S. Grimmond

Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse (2009)

Dawson, P. A., Huxley, S., Gardiner, B., Tran, T., McAuley, J. L., Grimmond, S., ...

Objective: Sulfate (SO42-) is an abundant component intestinal mucins and its content is decreased in certain gastrointestinal diseases, including inflammatory bowel disease. In this study, the...

The year of the 'Locust': Forest-atmosphere CO§2 exchange during an emergence of periodical cicada. (2009)

Schmid, H.P., Dragoni, D., Wayson, C., Grimmond, S.

ProcessNet/GDCh/DBG-Gemeinschaftsausschuss 'Chemie, Luftqualität, Klima' der Universität Essen, Garmisch-Partenkirchen, 23.-24.Oktober 2008

Kidney transcriptome reveals altered steroid homeostasis in NaS1 sulfate transporter null mice (2008)

Dawson, P. A., Gardiner, B., Lee, S., Grimmond, S., Markovich, D.

Sulfate is essential for human growth and development, and circulating sulfate levels are maintained by the NaS1 sulfate transporter which is expressed in the kidney. Previously, we generated a...

Zebrafish klf4 plays a global role in primitive erythropoiesis (2007)

Gardiner, MR, Gongora, M, Gardiner, B, Grimmond, S, Perkins, AC

Transcriptional analysis of early lineage commitment in human embryonic stem cells (2007)

Laslett, AL, Grimmond, S, Gardiner, B, Stamp, L, Lin, A, Hawes, SM, ...

Background: The mechanisms responsible for the maintenance of pluripotency in human embryonic stem cells, and those that drive their commitment into particular differentiation lineages, are poorly...

Characterization of the breast cancer associated ATM 7271T > G (V2424G) mutation by gene expression profiling (2006)

Waddell, N., Jonnalagadda, J., Marsh, A., Grist, S., Jenkins, M., Hobson, K., ...

Characterization of the breast cancer associated ATM 7271T > G (V2424G) mutation by gene expression profiling (2006)

Waddell, N., Jonnalagadda, J., Marsh, A., Grist, S., Jenkins, M., Hobson, K., ...

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome (2006)

Ravasi, T., Suzuki, H., Pang, K. C., Katayama, S., Furuno, M., Okunishi, R., ...

Recent large-scale analyses of mainly full-length cDNA libraries generated from a variety of mouse tissues indicated that almost half of all representative cloned sequences did flat contain ail...

Characterization of the breast cancer associated ATM 7271T > G (V2424G) mutation by gene expression profiling (2006)

Waddell, N., Jonnalagadda, J., Marsh, A., Grist, S., Jenkins, M., Hobson, K., ...

Mutations in ATM are responsible for the autosomal recessive disorder ataxia telangiectasia. Heterozygous mutations in ATM have been associated with an elevated risk of breast cancer. We previously...

Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice (2006)

Dawson, P. A., Gardiner, B., Grimmond, S., Markovich, D.

Sulfate plays an essential role in human growth and development, and its circulating levels are maintained by the renal Na+-SO42- cotransporter, NaS1. We previously generated a NaS1 knockout (...

Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice (2006)

Dawson, P. A., Gardiner, B., Grimmond, S., Markovich, D.

Sulfate plays an essential role in human growth and development, and its circulating levels are maintained by the renal Na+-SO42- cotransporter, NaS1. We previously generated a NaS1 knockout (...

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome (2006)

Ravasi, T., Suzuki, H., Pang, K. C., Katayama, S., Furuno, M., Okunishi, R., ...

Recent large-scale analyses of mainly full-length cDNA libraries generated from a variety of mouse tissues indicated that almost half of all representative cloned sequences did flat contain ail...

Characterization of the breast cancer associated ATM 7271T > G (V2424G) mutation by gene expression profiling (2006)

Waddell, N., Jonnalagadda, J., Marsh, A., Grist, S., Jenkins, M., Hobson, K., ...

Mutations in ATM are responsible for the autosomal recessive disorder ataxia telangiectasia. Heterozygous mutations in ATM have been associated with an elevated risk of breast cancer. We previously...

Effects of A(1) adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, K. J., Holmgren, K., Peart, J., Lankford, A. R., Matherne, G. P., Grimmond, S., ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A(1) adenosine receptors (A(1)ARs). Methods:...

Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection (2003)

Sousa-Nunes, R., Rana, A. A., Kettleborough, R., Brickman, J. M., Clements, M., Forrest, A., ...

This article investigates the expression patterns of 160 genes that are expressed during early mouse development. The cDNAs were isolated from 7.5 d postcoitum (dpc) encloderm, a region that...

Effects of A(1) adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, K. J., Holmgren, K., Peart, J., Lankford, A. R., Matherne, G. P., Grimmond, S., ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A(1) adenosine receptors (A(1)ARs). Methods:...

Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection (2003)

Sousa-Nunes, R., Rana, A. A., Kettleborough, R., Brickman, J. M., Clements, M., Forrest, A., ...

This article investigates the expression patterns of 160 genes that are expressed during early mouse development. The cDNAs were isolated from 7.5 d postcoitum (dpc) encloderm, a region that...

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bona, H., Kondo, S., ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bona, H., Kondo, S., ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bona, H., Kondo, S., ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Tissue-specific gene expression in soybean (Glycine max) detected by cDNA microarray analysis (2002)

Maguire, T. L., Grimmond, S., Forrest, A., Iturbe-Ormaetxe, I., Meksem, K., Gresshoff, P.

We have constructed cDNA microarrays for soybean (Glycine max L. Merrill), containing approximately 4,100 Unigene ESTs derived from axenic roots, to evaluate their application and utility for...

Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes (2002)

Ravasi, T., Wells, C., Forrest, A., Walsh, N., Underhill, D. M., Wainwright, B. J., ...

Microbial products such as LPS stimulate macrophages to produce a wide diversity of inducible gene products needed for immediate host defense and priming of an appropriate acquired immune response....

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Tissue-specific gene expression in soybean (Glycine max) detected by cDNA microarray analysis (2002)

Maguire, T. L., Grimmond, S., Forrest, A., Iturbe-Ormaetxe, I., Meksem, K., Gresshoff, P.

We have constructed cDNA microarrays for soybean (Glycine max L. Merrill), containing approximately 4,100 Unigene ESTs derived from axenic roots, to evaluate their application and utility for...

Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes (2002)

Ravasi, T., Wells, C., Forrest, A., Walsh, N., Underhill, D. M., Wainwright, B. J., ...

Microbial products such as LPS stimulate macrophages to produce a wide diversity of inducible gene products needed for immediate host defense and priming of an appropriate acquired immune response....

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bona, H., Kondo, S., ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development (2001)

Grimmond, S., Larder, R., Van Hateren, N., Siggers, P., Morse, S., Hacker, T., ...

We have recently reported the preliminary characterisation of a novel EGF-related gene, Scube1 (signal peptide-CUB domain-EGF-related, gene 1), that is expressed prominently in the developing gonad,...

Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development (2001)

Grimmond, S., Larder, R., Van Hateren, N., Siggers, P., Morse, S., Hacker, T., ...

We have recently reported the preliminary characterisation of a novel EGF-related gene, Scube1 (signal peptide-CUB domain-EGF-related, gene 1), that is expressed prominently in the developing gonad,...

Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1) (2000)

Grimmond, S., Larder, R., Hateren, N. Van, Siggers, P., Hulsebos, T.J.M., Arkell, R., ...

Microarray in Multiple Sclerosis (2000)

Tajouri, Lotfi, Griffiths, Lyn, Tannenberg, T., Grimmond, S.

No

Microarray in Multiple Sclerosis (2000)

Tajouri, Lotfi, Griffiths, Lyn, Tannenberg, T., Grimmond, S.

No

Microarray in Multiple Sclerosis (2000)

Tajouri, Lotfi, Griffiths, Lyn, Tannenberg, T., Grimmond, S.

Functional genomics in plants (2000)

Gresshoff, P. M., Men, A., Stiller, J., Maguire, T. L., Grimmond, S., Anderson, D.

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor (2000)

Clyde-Smith, J, Silins, G, Gartside, M, Grimmond, S, Etheridge, M, Apolloni, A, ...

Ras proteins operate as molecular switches in signal transduction pathways downstream of tyrosine kinases and G-protein-coupled receptors. Ras is switched from the inactive GDP-bound state to the...

Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours (2000)

Bergman, L, Boothroyd, C, Palmer, J, Grimmond, S, Walters, M, Teh, B, ...

Endocrine tumours of the pancreas, anterior pituitary or parathyroids arise either sporadically in the general population, or as a part of inherited syndromes such as multiple endocrine neoplasia...

Functional genomics in plants (2000)

Gresshoff, P. M., Men, A., Stiller, J., Maguire, T. L., Grimmond, S., Anderson, D.

Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours (2000)

Bergman, L., Boothroyd, C., Palmer, J., Grimmond, S., Walters, M., Teh, B., ...

Endocrine tumours of the pancreas, anterior pituitary or parathyroids arise either sporadically in the general population, or as a part of inherited syndromes such as multiple endocrine neoplasia...

Microarray in Multiple Sclerosis (2000)

Tajouri, Lotfi, Griffiths, Lyn, Tannenberg, T., Grimmond, S.

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor (2000)

Clyde-Smith, J., Silins, G., Gartside, M., Grimmond, S., Etheridge, M., Apolloni, A., ...

Ras proteins operate as molecular switches in signal transduction pathways downstream of tyrosine kinases and G-protein-coupled receptors. Ras is switched from the inactive GDP-bound state to the...

Report to the sixth international workshop on human chromosome 11 mapping 1998 (1999)

Gaudray, P., Carle, G.F., Gerhard, D.S., Gessler, M., Athanasiou, M., ...

A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13 (1999)

Bergman, L., Silins, G., Grimmond, S., Hummerich, H., Stewart, C., Little, P., ...

We have generated a transcript map of an approximately 1.2-Mb region from human chromosome band 11q13 between the loci VEGFB and CAPN1, which flank the multiple endocrine neoplasia type 1 (MEN 1)...

A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13 (1999)

Bergman, L., Silins, G., Grimmond, S., Hummerich, H., Stewart, C., Little, P., ...

We have generated a transcript map of an approximately 1.2-Mb region from human chromosome band 11q13 between the loci VEGFB and CAPN1, which flank the multiple endocrine neoplasia type 1 (MEN 1)...

Report of the Sixth International Workshop on Human Chromosome 11 Mapping 1998. Nice, France, May 2-5, 1998. (1999)

Gaudray, P, Carle, G F, Gerhard, D S, Gessler, M, Mannens, M M, Athanasiou, M, ...

The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region (1998)

Mazeyrat, S, Saut, N, Sargent, CA, Grimmond, S, Longepied, G, Ehrmann, IE, ...

Cloning and characterization of a novel human gene related to vascular endothelial growth factor (1996)

Grimmond, S, Lagercrantz, J, Drinkwater, C, Silins, G, Townson, S, Pollock, P, ...

Multiple Endocrine Neoplasia Type 1 - Clinical Syndrome to molecular genetics ome to Molecular Genetics (1995)

Teh, BT, Grimmond, S, Shepherd, JJ, Larsson, C, Hayward, N

Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1 (1995)

Grimmond, S, Weber, G, Larsson, C, Walters, M, Teh, BT, Shepherd, JJ, ...

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Okazaki, Y, Furuno, M, Kasukawa, T, Adachi, J, Bono, H, Kondo, S, ...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the...

Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome

Ravasi, T, Huber, T, Zavolan, M, Forrest, A, Gaasterland, T, Grimmond, S, ...

Zinc-finger-containing proteins can be classified into evolutionary and functionally divergent protein families that share one or more domains in which a zinc ion is tetrahedrally coordinated by...

Phosphoregulators: Protein kinases and protein phosphatases of mouse

Forrest, ARR, Ravasi, T, Taylor, D, Huber, T, Hume, DA, Grimmond, S, ...

With the completion of the human and mouse genome sequences, the task now turns to identifying their encoded transcripts and assigning gene function. In this study, we have undertaken a computational...

Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice

Dawson, PA, Gardiner, B, Grimmond, S, Markovich, D

Sulfate plays an essential role in human growth and development, and its circulating levels are maintained by the renal Na+-SO42- cotransporter, NaS1. We previously generated a NaS1 knockout (...

Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours

Bergman, L, Boothroyd, C, Palmer, J, Grimmond, S, Walters, M, Teh, B, ...

Endocrine tumours of the pancreas, anterior pituitary or parathyroids arise either sporadically in the general population, or as a part of inherited syndromes such as multiple endocrine neoplasia...