Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. (1994)
Rettig, J., Heinemann, S. H., Wunder, F., Lorra, C., Parcej, D. N., Dolly, J., ...
Structural and functional properties of cloned glutamate receptors. (1993)
Hollmann, M., Keller, B. U., Blaschke, M., Rivosecchi, R., Konnerth, A., Heinemann, S. H.
CALCIUM-CHANNEL CHARACTERISTICS CONFERRED ON THE SODIUM-CHANNEL BY SINGLE MUTATIONS (1992)
Heinemann, S. H., Terlau, H., Stuehmer, W., Imoto, K., Numa, S.
A SINGLE MUTATION ALTERS THE SODIUM-CHANNEL TO A CALCIUM-PERMEABLE CHANNEL (1992)
Heinemann, S. H., Terlau, H., Stuehmer, W., Imoto, K., Numa, S.
EXTRACELLULAR K+ SPECIFICALLY MODULATES A RAT-BRAIN K+ CHANNEL (1992)
Pardo, L. A., Heinemann, S. H., Terlau, H., Ludewig, U., Lorra, C., Pongs, O., ...
Voltage gated K-channels expressed in heart tissue. (1992)
Pongs, O., Wunder, F., Rettig, J., Stocker, M., Heinemann, S. H., Stuehmer, W.
DETERMINANTS OF SENSITIVITY TO TETRODOTOXIN AND SAXITOXIN OF SODIUM CHANNEL-II (1992)
Terlau, H., Heinemann, S. H., Stuehmer, W., Pusch, M., Conti, F., Imoto, K., ...
OPEN CHANNEL NOISE .6. ANALYSIS OF AMPLITUDE HISTOGRAMS TO DETERMINE RAPID KINETIC-PARAMETERS (1991)
REGULATION OF FAST INACTIVATION OF CLONED MAMMALIAN IK(A) CHANNELS BY CYSTEINE OXIDATION (1991)
Ruppersberg, J. P., Stocker, M., Pongs, O., Heinemann, S. H., Frank, R., Koenen, M.
SWAPPING OF FUNCTIONAL DOMAINS IN VOLTAGE-GATED K+ CHANNELS (1991)
Stocker, M., Pongs, O., Hoth, M., Heinemann, S. H., Stuehmer, W., Schroter, K. H., ...
MAPPING THE SITE OF BLOCK BY TETRODOTOXIN AND SAXITOXIN OF SODIUM CHANNEL-II (1991)
Terlau, H., Heinemann, S. H., Stuehmer, W., Pusch, M., Conti, F., Imoto, K., ...
Extracellular K+ specifically modulates a rat brain K+ channel.
Pardo, L A, Heinemann, S H, Terlau, H, Ludewig, U, Lorra, C, Pongs, O, ...
Extracellular potassium concentration is actively maintained within narrow limits in all higher organisms. Slight variations in extracellular potassium levels can induce major alterations of...
Single acetylcholine receptor channel currents recorded at high hydrostatic pressures.
Heinemann, S H, Stühmer, W, Conti, F
A technique for performing patch-clamp experiments under high hydrostatic (oil) pressure is described. The method allows the transfer of whole cell or membrane patches in a recording configuration...
Eismann, E, Müller, F, Heinemann, S H, Kaupp, U B
Ca2+ ions control the cGMP-gated channel of rod photoreceptor cells from the external and internal face. We studied ion selectivity and blockage by Ca2+ of wild-type and mutant channels in a...
Phosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activity.
Hehl, S, Stoyanov, B, Oehrl, W, Schönherr, R, Wetzker, R, Heinemann, S H
Type-I phosphoinositide 3-kinases (PI3Ks) were characterized as a group of intracellular signalling proteins expressing both protein and lipid kinase activities. Recent studies implicate PI3Ks as...
Unilateral exposure of Shaker B potassium channels to hyperosmolar solutions.
Starkus, J G, Schlief, T, Rayner, M D, Heinemann, S H
This study tests the hypothesis that ion channels will be affected differently by external (extracellular) versus internal (cytoplasmic) exposure to hyperosmolar media. We looked first for effects on...
Cooperative subunit interactions in C-type inactivation of K channels.
Ogielska, E M, Zagotta, W N, Hoshi, T, Heinemann, S H, Haab, J, Aldrich, R W
C-type inactivation of potassium channels is distinct from N-terminal mediated (N-type) inactivation and involves a closing of the outer mouth of the channel. We have investigated the role of the...
Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters.
Recently we reported that rapid fluctuations of ion currents flowing through open gramicidin A channels exceed the expected level of pure transport noise at low ion concentrations (Heinemann, S. H....
Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels.
We have measured the fluctuations in the current through gramicidin A (GA) channels in symmetrical solutions of monovalent cations of various concentrations, and compared the spectral density values...
Acceleration of P/C-type inactivation in voltage-gated K(+) channels by methionine oxidation.
Chen, J, Avdonin, V, Ciorba, M A, Heinemann, S H, Hoshi, T
Oxidation of amino acid residues causes noticeable changes in gating of many ion channels. We found that P/C-type inactivation of Shaker potassium channels expressed in Xenopus oocytes is...
Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels.
Blocking events in currents through biological ion channels occur over a wide range of characteristic times. The interruptions in single-channel currents from blocking events may be characterized by...
1. Defolliculated Xenopus oocytes were voltage clamped in bathing solutions containing 115 mM KCl and 1.8 mM CaCl2. External application of H2O2 transiently elicited voltage-dependent outward...
Functional characterization of Kv channel beta-subunits from rat brain.
Heinemann, S H, Rettig, J, Graack, H R, Pongs, O
1. The potassium channel beta-subunit from rat brain, Kv beta 1.1, is known to induce inactivation of the delayed rectifier channel Kv1.1 and Kv1.4 delta 1-110. 2. Kv beta 1.1 was co-expressed in...
1. The human eag-related potassium channel, HERG, gives rise to inwardly rectifying K+ currents when expressed in Xenopus oocytes. 2. The apparent inward rectification is caused by rapid...
Terlau, H, Heinemann, S H, Stühmer, W, Pongs, O, Ludwig, J
1. Rat eag potassium channels (r-eag) were expressed in Xenopus oocytes. They gave rise to delayed rectifying K+ currents with a strong Cole-Moore effect. 2. Deletions in the N-terminal structure of...
Extracellular K+ specifically modulates a rat brain K+ channel.
Pardo, L A, Heinemann, S H, Terlau, H, Ludewig, U, Lorra, C, Pongs, O, ...
Extracellular potassium concentration is actively maintained within narrow limits in all higher organisms. Slight variations in extracellular potassium levels can induce major alterations of...
Single acetylcholine receptor channel currents recorded at high hydrostatic pressures.
Heinemann, S H, Stühmer, W, Conti, F
A technique for performing patch-clamp experiments under high hydrostatic (oil) pressure is described. The method allows the transfer of whole cell or membrane patches in a recording configuration...
Eismann, E, Müller, F, Heinemann, S H, Kaupp, U B
Ca2+ ions control the cGMP-gated channel of rod photoreceptor cells from the external and internal face. We studied ion selectivity and blockage by Ca2+ of wild-type and mutant channels in a...
1. Defolliculated Xenopus oocytes were voltage clamped in bathing solutions containing 115 mM KCl and 1.8 mM CaCl2. External application of H2O2 transiently elicited voltage-dependent outward...
Functional characterization of Kv channel beta-subunits from rat brain.
Heinemann, S H, Rettig, J, Graack, H R, Pongs, O
1. The potassium channel beta-subunit from rat brain, Kv beta 1.1, is known to induce inactivation of the delayed rectifier channel Kv1.1 and Kv1.4 delta 1-110. 2. Kv beta 1.1 was co-expressed in...
1. The human eag-related potassium channel, HERG, gives rise to inwardly rectifying K+ currents when expressed in Xenopus oocytes. 2. The apparent inward rectification is caused by rapid...
Terlau, H, Heinemann, S H, Stühmer, W, Pongs, O, Ludwig, J
1. Rat eag potassium channels (r-eag) were expressed in Xenopus oocytes. They gave rise to delayed rectifying K+ currents with a strong Cole-Moore effect. 2. Deletions in the N-terminal structure of...
Phosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activity.
Hehl, S, Stoyanov, B, Oehrl, W, Schönherr, R, Wetzker, R, Heinemann, S H
Type-I phosphoinositide 3-kinases (PI3Ks) were characterized as a group of intracellular signalling proteins expressing both protein and lipid kinase activities. Recent studies implicate PI3Ks as...
Unilateral exposure of Shaker B potassium channels to hyperosmolar solutions.
Starkus, J G, Schlief, T, Rayner, M D, Heinemann, S H
This study tests the hypothesis that ion channels will be affected differently by external (extracellular) versus internal (cytoplasmic) exposure to hyperosmolar media. We looked first for effects on...
Cooperative subunit interactions in C-type inactivation of K channels.
Ogielska, E M, Zagotta, W N, Hoshi, T, Heinemann, S H, Haab, J, Aldrich, R W
C-type inactivation of potassium channels is distinct from N-terminal mediated (N-type) inactivation and involves a closing of the outer mouth of the channel. We have investigated the role of the...
Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters.
Recently we reported that rapid fluctuations of ion currents flowing through open gramicidin A channels exceed the expected level of pure transport noise at low ion concentrations (Heinemann, S. H....
Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels.
We have measured the fluctuations in the current through gramicidin A (GA) channels in symmetrical solutions of monovalent cations of various concentrations, and compared the spectral density values...
Acceleration of P/C-type inactivation in voltage-gated K(+) channels by methionine oxidation.
Chen, J, Avdonin, V, Ciorba, M A, Heinemann, S H, Hoshi, T
Oxidation of amino acid residues causes noticeable changes in gating of many ion channels. We found that P/C-type inactivation of Shaker potassium channels expressed in Xenopus oocytes is...
Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels.
Blocking events in currents through biological ion channels occur over a wide range of characteristic times. The interruptions in single-channel currents from blocking events may be characterized by...
Suessbrich, H, Schönherr, R, Heinemann, S H, Attali, B, Lang, F, Busch, A E
The antipsychotic drug haloperidol can induce a marked QT prolongation and polymorphic ventricular arrhythmias. In this study, we expressed several cloned cardiac K+ channels, including the human...