Scientific Commons: S. E.

Health Impact Assessment (HIA) assesses the positive and negative effects of a project, programme or policy on health, and on health inequalities through the distribution of those effects. Many...

Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo (2006)

Guo,
L.,
Salt,
T.E.,
Maass,
A.,
...

Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle (2006)

Carvalho,
L.S.,
Cowing,
J.A.,
Wilkie,
S.E.,
...

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. (2006)

Vaessen,
S.F.,
Schaap,
F.G.,
Kuivenhoven,
J.A.,
...

Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation. (2006)

Wong,
W.M.,
Gerry,
A.B.,
Putt,
W.,
...

Genetic causes of Familial Hypercholesterolaemia in UK patients: relation to plasma lipid levels and coronary heart disease risk. (2006)

Humphries,
S.E.,
Whittall,
R.A.,
Hubbart,
C.S.,
...

Role of the ephrin and Eph receptor tyrosine kinase (RTK) familes in angiogenesis of the cardiovascular system (2006)

Zhang,
J.C.,
Hughes,
S.E

A study of the nuclear trafficking of the splicing factor protein PRPF31 linked to autosomal dominant retinitis pigmentosa (ADRP). (2006)

Wilkie,
S. E.,
Morris,
K. J.,
Bhattacharya,
S. S.,
...

Mutation in the gene KCNV2, encoding a voltage-gated potassium channel subunit cause cone dystrophy with a supernormal rod electroretinogram in humans. (2006)

Wu,
H.,
Cowing,
J.A.,
Michaelides,
M.,
...

Vertebrate opsins belonging to different classes vary in constitutively active properties resulting from salt-bridge mutations (2006)

Nickle,
B.,
Wilkie,
S.E.,
Cowing,
J.A.,
...

Molecular basis of NCL (2006)

Mole,
S.E.,
Dawson,
D.&Jalanko,
A.

Molecular basis of the neuronal ceroid lipofuscinoses (2006)

Mole,
S.E.,
Dawson,
G.&Jalanko,
A.

Effect of Nauclea latifolia leaves aqueous extracts on blood glucose levels of normal and alloxan-induced diabetic rats (2005)

Gidado A.,
Ameh D.A.,
Atawodi,
S.E.

In Northern Nigeria, different parts of Nauclea latifolia (family: Rubiaceae) are prescribed as remedy for diabetes mellitus. This study was designed to evaluate the hypoglycemic property of...

CHOOSING CONGESTION PRICING POLICY: CORDON TOLLS VS. LINK-BASED TOLLS. (R831450) (2005)

S E.

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the...

Quantum walks with entangled coins (2005)

Venegas-Andraca,
S.E.,
Ball,
J.L.,
Burnett,
K.,
...

Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study (2005)

Harding,
D.,
Brull,
D.,
Humphries,
S.E.,
...

The pro-inflammatory cytokine IL-6 may be neurocytopathogenic, and elevated levels are associated with impaired neurological outcome among children born prematurely. However, the precise mechanisms...

Development and validation of a measure of the impact of epilepsy on an adolescent's quality of life: Glasgow epilepsy outcome scale-adolescents (GEOS-AD) (2005)

Townshend,
K.H.,
Dorris,
L.,
Aylett,
S.E.,
...

A strategy for molecular genetic mutation screening for familial hypercholesterolaemia (2005)

Tabrah,
S.,
Tabrah,
S.,
Taylor,
A.,
...

A CLN5 mutation causing an atypical neuronal ceroid lipofuscinosis of juvenile onset (2005)

Pineda-Trujillo,
N.,
Cornejo,
W.,
Carrizosa,
J.,
...

Three related patients from Colombia presented with a juvenile- onset neuronal ceroid lipofuscinosis. Electron microscopy of one case showed condensed fingerprint profiles, and genetic analyses...

Left ventricular non-compaction - Insights from cardiovascular magnetic resonance imaging (2005)

Petersen,
S.E.,
Selvanayagam,
J.B.,
Wiesmann,
F.,
...

OBJECTIVES We aimed to test the diagnostic accuracy of cardiovascular magnetic resonance (CMR) imaging in distinguishing pathological left ventricular non-compaction (LVNC) from lesser degrees of...

Chondrodysplasia punctata: case report and review of audiological and ENT features (2005)

Murdin,
L.,
Sirimanna,
T.,
Hartley,
B.E.,
...

Chondrodysplasia punctata is a term referring to a clinically heterogeneous group of bone and cartilage dysplasias which cause characteristic epiphyseal stippling. The condition can involve the ear,...

Identification of FOXP2 Truncation as a Novel Cause of Developmental Speech and Language Deficits (2005)

MacDermot,
K.D.,
Bonora,
E.,
Sykes,
N.,
...

FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a unique entry point into neuromolecular mechanisms influencing human speech and language acquisition....

New Alstrom syndrome phenotypes based on the evaluation of 182 cases (2005)

Marshall,
J.D.,
Bronson,
R.T.,
Collin,
G.B.,
...

BACKGROUND: Alstrom syndrome is a recessively inherited genetic disorder characterized by congenital retinal dystrophy that leads to blindness, hearing impairment, childhood obesity, insulin...

Family history of breast cancer and cost of life assurance: a test case comparison of current UK industry practice (2005)

Hunter,
A.,
Humphries,
S.E.

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? (2005)

Harding,
D.R.,
Dhamrait,
S.,
Devadason,
D.,
...

ABSTRACT : BACKGROUND : Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance...

Novel IL-6 haplotypes and disease association (2005)

Fife,
M.S.,
Ogilvie,
E.M.,
Kelberman,
D.,
...

Interleukin-6 (IL-6) is a pleiotropic cytokine crucial in both adaptive and innate immunity. Numerous genetic studies have shown association with variants of this gene in a multitude of diseases and...

Absence-tonic seizures: An unusual seizure phenotype (2005)

Das,
K.B.,
Boyd,
S.G.,
Aylett,
S.E.,
...

Acute lymphoblastic leukaemia has a poor outcome in children with Down syndrome due to infective death in remission - (Results of UK MRC ALL 97 trial) (2005)

De La Fuente,
J.,
Richards,
S.,
Webb,
D.K.,
...

Newborn Screening for Medium Chain Acyl CoA Dehydrogenase Deficiency: acylcarnitine C8/C10 ratio at day 6 differentiates affected cases from carriers (2005)

Downing,
M.,
Andresen,
B.S.,
Bonham,
J.,
...

Deekollu,
D.,
Besag,
F.M.C.,
Aylett,
S.E.

Purpose: To provide information on the incidence, types and circumstances of injuries sustained in a group of young people with epilepsy using protective helmets. Methods: Thirty-three residential...

A case of fatal ephedra intake associated with lipofuscin accumulation, caspase activation and cleavage of myofibrillary proteins (2005)

Chen-Scarabelli,
C.,
Hughes,
S.E.,
Landon,
G.,
...

Ephedra, a herb reported to suppress appetite and stimulate the sympathetic nervous system as well as cardiac performance, has recently been related to several adverse events, including seizure,...

Evaluation of the UNICEF UK Baby Friendly Initiative for the promotion of breastfeeding: findings from the Millennium Cohort Study (2005)

Bartington,
S.E.,
Foster,
L.J.,
Tate,
A.R.,
...

Aims: To evaluate the influence of the UNICEF UK Baby Friendly Initiative on breastfeeding initiation using data from the Millennium Cohort Study (MCS). Methods: The MCS is a disproportionately...

Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis (2005)

Broderick,
C.A.,
Smith,
A.J.,
Balaggan,
K.S.,
...

Autoimmune posterior uveitis is a chronic, potentially blinding inflammatory disease of the eye. It is commonly treated with immunosuppressive drugs that have adverse long-term effects. Advances in...

Prospective evaluation of efficacy and tolerability of levetiracetam for children and teenagers with epilepsy and learning disability (2005)

Aylett,
S.E.,
Das,
K.,
Fowler,
M.,
...

APOE polymorphism, socioeconomic status and cognitive function in mid-life The Whitehall II longitudinal study. (2005)

Zhao,
J.H.,
Brunner,
E.J.,
Kumari,
M.,
...

C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus. (2005)

D'Aiuto,
F.,
Casas,
J.P.,
Shah,
T.,
...

Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis (2005)

Broderick,
C.A.,
Smith,
A.J.,
Balaggan,
K.S.,
...

Autoimmune posterior uveitis is a chronic, potentially blinding inflammatory disease of the eye. It is commonly treated with immunosuppressive drugs that have adverse long-term effects. Advances in...

Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy (2005)

Michaelides,
M.,
Wilkie,
S.E.,
Jenkins,
S.,
...

PURPOSE: To determine the underlying molecular genetic basis of a retinal dystrophy identified in a 4-generation family and to examine the phenotype and the degree of intrafamilial variability....

Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix (2005)

Guo,
L.,
Moss,
S.E.,
Alexander,
R.A.,
...

PURPOSE: To investigate the effect of IOP on retinal ganglion cell (RGC) apoptosis and correlate the effects with IOP-induced changes in extracellular matrix (ECM) in the retina and optic nerve head...

The role of canonical transient receptor potential 7 in B-cell receptor-activated channels (2005)

Lievremont,
J.P.,
Numaga,
T.,
Vazquez,
G.,
...

Phospholipase C signaling stimulates Ca2+ entry across the plasma membrane through multiple mechanisms. Ca2+ store depletion stimulates store-operated Ca2+-selective channels, or alternatively, other...

Annexins: linking Ca2+ signalling to membrane dynamics (2005)

Gerke,
V.,
Creutz,
C.E.,
Moss,
S.E.

Eukaryotic cells contain various Ca(2+)-effector proteins that mediate cellular responses to changes in intracellular Ca(2+) levels. A unique class of these proteins - annexins - can bind to certain...

Combined orbital floor betamethasone and depot methylprednisolone in uveitis (2005)

Duguid,
I.G.,
Ford,
R.L.,
Horgan,
S.E.,
...

PURPOSE: To evaluate the outcome of orbital floor injection of betamethasone and methylprednisolone in the management of uveitis, with particular reference to its efficacy in avoiding increase in...

Oxytocin immunoreactive axons closely appose cardiovascular neurons in the nucleus of the solitary tract and dorsal vagal motor neurons in the rat (2005)

Llewellyn-Smith,
I.J.,
Kellett,
D.O.,
Jordan,
D.,
...

Statistical mechanics of adsorption of hydrocarbons on zeolites. (2005)

Jalili,
S.E.,
Manos,
G.,
Dunne,
L.J.

Mantle Plume IV Penrose Conference (2005)

Stofan,
E.R.,
Smrekar,
S.E.

Statistical distribution of inflation features on lava flows: Analysis of flow surfaces on Earth and Mars. (2005)

Glaze,
L.S.,
Anderson,
S.W.,
Stofan,
E.R.,
...

Triphenylphosphine-substituted selenido and sulfido clusters of osmium derived from Ph₃P=Se or Ph₃P=S (2005)

Akter,
H.,
Deeming,
A.J.,
Hossain,
G.M.G.,
...

3D modelling of high resolution devices (2005)

James,
R.,
Gardner,
M.C.,
Fernandez,
F.A.,
...

Modelling the effect of angular variations of the optical properties of a nematic liquid crystal in an LCOS rear projection TV system (2005)

Wang,
K.,
Gardner,
M.C.,
Day,
S.E.,
...

Inter-gray-level response times of a liquid crystal display (2005)

DeSmet,
H.,
Cuypers,
D.,
Fernandez,
F.A.,
...

New insights into the pathology of inherited cardiomyopathy (2005)

Hughes,
S.E.,
McKenna,
W.J

Matrix metalloproteinase-9 expression is associated with presence of Chlamydia pneumoniae in coronary atherosclerotic plaques (2005)

Arno,
G.,
Kaski,
J.C.,
Smith,
D.A.,
...

Dual task interference on encoding and retrieval processes in healthy and impaired working memory. (2004)

MacPherson,
S.E.,
Della Sala,
S.,
Logie,
R.H.

Public interest in genetic testing for susceptibility to heart disease: a population-based survey in the UK (2004)

Sanderson,
S.C.,
Wardle,
J.,
Jarvis,
M.,
...

Recent trends in HIV and other STIs in the United Kingdom: data to the end of 2002 (2004)

Brown,
A.E.,
Sadler,
K.E.,
Tomkins,
S.E.,
...

Sexual health in the United Kingdom has deteriorated in recent years with further increases in HIV and other sexually transmitted infections (STIs) reported in 2002. This paper describes results from...

Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts (2004)

Chen,
J.H.,
Stoeber,
K.,
Kingsbury,
S.,
...

Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. (2004)

Chen,
J.H.,
Stoeber,
K.,
Kingsbury,
S.,
...

Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis (2004)

Zijlmans,
J.C.,
Daniel,
S.E.,
Hughes,
A.J.,
...

Commentaries: quality of dental implants (2004)

Cooper,
L.,
De Grandmont,
P.,
Eckert,
S.E.,
...

Dynamics of DNA loop capture by the Sfil restriction endonuclease on supercoiled and relaxed DNA (2004)

Embleton,
M.L.,
Vologodskii,
A.V.,
Halford,
S.E.

Targeted Gene Delivery to Human Airway Epithelial Cells with Synthetic Vectors Incorporating Novel Targeting Peptides Selected by Phage Display (2004)

Writer,
M.J.,
Marshall,
B.,
Pilkington-Miksa,
M.A.,
...

Developmental outcome and seizure control in children with Sturge Weber syndrome (SWS) treated with epilepsy surgery (2004)

Aylett,
S.E.,
Harkness,
W.,
Clark,
C.,
...

Identification of foxp2 truncation as a novel cause of developmental speech disorder (2004)

MacDermot,
K.,
Bonora,
E.,
Sykes,
N.,
...

A bradykinin receptor gene variant and human physical performance (2004)

Williams,
A.G.,
Dhamrait,
S.,
Wootton,
P.T.,
...

Reduced thymocyte development in sonic hedgehog knockout embryos (2004)

Shah,
D.K.,
Hager-Theodorides,
A.L.,
Outram,
S.V.,
...

The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic...

Modelling of liquid crystal diffraction devices (2004)

Fernandez,
F.A.,
James,
R.,
Day,
S.E.,
...

Three-Dimensional Ion Transport in Liquid Crystals (2004)

Vermael,
S.,
Stojmenovik,
G.,
Neyts,
K.,
...

The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease. (2004)

Wong,
W.M.,
Stephens,
J.W.,
Acharya,
J.,
...

Inviscid mean flow through and around groups of bodies (2004)

Eames,
I.,
Hunt,
J.C.R.,
Belcher,
S.E.

How many camels are there in Italy? Cognitive estimates standardised on the Italian population. (2003)

Della Sala,
S.,
MacPherson,
S.E.,
Phillips,
L.H.,
...

Angiogenesis in anal warts, anal intraepithelial neoplasia and anal squamous cell carcinoma6 (2003)

Mullerat,
J.,
Wong Te Fong,
L.F.,
Davies,
S.E.,
...

Septo-optic dysplasia, subglottic stenosis and skeletal abnormalities: a case report (2003)

Wakeling,
E.L.,
Dattani,
M.T.,
Bloch-Zupan,
A.,
...

We report a girl with septo-optic dysplasia in association with subglottic stenosis, sagittal craniosynostosis, osteoporosis and dental anomalies. It is uncommon for patients with septo-optic...

Chicken DT40 cells stably transfected with the rat P2X7 receptor ion channel: a system suitable for the study of purine receptor-mediated cell death (2003)

Hillman,
K.A.,
Harada,
H.,
Chan,
C.M.,
...

We have generated and characterised a clone of chicken DT40 lymphocytes stably transfected with the rat P2X(7) receptor (rP2X(7)). Successful transfection was confirmed by Western blotting. Under...

Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6 (2003)

Cotton,
J.M.,
Hong,
Y.,
Hawe,
E.,
...

Thrombopoietin (TPO) is the major regulator of platelet production. Plasma levels of TPO are thought to be regulated by its binding to platelets and megakaryocytes. Here we have used a model of...

The 4830C>A polymorphism within intron 5 affects the pattern of alternative splicing occurring within exon 6 of the thrombopoietin gene (2003)

Webb,
K.E.,
Martin,
J.F.,
Cotton,
J.,
...

OBJECTIVE: A common variant in intron 5 of the thrombopoietin (TPO) gene (4830C>A) has been associated with risk of myocardial infarction (MI). To explore the molecular mechanism of this association,...

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. (2003)

Segurado,
R.,
Detera-Wadleigh,
S.D.,
Levinson,
D.F.,
...

Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...

Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension (2003)

Dhamrait,
S.S.,
Payne,
J.R.,
Li,
P.,
...

Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones (2003)

Wells,
S.E.,
Flavell,
D.M.,
Bisset,
G.W.,
...

Human growth hormone (hGH) and bovine neurophysin (bNP) DNA reporter fragments were inserted into the rat vasopressin (VP) and oxytocin (OT) genes in a 44 kb cosmid construct used to generate two...

Bone marrow transplantation for beta-thalassaemia major: the UK experience in two paediatric centres (2003)

Lawson,
S.E.,
Roberts,
I.A.,
Amrolia,
P.,
...

Stem cell transplantation (SCT) remains the only cure for thalassaemia major. Recent advances in medical treatment make it even more important that accurate information is available regarding outcome...

Antibiotics for toxoplasmic retinochoroiditis: an evidence-based systematic review (2003)

Stanford,
M.R.,
See,
S.E.,
Jones,
L.V.,
...

PURPOSE: To determine the effectiveness of systemic antibiotic treatment for toxoplasmic retinochoroiditis. CLINICAL RELEVANCE: Toxoplasma retinochoroiditis is a significant cause of visual...

Antibiotics for toxoplasmic retinochoroiditis: an evidence-based systematic review (2003)

Stanford,
M.R.,
See,
S.E.,
Jones,
L.V.,
...

PURPOSE: To determine the effectiveness of systemic antibiotic treatment for toxoplasmic retinochoroiditis. CLINICAL RELEVANCE: Toxoplasma retinochoroiditis is a significant cause of visual...

Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease (2003)

Zhu,
J.,
Quyyumi,
A.A.,
Wu,
H.,
...

OBJECTIVE: Previous studies suggest that heat shock protein (HSP) 60 has a contributory role in atherosclerosis development. We examined whether circulating HSP70 protein and anti-HSP70 antibodies...

Aspects in the modelling of liquid crystal devices (2003)

James,
R.,
Vermael,
S.,
Fernandez,
F.A.,
...

Domain Walls in Photo-Aligned Double-Domain Twisted-Nematic Liquid Crystal Displays (2003)

De Boer,
D.K.G.,
Nieuwkerk,
A.C.,
Cortie,
R.,
...

Liquid crystal VAN tilt bias by surface relief patterning (2003)

Gardner,
M.C.,
Day,
S.E.,
Fernandez,
F.A.

Modelling of ion transport in liquid crystal cells (2003)

James,
R.W.,
Vermail,
S.,
Fernandez,
F.A.,
...

Large enhancement of x-ray nagnetic scattering at the L edges of the 5d transition metal antiferromagnet K2ReCl6 (2003)

McMorrow,
D.F.,
Nagler,
S.E.,
McEwen,
K.A.,
...

Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation (2003)

Moodley,
Y.P.,
Scaffidi,
A.K.,
Misso,
N.L.,
...

Interleukin (IL)-6 and IL-11 are elevated in a variety of lung conditions and may impact on repair mechanisms in chronic inflammatory disorders. However, the mechanisms by which these cytokines...

Molecular cloning, complete sequence and biological characterization of a xenotropic murine leukaemia virus constitutively released from the human B-lymphoblastoid cell (2003)

Raisch,
K.P.,
Pizzato,
M.,
Sun,
H.Y.,
...

Detection of apoptosis by in situ markers for DNA strand breaks in the failing human heart. Fact or epiphenomenon (2003)

Hughes,
S.E

Adjustment of a turbulent boundary layer to a 'canopy' of roughness elements (2003)

Belcher,
S.E.,
Jerram,
N.,
Hunt,
J.C.R.

Eulerian and Lagrangian average velocity in and around groups of bodies. (2003)

Eames,
I.,
Hunt,
J.C.R.,
Belcher,
S.E.

6-10 July

Vortical dynamics beneath large amplitude and breaking waves (2003)

Hunt,
J.C.R.,
Eames,
I.,
Belcher,
S.E.

This book addresses ocean wave processes and turbulence as they affect oceanography, meteorology, marine and coastal engineering. It will enable applied mathematicians, seafarers, and all others...

Tubular aggregate myopathy with abnormal pupils and skeletal deformities (2002)

Jacques,
T.S.,
Holton,
J.,
Watts,
P.M.,
...

Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study (2002)

Rundek,
T.,
Elkind,
M.S.,
Pittman,
J.,
...

BACKGROUND AND PURPOSE: Atherosclerosis is a complex disorder with hereditary and environmental causes. Carotid artery intima-media wall thickness (IMT) is a useful measure of atherosclerosis. The...

A retrospective comparison of outcome of root canal treatment using two different protocols (2002)

Hoskinson,
S.E.,
Ng,
Y.L.,
Hoskinson,
A.E.,
...

Labial tuberculosis: a unique cause of lip swelling complicating HIV infection (2002)

Ilyas,
S.E.,
Chen,
F.F.,
Hodgson,
T.A.,
...

Monte-Carlo Simulation and Mean-field Theory Interpretation of Adsorption Preference Reversal in Isotherms of Alkane Binary Mixtures in Zeolites at Elevated Pressures (2002)

Ayache,
K.,
Jalili,
S.E.,
Dunne,
L.J.,
...

Angiogenesis in anal warts, anal intraepithelial neoplasia and anal squamous cell carcinoma (2002)

Mullerat,
J.,
Fong,
L.F.,
Davies,
S.E.,
...

Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example (2002)

Montgomery,
H.,
Brull,
D.,
Humphries,
S.E.

The human angiotensin converting enzyme (ACE) gene contains a length polymorphism consisting of the presence (insertion, I) or absence (deletion, D) of a 287 base pair "Alu" repeat sequence in intron...

Predisposition to atherosclerosis by infections: role of endothelial dysfunction (2002)

Prasad,
A.,
Zhu,
J.,
Halcox,
J.P.,
...

BACKGROUND: Several microorganisms have been implicated in the pathogenesis of atherosclerosis. We hypothesized that infections may predispose to atherosclerosis by inflicting endothelial injury....

Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy (2002)

Morris,
H.R.,
Gibb,
G.,
Katzenschlager,
R.,
...

Expression of the Fibrogrowth Factor (FgF and the Fibroblast Growth Factor Receptor (FGFR)Multigene Families in Normal and Atherosclerotic Human Arteries (2002)

Hughes,
S.E

Cardiac stem cells (2002)

Hughes,
S.E

Heart muscle disease (2002)

Hughes,
S.E

Angiotensin-converting enzyme inhibition enhances a subthreshold stimulus to elicit delayed preconditioning in pig myocardium (2001)

Jaberansari,
M.T.,
Baxter,
G.F.,
Muller,
C.A.,
...

OBJECTIVES: We assessed the effect of angiotensin-converting enzyme (ACE) inhibition in combination with a subthreshold preconditioning (PC) stimulus to elicit delayed preconditioning against...

Evidence that neutrophil elastase-deficient mice are resistant to bleomycin-induced fibrosis. (2001)

Dunsmore,
S.E.,
Roes,
J.,
Chua,
F.J.,
...

Features of carnitine palmitoyltransferase type I deficiency (2001)

Olpin,
S.E.,
Allen,
J.,
Bonham,
J.R.,
...

Carnitine palmitoyltransferase type I (CPT I) is unique among long- chain fatty acid oxidation enzymes in that there are two tissue- specific isoforms, 'hepatic' and 'muscle', which are encoded by...

Possible genetic influences on responses to hormone replacement therapy (HRT) in women (2001)

Onambele,
N.G.L.,
Woods,
D.,
Skelton,
D.A.,
...

Phosphatidylinositol transfer proteins and protein kinase C make separate but non-interacting contributions to the phosphorylation state necessary for secretory competence in rat mast cells (2001)

Pinxteren,
J.A.,
Gomperts,
B.D.,
Rogers,
D.,
...

Mast cells permeabilized by streptolysin O undergo exocytosis when stimulated with Ca(2+) and guanosine 5'-[gamma-thio]triphosphate but become progressively refractory to this stimulus if it is...

Preliminary analysis of an expanded corona database for Venus (2001)

Stofan,
E.R.,
Tapper,
S.W.,
Guest,
J.E.,
...

Polymorphisms in the thrombopoietin gene are associated with risk of myocardial infarction at a young age (2001)

Webb,
K.E.,
Martin,
J.F.,
Hamsten,
A.,
...

Five polymorphisms in the thrombopoietin (TPO) gene were identified, one in the 5' untranslated region (UTR) (C1796T), two within intron 5 (C4830A and A4877C), and two in the 3' UTR (A5713G and...

Potato microtubers as research tools: a review. (2001)

Coleman,
W. K.,
Donnelly,
D. J. And Coleman,
S. E.

Although in vitro production of potato tubers or microtuberization was achieved more than 40 years ago, the application of microtubers in reliable model research systems has been slow to develop....

A forkhead-domain gene is mutated in a severe speech and language disorder (2001)

Lai,
C.S.L.,
Fisher,
S.E.,
Hurst,
J.A.,
...

A novel forkhead-domain gene is mutated in a severe speech and language disorder (2001)

Fisher,
S.E.,
Lai,
CS L.,
Hurst,
J.A.,
...

A novel transcription factor is mutated in a severe speech and language disorder (2001)

Lai,
C.S.,
Fisher,
S.E.,
Hurst,
J.A.,
...

A novel forkhead-domain gene is mutated in a severe speech and language disorder (2001)

Lai,
C.S.L.,
Fisher,
S.E.,
Hurst,
J.A.,
...

Predisposing genes, high-risk environments and coronary artery disease: LPL and fibrinogen as examples (2001)

Humphries,
S.E.,
Montgomery,
H.E.,
Talmud,
P.J.

The effect of the interleukin-6-174G > C promoter gene polymorphism on endothelial function (2001)

Brull,
D.J.,
Leeson,
P.,
Mullen,
M.,
...

Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis (2001)

Zhu,
J.,
Quyyumi,
A.A.,
Rott,
D.,
...

BACKGROUND: Antibodies to mycobacterial heat-shock protein (HSP) 65 have been reported to be associated with carotid artery thickening. We examined whether antibodies to human HSP60 are associated...

The genetic basis of autosomal dominant familial Mediterranean fever (2000)

Booth,
D.R.,
Gillmore,
J.D.,
Lachmann,
H.J.,
...

Familial Mediterranean fever (FMF) is classically an autosomal recessive periodic inflammatory disease occurring in Mediterranean and Middle Eastern populations. lt is caused by mutations affecting...

Infections with Mycobacterium tuberculosis and Mycobacterium avium among HIV-infected patients after the introduction of highly active antiretroviral therapy. EuroSIDA Study Group JD (2000)

Kirk,
O.,
Gatell,
J.M.,
Mocroft,
A.,
...

The impact of highly active antiretroviral therapy (HAART) among human immunodeficiency virus (HIV)-infected patients on the incidences of mycobacterial infections has not been studied in detail. We...

DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. (2000)

Encalada,
S.E.,
Martin,
P.R.,
Phillips,
J.B.,
...

The SPCH 1 region of human 7q 31: genomic charactersation of the critical interval and localisation of translocations associated with speech and language disorder (2000)

Lai,
C.,
Fisher,
S.E.,
Hurst,
J.A.,
...

The Spch1 region on human 7q31: Genomic characterization of the critical interval and localization of translocations associated with speech and language disorder (2000)

Lai,
C.S.,
Fisher,
S.E.,
Hurst,
J.A.,
...

The ACE I/D polymorphism and human physical performance (2000)

Woods,
D.R.,
Humphries,
S.E.,
Montgomery,
H.E.

The D allele of the angiotensin-converting enzyme (ACE) I/D polymorphism is associated with elevated levels of serum and tissue ACE, increased production of the vasopressor angiotensin II and a...

Optical Response of Structured Vertically Aligned and In-Plane Switching LCD's (2000)