Possible Ion Channel Model in Crystals of Leu-Zervamicin, (9999)
Karle, I. L., Flippen-Anderson, J. L., Agarwalla, S., Balaram, P.
The best-studied members of this class are the alamethicins for which a crystal structure has been reported. The conformation of the peptide molecule was established to be a bent helix; however, the...
Karle, Isabella L, Flippen-Anderson, Judith L, Agarwalla, S, Balaram, P
The membrane channel-forming polypeptide, Leu '-zervamicin, Ac-Leu-Ile-Gln-ha-Ile5-Thr-Aib-Leu-Aib-Hyp'o-Gln-Aib-Hyp-Aib-Pro'5-Phol ( Aib: a-aminoisobutyric acid; Iva: isovaline; Hyp:...
Karle, Isabella L, Flippen-Anderson, Judith L, Agarwalla, S, Balaram, P
The membrane channel-forming polypeptide, Leu '-zervamicin, Ac-Leu-Ile-Gln-ha-Ile5-Thr-Aib-Leu-Aib-Hyp'o-Gln-Aib-Hyp-Aib-Pro'5-Phol ( Aib: a-aminoisobutyric acid; Iva: isovaline; Hyp:...
Karle, I L, Flippen-Anderson, J L, Agarwalla, S, Balaram, P
Structures in four different crystal forms of [Leu1]zervamicin (zervamicin Z-L, Ac-Leu-Ile-Gln-Iva-Ile5-Thr-Aib-Leu-Aib-Hyp10-Gln-Aib-Hyp-Aib-P ro15-Phol, where Iva is isovaline, Aib is alpha-amino...
Karle, I L, Flippen-Anderson, J L, Agarwalla, S, Balaram, P
Structures in four different crystal forms of [Leu1]zervamicin (zervamicin Z-L, Ac-Leu-Ile-Gln-Iva-Ile5-Thr-Aib-Leu-Aib-Hyp10-Gln-Aib-Hyp-Aib-P ro15-Phol, where Iva is isovaline, Aib is alpha-amino...
Covalent tethering of the dimer interface annuls aggregation in thymidylate synthase.
Agarwalla, S., Gokhale, R. S., Santi, D. V., Balaram, P.
Thymidylate synthase (TS), a dimeric enzyme, forms large soluble aggregates at concentrations of urea (3.3-5M), well below that required for complete denaturation, as established by fluorescence and...