Antoniou, A. C., Cunningham, A. P., Peto, J.l., Evans, D. G., Lalloo, F., Narod, S. A., ...
British Journal of Cancer Vol.98, 1457 - 1466
Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (2004)
Jernström, H, Lubinski, J, Lynch, H T, Ghadirian, P, Neuhausen, S, Isaacs, C, ...
Abstract is not available
Jernström, H, Klug, T L, Sepkovic, D W, Bradlow, H L, Narod, S A
Abstract is not available
Zweemer, R P, Shaw, P A, Verheijen, R M, Ryan, A, Berchuck, A, Ponder, B A, ...
BACKGROUND: Mutations in the BRCA1 or BRCA2 genes are responsible for up to 95% of hereditary ovarian cancer cases. Both genes function as tumour suppressor genes, and development of a cancer is...
Bignell, G R, Canzian, F, Shayeghi, M, Stark, M, Shugart, Y Y, Biggs, P, ...
Thyroid goiter is a common condition that is often associated with iodine deficiency. Familial forms of goiter in areas not known to feature iodine deficiency are much less common. We have performed...
Eeles, R A, Durocher, F, Edwards, S, Teare, D, Badzioch, M, Hamoudi, R, ...
Prostate cancer shows evidence of familial aggregation, particularly at young ages at diagnosis, but the inherited basis of familial prostate cancer is poorly understood. Smith et al. recently found...
Neuhausen, S L, Godwin, A K, Gershoni-Baruch, R, Schubert, E, Garber, J, Stoppa-Lyonnet, D, ...
Several BRCA2 mutations are found to occur in geographically diverse breast and ovarian cancer families. To investigate both mutation origin and mutation-specific phenotypes due to BRCA2, we...
A breast cancer patient of Scottish descent with germ-line mutations in BRCA1 and BRCA2.
Liede, A, Rehal, P, Vesprini, D, Jack, E, Abrahamson, J, Narod, S A
Founder BRCA1 and BRCA2 mutations in French Canadian breast and ovarian cancer families.
Tonin, P N, Mes-Masson, A M, Futreal, P A, Morgan, K, Mahon, M, Foulkes, W D, ...
We have identified four mutations in each of the breast cancer-susceptibility genes, BRCA1 and BRCA2, in French Canadian breast cancer and breast/ovarian cancer families from Quebec. To identify...
Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.
Rebbeck, T R, Kantoff, P W, Krithivas, K, Neuhausen, S, Blackwood, M A, Godwin, A K, ...
Compared with the general population, women who have inherited a germline mutation in the BRCA1 gene have a greatly increased risk of developing breast cancer. However, there is also substantial...
Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
Górski, B, Byrski, T, Huzarski, T, Jakubowska, A, Menkiszak, J, Gronwald, J, ...
We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at...
A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.
Feunteun, J, Narod, S A, Lynch, H T, Watson, P, Conway, T, Lynch, J, ...
Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74),...
Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.
Mazoyer, S, Lalle, P, Narod, S A, Bignon, Y J, Courjal, F, Jamot, B, ...
Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for...
Genetic analysis of 24 French families with multiple endocrine neoplasia type 2A.
Narod, S A, Lavoué, M F, Morgan, K, Calmettes, C, Sobol, H, Goodfellow, P J, ...
The gene for multiple endocrine neoplasia type 2A (MEN2A) has been mapped to the pericentromeric region of chromosome 10 by linkage analysis. Thirty-four families with multiple cases of medullary...
Estimating the power of linkage analysis in hereditary breast cancer.
Because evidence from several sources suggests the existence of a major genetic factor contributing to the risk for breast cancer, there is current interest in searching for genetic linkage between...
Zweemer, R P, Shaw, P A, Verheijen, R M, Ryan, A, Berchuck, A, Ponder, B A, ...
BACKGROUND: Mutations in the BRCA1 or BRCA2 genes are responsible for up to 95% of hereditary ovarian cancer cases. Both genes function as tumour suppressor genes, and development of a cancer is...
CHEK2 Is a Multiorgan Cancer Susceptibility Gene
Cybulski, C., Górski, B., Huzarski, T., Masojć, B., Mierzejewski, M., Dębniak, T., ...
A single founder allele of the CHEK2 gene has been associated with predisposition to breast and prostate cancer in North America and Europe. The CHEK2 protein participates in the DNA damage response...
Eeles, R A, Durocher, F, Edwards, S, Teare, D, Badzioch, M, Hamoudi, R, ...
Prostate cancer shows evidence of familial aggregation, particularly at young ages at diagnosis, but the inherited basis of familial prostate cancer is poorly understood. Smith et al. recently found...
Neuhausen, S L, Godwin, A K, Gershoni-Baruch, R, Schubert, E, Garber, J, Stoppa-Lyonnet, D, ...
Several BRCA2 mutations are found to occur in geographically diverse breast and ovarian cancer families. To investigate both mutation origin and mutation-specific phenotypes due to BRCA2, we...
A breast cancer patient of Scottish descent with germ-line mutations in BRCA1 and BRCA2.
Liede, A, Rehal, P, Vesprini, D, Jack, E, Abrahamson, J, Narod, S A
Founder BRCA1 and BRCA2 mutations in French Canadian breast and ovarian cancer families.
Tonin, P N, Mes-Masson, A M, Futreal, P A, Morgan, K, Mahon, M, Foulkes, W D, ...
We have identified four mutations in each of the breast cancer-susceptibility genes, BRCA1 and BRCA2, in French Canadian breast cancer and breast/ovarian cancer families from Quebec. To identify...
Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.
Rebbeck, T R, Kantoff, P W, Krithivas, K, Neuhausen, S, Blackwood, M A, Godwin, A K, ...
Compared with the general population, women who have inherited a germline mutation in the BRCA1 gene have a greatly increased risk of developing breast cancer. However, there is also substantial...
Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
Górski, B, Byrski, T, Huzarski, T, Jakubowska, A, Menkiszak, J, Gronwald, J, ...
We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at...
A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.
Feunteun, J, Narod, S A, Lynch, H T, Watson, P, Conway, T, Lynch, J, ...
Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74),...
Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.
Mazoyer, S, Lalle, P, Narod, S A, Bignon, Y J, Courjal, F, Jamot, B, ...
Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for...
Genetic analysis of 24 French families with multiple endocrine neoplasia type 2A.
Narod, S A, Lavoué, M F, Morgan, K, Calmettes, C, Sobol, H, Goodfellow, P J, ...
The gene for multiple endocrine neoplasia type 2A (MEN2A) has been mapped to the pericentromeric region of chromosome 10 by linkage analysis. Thirty-four families with multiple cases of medullary...
Estimating the power of linkage analysis in hereditary breast cancer.
Because evidence from several sources suggests the existence of a major genetic factor contributing to the risk for breast cancer, there is current interest in searching for genetic linkage between...
Serova, O M, Mazoyer, S, Puget, N, Dubois, V, Tonin, P, Shugart, Y Y, ...
To estimate the proportion of breast cancer families due to BRCA1 or BRCA2, we performed mutation screening of the entire coding regions of both genes supplemented with linkage analysis of 31...
Congenital anomalies and childhood cancer in Great Britain.
Narod, S A, Hawkins, M M, Robertson, C M, Stiller, C A
The presence of cancer and a congenital anomaly in the same child may be explained in certain cases by an underlying genetic abnormality. The study of these associations may lead to the...
Bignell, G R, Canzian, F, Shayeghi, M, Stark, M, Shugart, Y Y, Biggs, P, ...
Thyroid goiter is a common condition that is often associated with iodine deficiency. Familial forms of goiter in areas not known to feature iodine deficiency are much less common. We have performed...
The genetic basis of Muir-Torre syndrome includes the hMLH1 locus.
Bapat, B., Xia, L., Madlensky, L., Mitri, A., Tonin, P., Narod, S. A., ...
A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.
Serova, O., Montagna, M., Torchard, D., Narod, S. A., Tonin, P., Sylla, B., ...
We have analyzed 20 breast-ovarian cancer families, the majority of which show positive evidence of linkage to chromosome 17q12 for germ-line mutations in the BRCA1 gene. BRCA1 mutations...
Green, R. C., Narod, S. A., Morasse, J., Cox, J., Fitzgerald, G. W. N., ...
Hereditary nonpolyposis colon cancer (HNPCC) is an autosomal dominant trait responsible for approximately 6% of colorectal cancers. Linkage of the HNPCC trait to the D2S123 locus on 2p15-16 has...
Foulkes, W D, Bolduc, N, Lambert, D, Ginsburg, O, Olien, L, Yandell, D W, ...
Breast and colon cancer are among the most common cancers in the developed world. Several epidemiological studies suggest that the occurrence of one of these two cancers in a woman may predispose to...
Durocher, F, Tonin, P, Shattuck-Eidens, D, Skolnick, M, Narod, S A, Simard, J
Germline mutations in the BRCA1 tumour suppressor gene on chromosome 17q21 are responsible for approximately half of the cases of hereditary breast cancer, including the majority of familial...
Genetic implications of double primary cancers of the colorectum and endometrium.
Pal, T, Flanders, T, Mitchell-Lehman, M, MacMillan, A, Brunet, J S, Narod, S A, ...
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant condition predisposing to cancers of the colorectum and endometrium. Endometrial cancer is the most commonly occurring...
A large multisite cancer family is linked to BRCA2.
Tonin, P, Ghadirian, P, Phelan, C, Lenoir, G M, Lynch, H T, Letendre, F, ...
We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2...
Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study.
Foulkes, W. D., Brunet, J. S., Sieh, W., Black, M. J., Shenouda, G., Narod, S. A.
OBJECTIVE: To determine the contribution of inheritance to the incidence of squamous cell carcinoma of the head and neck. DESIGN: Historical cohort study. First degree relatives of cases with...