Russell L. Dedrick

In Vitro and In Vivo Pharmacology and Pharmacokinetics of a Human Engineered™ Monoclonal Antibody to Epithelial Cell Adhesion Molecule

Ammons, W Steve, Bauer, Robert J, Horwitz, Arnold H, Chen, Zhi J, Bautista, Eddie, Ruan, Harry H, ...

ING-1(heMAb), a Human Engineered™ monoclonal antibody to epithelial cell adhesion molecule (Ep-CAM), was evaluated for its in vitro and in vivo activity. The dissociation constant of ING-1(heMAb)...

In Vitro and In Vivo Pharmacology and Pharmacokinetics of a Human Engineered™ Monoclonal Antibody to Epithelial Cell Adhesion Molecule

Ammons, W Steve, Bauer, Robert J, Horwitz, Arnold H, Chen, Zhi J, Bautista, Eddie, Ruan, Harry H, ...

ING-1(heMAb), a Human Engineered™ monoclonal antibody to epithelial cell adhesion molecule (Ep-CAM), was evaluated for its in vitro and in vivo activity. The dissociation constant of ING-1(heMAb)...

Targeted Deletion of the Lipopolysaccharide (LPS)-binding Protein Gene Leads to Profound Suppression of LPS Responses Ex Vivo, whereas In Vivo Responses Remain Intact

Wurfel, Mark M., Monks, Brian G., Ingalls, Robin R., Dedrick, Russell L., Delude, Russell, Zhou, Dahua, ...

Gram-negative bacterial lipopolysaccharide (LPS) stimulates phagocytic leukocytes by interacting with the cell surface protein CD14. Cellular responses to LPS are markedly potentiated by the...