Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors (2006)
Lu, Shu, Shen, Kate, Wang, Yaolin, Santner, Steven J., Chen, Jie, Brooks, S.C., ...
Ataxia-telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer....
Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors (2006)
Lu, Shu, Shen, Kate, Wang, Yaolin, Santner, Steven J., Chen, Jie, Brooks, S. C., ...
Ataxia-Telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer....
Impaired hepatocyte survival and liver regeneration in Atm-deficient mice (2005)
Lu, Shu, Shen, Kate C., Wang, Yaolin, Brooks, S.C., Wang, Y. Alan
Atm is a stress-induced DNA damage checkpoint protein kinase with multiple roles in cell-cycle progression. Recent evidence indicates that Atm also plays a role in stem cell maintenance and...
Impaired hepatocyte survival and liver regeneration in Atm-deficient mice (2005)
Lu, Shu, Shen, Kate C., Wang, Yaolin, Brooks, S. C., Wang, Y. Alan
Atm is a stress-induced DNA damage checkpoint protein kinase with multiple roles in cell cycle progression. Recent evidence indicates that Atm also plays a role in stem cell maintenance and...
Characterization of the estrogen receptor transfected MCF10A breast cell line 139B6 (1996)
Pilat, Mary Josephine P., Christman, J. K., Brooks, S. C.
There has been increasing evidence which suggests that abnormal expression of the estrogen receptor (ER) protein in nonmalignant breast tissue may be important in the carcinogenic process. To examine...
Angiotensin AT1 receptor blockade abolishes the reflex sympatho-excitatory response to adenosine.
Rongen, G A, Brooks, S C, Ando, S I, Abramson, B L, Floras, J S
We tested the hypothesis that endogenous angiotensin II participates in the direct and reflex effects of adenosine on the sympathetic nervous system. Nine healthy men were studied after 1 wk of the...
Estrogen receptor and natural course of breast cancer.
Singhakowinta, A, Potter, H G, Buroker, T R, Samal, B, Brooks, S C, Vaitkevicius, V K
The tumors from approximately 50% of patients with breast cancer contained estrogen receptor (ER). ER appeared more often and at higher levels in the tumors of postmenopausal women. Eleven out of 12...
Treatment for partial tears of the lateral ligament of the ankle: a prospective trial.
Brooks, S C, Potter, B T, Rainey, J B
There is debate about the most appropriate form of treatment for partial tears of the lateral ligament of the ankle, which are common after inversion injuries. A prospective trial of four forms of...
Inversion injuries of the ankle: clinical assessment and radiographic review.
Brooks, S C, Potter, B T, Rainey, J B
Inversion injuries of the ankle are a common cause of referral and presentation to accident units. They impose a load on radiographic services. A prospective trial was carried out to determine the...
Angiotensin AT1 receptor blockade abolishes the reflex sympatho-excitatory response to adenosine.
Rongen, G A, Brooks, S C, Ando, S I, Abramson, B L, Floras, J S
We tested the hypothesis that endogenous angiotensin II participates in the direct and reflex effects of adenosine on the sympathetic nervous system. Nine healthy men were studied after 1 wk of the...
Estrogen receptor and natural course of breast cancer.
Singhakowinta, A, Potter, H G, Buroker, T R, Samal, B, Brooks, S C, Vaitkevicius, V K
The tumors from approximately 50% of patients with breast cancer contained estrogen receptor (ER). ER appeared more often and at higher levels in the tumors of postmenopausal women. Eleven out of 12...
Treatment for partial tears of the lateral ligament of the ankle: a prospective trial.
Brooks, S C, Potter, B T, Rainey, J B
There is debate about the most appropriate form of treatment for partial tears of the lateral ligament of the ankle, which are common after inversion injuries. A prospective trial of four forms of...
Inversion injuries of the ankle: clinical assessment and radiographic review.
Brooks, S C, Potter, B T, Rainey, J B
Inversion injuries of the ankle are a common cause of referral and presentation to accident units. They impose a load on radiographic services. A prospective trial was carried out to determine the...
One year's trauma in a district general hospital: injury severity and survival.
We studied the accident department management and survival of all seriously injured patients brought to the Kent and Canterbury hospital over one year. The physiological state on arrival and the...
Monitoring progress in major trauma care using TRISS.
We report on the outcome of major trauma patients brought to the Kent and Canterbury Hospital in 1989 and compare it with 1987. There is an improvement which followed changes in the management of...
A THEORY OF THE MECHANISM OF DISINFECTION, HEMOLYSIS, AND SIMILAR PROCESSES
1. The course of such processes as hemolysis is very largely dependent upon variations in resistance among the different individuals, and secondarily upon the course of the fundamental reaction. 2....
THE KINETICS OF INACTIVATION OF COMPLEMENT BY LIGHT
The photoinactivation of complement has been studied with a view to determining if possible how many kinds of molecules disappeared during the reaction. It was found that: 1. The apparent course of...
THE MECHANISM OF COMPLEMENT ACTION
It has been shown: 1. That complement exposed to ultra-violet light is not thereby sensitized to the action of heat (which indicates that it is not protein). 2. That inactivation of complement by...
CONDUCTIVITY AS A MEASURE OF VITALITY AND DEATH
The conductance of Laminaria, Saccharomyces, Bacillus coli and Bacillus butyricus, Chlorella, and of red blood cells has been studied by the writer's method, and Laminaria by that of Osterhout. For...
CONDUCTIVITY AS A MEASURE OF THE PERMEABILITY OF SUSPENDED CELLS
The problem of determining by means of measurements of electrolytic conductance the permeability of living cells in suspension is considered in some detail and it is pointed out that several factors,...
THE ELECTRICAL CONDUCTIVITY OF PURE PROTOPLASM
The electrical conductivity of the plasmodium of the slime-mold Brefeldia maxima (Fr.) Rost., which constitutes practically pure protoplasm, was found to be approximately equivalent under normal...
THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS
Ashby's work on the effects of KCl and NaCl on the resistance to hypotonic hemolysis of K•-rich and K•-poor erythrocytes has been repeated with great attention to purity of materials and...