to the activation of pathways that are involved in the innate immune response. Ubp43 is an ISG15-specific...
Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis
Ras small GTPases are activated in many hematopoietic growth factor signaling and in hematological malignancies, but their role in hematopoiesis and leukemogenesis is not completely known. Here we...
IRF-4 functions as a tumor suppressor in early B-cell development
Acquaviva, Jaime, Chen, Xiaoren, Ren, Ruibao
Interferon regulatory factor-4 (IRF-4) is a hematopoietic cell–restricted transcription factor important for hematopoietic development and immune response regulation. It was also originally...