EMPReSS: standardized phenotype screens for functional annotation of the mouse genome (2008)
Brown, S. D., Chambon, P., De Angelis, M. H., Eumorphia Consortium
Dipolar excitations at the LIII x-ray absorption edges of the heavy rare earth metals (2007)
Brown, S. D., Strange, P., Bouchenoire, L., Zarychta, B., Thompson, P. B. J., Mannix, D., ...
We report measured dipolar asymmetry ratios at the LIII edges of the heavy rare earth metals. The results are compared with a first principles calculation and excellent agreement is found. A simple...
Social networking technology: Place and identity in mediated communities (2007)
This is the authors' final draft of the paper published as Journal of Community & Applied Psychology, vol. 17, pp.463-476. The final published version is available at...
Profile of the U 5f magnetization in U/Fe multilayers (2007)
Brown, S. D., Bouchenoire, L., Thompson, P., Springell, R., Mirone, A., Stirling, W. G., ...
Recent calculations, concerning the magnetism of uranium in the U/Fe multilayer system have described the spatial dependence of the 5f polarization that might be expected. We have used the x-ray...
A study of uranium-based multilayers: I. Fabrication and structural characterisation (2007)
Springell, R, Zochowski, S W, Ward, R C C, Wells, M R, Brown, S D, Bouchenoire, L, ...
This paper addresses the structural characterisation of a series of U/Fe, U/Co and U/Gd multilayers. X-ray reflectivity has been employed to investigate the layer thickness and roughness parameters...
A study of uranium-based multilayers: II. Magnetic properties (2007)
Springell, R, Zochowski, S W, Ward, R C C, Wells, M R, Brown, S D, Bouchenoire, L, ...
SQUID magnetometry and polarised neutron reflectivity measurements have been employed to characterise the magnetic properties of U/Fe, U/Co and U/Gd multilayers. The field dependence of the...
Brown, S. D., Greenbaum, S. G., McLin, M. G., Wintersgill, M. C., Fontanella, J. J.
Complex impedance/electrical conductivity, differential scanning calorimetry and 7Li nuclear magnetic resonance measurements on poly (propylene oxide) complexed with two lithium salts LiN(SO2CF3)2...
Orbital bi-stripes in highly doped bilayer manganites. (2005)
Beale, T. A. W., Spencer, P. D., Hatton ., P. D., Wilkins, S. B., Von Zimmermann, M., Brown, S. D., ...
We present high-resolution high-energy and resonant x-ray-diffraction results from La2–2xSr1+2xMn2O7 for x=0.55, 0.575, and 0.60. These compounds show superlattice reflections at wave vectors of...
CRITICAL EVALUATION OF CERAMIC PROCESSING AT SUBCONVENTIONAL TEMPERATURES. (2005)
Brown, S. D., Accountius, O. E., Carpenter, W. H., Schroeder, T. F., Seric, M. J.
Reports and critical evaluations are presented for 11 categories of subconventional-temperature ceramic processes. The 11 categories are: (1) vapor deposition, (2) melt spraying, (3) hot forming, (4)...
Orbital Bi-Stripes in High Doped Bilayer Manganites (2004)
Beale, T. A. W., Spencer, P. D., Hatton, P. D., Wilkins, S. B., Von Zimmermann, M., Brown, S. D., ...
We present high resolution high energy and resonant x-ray diffraction results from La2-2xSr1+2xMn2O7 for x=0.55,0.575 and 0.60. These compounds show superlattice reflections at wavevectors of...
Magnetism of U/Fe multilayers (2004)
Thomas, M F, Beesley, A M, Bouchenoire, L, Brown, S D, Thompson, P, Herring, A D F, ...
Anomalous displacement of magnetic Bragg peaks in the presence of short range order (2004)
Bernhoeft, N, Lander, G H, Longfield, M J, Langridge, S, Mannix, D, Brown, S D, ...
Magnetism of uranium/iron multilayers: II. Magnetic Properties (2004)
Beesley, A M, Thomas, M F, Herring, A D F, Ward, R C C, Wells, M R, Langridge, S, ...
Magnetism of uranium/iron multilayers: I. Fabrication and characterization (2004)
Beesley, A M, Thomas, M F, Herring, A D F, Ward, R C C, Wells, M R, Langridge, S, ...
Wilkins, S. B., Spencer, P. D., Beale, T. A., Hatton, P. D., Zimmermann, M. V., Brown, S. D., ...
In this paper we present x-ray scattering results of charge and orbital ordering in the bilayer manganite La222xSr112xMn2O7 with doping levels x50.5 and x50.475. Using high-energy x-ray scattering,...
Resonant magnetic reflectivity from U/Fe multilayers (2003)
Brown, S D, Beesley, A, Herring, A, Mannix, D, Thomas, M F, Thompson, P, ...
A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice (2003)
Denny, P., Hopes, E., Gingles, N., Broman, K.W., McPheat, W., Morten, J., ...
Taylor, J. W., Duffy, J. A., Bebb, A. M., Lees, M. R., Bouchenoire, L., Brown, S. D., ...
Non-resonant ferromagnetic x-ray diffraction has been used to separate the spin and orbital contribution to the magnetization density of the proposed zero-moment ferromagnet $Sm_{0.982}Gd_{0.018}...
Castro-Diaz, M., Hall, P.J., Snape, C.E., Brown, S.D., Hughes, R.
Small-angle neutron scattering (SANS) has been performed on fresh and deactivated fluid catalytic cracking (FCC) equilibrium catalysts. The catalysts were coked using a vacuum gas oil feed and...
HIGH-MODULUS GLASSES BASED ON CERAMIC OXIDES. (1998)
An investigation was conducted of glass formation among alumina-base oxide compositions. Modulus measurements were made on those compositions which formed glasses to determine the influence of...
Schroeder,T. F., Carniglia,S. C., Brown,S. D.
Initial studies revealed that oxygen-deficient zirconia and thoria are more resistant to thermal shock conditions than the corresponding stoichiometric materials. This program was undertaken to...
Wallenberger, F. T., Brown, S. D.
Calcium aluminate glass fibers offer major new opportunities in transportation, infrastructure composites and new infrared sensor applications. they possess a higher modulus than s-glass, an...
Wallenberger, F. T., Brown, S. D.
Calcium aluminate glass fibers offer major new opportunities in transportation, infrastructure composites and new infrared sensor applications. They possess a higher modulus than S-glass, an...
High-Modulus Glasses Based On Ceramic Oxides (1998)
Initial studies on high-modulus glasses revealed that the aluminate system was a fruitful area for investigation. Exploration of this system was extended into the present effort. Among the many new...
Polarised neutron reflectivity from a [UAs/Co] multilayer (1997)
Mannix, D, Stirling, W G, Bucknall, D G, Haycock, P W, Brown, S D, Lander, G H, ...
The behaviour of oxidized sulphur forms in temperature programmed reduction (1997)
MAES, Inge, FRANCO, Dirk, YPERMAN, Jan, Brown, S.D., Sirkecioglu, O., Snape, C.E.
The behaviour of oxidized sulphur forms in temperature programmed reduction (1997)
MAES, Inge, FRANCO, Dirk, YPERMAN, Jan, Brown, S.D., Sirkecioglu, O., Snape, C.E.
The release of NO ̲x during the combustion of coals, E.F.R. chars and model carbons. (1994)
Brown, S.D, Newcastle Upon Tyne Univ. (GB).
Thesis (Ph.D.)
DNA topoisomerase I is essential in Drosophila melanogaster.
Lee, M P, Brown, S D, Chen, A, Hsieh, T S
Both biochemical and genetic experiments suggest that the type I DNA topoisomerase may participate in DNA replication, recombination, transcription, and other aspects of DNA metabolism. Despite its...
Nasir, J, Fisher, E M, Brockdorff, N, Disteche, C M, Lyon, M F, Brown, S D
The mouse genome contains 50 copies of a long complex repeat unit localized as a repeat sequence island to the A3 Giemsa-positive (dark) band on the mouse X chromosome. The repeat units are not...
Quality Control Limits for Broth Microdilution Susceptibility Tests of Ten Antifungal Agents
Barry, A. L., Pfaller, M. A., Brown, S. D., Espinel-Ingroff, A., Ghannoum, M. A., Knapp, C., ...
Broth microdilution susceptibility tests of Candida species have now been standardized by the National Committee for Clinical Laboratory Standards (NCCLS). An eight-laboratory collaborative study was...
Barry, A. L., Fuchs, P. C., Brown, S. D.
Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647,...
Barry, A. L., Pfaller, M. A., Rennie, R. P., Fuchs, P. C., Brown, S. D.
Interpretive agreements among the results of fluconazole broth microdilution tests, Etests, and disk diffusion tests were documented by evaluating 495 Candida spp. Microdilution reference test...
Barry, A L, Brown, S D, Novick, W J
The in vitro activities of four extended-spectrum cephalosporins and benzyl penicillin were evaluated against 698 clinical isolates of Streptococcus pneumoniae, including 130 (19%)...
Fuchs, P C, Barry, A L, Brown, S D
More than 3,000 consecutive clinical bacterial isolates from 10 U.S. medical centers were subjected to standard broth microdilution and disk diffusion tests to determine their susceptibilities to...
A new triazole derivative (voriconazole or UK-109,496) and fluconazole were tested against 249 isolates of Candida spp. representing six species. Voriconazole was 10 to 100 times more potent than...
Barry, A L, Fuchs, P C, Brown, S D
Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to...
Doern, G V, Glew, R H, Parker, D S, Pavuk, R A, Brown, S D
A new latex agglutination inhibition card test was compared with a microbiological method and radioimmunoassay for determining serum gentamicin levels. When 60 sera, each containing a known...
Fluconazole disk diffusion procedure for determining susceptibility of Candida species.
A simple disk diffusion test was defined for quick determination of the susceptibility of Candida species to fluconazole. The standard macrotube dilution reference method, the fluconazole E test, and...
Fuchs, P C, Barry, A L, Brown, S D
Two hundred twenty-eight strains of Haemophilus influenzae and 234 strains of Streptococcus pneumoniae were tested by broth microdilution and disk diffusion methods for susceptibility to trimethoprim...
Evaluation of the Repliscan system for identification of Enterobacteriaceae.
The Repliscan system, a semiautomated method for identifying gram-negative bacilli, was evaluated for its potential usefulness in clinical microbiology laboratories. A total of 1,877 isolates,...
DNA was isolated from a chinese hamster/mouse hybrid cell line containing a single mouse chromosome, the X-chromosome, and digested with a variety of restriction endonucleases known to cut mouse...
Satellites from two related species of the Apodemus genus, A. sylvaticus and A. flavicollis, have been analysed with restriction enzymes Taq I, Alu I and Hind III. The restriction maps are closely...
Nasir, J, Maconochie, M K, Brown, S D
A repeat sequence island, located at the A3 Giemsa dark band on the mouse X chromosome and consisting of 50 copies of a localised long complex repeat unit (LCRU), features an unusually high...
Brockdorff, N, Amar, L C, Brown, S D
Utilising pulse-field gel electrophoresis physical linkage between three mouse X-linked genes has been demonstrated. The three genes, P3, G6pd and Cf-8 all lie within 400 Kb of DNA. This physical...
Isolation and characterization of a gene encoding DNA topoisomerase I in Drosophila melanogaster.
Hsieh, T S, Brown, S D, Huang, P, Fostel, J
We synthesized a DNA probe specific for the gene encoding eucaryotic DNA topoisomerase I by the polymerase chain reaction. The sequences of the primers for this reaction were deduced from the regions...
Gottesdiener, K, Chung, H M, Brown, S D, Lee, M G, Van Der Ploeg, L H
The expressed variant cell surface glycoprotein (VSG) gene of Trypanosoma brucei is located at the 3' end of a large, telomeric, polycistronic transcription unit or expression site. We show that the...
Brown, S D, Huang, J, Van Der Ploeg, L H
All eukaryotic protein-coding genes are believed to be transcribed by RNA polymerase (Pol) II. An exception may exist in the protozoan parasite Trypanosoma brucei, in which the genes encoding the...
Microdissection of and microcloning from the short arm of human chromosome 2.
Bates, G P, Wainwright, B J, Williamson, R, Brown, S D
A bank of cloned DNA sequences from the distal half of the short arm of human chromosome 2 was generated by using microdissection and microcloning techniques. DNA was purified from 106 chromosomal...
Microdissection and microcloning of the mouse X chromosome.
Fisher, E M, Cavanna, J S, Brown, S D
A wild mouse (CD) karyotype in which all the chromosomes bar the X, 19, and Y, are fused as metacentrics has been used for the microdissection and microcloning of a specific mouse X chromosome...
Beta-Adrenergic Blocking Activity of Yersinia pestis Murine Toxin
Yersinia pestis plague murine toxin has been found to inhibit the mobilization of free fatty acids in mice in a manner similar to that of beta-adrenergic blocking agents. The blockage is detectable...
Recovery of energy metabolism in rat brain after carbon monoxide hypoxia.
Carbon monoxide (CO) may inhibit mitochondrial electron transport in the brain and increase the toxic effects of the gas. This hypothesis was investigated in anesthetized rats during CO exposure and...
Rapid restriction analysis of YAC clones.
Hamvas, R M, Francis, F, Cox, R D, Nizetic, D, Goldsworthy, M E, Brown, S D, ...
Brockdorff, N, Fisher, E M, Cavanna, J S, Lyon, M F, Brown, S D
A large number of microclones obtained by microdissection of the mouse X chromosome have been mapped using an interspecific Mus domesticus/Mus spretus cross. Clones displaying close linkage to a...
Posthospital needs of elderly people at home: findings from an eight-month follow-up study.
Jones, E W, Densen, P M, Brown, S D
In a study of 737 elderly hospital patients discharged to their homes in suburban areas northwest of Chicago, Illinois, 60 percent were assessed as needing help with personal care or housekeeping....
Todorov, P T, Hardisty, R E, Brown, S D
Myosin VIIA is a motor molecule with a conserved head domain and tail region unique to myosin VIIA, which probably defines its unique function in vivo. In an attempt to further characterize myosin...
Traczewski, M. M., Brown, S. D.
The in vitro activities of doripenem, imipenem, levofloxacin, piperacillin, ceftazidime, aztreonam, tobramycin, and cefepime were determined for 160 isolates of Pseudomonas aeruginosa (82 from cystic...
A mutation (2314delG) in the Usher syndrome type IIA gene: high prevalence and phenotypic variation.
Liu, X Z, Hope, C, Liang, C Y, Zou, J M, Xu, L R, Cole, T, ...
Asbestos and silica-induced changes in human alveolar macrophage phenotype.
Holian, A, Uthman, M O, Goltsova, T, Brown, S D, Hamilton, R F
The mechanism by which fibrogenic particulates induce inflammation that can progress to lung fibrosis is uncertain. The alveolar macrophage (AM) has been implicated in the inflammatory process...
Urban particle-induced apoptosis and phenotype shifts in human alveolar macrophages.
Holian, A, Hamilton, R F, Morandi, M T, Brown, S D, Li, L
Epidemiological studies report a small but positive association between short-term increases in airborne particulate matter and small increases in morbidity and mortality from respiratory and...
DNA topoisomerase I is essential in Drosophila melanogaster.
Lee, M P, Brown, S D, Chen, A, Hsieh, T S
Both biochemical and genetic experiments suggest that the type I DNA topoisomerase may participate in DNA replication, recombination, transcription, and other aspects of DNA metabolism. Despite its...
Nasir, J, Fisher, E M, Brockdorff, N, Disteche, C M, Lyon, M F, Brown, S D
The mouse genome contains 50 copies of a long complex repeat unit localized as a repeat sequence island to the A3 Giemsa-positive (dark) band on the mouse X chromosome. The repeat units are not...
Quality Control Limits for Broth Microdilution Susceptibility Tests of Ten Antifungal Agents
Barry, A. L., Pfaller, M. A., Brown, S. D., Espinel-Ingroff, A., Ghannoum, M. A., Knapp, C., ...
Broth microdilution susceptibility tests of Candida species have now been standardized by the National Committee for Clinical Laboratory Standards (NCCLS). An eight-laboratory collaborative study was...
Barry, A. L., Fuchs, P. C., Brown, S. D.
Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647,...