S. A. Roberts

Publication List Details

Period

1982 - 2005

Number

29

Co-Authors

RBE of the MIT Epithermal Neutron Beam for Crypt Cell Regeneration in Mice (2005)

J. Gueulette, P. J. Binns, X-Q. Lu, S. A. Roberts, K. J. Riley

Gueulette, J., Binns, P. J., De Coster, B. M., Lu, X-Q., Roberts, S. A. and Riley, K. J. RBE of the MIT Epithermal Neutron Beam for Crypt Cell Regeneration in Mice. Radiat. Res. 164, 805–809...

Observation and characterization of the interaction between a single immunoglobulin binding domain of protein L and two equivalents of human kappa light chains (2004)

Housden, N.G., Harrison, S., Housden, H.R., Beckingham, J.A., Roberts, S.A., ...

Detailed stopped-flow studies in combination with site-directed mutagenesis, isothermal titration calorimetry data and x-ray crystallographic knowledge have revealed that the biphasic pre-equilibrium...

Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover (2004)

Brison, D.R., Houghton, F.D., Falconer, D., Roberts, S.A., Hawkhead, J., Humpherson, P.G., ...

BACKGROUND: IVF is limited by low success rates and an unacceptably high multiple pregnancy rate. These outcomes would be improved significantly if a single embryo of high viability could be replaced...

Detection of Individual Differences in Radiation-Induced Apoptosis of Peripheral Blood Lymphocytes in Normal Individuals, Ataxia Telangiectasia Homozygotes and Heterozygotes, and Breast Cancer Patients after Radiotherapy (2000)

A. E. Kiltie, S. A. Roberts, D. Scott

Barber, J. B. P., West, C. M. L., Kiltie, A. E., Roberts, S. A. and Scott, D. Detection of Individual Differences in Radiation-Induced Apoptosis of Peripheral Blood Lymphocytes in Normal Individuals,...

A Mechanism for Automating Database Interface Design, Based on Extended E-R Modelling (1997)

S R Rollinson, S A Roberts

In this paper we present an investigation into the feasibility of semi-automating the building of an interface to a relational database. The approach taken is to identify the necessary extensions...

School Of Computer Studies Research Report Series (1997)

S R Rollinson, S A Roberts

In this paper we present an investigation into the feasibility of semi-automating the building of an interface to a relational database. The approach taken is to identify the necessary extensions...

Exploiting Object Oriented Methods for Multi-Modal Trip Planning Systems (1994)

J. E. Mccormack, S. A. Roberts

An object model of multi-modal transport networks is developed with particular emphasis on applications in trip planning. The model caters for both public and private transport modes, and...

Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells

Collis, S. J., Tighe, A., Scott, S. D., Roberts, S. A., Hendry, J. H., Margison, G. P.

The strand transferase RAD51 is a component of the homologous recombination repair pathway. To examine the contribution of RAD51 to the genotoxic effects of ionising radiation, we have used a novel...

Development of a novel rapid assay to assess the fidelity of DNA double-strand-break repair in human tumour cells

Collis, S. J., Sangar, V. K., Tighe, A., Roberts, S. A., Clarke, N. W., Hendry, J. H., ...

Cellular survival following ionising radiation-mediated damage is primarily a function of the ability to successfully detect and repair DNA double-strand breaks (DSBs). Previous studies have...

Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?

Roberts, S A, Spreadborough, A R, Bulman, B, Barber, J B, Evans, D G, Scott, D

Many inherited cancer-prone conditions show an elevated sensitivity to the induction of chromosome damage in cells exposed to ionizing radiation, indicative of defects in the processing of DNA...

Studies on cadmium-induced inhibition of hepatic microsomal drug biotransformation in the rat.

Schnell, R C, Means, J R, Roberts, S A, Pence, D H

Cadmium is a potent inhibitor of hepatic microsomal drug biotransformation in the rat. Male rats receiving a single intraperitoneal dose of cadmium exhibit significant decreases in hepatic microsomal...

Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells

Collis, S. J., Tighe, A., Scott, S. D., Roberts, S. A., Hendry, J. H., Margison, G. P.

The strand transferase RAD51 is a component of the homologous recombination repair pathway. To examine the contribution of RAD51 to the genotoxic effects of ionising radiation, we have used a novel...

Development of a novel rapid assay to assess the fidelity of DNA double-strand-break repair in human tumour cells

Collis, S. J., Sangar, V. K., Tighe, A., Roberts, S. A., Clarke, N. W., Hendry, J. H., ...

Cellular survival following ionising radiation-mediated damage is primarily a function of the ability to successfully detect and repair DNA double-strand breaks (DSBs). Previous studies have...

Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?

Roberts, S A, Spreadborough, A R, Bulman, B, Barber, J B, Evans, D G, Scott, D

Many inherited cancer-prone conditions show an elevated sensitivity to the induction of chromosome damage in cells exposed to ionizing radiation, indicative of defects in the processing of DNA...

Studies on cadmium-induced inhibition of hepatic microsomal drug biotransformation in the rat.

Schnell, R C, Means, J R, Roberts, S A, Pence, D H

Cadmium is a potent inhibitor of hepatic microsomal drug biotransformation in the rat. Male rats receiving a single intraperitoneal dose of cadmium exhibit significant decreases in hepatic microsomal...

Specific suppression of rat IgE responses with milk from immunized females and with feeds of serum antibody

Roberts, S. A., Turner, M. W.

Suckling by ovalbumin sensitized females suppressed the IgE anti-ovalbumin response of young rats. Suppression was also achieved after feeding rat pups with (i) immune adult rat serum and (ii)...

Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine.

Potten, C S, Kellett, M, Roberts, S A, Rew, D A, Wilson, G D

In vivo bromodeoxyuridine (BrdUrd) labelling of the human large bowel was performed and a detailed histochemical localisation of label in sections of crypts was undertaken using a monoclonal antibody...

Proliferation in human gastrointestinal epithelium using bromodeoxyuridine in vivo: data for different sites, proximity to a tumour, and polyposis coli.

Potten, C S, Kellett, M, Rew, D A, Roberts, S A

The distribution of DNA synthesising cells in the crypts of the epithelium in human small and large bowel after injection of bromodeoxyuridine into patients has been studied in relation to the...

Study of the proliferation in human gastric mucosa after in vivo bromodeoxyuridine labelling.

Patel, S, Rew, D A, Taylor, I, Potten, C S, Owen, C, Roberts, S A

Studies to measure human gastric crypt or gland cell proliferation may have a number of practical clinical applications in relation to both benign and malignant gastric conditions. Bromodeoxyuridine...

Specific antigen exclusion and non-specific facilitation of antigen entry across the gut in rats allergic to food proteins.

Roberts, S A, Reinhardt, M C, Paganelli, R, Levinsky, R J

The intestinal absorption of ovalbumin and beta-lactoglobulin was measured in Hooded Lister rats which had previously been made allergic to ovalbumin, and in unimmunized controls. The antigens were...

Cranial hemihypertrophy and neurodevelopmental prognosis.

Dean, J C, Cole, G F, Appleton, R E, Burn, J, Roberts, S A, Donnai, D

Three cases of congenital cranial hemihypertrophy are described. CT or ultrasound scans showed unilateral cerebral enlargement with dilatation of the ipsilateral ventricle. Seizures occurred in two...

Provocation of allergic response by supplementary feeds of cows' milk.

Roberts, S A, Soothill, J F

The postweaning IgE and IgG antiovalbumin antibody responses were greater in rat pups which had received a cows' milk-based supplementary feed than in litter mates which had not. This effect was...