Role of BH3-only protein Bim in autoimmune and degenerative diseases (2003)
Bouillet, P, Cory, S, Adams, J, Strasser, A
No abstract available.
bcl-W, a Novel Member of the bcl-2 Family, Promotes Cell Survival (1996)
Gibson, L., Holmgreen, S. P., Huang, D. C. S., Bernand, O., Copeland, N. G., Jenkins, N. A., ...
bcl-W, a Novel Member of the bcl-2 Family, Promotes Cell Survival (1996)
Gibson, L., Holmgreen, S. P., Huang, D. C. S., Bernand, O., Copeland, N. G., Jenkins, N. A., ...
Kanost, Dawn, Basten, Antony, McCluskey, James, Cory, S.
Hen egg lysozyme (HEL)-specific T hybridomas were used to study the presentation of HEL as a self component in tolerant, HEL-transgenic mice expressing different serum levels of HEL (AL3, 3–7 nM:...
Burrows, Scott R., Fernan, Annette, Argaet, Victor, Suhrbler, Andreas, Cory, S.
Cytotoxic T lymphocyte (CTL) mediated killing has classically been associated with a high level of specificity for the target cell. However, when CTL clones and specific target cells were copelleted...
Doolan, Denise L., Khamboonruang, Chirasak, Beck, Hans-Peter, Houghten, Richard A., Good, Michael F., Cory, S.
Cytotoxic T lymphocytes (CTL) specific for epitope(s) within the circumsporozoite (CS) protein of malaria sporozoites have been shown to play an important role in protective immunity against malaria,...
Strasser, A, Harris, A W, Von Boehmer, H, Cory, S
To explore the role of bcl-2 in T-cell development, a bcl-2 transgene was introduced into mice expressing a T-cell receptor (TCR) transgene encoding reactivity for the mouse male antigen HY presented...
Strasser, A, Whittingham, S, Vaux, D L, Bath, M L, Adams, J M, Cory, S, ...
The biological functions of the BCL2 gene were investigated in transgenic mice harboring human BCL2 cDNA under the control of an immunoglobulin heavy chain enhancer (E mu). Mice of a representative...
Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.
Perkins, A, Kongsuwan, K, Visvader, J, Adams, J M, Cory, S
In the murine myelomonocytic leukemia WEHI-3B, proviral insertions have induced expression of the Hox-2.4 homeobox gene and the gene for the myeloid growth factor interleukin 3 (IL-3). To assess...
Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes.
Bowtell, D D, Cory, S, Johnson, G R, Gonda, T J
In order to identify factors that influence expression by retroviral vectors in hemopoietic cells, we have compared viral RNA levels in cells infected with several different recombinant viruses. All...
Gonda, T J, Cory, S, Sobieszczuk, P, Holtzman, D, Adams, J M
Two murine monocytic leukemia cell lines, WEHI-265 and WEHI-274, were found to carry a rearranged c-myb gene. The rearrangements are due to insertion of a deleted Moloney murine leukemia virus...
Cloned embryonic DNA sequences flanking the mouse immunoglobulin C gamma 3 and C gamma 1 genes.
Adams, J M, Webb, E, Gerondakis, S, Cory, S
To investigate the DNA surrounding genes for immunoglobulin heavy chain constant (CH) regions, we have isolated two clones bearing a C gamma 3 gene and two bearing a C gamma 1 gene from a library of...
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors.
Adams, J M, Gerondakis, S, Webb, E, Mitchell, J, Bernard, O, Cory, S
A DNA region not associated with conventional immunoglobulin gene rearrangement is rearranged in many lymphoid tumors. This region, designated here as lymphoid rearranging (LyR) DNA, was cloned from...
Gough, N M, Kemp, D J, Tyler, B M, Adams, J M, Cory, S
To elucidate the structure of the gene for the constant region of immunoglobulin mu chains, we have cloned a 9.9-kilobase-pair fragment of mouse DNA bearing a gene for the constant region of the mu...
Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.
Kemp, D J, Harris, A W, Cory, S, Adams, J M
We have used cloned nucleotide sequences as probes to search for immunoglobulin RNA in T and B lymphoid and nonlymphoid tumor cell lines. Polyadenylated RNA from the cells was fractionated...
Somatic rearrangements forming active immunoglobulin mu genes in B and T lymphoid cell lines.
Cory, S, Adams, J M, Kemp, D J
We have cloned an active gene for an immunoglobulin mu heavy (H) chain, bearing the variable (VH), joining (JH), and constant (C mu) sequences expressed in the IgM-secreting mouse plasmacytoma...
Alexander, W S, Adams, J M, Cory, S
Although transgenic mice bearing a c-myc gene controlled by the immunoglobulin heavy-chain enhancer (E mu) eventually develop B-lymphoid tumors, B-lineage cells from preneoplastic bone marrow express...
A bcr-v-abl oncogene induces lymphomas in transgenic mice.
Hariharan, I K, Harris, A W, Crawford, M, Abud, H, Webb, E, Cory, S, ...
In chronic myeloid leukemia and some cases of acute lymphoblastic leukemia, a 9;22 chromosome translocation has fused most of the c-abl oncogene to a gene designated bcr. To explore in vivo the...
Irradiated mice reconstituted with bone marrow cells infected with a retrovirus carrying the bcr-abl oncogene of human chronic myeloid leukemia are subject to a range of neoplastic hematopoietic...
Adams, J M, Gerondakis, S, Webb, E, Corcoran, L M, Cory, S
Molecular cloning has recently established that the 15;12 chromosome translocations in murine plasmacytomas fuse DNA from chromosome 15 to the immunoglobulin heavy (H) chain locus, usually within the...
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.
Strasser, A, Harris, A W, Huang, D C, Krammer, P H, Cory, S
Activation of the cell surface receptor Fas/APO-1 (CD95) induces apoptosis in lymphocytes and regulates immune responses. The cytoplasmic membrane protein Bcl-2 inhibits lymphocyte killing by diverse...
Johnson, G R, Gonda, T J, Metcalf, D, Hariharan, I K, Cory, S
Murine bone marrow cells infected with a novel recombinant retrovirus, MPZen(GM-CSF), were engrafted into lethally irradiated recipients. The transplanted animals developed extremely high circulating...
Rosenbaum, H, Webb, E, Adams, J M, Cory, S, Harris, A W
To assess the impact of constitutive N-myc expression on lymphocytes, we generated lines of transgenic mice bearing the murine N-myc oncogene coupled to the immunoglobulin heavy chain enhancer (E...
Kemp, D J, Cory, S, Adams, J M
To investigate the organization of immunoglobulin genes, we have constructed a clone library containing 10(6) randomly generated fragments of mouse embryo DNA, corresponding to eight equivalents of...
The murine myelomonocytic cell line WEHI-3B exhibits ectopic expression of the genes encoding the homeobox protein, Hox-2.4, and the myeloid growth factor, interleukin-3 (IL-3). We showed previously...
Strasser, A, Elefanty, A G, Harris, A W, Cory, S
Mice expressing both a bcl-2 and a myc transgene within the B lymphoid cell compartment invariably develop novel immature haemopoietic tumours. The likely cell of origin of these tumours was...
Cory, S, Graham, M, Webb, E, Corcoran, L, Adams, J M
The variant (6;15) translocations in murine plasmacytomas join the myc oncogene-bearing band of chromosome 15 and the immunoglobulin kappa band of chromosome 6. We recently cloned a region from...
Cory, S, Adams, J M, Gerondakis, S D, Miller, J F, Gamble, J, Wiener, F, ...
Murine plasmacytomas frequently exhibit a translocation of the distal region of chromosome 15 to the end of chromosome 12, where the immunoglobulin heavy chain locus resides. A candidate for the DNA...
Cory, S, Gerondakis, S, Adams, J M
The 15:12 chromosome translocations found in most murine plasmacytomas involve the cellular gene (c-myc) homologous to the oncogene (v-myc) of avian retrovirus MC29, Translocation links the c-myc...
Bernard, O, Cory, S, Gerondakis, S, Webb, E, Adams, J M
The 15;12 chromosome translocation in murine plasmacytomas and the 8;14 in human Burkitt lymphomas often link the cellular myc oncogene to the locus for constant regions of immunoglobulin heavy...
Huang, D C, O'Reilly, L A, Strasser, A, Cory, S
The Bcl-2 family of proteins regulate apoptosis, some antagonizing cell death and others facilitating it. It has recently been demonstrated that Bcl-2 not only inhibits apoptosis but also restrains...
Bim: a novel member of the Bcl-2 family that promotes apoptosis.
O'Connor, L, Strasser, A, O'Reilly, L A, Hausmann, G, Adams, J M, Cory, S, ...
Certain members of the Bcl-2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl-2 yielded a small novel...
Huang, D C, Adams, J M, Cory, S
Bcl-2 and close homologues such as Bcl-xL promote cell survival, while other relatives such as Bax antagonize this function. Since only the pro-survival family members possess a conserved N-terminal...
An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene.
Rosenbaum, H, Harris, A W, Bath, M L, McNeall, J, Webb, E, Adams, J M, ...
To clarify how the v-abl oncogene of Abelson murine leukemia virus contributes to lymphoid tumorigenesis, we introduced the gene linked to an immunoglobulin heavy chain enhancer (E mu) into the mouse...
Elefanty, A G, Hariharan, I K, Cory, S
The chromosome translocation forming the hybrid bcr-abl gene is thought to be the initiating event in chronic myeloid leukaemia (CML) and some cases of acute lymphoblastic leukaemia. To assess the...
Strasser, A, Harris, A W, Von Boehmer, H, Cory, S
To explore the role of bcl-2 in T-cell development, a bcl-2 transgene was introduced into mice expressing a T-cell receptor (TCR) transgene encoding reactivity for the mouse male antigen HY presented...
Strasser, A, Whittingham, S, Vaux, D L, Bath, M L, Adams, J M, Cory, S, ...
The biological functions of the BCL2 gene were investigated in transgenic mice harboring human BCL2 cDNA under the control of an immunoglobulin heavy chain enhancer (E mu). Mice of a representative...
Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.
Perkins, A, Kongsuwan, K, Visvader, J, Adams, J M, Cory, S
In the murine myelomonocytic leukemia WEHI-3B, proviral insertions have induced expression of the Hox-2.4 homeobox gene and the gene for the myeloid growth factor interleukin 3 (IL-3). To assess...
Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes.
Bowtell, D D, Cory, S, Johnson, G R, Gonda, T J
In order to identify factors that influence expression by retroviral vectors in hemopoietic cells, we have compared viral RNA levels in cells infected with several different recombinant viruses. All...
Gonda, T J, Cory, S, Sobieszczuk, P, Holtzman, D, Adams, J M
Two murine monocytic leukemia cell lines, WEHI-265 and WEHI-274, were found to carry a rearranged c-myb gene. The rearrangements are due to insertion of a deleted Moloney murine leukemia virus...
Cloned embryonic DNA sequences flanking the mouse immunoglobulin C gamma 3 and C gamma 1 genes.
Adams, J M, Webb, E, Gerondakis, S, Cory, S
To investigate the DNA surrounding genes for immunoglobulin heavy chain constant (CH) regions, we have isolated two clones bearing a C gamma 3 gene and two bearing a C gamma 1 gene from a library of...
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors.
Adams, J M, Gerondakis, S, Webb, E, Mitchell, J, Bernard, O, Cory, S
A DNA region not associated with conventional immunoglobulin gene rearrangement is rearranged in many lymphoid tumors. This region, designated here as lymphoid rearranging (LyR) DNA, was cloned from...
Gough, N M, Kemp, D J, Tyler, B M, Adams, J M, Cory, S
To elucidate the structure of the gene for the constant region of immunoglobulin mu chains, we have cloned a 9.9-kilobase-pair fragment of mouse DNA bearing a gene for the constant region of the mu...
Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.
Kemp, D J, Harris, A W, Cory, S, Adams, J M
We have used cloned nucleotide sequences as probes to search for immunoglobulin RNA in T and B lymphoid and nonlymphoid tumor cell lines. Polyadenylated RNA from the cells was fractionated...
Somatic rearrangements forming active immunoglobulin mu genes in B and T lymphoid cell lines.
Cory, S, Adams, J M, Kemp, D J
We have cloned an active gene for an immunoglobulin mu heavy (H) chain, bearing the variable (VH), joining (JH), and constant (C mu) sequences expressed in the IgM-secreting mouse plasmacytoma...
Alexander, W S, Adams, J M, Cory, S
Although transgenic mice bearing a c-myc gene controlled by the immunoglobulin heavy-chain enhancer (E mu) eventually develop B-lymphoid tumors, B-lineage cells from preneoplastic bone marrow express...
A bcr-v-abl oncogene induces lymphomas in transgenic mice.
Hariharan, I K, Harris, A W, Crawford, M, Abud, H, Webb, E, Cory, S, ...
In chronic myeloid leukemia and some cases of acute lymphoblastic leukemia, a 9;22 chromosome translocation has fused most of the c-abl oncogene to a gene designated bcr. To explore in vivo the...
Irradiated mice reconstituted with bone marrow cells infected with a retrovirus carrying the bcr-abl oncogene of human chronic myeloid leukemia are subject to a range of neoplastic hematopoietic...
Adams, J M, Gerondakis, S, Webb, E, Corcoran, L M, Cory, S
Molecular cloning has recently established that the 15;12 chromosome translocations in murine plasmacytomas fuse DNA from chromosome 15 to the immunoglobulin heavy (H) chain locus, usually within the...
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.
Strasser, A, Harris, A W, Huang, D C, Krammer, P H, Cory, S
Activation of the cell surface receptor Fas/APO-1 (CD95) induces apoptosis in lymphocytes and regulates immune responses. The cytoplasmic membrane protein Bcl-2 inhibits lymphocyte killing by diverse...
Johnson, G R, Gonda, T J, Metcalf, D, Hariharan, I K, Cory, S
Murine bone marrow cells infected with a novel recombinant retrovirus, MPZen(GM-CSF), were engrafted into lethally irradiated recipients. The transplanted animals developed extremely high circulating...
Rosenbaum, H, Webb, E, Adams, J M, Cory, S, Harris, A W
To assess the impact of constitutive N-myc expression on lymphocytes, we generated lines of transgenic mice bearing the murine N-myc oncogene coupled to the immunoglobulin heavy chain enhancer (E...
Kemp, D J, Cory, S, Adams, J M
To investigate the organization of immunoglobulin genes, we have constructed a clone library containing 10(6) randomly generated fragments of mouse embryo DNA, corresponding to eight equivalents of...
The murine myelomonocytic cell line WEHI-3B exhibits ectopic expression of the genes encoding the homeobox protein, Hox-2.4, and the myeloid growth factor, interleukin-3 (IL-3). We showed previously...
Strasser, A, Elefanty, A G, Harris, A W, Cory, S
Mice expressing both a bcl-2 and a myc transgene within the B lymphoid cell compartment invariably develop novel immature haemopoietic tumours. The likely cell of origin of these tumours was...
An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene.
Rosenbaum, H, Harris, A W, Bath, M L, McNeall, J, Webb, E, Adams, J M, ...
To clarify how the v-abl oncogene of Abelson murine leukemia virus contributes to lymphoid tumorigenesis, we introduced the gene linked to an immunoglobulin heavy chain enhancer (E mu) into the mouse...
Elefanty, A G, Hariharan, I K, Cory, S
The chromosome translocation forming the hybrid bcr-abl gene is thought to be the initiating event in chronic myeloid leukaemia (CML) and some cases of acute lymphoblastic leukaemia. To assess the...
Cory, S, Graham, M, Webb, E, Corcoran, L, Adams, J M
The variant (6;15) translocations in murine plasmacytomas join the myc oncogene-bearing band of chromosome 15 and the immunoglobulin kappa band of chromosome 6. We recently cloned a region from...
Cory, S, Adams, J M, Gerondakis, S D, Miller, J F, Gamble, J, Wiener, F, ...
Murine plasmacytomas frequently exhibit a translocation of the distal region of chromosome 15 to the end of chromosome 12, where the immunoglobulin heavy chain locus resides. A candidate for the DNA...
Cory, S, Gerondakis, S, Adams, J M
The 15:12 chromosome translocations found in most murine plasmacytomas involve the cellular gene (c-myc) homologous to the oncogene (v-myc) of avian retrovirus MC29, Translocation links the c-myc...
Bernard, O, Cory, S, Gerondakis, S, Webb, E, Adams, J M
The 15;12 chromosome translocation in murine plasmacytomas and the 8;14 in human Burkitt lymphomas often link the cellular myc oncogene to the locus for constant regions of immunoglobulin heavy...
Huang, D C, O'Reilly, L A, Strasser, A, Cory, S
The Bcl-2 family of proteins regulate apoptosis, some antagonizing cell death and others facilitating it. It has recently been demonstrated that Bcl-2 not only inhibits apoptosis but also restrains...
Bim: a novel member of the Bcl-2 family that promotes apoptosis.
O'Connor, L, Strasser, A, O'Reilly, L A, Hausmann, G, Adams, J M, Cory, S, ...
Certain members of the Bcl-2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl-2 yielded a small novel...
Huang, D C, Adams, J M, Cory, S
Bcl-2 and close homologues such as Bcl-xL promote cell survival, while other relatives such as Bax antagonize this function. Since only the pro-survival family members possess a conserved N-terminal...