The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis (1990)
Xu, T, Rebay, I, Fleming, RJ, Scottgale, TN, Artavanis-Tsakonas, S
Alterations in Notch signaling in neoplastic lesions of the human cervix.
Zagouras, P, Stifani, S, Blaumueller, C M, Carcangiu, M L, Artavanis-Tsakonas, S
The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been...
Delidakis, C, Artavanis-Tsakonas, S
The E(spl) locus is thought to participate in a cell interaction mechanism that controls the choice of many cell fates during Drosophila development, including the segregation of neural precursors....
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.
Capobianco, A J, Zagouras, P, Blaumueller, C M, Artavanis-Tsakonas, S, Bishop, J M
The Notch genes of Drosophila melanogaster and vertebrates encode transmembrane receptors that help determine cell fate during development. Although ligands for Notch proteins have been identified,...
Transfer RNA genes of Drosophila melanogaster.
Dudler, R, Egg, A H, Kubli, E, Artavanis-Tsakonas, S, Gehring, W J, Steward, R, ...
Three recombinant plasmids containing randomly sheared genomic D. melanogaster tRNAs have been identified and characterized in detail. One of these, the plasmid 14C4, has a D. melanogaster (Dm) DNA...
Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster.
Artavanis-Tsakonas, S, Muskavitch, M A, Yedvobnick, B
The Notch locus is one of the best characterized loci in Drosophila melanogaster in terms of its genetic structure and developmental effects. Mutations in this locus profoundly affect the...
Mirault, M E, Goldschmidt-Clermont, M, Artavanis-Tsakonas, S, Schedl, P
The organization and number of 70,000-dalton heat-shock protein genes of Drosophila melanogaster has been investigated in a wild-type Oregon R fly stock and in a KC cell line. Six copies were found...
Preiss, A, Hartley, D A, Artavanis-Tsakonas, S
In Drosophila, the very first steps in neurogenesis appear to be controlled by a small group of zygotically acting genes termed the neurogenic loci. Mutations in any of these genes result in a...
Hartley, D A, Xu, T A, Artavanis-Tsakonas, S
The Notch locus of Drosophila melanogaster is one of a small number of zygotically acting 'neurogenic' genes necessary for the correct segregation of neural from epidermal lineages during...
Markopoulou, K., Welshons, W. J., Artavanis-Tsakonas, S.
The function of the Notch locus of Drosophila melanogaster is essential for normal development both during embryogenesis and during postembryonic stages. In the embryo its function is necessary for...
Physical and Functional Definition of the Drosophila Notch Locus by P Element Transformation
Ramos, RGP., Grimwade, B. G., Wharton, K. A., Scottgale, T. N., Artavanis-Tsakonas, S.
Notch is a developmentally regulated locus which controls the differentiation of various Drosophila tissues, among them the embryonic nervous system. Molecular analysis has suggested that Notch is...
Xu, T., Artavanis-Tsakonas, S.
The Notch locus of Drosophila melanogaster, which codes for a transmembrane protein sharing homology with the mammalian epidermal growth factor, is one of a small number of zygotically acting genes,...
Delidakis, C., Preiss, A., Hartley, D. A., Artavanis-Tsakonas, S.
Molecular correlation of the genetic aspects of the function of the neurogenic gene Enhancer of split [E(spl)] has previously been hampered by the densely transcribed nature of the chromosomal region...
A Member of the Notch Group of Interacting Loci, Deltex Encodes a Cytoplasmic Basic Protein
Busseau, I., Diederich, R. J., Xu, T., Artavanis-Tsakonas, S.
Prior genetic studies have suggested a functional relationship between the product of the deltex gene and those of three of the so-called ``neurogenic'' loci, Notch, Delta and mastermind. To gain...
Analysis of Dominant Enhancers and Suppressors of Activated Notch in Drosophila
Verheyen, E. M., Purcell, K. J., Fortini, M. E., Artavanis-Tsakonas, S.
The Notch receptor controls cell fate decisions throughout Drosophila development. Truncated, ligand-independent forms of this protein delay or block differentiation. We have previously shown that...
Go, M J, Artavanis-Tsakonas, S
The Notch receptor is the central element in a cell signaling mechanism controlling a broad spectrum of cell fate choices. Genetic modifier screens in Drosophila and subsequent molecular studies have...
Fostier, M, Evans, D A, Artavanis-Tsakonas, S, Baron, M
The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number of genes are known to be components of the pathway or regulators of the...
Cornell, M, Evans, D A, Mann, R, Fostier, M, Flasza, M, Monthatong, M, ...
During development, the Notch receptor regulates many cell fate decisions by a signaling pathway that has been conserved during evolution. One positive regulator of Notch is Deltex, a cytoplasmic,...
Alterations in Notch signaling in neoplastic lesions of the human cervix.
Zagouras, P, Stifani, S, Blaumueller, C M, Carcangiu, M L, Artavanis-Tsakonas, S
The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been...
Delidakis, C, Artavanis-Tsakonas, S
The E(spl) locus is thought to participate in a cell interaction mechanism that controls the choice of many cell fates during Drosophila development, including the segregation of neural precursors....
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.
Capobianco, A J, Zagouras, P, Blaumueller, C M, Artavanis-Tsakonas, S, Bishop, J M
The Notch genes of Drosophila melanogaster and vertebrates encode transmembrane receptors that help determine cell fate during development. Although ligands for Notch proteins have been identified,...
Transfer RNA genes of Drosophila melanogaster.
Dudler, R, Egg, A H, Kubli, E, Artavanis-Tsakonas, S, Gehring, W J, Steward, R, ...
Three recombinant plasmids containing randomly sheared genomic D. melanogaster tRNAs have been identified and characterized in detail. One of these, the plasmid 14C4, has a D. melanogaster (Dm) DNA...
Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster.
Artavanis-Tsakonas, S, Muskavitch, M A, Yedvobnick, B
The Notch locus is one of the best characterized loci in Drosophila melanogaster in terms of its genetic structure and developmental effects. Mutations in this locus profoundly affect the...
Mirault, M E, Goldschmidt-Clermont, M, Artavanis-Tsakonas, S, Schedl, P
The organization and number of 70,000-dalton heat-shock protein genes of Drosophila melanogaster has been investigated in a wild-type Oregon R fly stock and in a KC cell line. Six copies were found...
Preiss, A, Hartley, D A, Artavanis-Tsakonas, S
In Drosophila, the very first steps in neurogenesis appear to be controlled by a small group of zygotically acting genes termed the neurogenic loci. Mutations in any of these genes result in a...
Hartley, D A, Xu, T A, Artavanis-Tsakonas, S
The Notch locus of Drosophila melanogaster is one of a small number of zygotically acting 'neurogenic' genes necessary for the correct segregation of neural from epidermal lineages during...
Markopoulou, K., Welshons, W. J., Artavanis-Tsakonas, S.
The function of the Notch locus of Drosophila melanogaster is essential for normal development both during embryogenesis and during postembryonic stages. In the embryo its function is necessary for...
Physical and Functional Definition of the Drosophila Notch Locus by P Element Transformation
Ramos, RGP., Grimwade, B. G., Wharton, K. A., Scottgale, T. N., Artavanis-Tsakonas, S.
Notch is a developmentally regulated locus which controls the differentiation of various Drosophila tissues, among them the embryonic nervous system. Molecular analysis has suggested that Notch is...
Xu, T., Artavanis-Tsakonas, S.
The Notch locus of Drosophila melanogaster, which codes for a transmembrane protein sharing homology with the mammalian epidermal growth factor, is one of a small number of zygotically acting genes,...
Delidakis, C., Preiss, A., Hartley, D. A., Artavanis-Tsakonas, S.
Molecular correlation of the genetic aspects of the function of the neurogenic gene Enhancer of split [E(spl)] has previously been hampered by the densely transcribed nature of the chromosomal region...
A Member of the Notch Group of Interacting Loci, Deltex Encodes a Cytoplasmic Basic Protein
Busseau, I., Diederich, R. J., Xu, T., Artavanis-Tsakonas, S.
Prior genetic studies have suggested a functional relationship between the product of the deltex gene and those of three of the so-called ``neurogenic'' loci, Notch, Delta and mastermind. To gain...
Analysis of Dominant Enhancers and Suppressors of Activated Notch in Drosophila
Verheyen, E. M., Purcell, K. J., Fortini, M. E., Artavanis-Tsakonas, S.
The Notch receptor controls cell fate decisions throughout Drosophila development. Truncated, ligand-independent forms of this protein delay or block differentiation. We have previously shown that...
Go, M J, Artavanis-Tsakonas, S
The Notch receptor is the central element in a cell signaling mechanism controlling a broad spectrum of cell fate choices. Genetic modifier screens in Drosophila and subsequent molecular studies have...
Fostier, M, Evans, D A, Artavanis-Tsakonas, S, Baron, M
The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number of genes are known to be components of the pathway or regulators of the...
Cornell, M, Evans, D A, Mann, R, Fostier, M, Flasza, M, Monthatong, M, ...
During development, the Notch receptor regulates many cell fate decisions by a signaling pathway that has been conserved during evolution. One positive regulator of Notch is Deltex, a cytoplasmic,...