S. Hemmi

Cloning of murine interferon gamma receptor cDNA: expression in human cells mediates high-affinity binding but is not sufficient to confer sensitivity to murine interferon gamma (2007)

Hemmi, S., Peghini, P., Metzler, M., Merlin, G., Dembic, Z., Aguet, M.

A full-length cDNA encoding the murine interferon gamma (IFN-gamma) receptor was isolated from a lambda gt11 library using a human IFN-gamma receptor cDNA probe. The deduced amino acid sequence of...

Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer (2007)

Hemmi, S., Merlin, G., Aguet, M.

The human interferon gamma (IFN-gamma) receptor expressed in mouse cells displays binding properties indistinguishable from those of the resident receptor on human cells. Still, mouse cells...

Immune response in mice that lack the interferon-gamma receptor (2007)

Huang, S., Hendriks, W., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., ...

Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility...

Signaling Steps Involving the Cytoplasmic Domain of the Interferon-Gamma Receptor Alpha-Subunit Are Not Species-Specific (2007)

Bohni, R., Hemmi, S., Aguet, M.

The ligand binding chain of the interferon-gamma receptor (IFN-gamma R) is a unique cell surface protein which has no similarities to other cytokine receptors. Expression of this receptor chain...

A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells (2007)

Hemmi, S., Bohni, R., Stark, G., Di Marco, F., Aguet, M.

Expression of the human interferon gamma receptor (IFN-gamma R) in mouse cells is not sufficient to confer biological responsiveness to human IFN-gamma and vice versa. An additional species-specific...

Functional role of type I and type II interferons in antiviral defense (2007)

Muller, U., Steinhoff, U., Reis, L. F., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., ...

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal...

Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor. (2007)

Fleischli, C, Sirena, D, Lesage, G, Havenga, M J E, Cattaneo, R, Greber, U F, ...

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Melanoma cultures show different susceptibility towards E1A-, E1B-19 kDa- and fiber-modified replication-competent adenoviruses. (2006)

Schmitz, M, Graf, C, Gut, T, Sirena, D, Peter, I, Dummer, R, ...

Replicating adenovirus (Ad) vectors with tumour tissue specificity hold great promise for treatment of cancer. We have recently constructed a conditionally replicating Ad5 AdDeltaEP-TETP inducing...

The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3. (2005)

Sirena, D, Ruzsics, Z, Schaffner, Walter, Greber, U F, Hemmi, S

Human adenovirus (Ad) serotype 3 causes respiratory infections. It is considered highly virulent, accounting for about 13% of all Ad isolates. We report here the complete Ad3 DNA sequence of 35,343...

The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35. (2005)

Fleischli, C, Verhaagh, S, Havenga, M, Sirena, D, Schaffner, Walter, Cattaneo, R, ...

The human regulator of complement activation membrane cofactor protein (CD46) has recently been identified as an attachment receptor for most species B adenoviruses (Ads), including Ad type 3 (Ad3),...

Regulation of neural progenitor proliferation and survival by beta 1 integrins (2005)

Leone,D. P., Relvas,J. B., Campos,L. S., Hemmi,S., Brakebusch,C., Fässler,R., ...

Early steps of clathrin-mediated endocytosis involved in phagosomal escape of Fcgamma receptor-targeted adenovirus. (2005)

Meier, O, Gastaldelli, M, Boucke, K, Hemmi, S, Greber, U F

Adenovirus type 2 (Ad2) and Ad5 enter epithelial cells via the coxsackievirus B Ad receptor (CAR) and alpha(v) integrin coreceptors. In the absence of CAR, they can be directed to the Fcgamma...

Regulation of neural progenitor proliferation and survival by beta 1 integrins (2005)

Leone, D. P., Relvas, J. B., Campos, L. S., Hemmi, S., Brakebusch, C., Fässler, R., ...

The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3. (2004)

Sirena, D, Lilienfeld, B, Eisenhut, M, Kälin, S, Boucke, K, Beerli, R R, ...

Many human adenovirus (Ad) serotypes use the coxsackie B virus-Ad receptor (CAR). Recently, CD46 was suggested to be a receptor of species B Ad serotype 11 (Ad11), Ad14, Ad16, Ad21, Ad35, and Ad50....

Cholesterol is required for endocytosis and endosomal escape of adenovirus type 2. (2004)

Imelli, N, Meier, O, Boucke, K, Hemmi, S, Greber, U F

The species C adenovirus type 2 (Ad2) and Ad5 bind the coxsackievirus B Ad receptor and alphav integrin coreceptors and enter epithelial cells by clathrin-mediated endocytosis. This pathway is rapid...

The alphavbeta5 integrin of hematopoietic and nonhematopoietic cells is a transduction receptor of RGD-4C fiber-modified adenoviruses. (2003)

Nagel, H, Maag, S, Tassis, A, Nestlé, F O, Greber, U F, Hemmi, S

Epithelial and endothelial cells expressing the primary Coxsackie virus B adenovirus (Ad) receptor (CAR) and integrin coreceptors are natural targets of human Ad infections. The fiber knob of species...

A novel attenuated replication-competent adenovirus for melanoma therapy. (2003)

Peter, I, Graf, C, Dummer, R, Schaffner, W, Greber, U F, Hemmi, S

To generate a replication-competent adenovirus (Ad) with specificity for melanoma, we constructed a tissue-specific promoter restricting E1A expression to melanoma cells. The combination of four...

Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake. (2002)

Meier, O, Boucke, K, Hammer, S V, Keller, S, Stidwill, R P, Hemmi, S, ...

Adenovirus type 2 (Ad2) binds the coxsackie B virus Ad receptor and is endocytosed upon activation of the alphav integrin coreceptors. Here, we demonstrate that expression of dominant negative...

Functional and selective targeting of adenovirus to high-affinity Fcgamma receptor I-positive cells by using a bispecific hybrid adapter. (2001)

Ebbinghaus, C, Al-Jaibaji, A, Operschall, E, Schöffel, A, Peter, I, Greber, U F, ...

Adenovirus (Ad) efficiently delivers its DNA genome into a variety of cells and tissues, provided that these cells express appropriate receptors, including the coxsackie-adenovirus receptor (CAR),...

Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer.

Hemmi, S, Merlin, G, Aguet, M

The human interferon gamma (IFN-gamma) receptor expressed in mouse cells displays binding properties indistinguishable from those of the resident receptor on human cells. Still, mouse cells...

Cloning of murine interferon gamma receptor cDNA: expression in human cells mediates high-affinity binding but is not sufficient to confer sensitivity to murine interferon gamma.

Hemmi, S, Peghini, P, Metzler, M, Merlin, G, Dembic, Z, Aguet, M

A full-length cDNA encoding the murine interferon gamma (IFN-gamma) receptor was isolated from a lambda gt11 library using a human IFN-gamma receptor cDNA probe. The deduced amino acid sequence of...

Secretion of mammalian ribonucleases from Escherichia coli using the signal sequence of murine spleen ribonuclease.

Schein, C H, Boix, E, Haugg, M, Holliger, K P, Hemmi, S, Frank, G, ...

A nucleotide sequence identical with that of the recently identified murine pancreatic ribonuclease (RNAase) was isolated from a murine spleen cDNA library. Active RNAase was expressed and secreted...

Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer.

Hemmi, S, Merlin, G, Aguet, M

The human interferon gamma (IFN-gamma) receptor expressed in mouse cells displays binding properties indistinguishable from those of the resident receptor on human cells. Still, mouse cells...

Cloning of murine interferon gamma receptor cDNA: expression in human cells mediates high-affinity binding but is not sufficient to confer sensitivity to murine interferon gamma.

Hemmi, S, Peghini, P, Metzler, M, Merlin, G, Dembic, Z, Aguet, M

A full-length cDNA encoding the murine interferon gamma (IFN-gamma) receptor was isolated from a lambda gt11 library using a human IFN-gamma receptor cDNA probe. The deduced amino acid sequence of...

Secretion of mammalian ribonucleases from Escherichia coli using the signal sequence of murine spleen ribonuclease.

Schein, C H, Boix, E, Haugg, M, Holliger, K P, Hemmi, S, Frank, G, ...

A nucleotide sequence identical with that of the recently identified murine pancreatic ribonuclease (RNAase) was isolated from a murine spleen cDNA library. Active RNAase was expressed and secreted...