Corfe, B.M., Williams, E.A., Bury, J.P., Riley, S.A., Croucher, L.J., Lai, D.Y.L., ...
Background: A number of studies, notably EPIC, have shown a descrease in colorectal cancer risk associated with increased fibre consumption. Whilst the underlying mechanisms are likely to be...
Corfe, B.M., Williams, E.A., Bury, J.P., Riley, S.A., Croucher, L.J., Lai, D.Y.L., ...
BACKGROUND: A number of studies, notably EPIC, have shown a descrease in colorectal cancer risk associated with increased fibre consumption. Whilst the underlying mechanisms are likely to be...
Croucher, L.J., Bury, J.P., Williams, E.A., Riley, S.A., Corfe, B.M.
BACKGROUND: Markers of crypt cell proliferation are frequently employed in studies of the impact of genetic and exogenous factors on human colonic physiology. Human studies often rely on the...
Cell cycle regulation in patients with intestinal metaplasia at the gastro–oesophageal junction
Trudgill, N J, Suvarna, S K, Royds, J A, Riley, S A
Background/Aims: The incidence of oesophageal adenocarcinoma is increasing rapidly and this may be related to the presence of intestinal metaplasia (IM) at the gastro–oesophageal junction (GOJ)....
Cell cycle regulation in patients with intestinal metaplasia at the gastro–oesophageal junction
Trudgill, N J, Suvarna, S K, Royds, J A, Riley, S A
Background/Aims: The incidence of oesophageal adenocarcinoma is increasing rapidly and this may be related to the presence of intestinal metaplasia (IM) at the gastro–oesophageal junction (GOJ)....
Why do patients with ulcerative colitis relapse?
Riley, S A, Mani, V, Goodman, M J, Lucas, S
To determine the factors responsible for ulcerative colitis relapse a cohort of 92 patients (18 to 78 years, 50 men) with clinically inactive disease have been followed for over 48 weeks. At 12...
Microscopic activity in ulcerative colitis: what does it mean?
Riley, S A, Mani, V, Goodman, M J, Dutt, S, Herd, M E
To determine the prognostic importance of microscopic rectal inflammation we followed up 82 patients (aged 21 to 78 years, 44 men) with chronic quiescent ulcerative colitis over 12 months. At trial...
Tests of renal function in patients with quiescent colitis: effects of drug treatment.
Riley, S A, Lloyd, D R, Mani, V
Mesalazine has structural similarities to aspirin and phenacetin and is nephrotoxic when given intravenously in high doses to rats. A number of cases of nephrotoxicity has been reported recently in...
Riley, S A, Lecarpentier, J, Mani, V, Goodman, M J, Mandal, B K, Turnberg, L A
Seminal abnormalities are commonly found during sulphasalazine treatment. Although these changes appear reversible after drug withdrawal this may result in colitis relapse. Animal studies suggest...
Riley, S A, Mani, V, Goodman, M J, Herd, M E, Dutt, S, Turnberg, L A
Oral formulations of 5-aminosalicylic acid (mesalazine) appear less toxic than sulphasalazine. We have therefore compared sulphasalazine, low dose mesalazine and high dose mesalazine in the treatment...
Genetic influences in gastro-oesophageal reflux disease: a twin study
Mohammed, I, Cherkas, L F, Riley, S A, Spector, T D, Trudgill, N J
Background: A number of families have been described which include multiple members with symptomatic, endoscopic, or complicated gastro-oesophageal reflux disease (GORD). First degree relatives of...
Mesalazine release from coated tablets: effect of dietary fibre.
Riley, S A, Tavares, I A, Bishai, P M, Bennett, A, Mani, V
Delayed-release mesalazine formulations relay on pH-dependent coat dissolution to ensure delivery of 5-aminosalicylic acid (5-ASA) to the colon. As dietary fibre acidifies the colonic lumen we have...
The influence of gastrointestinal transit on drug absorption in healthy volunteers.
Riley, S A, Sutcliffe, F, Kim, M, Kapas, M, Rowland, M, Turnberg, L A
1. The effect of variability of gastric emptying and oro-caecal transit on the absorption of a multicomponent solution of frusemide, atenolol, hydrochlorthiazide and salicylic acid has been studied...
Effects of a non-absorbable osmotic load on drug absorption in healthy volunteers.
Riley, S A, Kim, M, Sutcliffe, F, Kapas, M, Rowland, M, Turnberg, L A
1. We have studied the effects of a non-absorbable osmotic load on the absorption of a multicomponent solution of frusemide, atenolol, hydrochlorothiazide and salicylic acid in six healthy...
Riley, S A, Tavares, I A, Bennett, A, Mani, V
1. Delayed-release mesalazine has been formulated to deliver 5-aminosalicylic acid to the colon. We have therefore studied the ileostomy excretion and coat dissolution of this preparation. 2....
Hereditary pancreatitis presenting with ascites.
Rao, S. S., Riley, S. A., Foster, P. N., Losowsky, M. S., Stone, W. D.
We report a case of an adolescent girl who presented with painless massive ascites secondary to chronic pancreatitis and a ductal fistula. The diagnosis was delayed and an unnecessary laparotomy was...