Functional Blocking of Staphylococcus aureus Adhesins following Growth in Ex Vivo Media
Massey, Ruth C., Dissanayeke, Shobana R., Cameron, Brian, Ferguson, David, Foster, Timothy J., Peacock, Sharon J.
Defining the role of Staphylococcus aureus adhesins in disease pathogenesis may depend on the use of bacteria grown in culture media that more closely reflect the human milieu than conventional...
Buckling, Angus, Neilson, James, Lindsay, Jodi, Ffrench-Constant, Richard, Enright, Mark, Day, Nicholas, ...
The mapW gene of Staphylococcus aureus strain N315 contains a poly(A) tract which truncates translation of the protein. This study demonstrates that mapW is an allelic variant of the map/eap genes...
Functional Blocking of Staphylococcus aureus Adhesins following Growth in Ex Vivo Media
Massey, Ruth C., Dissanayeke, Shobana R., Cameron, Brian, Ferguson, David, Foster, Timothy J., Peacock, Sharon J.
Defining the role of Staphylococcus aureus adhesins in disease pathogenesis may depend on the use of bacteria grown in culture media that more closely reflect the human milieu than conventional...
Buckling, Angus, Neilson, James, Lindsay, Jodi, Ffrench-Constant, Richard, Enright, Mark, Day, Nicholas, ...
The mapW gene of Staphylococcus aureus strain N315 contains a poly(A) tract which truncates translation of the protein. This study demonstrates that mapW is an allelic variant of the map/eap genes...
Agr Interference between Clinical Staphylococcus aureus Strains in an Insect Model of Virulence▿†
Fleming, Vicki, Feil, Ed, Sewell, Andrew K., Day, Nicholas, Buckling, Angus, Massey, Ruth C.
Repression of virulence by Staphylococcus aureus strains from different Agr groups has been demonstrated in vitro and is proposed as a means of competitive interference. Here, using the insect...
Interference competition and parasite virulence.
Massey, Ruth C, Buckling, Angus, Ffrench-Constant, Richard
Within-host competition between parasites, a consequence of infection by multiple strains, is predicted to favour rapid host exploitation and greater damage to hosts (virulence). However, the...
Antagonistic coevolution with parasites increases the cost of host deleterious mutations
Buckling, Angus, Wei, Yan, Massey, Ruth C, Brockhurst, Michael A, Hochberg, Michael E
The fitness consequences of deleterious mutations are sometimes greater when individuals are parasitized, hence parasites may result in the more rapid purging of deleterious mutations from host...
Massey, Ruth C., Scriba, Thomas J., Brown, Eric L., Phillips, Rodney E., Sewell, Andrew K.
In this study, we report the use of peptide-major histocompatibility complex tetramer technology to study the interactions that occur between Staphylococcus aureus proteins and human leukocytes. We...
The Staphyloccous aureus Eap Protein Activates Expression of Proinflammatory Cytokines▿
Scriba, Thomas J., Sierro, Sophie, Brown, Eric L., Phillips, Rodney E., Sewell, Andrew K., Massey, Ruth C.
The extracellular adhesion protein (Eap) secreted by the major human pathogen Staphylococcus aureus is known to have several effects on human immunity. We have recently added to knowledge of these...
Collins, James, Buckling, Angus, Massey, Ruth C.
We examined the ability of 206 clinical isolates of Staphylococcus aureus to lyse T cells and found differences between Agr groups. We found that the beta and delta hemolysins are involved and that...