S. D. Baker

Publication List Details

Period

1974 - 2008

Number

23

Co-Authors

Phase I study of troxacitabine administered by continuous infusion in subjects with advanced solid malignancies (2008)

Jimeno, A., Messersmith, W. A., Lee, C. K., Ma, W. W., Laheru, D., Donehower, R. C., ...

Background: Troxacitabine is a novel L-nucleoside analogue. Preclinical studies showed improved activity with infusions of at least 3 days compared with bolus regimens, especially at concentrations...

Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies (2003)

Sparreboom, A., Wolff, A.C., Verweij, J., Zabelina, Y., Zomereen, D.M. Van, McIntire, G.L., ...

PURPOSE: Docosahexaenoic acid-paclitaxel is as an inert prodrug composed of the natural fatty acid DHA covalently linked to the C2'-position of paclitaxel (M. O. Bradley et al., Clin. Cancer Res., 7:...

Irinotecan pathway genotype analysis to predict pharmacokinetics (2003)

Mathijssen, R.H., Marsh, S., Karlsson, M.O., Xie, R., Baker, S.D., Verweij, J., ...

PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of...

High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: A phase II and pharmacodynamic study (1998)

Rowinsky, E. K., Baker, S. D., Burks, K., O'Reilly, S., Donehower, R. C., Grochow, L. B.

Purpose: The premise for the study was that topotecan (TPT) resistance in preclinical studies is associated with low level expression of the p-glycoprotein (Pgp) multi-drug transporter conferred by...

A phase I and pharmacologic study of DMP 840 administered by 24-hour infusion (1998)

O'Reilly, S., Baker, S. D., Sartorius, S., Rowinsky, E. K., Finizio, M., Lubiniecki, G. M., ...

Purpose: DMP 840, a novel bisnaphthalimide, has demonstrated promising schedule dependent anti-tumor activity in vitro and in vivo against several tumor cell lines. A phase I study was conducted to...

Modulation of erlotinib pharmacokinetics in mice by a novel cytochrome P450 3A4 inhibitor, BAS 100

Smith, N F, Baker, S D, Gonzalez, F J, Harris, J W, Figg, W D, Sparreboom, A

Administration of BAS 100, a novel mechanism-based CYP3A4 inhibitor isolated from grapefruit juice, resulted in a 2.1-fold increase in erlotinib exposure following oral administration to wild-type...