A Perl toolkit for LIMS development (2008)
Morris, J. A., Gayther, S. A., Jacobs, I. J., Jones, C.
Background High throughput laboratory techniques generate huge quantities of scientific data. Laboratory Information Management Systems (LIMS) are a necessary requirement, dealing with sample...
Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer (2007)
Ramus, S.J., Harrington, P.A., Pye, C., DiCioccio, R.A., Cox, M.J., Garlinghouse-Jones, K., ...
A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and...
Gayther, S.A., Song, H., Ramus, S.J., Kjaer, S.K., Whittemore, A.S., Quaye, L., ...
High-risk susceptibility genes explain
Khalique, L., Ayhan, A., Weale, M.E., Jacobs, I.J., Ramus, S.J., Gayther, S.A.
Genetic analysis of solid tumours using DNA or cDNA expression microarrays may enable individualized treatment based on the profiles of genetic changes that are identified from each patient. This...
A molecular genetic and statistical approach for the diagnosis of dual-site cancers (2004)
Brinkmann, D., Ryan, A., Ayhan, A., McCluggage, W.G., Feakins, R., Santibanez-Koref, M.F., ...
Background: Concurrent tumors can be synchronous, independently derived, non-metastatic tumors or metastatic tumors. The prognosis and clinical management of patients with these different concurrent...
Ramus, S.J., Pharoah, P.D.P., Harrington, P., Pye, C., Werness, B., Bobrow, L., ...
Metaphase comparative genomic hybridization was used to analyze the spectrum of genetic alterations in 141 epithelial ovarian cancers from BRCA1 and BRCA2 mutation carriers, individuals with familial...
Ford, D, Easton, D F, Stratton, M, Narod, S, Goldgar, D, Devilee, P, ...
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families, each with at least four cases of breast cancer, collected by the Breast...
Ford, D, Easton, D F, Stratton, M, Narod, S, Goldgar, D, Devilee, P, ...
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families, each with at least four cases of breast cancer, collected by the Breast...
Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population.
Friedman, L S, Gayther, S A, Kurosaki, T, Gordon, D, Noble, B, Casey, G, ...
A population-based series of 54 male breast cancer cases from Southern California were analyzed for germ-line mutations in the inherited breast/ovarian cancer genes, BRCA1 and BRCA2. Nine (17%) of...
Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia.
Gayther, S A, Harrington, P, Russell, P, Kharkevich, G, Garkavtseva, R F, Ponder, B A
Analysis of BRCA1 and BRCA2 mutations in Hungarian families with breast or breast-ovarian cancer.
Ramus, S J, Kote-Jarai, Z, Friedman, L S, Gayther, S A, Csokay, B, ...
Gayther, S. A., Harrington, P., Russell, P., Kharkevich, G., Garkavtseva, R. F., Ponder, B. A.
Germ-line mutations of the BRCA1 gene are responsible for a substantial proportion of families with multiple cases of early-onset breast and/or ovarian cancer. Since the isolation of BRCA1 last year,...
Gayther, S A, Sud, R, Wells, D, Tsioupra, K, Delhanty, J D
During the course of screening the 5' half of exon 15 of the APC gene for germline and somatic mutations in two groups of patients, those with the inherited cancer prone syndrome adenomatous...