Aaron T. Haselton, Ruthann Nichols, Chih-Ming Yin
Dromyosuppressin (DMS) immunoreactive neurons were discovered running along the crop duct and on the surface of the crop in the house fly, Musca domestica L. DMS is a myoinhibitory neuropeptide that...
The discovery of novel neuropeptides takes flight (2002)
Abstract Structural data are critical for the elucidation of how peptides are synthesized and how they function. Two recent studies have used nanoscale chromatography together with mass spectrometry...
Neuropeptide precursor processing detected by triple immunolabeling (1999)
McCormick, John P., Nichols, Ruthann, Lim, I.
Peptides that play critical physiological roles are often encoded in precursors that contain several gene products. Differential processing of a polypeptide precursor by cell-specific proteolytic...
Regulation of Drosophila FMRFamide neuropeptide gene expression (1999)
Nichols, Ruthann, McCormick, John P., Lim, I.
Physiologically important peptides are often encoded in precursors that contain several gene products; thus, regulation of expression of polypeptide proteins is crucial to transduction pathways....
Pendleton, Michael W., Olson, Jimmy K., Clottens, Frank L., Nachman, Ronald J., Holman, G. Mark, Meola, Shirlee M., ...
Three myotropic peptides belonging to the Arg-amide insect tachykinin family were isolated from whole-body extracts of the mosquito, Culex salinarius . The peptides, APSGFMGMR-NH 2 , APYGFTGMR-NH 2...
The spatial and temporal distribution of three peptides, DSK I, DSK II, and DSK 0, encoded by the Drosophila melanogaster drosulfakinin (Dsk) gene, have been examined in the central nervous system....
Tomas Lundquist, C., Clottens, Frank L., Mark Holman, G., Nichols, Ruthann, Nachman, Ronald J., Nassel, Dick R.
Two peptides, related to the locust myotropic peptides locustatachykinin I-IV, were isolated from the blowfly Calliphora vomitoria. Whole, frozen flies were used for extraction with acidified...
McCormick, John P., Nichols, Ruthann
The Drosophila dromyosuppressin peptide (TDVDHVFLRFamide) is a member of a family of peptides containing the common C-terminal sequence - RFamide. Dromyosuppressin shares a high degree of sequence...
Immunocytochemistry of sequence-related neuropeptides in Drosophila (1993)
Tibbetts, Michael F., Nichols, Ruthann
Based on structure, activity, and expression, the Drosophila drosulfakinin I peptide (DSK I; FDDY(OSO3H)GHMRFamide) is similar to the vertebrate peptide, cholecystokinin.1 Dromyosuppressin (DMS;...
Isolation and expression of the Drosophila drosulfakinin neural peptide gene product, DSK-I (1992)
The Drosophila drosulfakinin (dsk) gene encodes the cholecystokinin homologues drosulfakinin-I (DSK-I) and drosulfakinin-II (DSK-II). The naturally occurring DSKI peptide was isolated from an extract...
Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor
Meeusen, Tom, Mertens, Inge, Clynen, Elke, Baggerman, Geert, Nichols, Ruthann, Nachman, Ronald J., ...
We here describe the cloning and characterization of the functionally active Drosophila melanogaster (Drm) FMRFamide receptor, which we designated as DrmFMRFa-R. The full-length ORF of a D....
The discovery of novel neuropeptides takes flight
Recent studies have used nanoscale chromatography and mass spectrometry to determine the structures of novel neuropeptides in rat and Drosophila. The results shed light on neuropeptide synthesis and...
Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor
Meeusen, Tom, Mertens, Inge, Clynen, Elke, Baggerman, Geert, Nichols, Ruthann, Nachman, Ronald J., ...
We here describe the cloning and characterization of the functionally active Drosophila melanogaster (Drm) FMRFamide receptor, which we designated as DrmFMRFa-R. The full-length ORF of a D....
The discovery of novel neuropeptides takes flight
Recent studies have used nanoscale chromatography and mass spectrometry to determine the structures of novel neuropeptides in rat and Drosophila. The results shed light on neuropeptide synthesis and...