Idris, A.I., Sophocleous, A., Landao-Bassonga, E., Merkouris, M., Milligan, G., Baker, D., ...
Osteoporosis is characterised by reduced bone formation with replacement of the bone marrow compartment by fat, due to an age-dependent reduction in osteoblast differentiation and a reciprocal...
Langdahl, B.L., Uitterlinden, A.G., Ralston, S.H., Trikalinos, T.A., Balcells, S., Brandi, M.L., ...
INTRODUCTION: The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone...
PTHR1 Polymorphisms Influence BMD Variation through Effects on the Growing Skeleton (2007)
Vilarino-Guell, C., Miles, L.J., Duncan, E.L., Ralston, S.H., Compston, J.E., Langdahl, B.L., ...
Reid, D.M., Mackay, I., Wilkinson, S., Miller, C., Schuette, D.G., Compston, J., ...
Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and an increased risk of fragility fractures. Bone mineral density (BMD) is the most important...
Reid, D. M., Mackay, I., Wilkinson, S., Miller, C., Schuette, D. G., Compston, J., ...
Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and an increased risk of fragility fractures. Bone mineral density (BMD) is the most important...
Stephens, Alexandre, Doecke, James David, Ralston, S.H., Prince, R., Nicholson, G.C., Morrison, Nigel Alexander
No
Stephens, Alexandre, Doecke, James David, Ralston, S.H., Prince, R., Nicholson, G.C., Morrison, Nigel Alexander
No
Stephens, Alexandre, Doecke, James David, Ralston, S.H., Prince, R., Nicholson, G.C., Morrison, Nigel Alexander
Stephens, Alexandre, Doecke, James David, Ralston, S.H., Prince, R., Nicholson, G.C., Morrison, Nigel Alexander
Ralston, S. H., Galwey, N., MacKay, I., Albagha, O. M. E., Cardon, L., Compston, J. E., ...
Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mass and an increased risk of fracture. Bone mineral density (BMD) is a highly heritable trait and a...
Management of Paget's disease of bone (2004)
Langston, A. L., Ralston, S. H.
Paget's disease of bone is a common condition with a strong genetic component, characterized by focal increases in bone turnover, affecting one or more bones throughout the skeleton. Paget's disease...
Management of Paget's disease of bone (2004)
Langston, A. L., Ralston, S. H.
Paget's disease of bone is a common condition with a strong genetic component, characterized by focal increases in bone turnover, affecting one or more bones throughout the skeleton. Paget's disease...
Management of Paget's disease of bone (2004)
Langston, A. L., Ralston, S. H.
Paget's disease of bone is a common condition with a strong genetic component, characterized by focal increases in bone turnover, affecting one or more bones throughout the skeleton. Paget's disease...
Herbert, C A, Nicholls, R K, Williams, F, Bennett, S T, Cundy, T, ...
Paget disease of bone (PDB) is a common disorder characterized by focal abnormalities of increased and disorganized bone turnover. Genetic factors are important in the pathogenesis of PDB, and...
Eastell, R., Reid, D.M., Compston, J., Cooper, C., Fogelman, I., Francis, R.M., ...
The burden of non-vertebral fractures is enormous. Hip fractures account for nearly 10% of all fractures (and a much greater proportion in the elderly), while wrist fractures may account for up to...
Eastell, R., Reid, D.M., Compston, J., Cooper, C., Fogelman, I., Francis, R.M., ...
The burden of non‐vertebral fractures is enormous. Hip fractures account for nearly 10% of all fractures (and a much greater proportion in the elderly), while wrist fractures...
Nitric oxide is a mediator of apoptosis in the rheumatoid joint (2000)
Van't Hof, R. J., Hocking, L., Wright, P. K., Ralston, S. H.
Objective. To study the role of nitric oxide (NO) derived from the inducible nitric oxide synthase (iNOS) pathway in the induction of apoptosis in the rheumatoid joint....
Uitterlinden, A.G., Burger, H., Huang, Q., Yue, F., McGuigan, F.E., Grant, S.F., ...
BACKGROUND: Osteoporosis is a common disorder with a strong genetic component. One way in which the genetic component could be expressed is through polymorphism of COLIA1, the gene for collagen type...
NITRIC OXIDE PRODUCTION IN CELLS DERIVED FROM THE HUMAN JOINT (1996)
GRABOWSKI, P. S., MACPHERSON, H., RALSTON, S. H.
We have investigated the ability of cells derived from the human joint to generate nitric oxide (NO). Synovial fibroblasts, articular chondrocytes and osteoblasts were cultured from tissues of...
RALSTON, S. H., HOEY, S. A., GALLACHER, S. J., ADAMSON, B. B., BOYLE, I. T.
We investigated expression of several cytokines and growth factors in explants of Pagetic and non-Pagetic bone samples using the technique of reverse-transcription/polymerase chain reaction...
HIGH PREVALENCE OF UNRECOGNIZED OSTEOMALACIA IN HOSPITAL PATIENTS WITH RHEUMATOID ARTHRITIS (1988)
RALSTON, S. H., WILLOCKS, LORNA, PITKEATHLY, D. A., MORTON, R., SMITH, G. D.
A consecutive series of 31 patients with rheumatoid arthritis (RA) admitted over a 6-month period to the rheumatology unit of a District General Hospital were screened for possible osteomalacia....
Macrocytosis and Sulphasalazine Treatment of Rheumatoid Arthritis (1987)
RALSTON, S. H., WILLOCKS, LORNA J., SHAW, R. W., PITKEATHLY, D. A.
RALSTON, S. H., BOYCE, B. F., COWAN, R. A., GARDNER, M. D., DRYBURGH, F. J., BOYLE, I. T.
Several aspects of calcium metabolism were studied in five patients during the surgical exploration of malignant tumours associated with humorally-mediated hypercalcaemia. Before operation in all...
Van't Hof, R. J., Armour, K. J., Smith, L. M., Armour, K. E., Wei, X. Q., Liew, F. Y., ...
Nitric oxide has been suggested to be involved in the regulation of bone turnover, especially in pathological conditions characterized by release of bone-resorbing cytokines. The cytokine IL-1 is...
Ralston, S H, Danks, J, Hayman, J, Fraser, W D, Stewart, C S, Martin, T J
Immunohistochemical staining for parathyroid hormone-related protein was performed in 27 tumours from 19 normocalcaemic and eight hypercalcaemic patients with cancer. All the tumours from...
Ralston, S H, Gardner, M D, Dryburgh, F J, Cowan, R A, Boyle, I T
The relation between urinary sodium excretion (NaE) and renal tubular calcium reabsorption (TmCa/GFR) was assessed in patients with hypercalcaemia associated with malignancy and primary...
Abnormal growth factor and cytokine expression in Dupuytren's contracture.
Baird, K S, Crossan, J F, Ralston, S H
AIM--To analyse patterns of gene expression for peptide regulatory factors in patients with Dupuytren's contracture. METHODS--Tissue samples (palmer fascia) from 12 patients with Dupuytren's...
Ralston, S H, Alzaid, A A, Gardner, M D, Boyle, I T
Eight patients with cancer associated hypercalcaemia were treated with the combination of aminohydroxypropylidene diphosphonate and salmon calcitonin for six days. Serum calcium concentration fell...
Ralston, S H, Fogelman, I, Gardiner, M D, Boyle, I T
Some relations between metastatic bone disease and calcium homoeostasis were determined in a consecutive series of 81 patients with solid malignant tumours attending for radionuclide bone scans....
Too much heparin: possible source of error in blood gas analysis.
Hutchison, A S, Ralston, S H, Dryburgh, F J, Small, M, Fogelman, I
Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis.
Ralston, S H, Urquhart, G D, Brzeski, M, Sturrock, R D
OBJECTIVE--To determine the prevalence of vertebral compression fractures due to osteoporosis in patients with ankylosing spondylitis. DESIGN--Prospective study of 111 consecutive patients; patients...
Van't Hof, R. J., Armour, K. J., Smith, L. M., Armour, K. E., Wei, X. Q., Liew, F. Y., ...
Nitric oxide has been suggested to be involved in the regulation of bone turnover, especially in pathological conditions characterized by release of bone-resorbing cytokines. The cytokine IL-1 is...
Ralston, S H, Danks, J, Hayman, J, Fraser, W D, Stewart, C S, Martin, T J
Immunohistochemical staining for parathyroid hormone-related protein was performed in 27 tumours from 19 normocalcaemic and eight hypercalcaemic patients with cancer. All the tumours from...
Ralston, S H, Gardner, M D, Dryburgh, F J, Cowan, R A, Boyle, I T
The relation between urinary sodium excretion (NaE) and renal tubular calcium reabsorption (TmCa/GFR) was assessed in patients with hypercalcaemia associated with malignancy and primary...
Abnormal growth factor and cytokine expression in Dupuytren's contracture.
Baird, K S, Crossan, J F, Ralston, S H
AIM--To analyse patterns of gene expression for peptide regulatory factors in patients with Dupuytren's contracture. METHODS--Tissue samples (palmer fascia) from 12 patients with Dupuytren's...
Ralston, S H, Alzaid, A A, Gardner, M D, Boyle, I T
Eight patients with cancer associated hypercalcaemia were treated with the combination of aminohydroxypropylidene diphosphonate and salmon calcitonin for six days. Serum calcium concentration fell...
Ralston, S H, Fogelman, I, Gardiner, M D, Boyle, I T
Some relations between metastatic bone disease and calcium homoeostasis were determined in a consecutive series of 81 patients with solid malignant tumours attending for radionuclide bone scans....
Too much heparin: possible source of error in blood gas analysis.
Hutchison, A S, Ralston, S H, Dryburgh, F J, Small, M, Fogelman, I
Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis.
Ralston, S H, Urquhart, G D, Brzeski, M, Sturrock, R D
OBJECTIVE--To determine the prevalence of vertebral compression fractures due to osteoporosis in patients with ankylosing spondylitis. DESIGN--Prospective study of 111 consecutive patients; patients...
Ralston, S H, Caine, N, Richards, I, O'Reilly, D, Sturrock, R D, Capell, H A
Measurements of protein/creatinine ratio in 'spot' urine samples were compared with measurements of 24 hour quantitative proteinuria and side room 'dipstick' testing in 104 samples from 90 patients...
Ralston, S H, Hacking, L, Willocks, L, Bruce, F, Pitkeathly, D A
A placebo controlled, double blind study of aminohydroxypropylidene bisphosphonate (APD), given by monthly intravenous infusion, was conducted in 40 patients with rheumatoid arthritis. Biochemical...
Hypercalcaemia in rheumatoid arthritis revisited.
Ralston, S H, Fraser, W D, Jankowski, J, Richards, I M, Cowan, R A, Capell, H A, ...
The prevalence and mechanisms of hypercalcaemia were studied in a series of patients attending a regional referral centre for rheumatic diseases. In a prospective study one case of hypercalcaemia due...
An unusual case of pustulotic arthro-osteitis affecting the leg, and erosive polyarthritis.
Ralston, S H, Scott, P D, Sturrock, R D
Pustulotic arthro-osteitis is a syndrome, originally described in Japan, in which a sterile inflammatory osteitis of the sternoclavicular region occurs in combination with a non-erosive arthritis,...
Clinical experience with pamidronate in the treatment of Paget's disease of bone.
Gallacher, S J, Boyce, B F, Patel, U, Jenkins, A, Ralston, S H, Boyle, I T
Bisphosphonates have been shown to be effective in treating the increased bone turnover associated with Paget's disease of bone. In this study two groups of patients were treated with pamidronate by...
A new method for the radiological assessment of vertebral squaring in ankylosing spondylitis.
Ralston, S H, Urquhart, G D, Brzeski, M, Sturrock, R D
A method has been developed for the objective assessment of vertebral 'squaring' based on quantitative morphometric analysis of vertebral 'concavity' in lateral radiographs of the lumbar spine. The...
MacDonald, A G, Murphy, E A, Capell, H A, Bankowska, U Z, Ralston, S H
AIMS--To study the effects of ovarian hormone replacement therapy (HRT) on bone mineral density and disease activity in postmenopausal women with rheumatoid arthritis (RA). METHOD--A placebo...
Steroid induced osteoporosis: an opportunity for prevention?
Peat, I D, Healy, S, Reid, D M, Ralston, S H
OBJECTIVE--To determine the frequency with which osteoporosis prophylaxis is given to corticosteroid treated hospital inpatients. METHODS--All patients receiving systemic corticosteroids in a large...
Medical management of hypercalcaemia.
1. Hypercalcaemia is a common disorder, which frequently requires specific treatment either to control symptoms, or to prevent the development of irreversible organ damage or death. Although the best...
Oat cell carcinoma of bronchus presenting as an acute psychiatric illness in young women
Ralston, S. H., Fogelman, I., Lowe, G. D. O.
Two young women are described who presented with an acute psychiatric illness, due to the metabolic effects of inappropriate anti-diuretic hormone (ADH) secretion. In both patients symptoms were...
Ralston, S. H., Fraser, W. D., Soukop, M., McKillop, J. H.
A patient with thyrotoxicosis presented with weight loss and hypercalcaemia, leading to an erroneous diagnosis of occult malignant disease. Intercurrent illness and drug treatment of hypercalcaemia...
Immobilization-related hypercalcaemia--a possible novel mechanism and response to pamidronate.
Gallacher, S. J., Ralston, S. H., Dryburgh, F. J., Logue, F. C., Allam, B. F., Boyce, B. F., ...
Immobilization-related hypercalcaemia is an uncommon but important condition being associated not infrequently with both urolithiasis and osteoporosis. In this study 5 patients who had been...
Chung, P. Y. J., Beyens, G., Riches, P. L., Van Wesenbeeck, L., Jennes, K., Daroszewska, A., ...
[Chung, P. Y. J.; Beyens, G.; Van Wesenbeeck, L.; Jennes, K.; Van Hul, W.] Univ Antwerp, Dept Med Genet, B-2020 Antwerp, Belgium. [Chung, P. Y. J.; Beyens, G.; Van Wesenbeeck, L.; Jennes, K.; Van...
Dose-response study of ibandronate in the treatment of cancer-associated hypercalcaemia.
Ralston, S. H., Thiébaud, D., Herrmann, Z., Steinhauer, E. U., Thürlimann, B., Walls, J., ...
Hypercalcaemia is an important cause of morbidity in malignant disease. We studied the efficacy and safety of intravenous ibandronate (a new, potent bisphosphonate) in a multicentre study of 147...