Association of asthma with a functional promoter polymorphism in the IL16 gene (2006)
Burkart, K. M., Barton, S. J., Holloway, J. W., Yang, I. A., Cakebread, J. A., Cruikshank, W., ...
Association of asthma with a functional promoter polymorphism in the IL16 gene (2006)
Burkart, KM, Barton, SJ, Holloway, JW, Yang, IA, Cakebread, JA, Cruikshank, W, ...
Background: IL-16, a multifunctional cytokine with increased expression in the airways of asthmatic subjects, inhibits allergic airway inflammation in animal models. A T -> C single nucleotide...
Bousquet, J., Cabrera, P., Berkman, N., Buhl, R., Holgate, S., Wenzel, S., ...
Background: Patients with severe persistent asthma who are inadequately controlled despite treatment according to current asthma management guidelines have a significant unmet medical need. Such...
Holgate, S., Casale, T., Wenzel, S., Bousquet, J., Deniz, Y., Reisner, C.
Anti-IgE therapy with omalizumab reduces serum levels of free IgE and downregulates expression of IgE receptors (FcεRI) on mast cells and basophils. In the airways of patients with mild allergic...
Norris, Virginia, Choong, Lee, Tran, Duyen, Corden, Zoe, Boyce, Malcom, Arshad, Hasan, ...
Background: Very late antigen (VLA-4) antagonists have been proposed as potential therapies for diseases in which cell recruitment and accumulation are causative. Asthma, which is characterized by...
World Allergy Organization guidelines for prevention of allergy and allergic asthma (2004)
Asher, I., Baena-Cagnani, C., Boner, A., Canonica, G.W., Chuchalin, A., Custovic, A., ...
Powell, R., Ren, J., Lewith, G., Barclay, W., Holgate, S., Almond, J.
BACKGROUND: Chronic fatigue syndrome (CFS) is an increasing medical phenomenon of unknown aetiology leading to high levels of chronic morbidity. Of the many hypotheses that purport to explain this...
Powell, R., Ren, J., Lewith, G., Barclay, W., Holgate, S., Almond, J.
Background: Chronic fatigue syndrome (CFS) is an increasing medical phenomenon of unknown aetiology leading to high levels of chronic morbidity. Of the many hypotheses that purport to explain this...
Letter to the editor: Inhaled sodium cromoglycate in children with asthma (2002)
Edwards, A., Stevens, M., Holgate, S., Iikura, Y., Åberg, N., König, P., ...
Wallin, A.T., Cioppa, G.D., Holgate, S., Wilson, S.
In a recent placebo-controlled study in mild atopic asthmatics, we observed a significant decrease in eosinophils in the bronchial submucosa, after 2 months of treatment with inhaled formoterol and...
Letter to the editor: Sodium cromoglycate in childhood asthma (2001)
Edwards, A., Holgate, S., Howell, J., Warner, J., Stevens, M., Åberg, N., ...
The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al1 concludes that "there is insufficient evidence that SCG has a beneficial effect as...
Holgate, S., Bousquet, J., Wenzel, S., Fox, H., Liu, J., Castellsague, J.
Aim: Add-on therapy with omalizumab, an anti-immunoglobulin E antibody, is effective in improving disease control in patients with allergic asthma of varying severity. The aim of the present study...
Corne, J, Djukanovic, R, Thomas, L, Warner, J, Botta, L, Grandordy, B, ...
CGP 51901 is a non-anaphylactogenic mouse/human chimeric anti-human IgE antibody that binds to free IgE and surface IgE of IgE-expressing B cells but not to IgE bound to high affinity IgE receptors...
Corne, J, Djukanovic, R, Thomas, L, Warner, J, Botta, L, Grandordy, B, ...
CGP 51901 is a non-anaphylactogenic mouse/human chimeric anti-human IgE antibody that binds to free IgE and surface IgE of IgE-expressing B cells but not to IgE bound to high affinity IgE receptors...
Richards, R, Haas, A, Simpson, S, Britten, A, Renwick, A, Holgate, S
Inhalation treatment may be less effective in the presence of bronchoconstriction because of the reduced penetration of drugs into the airways. The effect of bronchoconstriction on the lung...
Respiratory symptoms in children at schools near a foundry.
Symington, P, Coggon, D, Holgate, S
A survey was carried out in response to complaints of increased respiratory symptoms in children at schools near a foundry in Walsall, West Midlands. Air monitoring around the factory had shown...
Personal exposures of children to nitrogen dioxide relative to concentrations in outdoor air
Linaker, C., Chauhan, A., Inskip, H., Holgate, S., Coggon, D.
OBJECTIVES—To investigate the relation between fluctuations in personal exposure to nitrogen dioxide (NO2) in school children and changes in outdoor NO2 concentrations. METHODS—114 Asthmatic...
Pathmanathan, S, Krishna, M, Blomberg, A, Helleday, R, Kelly, F, Sandstrom, T, ...
Background: Repeated daily exposure of healthy human subjects to NO2 induces an acute airway inflammatory response characterised by neutrophil influx in the bronchial mucosa
A confidential inquiry into asthma deaths in Wales
Burr, M, Davies, B, Hoare, A, Jones, A, Williamson, I, Holgate, S, ...
BACKGROUND—Death from asthma is regarded as preventable in principle, especially under the age of 65years. METHODS—In 1994 a confidential inquiry was set up to investigate deaths attributable...
Linaker, C, Coggon, D, Holgate, S, Clough, J, Josephs, L, Chauhan, A, ...
BACKGROUND—Several studies have linked air pollution by nitrogen dioxide (NO2) with increased hospital admissions for asthma in children. Exacerbations of asthma in children are often precipitated...
Sodium cromoglycate in childhood asthma
EDWARDS, A, HOLGATE, S, HOWELL, J, WARNER, J, STEVENS, M, ABERG, N, ...
Redington, A, Meng, Q, Springall, D, Evans, T, Creminon, C, Maclouf, J, ...
BACKGROUND—Nitric oxide (NO) and prostanoids are mediators of vascular and bronchial tone that are postulated to be involved in asthma. Increased levels of both are found in asthmatic subjects and...
Prevalence of untreated asthma in a population sample of 6000 older adults in Bristol, UK
Dow, L, Fowler, L, Phelps, L, Waters, K, Coggon, D, Kinmonth, A, ...
BACKGROUND—A study was undertaken to estimate the prevalence of untreated asthma in older adults. METHODS—A cross sectional population based survey of 6000 men and women aged 65 years and over...
Inhaled sodium cromoglycate in children with asthma
Edwards, A, Stevens, M, Holgate, S, Iikura, Y, Aberg, N, Konig, P, ...
Role of cysteinyl leukotrienes in adenosine 5`-monophosphate induced bronchoconstriction in asthma
Rorke, S, Jennison, S, Jeffs, J, Sampson, A, Arshad, H, Holgate, S
Background: Adenosine induced bronchoconstriction in patients with asthma is thought to be mediated by the synthesis and release of autacoids from airway mast cells. In vitro, adenosine induced...
A defective type 1 response to rhinovirus in atopic asthma
Papadopoulos, N, Stanciu, L, Papi, A, Holgate, S, Johnston, S
Background: Rhinoviruses (RVs) are the most frequent precipitants of the common cold and asthma exacerbations, but little is known about the immune response to these viruses and its potential...
Sayers, I, Barton, S, Rorke, S, Beghe, B, Hayward, B, Van Eerdewegh, P, ...
Background: LTC4 synthase is essential for the production of cysteinyl leukotrienes (Cys-LT), critical mediators in asthma. We have identified a novel promoter polymorphism at position -1072 (G/A)...
Mansur, A, Bishop, D, Holgate, S, Markham, A, Morrison, J
Background: A study was undertaken to validate a locus modulating total serum IgE levels on 14q13–24.
O'Donnell, R, Peebles, C, Ward, J, Daraker, A, Angco, G, Broberg, P, ...
Background: Considerable research has been conducted into the nature of airway inflammation in chronic obstructive pulmonary disease (COPD) but the relationship between proximal airways inflammation...
Expression of ErbB receptors and mucins in the airways of long term current smokers
O'Donnell, R, Richter, A, Ward, J, Angco, G, Mehta, A, Rousseau, K, ...
Background: Airway epithelial goblet cell hyperplasia is known to occur in chronic smokers. Although the epidermal growth factor receptor has been implicated in this process, neither ErbB receptor...
Case-control study of salmeterol and near-fatal attacks of asthma
Williams, C., Crossland, L., Finnerty, J., Crane, J., Holgate, S., Pearce, N., ...
Respiratory symptoms in older people and use of domestic gas appliances
Dow, L, Phelps, L, Fowler, L, Waters, K, Coggon, D, Holgate, S
BACKGROUND—Studies in children and young women have indicated an increased risk of respiratory illness in association with the use of domestic gas appliances, possibly caused by oxides of nitrogen...
Osteocalcin, growth, and inhaled corticosteroids: a prospective study.
Doull, I, Freezer, N, Holgate, S
OBJECTIVES: To determine the relationship between biochemical markers of bone metabolism and statural growth, and their suitability as surrogate markers of inhaled corticosteroid induced growth...
Duration of growth suppressive effects of regular inhaled corticosteroids
Doull, I., Campbell, M., Holgate, S.
The growth of 50 children receiving regular inhaled corticosteroids was segregated into divisions of six weeks from the start of treatment and compared with their growth when not receiving regular...
Epithelial stress and structural remodelling in childhood asthma
Fedorov, I, Wilson, S, Davies, D, Holgate, S
Background: In adult asthma the bronchial epithelium shows high expression of the epidermal growth factor receptor (EGFR) and the cyclin dependent kinase inhibitor, p21waf, linked to ongoing stress...