Lockwood, D.N.J., Lucas, S.B., Desikan, K.V., Ebenezer, G., Suneetha, S., Nicholls, P.
Background: Type 1 leprosy reactions (T1R) are a major inflammatory complication of leprosy affecting 30% of patients with borderline leprosy, but there has been no diagnostic evaluation of the...
Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.
Dockrell, H M, Young, S K, Britton, K, Brennan, P J, Rivoire, B, Waters, M F, ...
Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae...
De Wit, M Y, Faber, W R, Krieg, S R, Douglas, J T, Lucas, S B, Montreewasuwat, N, ...
The polymerase chain reaction (PCR) based on the selective amplification of a 530-bp fragment of the gene encoding the proline-rich antigen of Mycobacterium leprae was applied on sections of fixed or...
T-cell recognition of the 18-kilodalton antigen of Mycobacterium leprae.
Dockrell, H M, Stoker, N G, Lee, S P, Jackson, M, Grant, K A, Jouy, N F, ...
The 18-kilodalton (kDa) antigen of Mycobacterium leprae was expressed as a fusion protein with a 2-kDa leader peptide and used in proliferation assays with peripheral blood cells. Fifty percent of...
HHV8 and Kaposi's sarcoma: a time cohort study.
Kennedy, M M, Lucas, S B, Jones, R R, Howells, D D, Picton, S J, Hanks, E E, ...
AIMS: The recent finding that human herpes virus 8 (HHV8) is found in the majority of Kaposi's sarcoma (KS) cases supports the epidemiological observation that the tumour may be caused by an...
Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis.
Kennedy, M M, Cooper, K, Howells, D D, Picton, S, Biddolph, S, Lucas, S B, ...
AIMS: Kaposi's sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. Accumulating solution phase polymerase chain reaction...
Kennedy, M M, O'Leary, J J, Oates, J L, Lucas, S B, Howells, D D, Picton, S, ...
AIMS: Human herpes virus 8 (HHV-8) is the infectious agent implicated in the pathogenesis of Kaposi's sarcoma, although its mode of action is unclear. Recent work indicates that the HHV-8 genome...
CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
AIMS: Human herpesvirus 8 (HHV-8) is now acknowledged as the infective cofactor in the pathogenesis of Kaposi's sarcoma. The mode by which HHV-8 causes Kaposi's sarcoma is unresolved and it is...
Disseminated pneumocystis carinii infection in AIDS.
Coker, R J, Clark, D, Claydon, E L, Gompels, M, Ainsworth, J G, Lucas, S B, ...
Eight patients with AIDS and Pneumocystis carinii infection were studied. Protean manifestations were a feature not untypical of disseminated pneumocystosis. Aerosolised pentamidine as prophylaxis...
Cyclin D1 expression and HHV8 in Kaposi sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
BACKGROUND: Human herpesvirus 8 (HHV8) appears to be the agent responsible for Kaposi sarcoma. The mechanism remains undetermined but may involve cell cycle regulating genes including D type cyclins...
Diagnosis of intestinal microsporidiosis in patients with AIDS.
Lucas, S B, Papadaki, L, Conlon, C, Sewankambo, N, Goodgame, R, Serwadda, D
Localisation of HHV-8 in AIDS related lymphadenopathy
O'Leary, J J, Kennedy, M, Luttich, K, Uhlmann, V, Silva, I, Russell, J, ...
Background—Many lymph node abnormalities have been described in AIDS. These include opportunistic infections that sometimes result in spindle cell pseudotumours, Kaposi's sarcoma (KS), malignant...
Obscure splenomegaly in the tropics that is not the tropical splenomegaly syndrome.
DeCock, K M, Lucas, S B, Rees, P H, Hodgen, A N, Jupp, R A, Slavin, B
Clinical research, prophylaxis, therapy, and care for HIV disease in Africa.
De Cock, K M, Lucas, S B, Lucas, S, Agness, J, Kadio, A, Gayle, H D
By the end of the century, citizens of resource-poor countries will constitute 90% of the world's human immunodeficiency virus (HIV)-infected people. Clinical management of such persons in developing...
Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.
Dockrell, H M, Young, S K, Britton, K, Brennan, P J, Rivoire, B, Waters, M F, ...
Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae...
De Wit, M Y, Faber, W R, Krieg, S R, Douglas, J T, Lucas, S B, Montreewasuwat, N, ...
The polymerase chain reaction (PCR) based on the selective amplification of a 530-bp fragment of the gene encoding the proline-rich antigen of Mycobacterium leprae was applied on sections of fixed or...
T-cell recognition of the 18-kilodalton antigen of Mycobacterium leprae.
Dockrell, H M, Stoker, N G, Lee, S P, Jackson, M, Grant, K A, Jouy, N F, ...
The 18-kilodalton (kDa) antigen of Mycobacterium leprae was expressed as a fusion protein with a 2-kDa leader peptide and used in proliferation assays with peripheral blood cells. Fifty percent of...
HHV8 and Kaposi's sarcoma: a time cohort study.
Kennedy, M M, Lucas, S B, Jones, R R, Howells, D D, Picton, S J, Hanks, E E, ...
AIMS: The recent finding that human herpes virus 8 (HHV8) is found in the majority of Kaposi's sarcoma (KS) cases supports the epidemiological observation that the tumour may be caused by an...
Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis.
Kennedy, M M, Cooper, K, Howells, D D, Picton, S, Biddolph, S, Lucas, S B, ...
AIMS: Kaposi's sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. Accumulating solution phase polymerase chain reaction...
Kennedy, M M, O'Leary, J J, Oates, J L, Lucas, S B, Howells, D D, Picton, S, ...
AIMS: Human herpes virus 8 (HHV-8) is the infectious agent implicated in the pathogenesis of Kaposi's sarcoma, although its mode of action is unclear. Recent work indicates that the HHV-8 genome...
CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
AIMS: Human herpesvirus 8 (HHV-8) is now acknowledged as the infective cofactor in the pathogenesis of Kaposi's sarcoma. The mode by which HHV-8 causes Kaposi's sarcoma is unresolved and it is...
Disseminated pneumocystis carinii infection in AIDS.
Coker, R J, Clark, D, Claydon, E L, Gompels, M, Ainsworth, J G, Lucas, S B, ...
Eight patients with AIDS and Pneumocystis carinii infection were studied. Protean manifestations were a feature not untypical of disseminated pneumocystosis. Aerosolised pentamidine as prophylaxis...
Cyclin D1 expression and HHV8 in Kaposi sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
BACKGROUND: Human herpesvirus 8 (HHV8) appears to be the agent responsible for Kaposi sarcoma. The mechanism remains undetermined but may involve cell cycle regulating genes including D type cyclins...
Diagnosis of intestinal microsporidiosis in patients with AIDS.
Lucas, S B, Papadaki, L, Conlon, C, Sewankambo, N, Goodgame, R, Serwadda, D
Localisation of HHV-8 in AIDS related lymphadenopathy
O'Leary, J J, Kennedy, M, Luttich, K, Uhlmann, V, Silva, I, Russell, J, ...
Background—Many lymph node abnormalities have been described in AIDS. These include opportunistic infections that sometimes result in spindle cell pseudotumours, Kaposi's sarcoma (KS), malignant...
Obscure splenomegaly in the tropics that is not the tropical splenomegaly syndrome.
DeCock, K M, Lucas, S B, Rees, P H, Hodgen, A N, Jupp, R A, Slavin, B
Clinical research, prophylaxis, therapy, and care for HIV disease in Africa.
De Cock, K M, Lucas, S B, Lucas, S, Agness, J, Kadio, A, Gayle, H D
By the end of the century, citizens of resource-poor countries will constitute 90% of the world's human immunodeficiency virus (HIV)-infected people. Clinical management of such persons in developing...
Human retroviral infections in The Gambia: prevalence and clinical features
Mabey, D C W, Tedder, R S, Hughes, A S B, Corrah, P T, Goodison, S J F, O'Connor, T, ...
The prevalence of infection with human immunodeficiency virus type 1 (HIV 1) is lower in west Africa than in other parts of Africa. Human immunodeficiency virus type 2 (HIV 2) has been isolated from...
Computed tomographic appearances of cardiac amyloidosis.
Sekiya, T, Foster, C J, Isherwood, I, Lucas, S B, Kahn, M K, Miller, J P
Computed tomography was used to identify the characteristic appearances of histologically confirmed cardiac amyloidosis in two patients. Mean myocardial density and 95% confidence limits in one of...
Acute myocardial infarction as a cause of death in palliated hypoplastic left heart syndrome
Andrews, R E, Tulloh, R M R, Anderson, D R, Lucas, S B
A 20 month old child with hypoplastic left heart syndrome died suddenly from a massive myocardial infarction 15 months after a hemi-Fontan operation. This was confirmed at postmortem examination and...
Carcinoma of the conjunctiva and HIV infection in Uganda and Malawi.
Waddell, K. M., Lewallen, S., Lucas, S. B., Atenyi-Agaba, C., Herrington, C. S., Liomba, G.
AIM--To investigate the association of human immunodeficiency virus (HIV) infection and carcinoma of the conjunctiva in Africa, and the role of human papilloma virus type 16 (HPV-16)....
Hercules, B L, Gayed, I I, Lucas, S B, Jeacock, J
A randomised controlled trial is reported of 94 patients with a symmetrical proliferative diabetic retinopathy involving the optic disc, who were treated by a peripheral retinal ablation technique...
Prescribing aids for gentamicin
Mawer, G. E., Ahmad, R., Dobbs, Sylvia M., McGough, J. G., Lucas, S. B., Tooth, J. A.
1 A nomogram and a digital computer program have been developed to calculate dosage schedules of gentamicin for individual patients. The minimum input data consist of the patients' age, sex, body...
Phenytoin dose adjustment in epileptic patients
Mawer, G. E., Mullen, P. W., Rodgers, Margaret, Robins, A. J., Lucas, S. B.
1 A preliminary survey showed that many outpatients with partially controlled epilepsy had serum concentrations of phenytoin below the recommended therapeutic range (10-20 μg/ml). A phenytoin...
Can digoxin dose requirements be predicted?
Dobbs, S M, Mawer, G E, Rodgers, M, Woodcock, B G, Lucas, S B
A search for patient variables relevant to digoxin dose requirements was made in fourty-three patients with a wide range of renal and hepatic function. The daily dose of digoxin to achieve a mean...
Computer-assisted prescribing of kanamycin for patients with renal insufficiency (T)
Knowles, B. R., Lucas, S. B., Mawer, G. E., Stirland, R. M., Tooth, J. A.
The kinetics of amylobarbitone metabolism in healthy men and women
Balasubramaniam, K., Lucas, S. B., Mawer, G. E., Simons, P. J.
1. Sodium amylobarbitone (3·54 mg/kg) was given by intravenous injection to seven healthy men and nine healthy women who were not receiving other drugs. Serum amylobarbitone and urine...
Miller, R F, Lucas, S B, Hall-Craggs, M A, Brink, N S, Scaravilli, F, Chinn, R J, ...
OBJECTIVES: To compare the results of clinical assessment and MRI with neuropathological findings in the diagnosis of HIV and cytomegalovirus (CMV) associated CNS disease. METHODS: A retrospective...
Complications of treatment for cryptosporidial diarrhoea.
Anderson, J, George, R J, Weller, I V, Lucas, S B, Miller, R F
Recurrent pseudomembranous colitis due to Clostridium difficile in AIDS.
Churchill, D R, Lucas, S B, Williams, I, Foley, N M, Miller, R F
Fatal haemorrhage following liver biopsy in patients with HIV infection.
Churchill, D R, Mann, D, Coker, R J, Miller, R F, Glazer, G, Goldin, R D, ...
A retrospective review of all 248 liver biopsies performed in patients with HIV infection at two referral centres in London over a 12 year period revealed five cases of major bleeding following...
Occult miliary tuberculosis in advanced HIV disease.
Corbett, E L, Davidson, R N, Lucas, S B, Shetty, N, Miller, R F
Miller, R. F., Hall-Craggs, M. A., Costa, D. C., Brink, N. S., Scaravilli, F., Lucas, S. B., ...
OBJECTIVES: To compare the results of magnetic resonance imaging (MRI) and thallium-201 (201Tl) SPET scanning with laboratory analyses including CSF DNA detection, brain biopsy, and necropsy in the...
Disease in children infected with HIV in Abidjan, Côte d'Ivoire.
Lucas, S. B., Peacock, C. S., Hounnou, A., Brattegaard, K., Koffi, K., Hondé, M., ...
OBJECTIVE--To document the range of disease in African children infected with HIV. DESIGN--Necropsy results in consecutive children aged 1 month or more who were HIV positive and in children who were...
Kaposi's sarcoma associated with hairy cell leukaemia
De Cock, K. M., Lucas, S. B., Gichuyia, N. R., Kasili, E. G., Radia, K., Wankya, B. M.
The case is described of a patient with hairy cell leukaemia who later developed Kaposi's sarcoma. This association has not been reported before and the coexistence of hairy cell leukaemia with...
Contribution of tuberculosis to slim disease in Africa.
Lucas, S. B., De Cock, K. M., Hounnou, A., Peacock, C., Diomande, M., Hondé, M., ...
OBJECTIVES--To assess the contribution of tuberculosis to the aetiology of the HIV wasting syndrome (slim) in Africa, a condition usually considered an enteropathy. METHODS--Clinical examination and...
Human retroviral infections in The Gambia: prevalence and clinical features
Mabey, D C W, Tedder, R S, Hughes, A S B, Corrah, P T, Goodison, S J F, O'Connor, T, ...
The prevalence of infection with human immunodeficiency virus type 1 (HIV 1) is lower in west Africa than in other parts of Africa. Human immunodeficiency virus type 2 (HIV 2) has been isolated from...