Sadahira, Y, Ruan, F, Hakomori, S, Igarashi, Y
Sphingosine 1-phosphate (Sph-1-P), the initial product of Sph degradation by Sph kinase, was shown to be a strong inhibitor of cell motility and phagokinesis of B16 melanoma and other types of cells...
Polley, M J, Phillips, M L, Wayner, E, Nudelman, E, Singhal, A K, Hakomori, S, ...
The leukocyte receptor CD62, which is expressed on activated platelets and endothelial cells, is shown to mediate cell adhesion by binding a sialylated carbohydrate structure, sialyl-Lewis x, found...
Stapleton, A, Nudelman, E, Clausen, H, Hakomori, S, Stamm, W E
Women with a history of recurrent Escherichia coli urinary tract infections (UTIs) are two to three times more likely to be nonsecretors of histo-blood group antigens than are women without such a...
Possible role of ceramide in defining structure and function of membrane glycolipids.
Kannagi, R, Nudelman, E, Hakomori, S
A possible role of ceramide in defining the carbohydrate structure of glycolipids and the expression of glycolipid function has been proposed, on the basis of our finding that the ceramide...
Functional domain structure of fibronectin.
Structural domains of fibronectin (FN) and their ability to associate with cell surface components have been systematically investigated. Plasma FN was cleaved into three structural domains (Mr...
Nichols, E J, Manger, R, Hakomori, S, Herscovics, A, Rohrschneider, L R
The effect of glycosylational-processing inhibitors on the synthesis, cell surface expression, endocytosis, and transforming function of the v-fms oncogene protein (gp140fms) was examined in...
An IgG1 monoclonal antibody, FDC-6, was established, which defines a unique fibronectin (FN) domain, located between the "Hep-2" and the "Fib-2" domains, in the COOH-terminal region of FNs isolated...
Hirohashi, S, Clausen, H, Yamada, T, Shimosato, Y, Hakomori, S
Two monoclonal antibodies, NCC-LU-35 and NCC-LU-81, have been established after immunization of mice with membrane preparations of human lung cancer Lu65 tumor xenograft cells grown in vivo and...
Lingwood, C. A., Ng, A., Hakomori, S.
Monovalent antibodies (Fab) directed to two classes of transformation-sensitive cell surface components, ganglioside and galactoprotein a (Gap a), inhibit the process of oncogenic viral...
Kannagi, R, Levery, S B, Hakomori, S
Cell surface carbohydrate antigens and their metabolism were investigated during the course of differentiation of murine cultured leukemia cells (M1) into macrophage-like cells. The major glycolipids...
Clausen, H, Levery, S B, Nudelman, E, Tsuchiya, S, Hakomori, S
The IgG2a monoclonal antibody TH-1, which reacts specifically with blood group A1 but with neither A2 nor O erythrocytes, has been established. The antibody reacted only with A1 erythrocytes in...
The heterogenetic Forssman antigen is a glycosphingolipid, a ceramide pentasaccharide with the structure GalNAcα1→3GalNAcβ1→3Galα1→4Galβ1→4Glc→ceramide. Forssman-positive animals are...
Kalckar, H. M., Ullrey, D., Kijomoto, S., Hakomori, S.
Untransformed as well as polyoma virus-transformed hamster cells can be grown equally well on a slow catabolite like galactose as on a rapid catabolite like glucose. The rate of uptake of galactose...
Kuo, C, Takahashi, N, Swanson, A F, Ozeki, Y, Hakomori, S
The structure of the carbohydrate of the 40-kD major outer membrane component of Chlamydia trachomatis and its role in defining infectivity of the organism were investigated. The oligosaccharides...
Neutral glycolipids and gangliosides of NIH 3T3 cells oncogenically transformed by transfection of DNAs from human lung carcinoma (Lx-1) and human bladder carcinoma (Ej) have been investigated. The...
Kannagi, R, Cochran, N A, Ishigami, F, Hakomori, S, Andrews, P W, Knowles, B B, ...
Two monoclonal antibodies (MC631 and MC813-70) raised against 4- to 8-cell stage mouse embryos and a human teratocarcinoma cell line, respectively, detect the stage-specific embryonic antigens, the...
Sadahira, Y, Ruan, F, Hakomori, S, Igarashi, Y
Sphingosine 1-phosphate (Sph-1-P), the initial product of Sph degradation by Sph kinase, was shown to be a strong inhibitor of cell motility and phagokinesis of B16 melanoma and other types of cells...
Polley, M J, Phillips, M L, Wayner, E, Nudelman, E, Singhal, A K, Hakomori, S, ...
The leukocyte receptor CD62, which is expressed on activated platelets and endothelial cells, is shown to mediate cell adhesion by binding a sialylated carbohydrate structure, sialyl-Lewis x, found...
Stapleton, A, Nudelman, E, Clausen, H, Hakomori, S, Stamm, W E
Women with a history of recurrent Escherichia coli urinary tract infections (UTIs) are two to three times more likely to be nonsecretors of histo-blood group antigens than are women without such a...
Possible role of ceramide in defining structure and function of membrane glycolipids.
Kannagi, R, Nudelman, E, Hakomori, S
A possible role of ceramide in defining the carbohydrate structure of glycolipids and the expression of glycolipid function has been proposed, on the basis of our finding that the ceramide...
Functional domain structure of fibronectin.
Structural domains of fibronectin (FN) and their ability to associate with cell surface components have been systematically investigated. Plasma FN was cleaved into three structural domains (Mr...
Nichols, E J, Manger, R, Hakomori, S, Herscovics, A, Rohrschneider, L R
The effect of glycosylational-processing inhibitors on the synthesis, cell surface expression, endocytosis, and transforming function of the v-fms oncogene protein (gp140fms) was examined in...
An IgG1 monoclonal antibody, FDC-6, was established, which defines a unique fibronectin (FN) domain, located between the "Hep-2" and the "Fib-2" domains, in the COOH-terminal region of FNs isolated...
Hirohashi, S, Clausen, H, Yamada, T, Shimosato, Y, Hakomori, S
Two monoclonal antibodies, NCC-LU-35 and NCC-LU-81, have been established after immunization of mice with membrane preparations of human lung cancer Lu65 tumor xenograft cells grown in vivo and...
Lingwood, C. A., Ng, A., Hakomori, S.
Monovalent antibodies (Fab) directed to two classes of transformation-sensitive cell surface components, ganglioside and galactoprotein a (Gap a), inhibit the process of oncogenic viral...
Kannagi, R, Levery, S B, Hakomori, S
Cell surface carbohydrate antigens and their metabolism were investigated during the course of differentiation of murine cultured leukemia cells (M1) into macrophage-like cells. The major glycolipids...
Clausen, H, Levery, S B, Nudelman, E, Tsuchiya, S, Hakomori, S
The IgG2a monoclonal antibody TH-1, which reacts specifically with blood group A1 but with neither A2 nor O erythrocytes, has been established. The antibody reacted only with A1 erythrocytes in...
The heterogenetic Forssman antigen is a glycosphingolipid, a ceramide pentasaccharide with the structure GalNAcα1→3GalNAcβ1→3Galα1→4Galβ1→4Glc→ceramide. Forssman-positive animals are...
Kalckar, H. M., Ullrey, D., Kijomoto, S., Hakomori, S.
Untransformed as well as polyoma virus-transformed hamster cells can be grown equally well on a slow catabolite like galactose as on a rapid catabolite like glucose. The rate of uptake of galactose...
Kuo, C, Takahashi, N, Swanson, A F, Ozeki, Y, Hakomori, S
The structure of the carbohydrate of the 40-kD major outer membrane component of Chlamydia trachomatis and its role in defining infectivity of the organism were investigated. The oligosaccharides...
Neutral glycolipids and gangliosides of NIH 3T3 cells oncogenically transformed by transfection of DNAs from human lung carcinoma (Lx-1) and human bladder carcinoma (Ej) have been investigated. The...
Kannagi, R, Cochran, N A, Ishigami, F, Hakomori, S, Andrews, P W, Knowles, B B, ...
Two monoclonal antibodies (MC631 and MC813-70) raised against 4- to 8-cell stage mouse embryos and a human teratocarcinoma cell line, respectively, detect the stage-specific embryonic antigens, the...
Okada, Y., Shimoe, T., Muguruma, M., Usumoto, R., Tsuji, T., Jinno, K., ...
Hepatic expression of sialylated difucosyl Lex antigen (SDLex, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-) was studied with monoclonal antibody...
The occurrence of α-mannosidase activity at the surface of hamster embryo (NIL) fibroblasts is indicated by the following findings: (a) When NIL cells were incubated on the glass surfaces on which...