Lavallee, M., Cox, D. A., Vatner, S. F.
The effects of coronary artery occlusion and reperfusion at 1 h (1-h group), 2 h (2-h group) and 3-h (3-h group) were compared with a permanently occluded group (P group) on measurements of overall...
Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.
Kiuchi, K, Shannon, R P, Komamura, K, Cohen, D J, Bianchi, C, Homcy, C J, ...
The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = 6), and 3-4 wk (n = 7). Left...
Ishikawa, Y, Sorota, S, Kiuchi, K, Shannon, R P, Komamura, K, Katsushika, S, ...
We have shown that the heart expresses two distinct forms of adenylylcyclase mRNA, types V and VI. In this study we have characterized the expression of these two mRNA species in heart failure...
Chen, L A, Vatner, D E, Vatner, S F, Hittinger, L, Homcy, C J
We have previously reported that there is a global reduction in adenylyl cyclase associated with a decrement in Gs functional activity in cardiac sarcolemma from animals with pressure...
Komamura, K, Shannon, R P, Pasipoularides, A, Ihara, T, Lader, A S, Patrick, T A, ...
We investigated in conscious dogs (a) the effects of heart failure induced by chronic rapid ventricular pacing on the sequence of development of left ventricular (LV) diastolic versus systolic...
Effects of morphine on coronary and left ventricular dynamics in conscious dogs.
Vatner, S F, Marsh, J D, Swain, J A
We studied the effects of i.v. 2 mg/kg morphine sulfate (MS) on coronary blood flow and resistance, left ventricular (LV) diameter and pressure (P), rate of change of pressure (dP/dt), and dP/dt/P in...
Heyndrickx, G R, Millard, R W, McRitchie, R J, Maroko, P R, Vatner, S F
The time relationship for recovery of mechanical function, the intramyocardial electrogram and coronary flow after brief periods of regional myocardial ischemia, was studied in conscious dogs. Total...
Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor.
Vatner, D E, Vatner, S F, Nejima, J, Uemura, N, Susanni, E E, Hintze, T H, ...
The goal of this study was to determine the mechanism of beta-adrenergic receptor desensitization after chronic elevation of circulating NE levels. Osmotic minipumps containing either NE or saline...
Longabaugh, J P, Vatner, D E, Vatner, S F, Homcy, C J
Alterations in the level and function of the stimulatory guanyl nucleotide binding protein (Gs) from the cardiac sarcolemma were examined in a canine model of heart failure. The present study is...
Nejima, J, Uemura, N, Vatner, D E, Homcy, C J, Hintze, T H, Vatner, S F
To study chronic catecholamine desensitization, mini-osmotic pumps were implanted subcutaneously to deliver NE, (0.5 micrograms/kg/min) or saline over 3-4 wk in dogs instrumented with left...
Cellular mechanisms of impaired adrenergic responsiveness in neonatal dogs.
Rockson, S G, Homcy, C J, Quinn, P, Manders, W T, Haber, E, Vatner, S F
The myocardial responsiveness of conscious, instrumental dogs to exogenously administered isoproterenol and norepinephrine was investigated in neonatal, 6-wk-old, and adult animals. Comparable...
Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy.
Measurements of right coronary artery blood flow, aortic and right ventricular (RV) pressures and heart rate were radiotelemetered during strenuous, spontaneous exercise in normal dogs and dogs with...
Effects of exerimental right ventricular hypertrophy on myocardial blood flow in conscious dogs.
Murray, P A, Baig, H, Fishbein, M C, Vatner, S F
The effects of right ventricular hypertrophy on the overall and regional distribution of myocardial blood flow in the absence of an elevated coronary arterial driving pressure were evaluated in 18...
Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure.
Vatner, D E, Vatner, S F, Fujii, A M, Homcy, C J
We studied the alterations in myocardial beta-adrenergic receptor-adenylate cyclase activity and muscarinic receptor density in a canine model of left ventricular (LV) failure. LV failure was...
Vatner, D E, Homcy, C J, Sit, S P, Manders, W T, Vatner, S F
Pressure overload left ventricular (LV) hypertrophy was produced by banding the ascending aorta of puppies and allowing them to grow to adulthood. LV free wall weight per body weight increased by 87%...
Vatner, S F, Millard, R W, Patrick, T A, Heyndrickx, G R
The effects of coronary occlusion and of subsequent isoproterenol infusion were examined in conscious dogs. Left ventricular (LV) function was assessed by measurements of LV diameter, pressure,...
Impaired cardiac muscarinic receptor function in dogs with heart failure.
Vatner, D E, Lee, D L, Schwarz, K R, Longabaugh, J P, Fujii, A M, Vatner, S F, ...
Prior physiological studies have suggested that parasympathetic control is altered in heart failure. The goal of our studies was to investigate the influence of heart failure on the muscarinic...
Perreault, C L, Shannon, R P, Komamura, K, Vatner, S F, Morgan, J P
24 d of rapid ventricular pacing induced dilated cardiomyopathy with both systolic and diastolic dysfunction in conscious, chronically instrumented dogs. We studied mechanical properties and...
Von Harsdorf, R, Edwards, J G, Shen, Y T, Kudej, R K, Dietz, R, Leinwand, L A, ...
To identify the cis-acting regulatory element(s) which control the induction of the atrial natriuretic factor (ANF) gene in acute pressure overload, DNA constructs consisting of promoter elements...
Vatner, D E, Asai, K, Iwase, M, Ishikawa, Y, Wagner, T E, Shannon, R P, ...
Inotropic and chronotropic responses to catecholamines in young adult transgenic mice overexpressing myocardial Gsalpha are enhanced. One might predict that over the life of the animal, this...
Effects of anesthesia on cardiovascular control mechanisms.
The manner in which general anesthesia affects circulatory control was studied by examining the effects of commonly employed anesthetics on left ventricular function and distribution of cardiac...
Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.
Kiuchi, K, Shannon, R P, Komamura, K, Cohen, D J, Bianchi, C, Homcy, C J, ...
The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = 6), and 3-4 wk (n = 7). Left...
Ishikawa, Y, Sorota, S, Kiuchi, K, Shannon, R P, Komamura, K, Katsushika, S, ...
We have shown that the heart expresses two distinct forms of adenylylcyclase mRNA, types V and VI. In this study we have characterized the expression of these two mRNA species in heart failure...
Chen, L A, Vatner, D E, Vatner, S F, Hittinger, L, Homcy, C J
We have previously reported that there is a global reduction in adenylyl cyclase associated with a decrement in Gs functional activity in cardiac sarcolemma from animals with pressure...
Komamura, K, Shannon, R P, Pasipoularides, A, Ihara, T, Lader, A S, Patrick, T A, ...
We investigated in conscious dogs (a) the effects of heart failure induced by chronic rapid ventricular pacing on the sequence of development of left ventricular (LV) diastolic versus systolic...
Effects of morphine on coronary and left ventricular dynamics in conscious dogs.
Vatner, S F, Marsh, J D, Swain, J A
We studied the effects of i.v. 2 mg/kg morphine sulfate (MS) on coronary blood flow and resistance, left ventricular (LV) diameter and pressure (P), rate of change of pressure (dP/dt), and dP/dt/P in...
Heyndrickx, G R, Millard, R W, McRitchie, R J, Maroko, P R, Vatner, S F
The time relationship for recovery of mechanical function, the intramyocardial electrogram and coronary flow after brief periods of regional myocardial ischemia, was studied in conscious dogs. Total...
Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor.
Vatner, D E, Vatner, S F, Nejima, J, Uemura, N, Susanni, E E, Hintze, T H, ...
The goal of this study was to determine the mechanism of beta-adrenergic receptor desensitization after chronic elevation of circulating NE levels. Osmotic minipumps containing either NE or saline...
Longabaugh, J P, Vatner, D E, Vatner, S F, Homcy, C J
Alterations in the level and function of the stimulatory guanyl nucleotide binding protein (Gs) from the cardiac sarcolemma were examined in a canine model of heart failure. The present study is...
Nejima, J, Uemura, N, Vatner, D E, Homcy, C J, Hintze, T H, Vatner, S F
To study chronic catecholamine desensitization, mini-osmotic pumps were implanted subcutaneously to deliver NE, (0.5 micrograms/kg/min) or saline over 3-4 wk in dogs instrumented with left...
Cellular mechanisms of impaired adrenergic responsiveness in neonatal dogs.
Rockson, S G, Homcy, C J, Quinn, P, Manders, W T, Haber, E, Vatner, S F
The myocardial responsiveness of conscious, instrumental dogs to exogenously administered isoproterenol and norepinephrine was investigated in neonatal, 6-wk-old, and adult animals. Comparable...
Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy.
Measurements of right coronary artery blood flow, aortic and right ventricular (RV) pressures and heart rate were radiotelemetered during strenuous, spontaneous exercise in normal dogs and dogs with...
Effects of exerimental right ventricular hypertrophy on myocardial blood flow in conscious dogs.
Murray, P A, Baig, H, Fishbein, M C, Vatner, S F
The effects of right ventricular hypertrophy on the overall and regional distribution of myocardial blood flow in the absence of an elevated coronary arterial driving pressure were evaluated in 18...
Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure.
Vatner, D E, Vatner, S F, Fujii, A M, Homcy, C J
We studied the alterations in myocardial beta-adrenergic receptor-adenylate cyclase activity and muscarinic receptor density in a canine model of left ventricular (LV) failure. LV failure was...
Vatner, D E, Homcy, C J, Sit, S P, Manders, W T, Vatner, S F
Pressure overload left ventricular (LV) hypertrophy was produced by banding the ascending aorta of puppies and allowing them to grow to adulthood. LV free wall weight per body weight increased by 87%...
Vatner, S F, Millard, R W, Patrick, T A, Heyndrickx, G R
The effects of coronary occlusion and of subsequent isoproterenol infusion were examined in conscious dogs. Left ventricular (LV) function was assessed by measurements of LV diameter, pressure,...
Impaired cardiac muscarinic receptor function in dogs with heart failure.
Vatner, D E, Lee, D L, Schwarz, K R, Longabaugh, J P, Fujii, A M, Vatner, S F, ...
Prior physiological studies have suggested that parasympathetic control is altered in heart failure. The goal of our studies was to investigate the influence of heart failure on the muscarinic...
Perreault, C L, Shannon, R P, Komamura, K, Vatner, S F, Morgan, J P
24 d of rapid ventricular pacing induced dilated cardiomyopathy with both systolic and diastolic dysfunction in conscious, chronically instrumented dogs. We studied mechanical properties and...
Von Harsdorf, R, Edwards, J G, Shen, Y T, Kudej, R K, Dietz, R, Leinwand, L A, ...
To identify the cis-acting regulatory element(s) which control the induction of the atrial natriuretic factor (ANF) gene in acute pressure overload, DNA constructs consisting of promoter elements...
Vatner, D E, Asai, K, Iwase, M, Ishikawa, Y, Wagner, T E, Shannon, R P, ...
Inotropic and chronotropic responses to catecholamines in young adult transgenic mice overexpressing myocardial Gsalpha are enhanced. One might predict that over the life of the animal, this...
Effects of anesthesia on cardiovascular control mechanisms.
The manner in which general anesthesia affects circulatory control was studied by examining the effects of commonly employed anesthetics on left ventricular function and distribution of cardiac...