Designing CD4 immunoadhesins for AIDS therapy (2007)
Capon, D. J., Chamow, S. M., Mordenti, J., Marsters, S. A., Gregory, T., Mitsuya, H., ...
A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma...
Biological properties of a CD4 immunoadhesin (2007)
Byrn, R. A., Mordenti, J., Lucas, C., Smith, D., Marsters, S. A., Johnson, J. S., ...
Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of...
Jin, H., Yang, R., Marsters, S. A., Bunting, S. A., Wurm, F. M., Chamow, S. M., ...
The protective efficacy of a p55 tumor necrosis factor receptor immunoadhesin (TNFR-IgG) was compared with that of an anti-TNF monoclonal antibody (MAb) in a rat endotoxic shock model. TNFR-IgG (5...
Marsters, S A, Pennica, D, Bach, E, Schreiber, R D, Ashkenazi, A
Signaling by interferon gamma (IFN-gamma) requires two structurally related cell surface proteins: a ligand-binding polypeptide, known as the IFN-gamma receptor (IFN-gamma R), and an accessory...
Ashkenazi, A, Smith, D H, Marsters, S A, Riddle, L, Gregory, T J, Ho, D D, ...
The infection of human cells by laboratory strains of human immunodeficiency virus type 1 (HIV-1) can be blocked readily in vitro by recombinant soluble CD4 and CD4-immunoglobulin hybrid molecules....
Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.
Ashkenazi, A, Marsters, S A, Capon, D J, Chamow, S M, Figari, I S, Pennica, D, ...
Tumor necrosis factors (TNF) alpha and beta are structurally related cytokines that mediate a wide range of immunological, inflammatory, and cytotoxic effects. During bacterial infection of the...
Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.
Ashkenazi, A, Presta, L G, Marsters, S A, Camerato, T R, Rosenthal, K A, Fendly, B M, ...
Infection of mononuclear cells by human immunodeficiency virus (HIV) begins with binding of the viral envelope glycoprotein, gp120, to its receptor, CD4. CD4 contains four extracellular...
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.
Shak, S, Capon, D J, Hellmiss, R, Marsters, S A, Baker, C L
Respiratory distress and progressive lung destruction in cystic fibrosis can be attributed to bacterial persistence and the accumulation of viscous purulent secretions in the airways. More than 30 yr...
Marsters, S A, Pennica, D, Bach, E, Schreiber, R D, Ashkenazi, A
Signaling by interferon gamma (IFN-gamma) requires two structurally related cell surface proteins: a ligand-binding polypeptide, known as the IFN-gamma receptor (IFN-gamma R), and an accessory...
Ashkenazi, A, Smith, D H, Marsters, S A, Riddle, L, Gregory, T J, Ho, D D, ...
The infection of human cells by laboratory strains of human immunodeficiency virus type 1 (HIV-1) can be blocked readily in vitro by recombinant soluble CD4 and CD4-immunoglobulin hybrid molecules....
Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.
Ashkenazi, A, Marsters, S A, Capon, D J, Chamow, S M, Figari, I S, Pennica, D, ...
Tumor necrosis factors (TNF) alpha and beta are structurally related cytokines that mediate a wide range of immunological, inflammatory, and cytotoxic effects. During bacterial infection of the...
Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.
Ashkenazi, A, Presta, L G, Marsters, S A, Camerato, T R, Rosenthal, K A, Fendly, B M, ...
Infection of mononuclear cells by human immunodeficiency virus (HIV) begins with binding of the viral envelope glycoprotein, gp120, to its receptor, CD4. CD4 contains four extracellular...
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.
Shak, S, Capon, D J, Hellmiss, R, Marsters, S A, Baker, C L
Respiratory distress and progressive lung destruction in cystic fibrosis can be attributed to bacterial persistence and the accumulation of viscous purulent secretions in the airways. More than 30 yr...
Inhibition of interferon-gamma by an interferon-gamma receptor immunoadhesin.
Haak-Frendscho, M, Marsters, S A, Chamow, S M, Peers, D H, Simpson, N J, Ashkenazi, A
Interferon-gamma (IFN-gamma) is an important cytokine which regulates inflammatory and immune response mechanisms. IFN-gamma enhances the presentation and recognition of antigens by inducing the...