Cells from patients with Cockayne syndrome (CS), which are sensitive to killing by UV although overall damage removal appears normal, are specifically defective in repair of UV damage in actively...
Leadon, S A, Stampfer, M R, Bartley, J
We have studied the generation of reactive oxygen species during the metabolism of a carcinogen, benzo[a]pyrene, by human mammary epithelial cells. We have quantitated the production of one type of...
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Basu, A K, Loechler, E L, Leadon, S A, Essigmann, J M
The mutational specificity and genetic requirements for mutagenesis by 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol), one of the principal DNA lesions induced by oxidation and ionizing radiation,...
Differential repair of DNA damage in specific nucleotide sequences in monkey cells.
An immunological method was developed that isolates DNA fragments containing bromouracil in repair patches from unrepaired DNA using a monoclonal antibody that recognizes bromouracil. Cultured monkey...
Restricted repair of aflatoxin B1 induced damage in alpha DNA of monkey cells.
Leadon, S A, Zolan, M E, Hanawalt, P C
We have investigated the processing of adducts formed by covalent binding of aflatoxin B1 (AFB1) to DNA in confluent cultures of African green monkey cells. Repair synthesis elicited by AFB1 adducts...
Differential repair of DNA damage in the human metallothionein gene family.
We studied the repair of UV- and aflatoxin B1 (AFB1)-induced damage in the human metallothionein (hMT) gene family. After exposure to either UV or AFB1, DNA damage was initially repaired faster in...
Cells from patients with Cockayne syndrome (CS), which are sensitive to killing by UV although overall damage removal appears normal, are specifically defective in repair of UV damage in actively...
Leadon, S A, Stampfer, M R, Bartley, J
We have studied the generation of reactive oxygen species during the metabolism of a carcinogen, benzo[a]pyrene, by human mammary epithelial cells. We have quantitated the production of one type of...
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Basu, A K, Loechler, E L, Leadon, S A, Essigmann, J M
The mutational specificity and genetic requirements for mutagenesis by 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol), one of the principal DNA lesions induced by oxidation and ionizing radiation,...
Differential repair of DNA damage in specific nucleotide sequences in monkey cells.
An immunological method was developed that isolates DNA fragments containing bromouracil in repair patches from unrepaired DNA using a monoclonal antibody that recognizes bromouracil. Cultured monkey...
Restricted repair of aflatoxin B1 induced damage in alpha DNA of monkey cells.
Leadon, S A, Zolan, M E, Hanawalt, P C
We have investigated the processing of adducts formed by covalent binding of aflatoxin B1 (AFB1) to DNA in confluent cultures of African green monkey cells. Repair synthesis elicited by AFB1 adducts...
Differential repair of DNA damage in the human metallothionein gene family.
We studied the repair of UV- and aflatoxin B1 (AFB1)-induced damage in the human metallothionein (hMT) gene family. After exposure to either UV or AFB1, DNA damage was initially repaired faster in...