S. Ito

Publication List Details

Period

1974 - 2009

Number

338

Co-Authors

Gauge-independent derivation of "Abelian" dominance and magnetic monopole dominance in the string tension (2009)

Kato, S., Shibata, A., Shinohara, T., Ito, S.

Recently, we have developed a reformulation of the lattice Yang-Mills theory based on the change of variables a la Cho-Faddeev-Niemi combined with a non-Abelian Stokes theorem. In this talk, we give...

New descriptions of lattice SU(N) Yang-Mills theory towards quark confinement (2008)

Shibata, A., Shinohara, T., Murakami, T., Kato, S., Ito, S.

We give new descriptions of lattice SU(N) Yang-Mills theory in terms of new lattice variables. The validity of such descriptions has already been demonstrated in the SU(2) Yang-Mills theory by our...

Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-{alpha} monoclonal antibody, infliximab (2008)

Sekiguchi, N., Kawauchi, S., Furuya, T., Inaba, N., Matsuda, K., Ando, S., ...

Objectives. We monitored the mRNA expression profiles of peripheral blood cells during treatment with a TNF-α inhibitor, infliximab, in patients with RA. Using a DNA microarray analysis, we...

12CO 4-3 and [CI] 1-0 at the centers of NGC 4945 and Circinus (2007)

Hitschfeld, M., Aravena, M., Kramer, C., Bertoldi, F., Stutzki, J., Bensch, F., ...

Studying molecular gas in the central regions of the star burst galaxies NGC4945 and Circinus enables us to characterize the physical conditions and compare them to previous local and high-z studies....

Clinical application of QT dispersion on ventricular hypertrophy (2007)

Using Magnetocardiogram Nomura, M. Nomura, Y. Nakaya, H. Miyajima, T. Nada, S. Morishita, ...

Introduction QT dispersion is defined as the difference between the maximum QT and minimum QT intervals on standard 12-lead electrocardiogram (ECG). It is a new index of the homogeneity of...

Clumpy photon-dominated regions in Carina. I. [CI] and mid-J CO lines in two 4'x4' fields (2007)

Kramer, C., Cubick, M., Roellig, M., Sun, K., Yonekura, Y., Aravena, M., ...

The Carina region is an excellent astrophysical laboratory for studying the feedback mechanisms of newly born, very massive stars within their natal giant molecular clouds (GMCs) at only 2.35 kpc...

Toward gauge independent study of confinement in SU(3) Yang-Mills theory (2007)

Shibata, A., Kato, S., Murakami, T., Shinohara, T., Ito, S.

Dual superconductivity is believed to be a promising mechanism for quark confinement and has been investigated on a lattice effectively by a particular gauge called the maximal Abelian (MA) gauge. We...

Usefulness of multi-detector row Computed Tomography for accurate preoperative assessment of pancreatic adenocarcinoma: report of a case (2007)

Maeda, H, Okabayashi, T, Kobayashi, M, Morishita, S, Nishimori, I, Ito, S, ...

A 74-year-old female underwent surgical treatment for adenocarcinoma of the pancreatic head. Preoperative multi-detector row computed tomography (MD-CT) demonstrated tumor invasion into the accessory...

Compact lattice formulation of Cho-Faddeev-Niemi decomposition: gluon mass generation and infrared Abelian dominance (2007)

Shibata, A., Kato, S., Murakami, T., Shinohara, T., Ito, S.

This paper complements a new lattice formulation of SU(2) Yang-Mills theory written in terms of new variables in a compact form proposed in the previous paper. The new variables used in the...

A broadband study of galactic dust emission (2007)

Paladini, R., Montier, L., Giard, M., Dame, T., Ito, S., ...

We have combined infrared data with HI, H2 and HII surveys in order to spatially decompose the observed dust emission into components associated with different phases of the gas. An inversion...

A broadband study of galactic dust emission (2007)

Paladini, R., Montier, L., Giard, M., Dame, T., Ito, S., ...

We have combined infrared data with HI, H2 and HII surveys in order to spatially decompose the observed dust emission into components associated with different phases of the gas. An inversion...

A broadband study of galactic dust emission (2007)

Paladini, R., Montier, L., Giard, M., Dame, T., Ito, S., ...

We have combined infrared data with HI, H2 and HII surveys in order to spatially decompose the observed dust emission into components associated with different phases of the gas. An inversion...

Projectile fragmentation reactions and production of nuclei near the neutron drip-line (2007)

Notani, M., Sakurai, H., Aoi, N., Iwasaki, H., Fukuda, N., Liu, Z., ...

The reaction mechanism of projectile fragmentation at intermediate energies has been investigated observing the target dependence of the production cross sections of very neutron-rich nuclei....

Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. (2007)

Taylor, R C, Brumatti, G, Ito, S, Hengartner, M O, Derry, W B, Martin, S J

Genetic studies have established that the cysteine protease CED-3 plays a central role in coordinating programmed cell death in Caenorhabditis elegans. However, it remains unclear how CED-3...

High-Tc Superconducting Fault Current Limiting Transformer ( HTc-SFCLT ) With 2G Coated Conductors (2007)

Okubo, H., Kurupakorn, C., Ito, S., Kojima, H., Hayakawa, N., Endo, F., ...

We developed a 3-phase, 100 kVA, 6600 V/210 V high temperature Superconducting Fault Current Limiting Transformer (HTc-SFCLT) with functions of both superconducting transformer and fault current...

A Broadband Study of Galactic Dust Emission (2006)

Paladini, R., Montier, L., Giard, M., Dame, T., Ito, S., ...

We have combined infrared data with HI, H2 and HII surveys in order to spatially decompose the observed dust emission into components associated with different phases of the gas. An inversion...

On substitution Invariant Sturmian Words: An Application of Rauzy Fractals (2006)

Berthe, V., H., Ei, Ito, S., Rao, H.

On substitution Invariant Sturmian Words: An Application of Rauzy Fractals

Quark confinement and gauge invariant monopoles in SU(2) YM (2006)

Kato, S., Ito, S., Murakami, T., Shibata, A., Shinohara, T.

We give a short review of recently obtained results on a new lattice formulation of the non-linear change of variables which was once called the Cho--Faddeev--Niemi decomposition in SU(2) Yang-Mills...

Gluon mass generation and infrared Abelian dominance in Yang-Mills theory (2006)

Shibata, A., Ito, S., Kato, S., Murakami, T., Shinohara, T.

The dual superconductivity is believed to be a promising mechanism for quark confinement. Indeed, what this picture is true has been confirmed in the maximal Abelian (MA) gauge. However, it is not...

Mechanism of plasma glutathione peroxidase production in bovine adipocytes (2006)

Yamasaki, T., Tahara, K., Takano, S., Inoue-Murayama, M., Rose, Michael T., Minashima, T., ...

Plasma glutathione peroxidase (pGPx) is an anti-oxidative enzyme. Using the polymerase chain reaction subtraction method, we have previously identified pGPx as a large part of the genes that are...

Compact lattice formulation of Cho-Faddeev-Niemi decomposition: string tension from magnetic monopoles (2006)

Ito, S., Kato, S., Murakami, T., Shibata, A., Shinohara, T.

In this paper we begin on a new lattice formulation of the non-linear change of variables called the Cho--Faddeev--Niemi decomposition in SU(2) Yang-Mills theory. This is a compact lattice...

In Search of Microscopic Evidence for Molecular Level Negative Thermal Expansion in Fullerenes (2006)

Brown, S., Cao, J., Musfeldt, J. L., Dragoe, N., Cimpoesu, F., Ito, S., ...

We report the high-resolution far infrared vibrational properties of C60 and endohedral Kr@C60 fullerene as a function of temperature. Anomalous softening of the F1u(1) mode (526 cm-1) is observed...

Zinc modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro (2006)

Otsuguro, K., Ohta, T., Ito, S., 乙黒, 兼一

Zinc ions (Zn2+) are known to modulate the functions of a variety of channels, receptors and transporters. We examined the effects of Zn2+ on the reflex potentials evoked by electrical stimulation...

Zinc modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro (2006)

Otsuguro, K., Ohta, T., Ito, S.

Zinc ions (Zn2+) are known to modulate the functions of a variety of channels, receptors and transporters. We examined the effects of Zn2+ on the reflex potentials evoked by electrical stimulation...

Zinc modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro (2006)

Otsuguro, K., Ohta, T., Ito, S.

Zinc ions (Zn2+) are known to modulate the functions of a variety of channels, receptors and transporters. We examined the effects of Zn2+ on the reflex potentials evoked by electrical stimulation...

Continuous Energy Management of the HVAC&R System in an Office Building System Operation and Energy Consumption for the Eight Years after Building Completion (2006)

Akashi, Y., Shinozaki, M., Kusuda, R., Ito, S.

The authors continuously studied the energy consumption of a heating, ventilating, air- conditioning and refrigerating (HVAC&R) system in an office for the operation of the system in terms of its...

Synthesis, Characterization, and DFT-TDDFT Computational Study of a Ruthenium Complex Containing a Functionalized Tetradentate Ligand (2006)

Barolo, C., Nazeeruddin, Md. K., Fantacci, S., Di Censo, D., Comte, P., Liska, P., ...

A ruthenium complex trans-[Ru(L)(NCS)2], L ) 4,4¢¢¢-di- tert-butyl-4¢,4¢¢-bis(carboxylic acid)-2,2¢:6¢,2¢¢:6¢¢,2¢¢¢- quaterpyridine (N886), was synthesized and characterized by...

High-efficiency (7.2%) flexible dye-sensitized solar cells with Ti-metal substrate for nanocrystalline-TiO2 photoanode (2006)

Ito, S., Rothenberger, G., Liska, P., Comte, P., Zakeeruddin, S.M., ...

High-efficiency flexible dye-sensitized solar cells were fabricated with a Ti-metal foil substrate for photo anode and using a Pt-electrodeposited counter electrode on ITO/polyethylene naphthalate...

Continuous Energy Management of the HVAC&R System in an Office Building System Operation and Energy Consumption for the Eight Years after Building Completion (2006)

Akashi, Y., Shinozaki, M., Kusuda, R., Ito, S.

The authors continuously studied the energy consumption of a heating, ventilating, air- conditioning and refrigerating (HVAC&R) system in an office for the operation of the system in terms of its...

Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin (2006)

Wakamatsu, K., Kavanagh, R., Kadekaro, A. L., Terzieva, S., Sturm, R. A., Leachman, S., ...

Cultured human melanocytes differ tremendously in visual pigmentation, and recapitulate the pigmentary phenotype of the donor's skin. This diversity arises from variation in type as well as quantity...

Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin (2006)

Wakamatsu, K., Kavanagh, R., Kadekaro, A. L., Terzieva, S., Sturm, R. A., Leachman, S., ...

Cultured human melanocytes differ tremendously in visual pigmentation, and recapitulate the pigmentary phenotype of the donor's skin. This diversity arises from variation in type as well as quantity...

Lattice construction of Cho-Faddeev-Niemi decomposition and gauge invariant monopole (2005)

Kato, S., Murakami, T., Shibata, A., Shinohara, T., Ito, S.

We present the first implementation of the Cho--Faddeev--Niemi decomposition of the SU(2) Yang-Mills field on a lattice. Our construction retains the color symmetry (global SU(2) gauge invariance)...

INNER AND OUTER FLOW VELOCITY DISTRIBUTIONS THROUGH TALL SIMULATED VEGETATION. (2005)

Ito,S., Cermak,J. E.

The velocity distribution in and above model vegetation is the subject of this study. Experiments have revealed that flow over a surface which has been made rough by covering it with tall simulated...

Radiation protection system at the RIKEN RI beam factory (2005)

Uwamino, Y., Fujita, S., Sakamoto, H., Ito, S., Fukunishi, N., Yabutani, T., ...

The RIKEN RI (radioactive isotope) Beam Factory is scheduled to commence operations in 2006, and its maximum energy will be 400 MeV u−1 for ions lighter than Ar and 350 MeV u−1 for uranium. The...

In vitro effect of nanoleakage expression on resin-dentin bond strengths analyzed by microtensile bond test, SEM/EDX and TEM (2004)

Ito, S, Sano, H, Kaga, M, Oguchi, H, ...

This study evaluated the effect of multiple consecutive adhesive resin coatings of adhesive bonded to human dentin on nanoleakage and resin-dentin bond strength. Resin bonded dentin specimens were...

RESEARCH REPORTS (2004)

Biomaterials Bioengineering, M. Hashimoto, S. Ito, F. R. Tay, N. R. Svizero, H. Sano, ...

This study evaluated the extent of water penetration through resin-dentin interfaces before and after being sealed with adhesives. Four adhesive resin systems (2 total-etch adhesives and 2...

INDUCED RADIOACTIVITY IN CU TARGETS PRODUCED BY HIGH-ENERGY HEAVY IONS AND THE CORRESPONDING ESTIMATED PHOTON DOSE RATES (2004)

Yashima, H., Uwamino, Y., Sugita, H., Ito, S., Nakamura, T., Fukumura, A.

Irradiation experiments were performed at the Heavy Ion Medical Accelerator in Chiba (HIMAC) facility, National Institute of Radiological Sciences. The radioactive spallation products in a thick Cu...

Induced radioactivity in CU targets produced by high-energy heavy ions and the corresponding estimated photon dose rates (2004)

Yashima, H., Uwamino, Y., Sugita, H., Ito, S., Nakamura, T., Fukumura, A.

Irradiation experiments were performed at the Heavy Ion Medical Accelerator in Chiba (HIMAC) facility, National Institute of Radiological Sciences. The radioactive spallation products in a thick Cu...

INDUCED RADIOACTIVITY IN CU TARGETS PRODUCED BY HIGH-ENERGY HEAVY IONS AND THE CORRESPONDING ESTIMATED PHOTON DOSE RATES (2004)

Yashima, H., Uwamino, Y., Sugita, H., Ito, S., Nakamura, T., Fukumura, A.

Irradiation experiments were performed at the Heavy Ion Medical Accelerator in Chiba (HIMAC) facility, National Institute of Radiological Sciences. The radioactive spallation products in a thick Cu...

Self-pulsation in an InGaN laser - theory and experiment - (2003)

Tronciu, V.Z., Yamada, M., Ohno, T., Ito, S., Kawakami, T., Taneya, M.

Room-temperature operation of self-pulsating InGaN lasers was obtained at a wavelength of 395 nm. The laser structure consists of a multiquantum-well InGaN active layer and a p-type InGaN...

Alignment following Au L3 photoionization by synchrotron radiation (2003)

Yamaoka,H., Oura,M., Takahiro,K., Morikawa,T., Ito,S., Mizumaki,M., ...

The alignment of Au+ ions following L3 photoionization has been studied using a high-resolution x-ray spectrometer. We observed a small anisotropy for the angular dependence of Au L and L emissions....

Alignment following Au L3 photoionization by synchrotron radiation (2003)

Yamaoka, H., Oura, M., Takahiro, K., Morikawa, T., Ito, S., Mizumaki, M., ...

The alignment of Au+ ions following L3 photoionization has been studied using a high-resolution x-ray spectrometer. We observed a small anisotropy for the angular dependence of Au L and L emissions....

Discrete planes, Z 2 -actions, Jacobi-Perron algorithm and substitutions (2002)

P. Arnoux, V. Berth E, S. Ito

Abstract. We introduce two-dimensional substitutions generating two-dimensional sequences related to discrete approximations of irrational planes. These two-dimensional substitutions are produced by...

Discrete planes, Z 2 -actions, Jacobi-Perron algorithm and substitutions (2002)

P. Arnoux, V. Berthe, S. Ito

Abstract. We introduce two-dimensional substitutions generating two-dimensional sequences related to discrete approximations of irrational planes. These two-dimensional substitutions are produced by...

Topics of monopole dynamics in gluodynamics (2001)

Suzuki, T., Koma, Y., Ito, S., Park, T. W., Polikarpov, M. I., ...

Three topics of monopole dynamics in gluodynamics are presented. 1)Gauge (in)dependence of the monopole effective action (S.Ito, T.W.Park, T.Suzuki): Four different abelian projections are studied....

A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosmaminoglycan and proteoglycan distribution in transgenic mice (2001)

Jacenko, O, Chan, D, Franklin, A, Ito, S, Underhill, CB, Bateman, JF, ...

Collagen X transgenic (Tg) mice displayed skeleto-hematopoietic defects in tissues derived by endochondral skeletogenesis.(1) Here we demonstrate that co-expression of the transgene product...

Breed Differences in Allele Frequency of the Dopamine Receptor D4 Gene in Dogs (2001)

Niimi, Y., Inoue-Murayama, M., Kato, K., Matsuura, N., Murayama, Y., Ito, S., ...

We previously reported that the dog dopamine receptor D4 (DRD4) gene is polymorphic as observed in humans, and four alleles were identified based on the number and/or order of the 12 and 39 bp...

Brief communication. Genetic analyses of plumage color mutations on the Z chromosome of Japanese quail (2000)

Minvielle, F, Ito, S, Inoue-Murayama, M, Mizutani, M, Wakasugi, N

Genetic analyses were performed with four sex-linked plumage color mutations (roux, brown, imperfect albino, and cinnamon) in Japanese quail (Coturnix japonica). Roux and brown quail have similar...

Brief communication. Fifty microsatellite markers for Japanese quail (2000)

Kayang, BB, Inoue-Murayama, M, Nomura, A, Kimura, K, Takahashi, H, Mizutani, M, ...

A Japanese quail genomic library enriched for (CA/GT)n simple sequence was screened and positive clones were sequenced. Fifty original microsatellite sequences were isolated that consisted mainly of...

Recent topics of infrared effective lattice QCD (1999)

Yamagishi, K., Kitahara, S., Ito, S., Tsunemi, T., Fujimoto, S., Kato, S., ...

Three topics concerning infrared effective lattice QCD are discussed. (1)Perfect lattice action of infrared SU(3) QCD and perfect operators for the static potential are analytically given when we...

Tensile Strength and Fracture Defects Expanded by Subcritical Crack Growth of Silicon Nitride at High Temperatures. (1998)

Ohji, T., Yamauchi, Y., Kanematsu, W., Ito, S.

A fractographic study was undertaken to investigate the effects of fracture defects expanded by subcritical crack growth (SCG) at 1200 C on the strength properties of silicon nitride. Using scanning...

K+-β-Ferrite as a New Cathode Active Material for Lithium Secondary Battery (1997)

Ito, S., Ui, K., Hoshi, N., Kurosawa, H., Koura, N., Akashi, K.

The possibility of K+-β-ferrite (Kl.33Fe11O17) as a cathode active material for lithium secondary battery was investigated. It was confirmed that lithium ions certainly inserted into...

Preparation of (Zn, Fe)Fe2O4 Thin Film by MOCVD (1997)

Ito, S., Mochizuki, T., Chiba, M., Akashi, K., Yoneda, N.

(Zn,Fe)Fe2O4 thin films have been prepared by MOCVD, applying a novel evaporation method for MO reagents ; Zn(acac)2 and Fe(acac)3. These reagents were mixed with a composition of Fe/Zn=0.5-2.0 and...

K+-β-Ferrite as a New Cathode Active Material for Lithium Secondary Battery (1997)

Ito, S., Ui, K., Hoshi, N., Kurosawa, H., Koura, N., Akashi, K.

The possibility of K+-β-ferrite (Kl.33Fe11O17) as a cathode active material for lithium secondary battery was investigated. It was confirmed that lithium ions certainly inserted into...

Preparation of (Zn, Fe)Fe2O4 Thin Film by MOCVD (1997)

Ito, S., Mochizuki, T., Chiba, M., Akashi, K., Yoneda, N.

(Zn,Fe)Fe2O4 thin films have been prepared by MOCVD, applying a novel evaporation method for MO reagents ; Zn(acac)2 and Fe(acac)3. These reagents were mixed with a composition of Fe/Zn=0.5-2.0 and...

K+-β-Ferrite as a New Cathode Active Material for Lithium Secondary Battery (1997)

Ito, S., Ui, K., Hoshi, N., Kurosawa, H., Koura, N., Akashi, K.

The possibility of K+-β-ferrite (Kl.33Fe11O17) as a cathode active material for lithium secondary battery was investigated. It was confirmed that lithium ions certainly inserted into...

Preparation of (Zn, Fe)Fe2O4 Thin Film by MOCVD (1997)

Ito, S., Mochizuki, T., Chiba, M., Akashi, K., Yoneda, N.

(Zn,Fe)Fe2O4 thin films have been prepared by MOCVD, applying a novel evaporation method for MO reagents ; Zn(acac)2 and Fe(acac)3. These reagents were mixed with a composition of Fe/Zn=0.5-2.0 and...

Fawn-2: A Dominant Plumage Color Mutation in Japanese Quail (1996)

Tsudzuki, M., Ito, S., Sato, K., Takahashi, S., Uchida, H.

A plumage color mutation fawn-2 in Japanese quail (Coturnix japonica) is controlled by an incompletely dominant autosomal gene allelic to and incompletely dominant over the yellow (Y) gene. The...

Orange: A Plumage Color Mutation Accompanied by Semi-Lethality in Japanese Quail (1994)

Ito, S., Tsudzuki, M.

A new plumage color mutant, orange, in Japanese quail (Coturnix japonica) was characterized by the same plumage pattern as in the wild type but with diluted pigmentation on the whole body. Light...

Celadon: An Eggshell Color Mutation in Japanese Quail (1993)

Ito, S., Tsudzuki, M., Komori, M., Mizutani, M.

A new eggshell color mutant was discovered in the Japanese quail. This trait was named “celadon” and was shown to be controlled by an autosomal recessive gene. Therefore, the gene symbol ce was...

Light Down--Dominant Plumage Color Mutation with Homozygous Lethality in Japanese Quail (1993)

Ito, S., Tsudzuki, M.

A new plumage color mutation in Japanese quail (Coturnix japonica) was named light down (LD) from its external appearance at hatching; it was expressed as an incompletely dominant autosomal gene, for...

Microscopic Spatial Inhomogeneity of Radiopharmaceutical Deposition in Mammalian Tissues: Dosimetry at the Cellular Level and Comparison with Conventional Dosimetry (1990)

Makrigiorgos, G.M., Baranowska-Kortylewicz, J., Van Den Abbeele, A.D., Ito, S., Vinter, D.W., Adelstein, S.J., ...

An experimental and a theoretical examination of the validity of the dosimetric assumptions of conventional internal dosimetry at the cellular level has been performed. Conventional dosimetry assumes...

Finite element analysis of magnetic circuits composed of axisymmetric and rectangular regions (1985)

Nakata, Takayoshi, Takahashi, N., Kawase, Y., Funakoshi, H., Ito, S.

A new approximate method is developed for calculating three-dimensional magnetic fields in magnetic circuits composed of connected axisymmetric and rectangular regions. Using this new method, fairly...

DYNAMIC FATIGUE OF SODIUM-SILICATE GLASSES WITH HIGH WATER CONTENT (1982)

Ito, S., Tomazawa, M.

The stress-rate dependency of the mechanical strength of sodium silicate glass with high water content (up to ~25% by weight) was investigated. The glasses were prepared by drying commercial sodium...

DYNAMIC FATIGUE OF SODIUM-SILICATE GLASSES WITH HIGH WATER CONTENT (1982)

Ito, S., Tomazawa, M.

The stress-rate dependency of the mechanical strength of sodium silicate glass with high water content (up to ~25% by weight) was investigated. The glasses were prepared by drying commercial sodium...

DYNAMIC FATIGUE OF SODIUM-SILICATE GLASSES WITH HIGH WATER CONTENT (1982)

Ito, S., Tomazawa, M.

The stress-rate dependency of the mechanical strength of sodium silicate glass with high water content (up to ~25% by weight) was investigated. The glasses were prepared by drying commercial sodium...

Loss of all ndh genes as determined by sequencing the entire chloroplast genome of the black pine Pinus thunbergii.

Wakasugi, T, Tsudzuki, J, Ito, S, Nakashima, K, Tsudzuki, T, Sugiura, M

The complete nucleotide sequence (119,707 bp) of the black pine (Pinus thunbergii) chloroplast genome has been determined. It contains 4 rRNA genes and 32 tRNA genes. To our knowledge, the tRNAPro...

Single type-2 astrocytes show multiple independent sites of Ca2+ signaling in response to histamine.

Inagaki, N, Fukui, H, Ito, S, Yamatodani, A, Wada, H

Intracellular Ca2+ plays an important role in signal transduction as a second messenger. In various types of cells, inositol 1,4,5-trisphosphate-induced elevations of intracellular free Ca2+...

Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

Yamashita, M, Fukui, H, Sugama, K, Horio, Y, Ito, S, Mizuguchi, H, ...

A functional cDNA clone for the histamine H1 receptor was isolated from a cDNA library of bovine adrenal medulla by a combination of molecular cloning in an expression vector and electrophysiological...

Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan.

Ito, Y, Azuma, T, Ito, S, Miyaji, H, Hirai, M, Yamazaki, Y, ...

Approximately 50% of Helicobacter pylori strains produce a cytotoxin that is encoded by vacA and that induces vacuolation of eukaryotic cells. Mosaicism in vacA alleles was reported, and there are...

Sophorolipids from Torulopsis bombicola: possible relation to alkane uptake.

Ito, S, Inoue, S

Torulopsis bombicola produces extracellular sophorolipids when it is grown on water-insoluble alkanes. Sophorolipids and related model compounds, which were not themselves used for growth, were found...

D-Alanine-requiring cell wall mutant of Escherichia coli.

Olden, K, Ito, S, Wilson, T H

A mutant of Escherichia coli is described whose cells show a spherical or irregular morphology, associated with leakage of beta-galactosidase and other intracellular proteins. The expression of the...

Bacteriocinlike killing action of a temperate bacteriophage phiBA1 of Bacillus aneurinolyticus.

Ito, S, Nishimune, T, Abe, M, Kimoto, M, Hayashi, R

A new temperate phage, phiBA1, was isolated from Bacillus aneurinolyticus, phiBA1 had an icosahedral head with a diameter of about 70 nm and a tail about 20 nm long and contained a circularly...

Comparison of three blood-clotting substances in Staphylococcus aureus strains.

Yoshida, K, Takahashi, M, Haga, K, Kono, E, Kushiro, H, Ito, S

Besides the two well-known blood-clotting substances, coagulase and clumping factor, a third one has been identified from the staphylococci which is a cell surface polysaccharide, is alkali stable,...

Vasodilator and constrictor actions of platelet-activating factor in the isolated microperfused afferent arteriole of the rabbit kidney. Role of endothelium-derived relaxing factor/nitric oxide and cyclooxygenase products.

Juncos, L A, Ren, Y L, Arima, S, Ito, S

It has been suggested that platelet-activating factor (PAF) plays a prominent role in the control of glomerular hemodynamics in various physiological and pathological conditions. We examined the...

Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.

Ito, S, Arima, S, Ren, Y L, Juncos, L A, Carretero, O A

It has been reported that sensitivity to angiotensin II (Ang II) is higher in efferent (Ef) than afferent (Af) arterioles (Arts). We tested the hypothesis that this is due to arteriolar differences...

Disparate effects of insulin on isolated rabbit afferent and efferent arterioles.

Juncos, L A, Ito, S

Despite evidence that insulin per se may be an important regulator of glomerular hemodynamics, little is known about its direct action on the glomerular afferent arterioles (Af-Art) and efferent...

Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.

Ito, S, Ren, Y

There is evidence that nitric oxide, an endothelium-derived relaxing factor, may be produced by the macula densa, as well as by blood vessels, within the kidney. To examine the role of nitric oxide...

Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.

Ito, S, Johnson, C S, Carretero, O A

Although endothelium-derived relaxing factor (EDRF) has been studied extensively in large vessels, little is known about its role in the preglomerular afferent arteriole (Af-Art). We tested the...

Diminished expression of CD40 ligand by activated neonatal T cells.

Nonoyama, S, Penix, L A, Edwards, C P, Lewis, D B, Ito, S, Aruffo, A, ...

CD40 and CD40 ligand (gp39) mediate contact-dependent T-B cell interaction. We determined the expression of CD40 ligand by activated neonatal T cells and the response of neonatal B cells when...

Flow modulates myogenic responses in isolated microperfused rabbit afferent arterioles via endothelium-derived nitric oxide.

Juncos, L A, Garvin, J, Carretero, O A, Ito, S

Flow may be a physiological stimulus of the endothelial release of nitric oxide (NO) and prostaglandins (PGs). We tested the hypothesis that pressure-induced constriction of the glomerular afferent...

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

Kinoshita, T, Shimoyama, M, Tobinai, K, Ito, M, Ito, S, Ikeda, S, ...

Expression of human T-cell leukemia virus type I (HTLV-I) is not detectable by immunofluorescence analysis or RNA blot analysis in most fresh peripheral blood mononuclear cells of patients with adult...

Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells.

Uzumaki, H, Okabe, T, Sasaki, N, Hagiwara, K, Takaku, F, Tobita, M, ...

Since radioiodination of human granulocyte colony-stimulating factor (G-CSF) is difficult, we synthesized a mutein of human G-CSF that retains full biological activity and receptor-binding capacity...

Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virus.

Ito, S, Richert, N, Pastan, I

The phosphorylation of vinculin by a highly purified tyrosine-specific protein kinase was enhanced more than 10-fold by anionic phospholipids: the phosphorylation of casein, actin, and alpha-actinin...

Entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes.

Rikihisa, Y, Ito, S

Factors involved in the phagocytosis and entry into polymorphonuclear leukocytes (PMNs) of Rickettsia tsutsugamushi were studied by electron microscopy. R. tsutsugamushi propagated in baby hamster...

Effect of antibody on entry of Rickettsia tsutsugamushi into polymorphonuclear leukocyte cytoplasm.

Rikihisa, Y, Ito, S

The effects of rickettsial antibodies on the entry of Rickettsia tsutsugamushi, Gilliam strain, into guinea pig polymorphonuclear leukocyte cytoplasm were studied by electron microscopy....

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

Xu, Y H, Richert, N, Ito, S, Merlino, G T, Pastan, I

To investigate the possibility that the epidermal growth factor (EGF) receptor functions as an oncogene product, we have determined the levels of EGF receptor protein and RNA in a variety of...

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

Beguinot, L, Hanover, J A, Ito, S, Richert, N D, Willingham, M C, Pastan, I

4 beta-Phorbol 12-myristate 13-acetate (PMA) treatment of KB cells at 37 degrees C rapidly induces a 50% reduction in epidermal growth factor (EGF) binding that is maximal by 30 min. EGF binding...

Cellular site of gastric acid secretion.

DiBona, D R, Ito, S, Berglindh, T, Sachs, G

Isolated gastric glands of the rabbit were examined both with differential interference-contrast microscopy and with electron microscopy to describe the morphologic correlates of acid secretion....

Changes in immunoferritin labeling of Rickettsia tsutsugamushi after serial cultivation in 60Co-irradiated BHK cells.

Rikihisa, Y, Rota, T, Lee, T H, MacDonald, A B, Ito, S

The immunolabeling characteristics of Rickettsia tsutsugamushi (Gilliam strain) were examined by using a purified immunoglobulin G fraction of antibody to R. tsutsugamushi raised in rabbits....

Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole.

Arima, S, Endo, Y, Yaoita, H, Omata, K, Ogawa, S, Tsunoda, K, ...

Although angiotensin II type 2 (AT2) receptor has recently been cloned, its functional role is not well understood. We tested the hypothesis that selective activation of AT2 receptor causes...

Localization of electron-dense tracers during entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes.

Rikihisa, Y, Ito, S

The invasion of Rickettsia tsutsugamushi, Gilliam strain, into guinea pig polymorphonuclear leukocytes (PMNs) and the localization and distribution of tracers were followed during the process by...

Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells.

Yokohama, H, Negishi, M, Sugama, K, Hayashi, H, Ito, S, Hayaishi, O

In bovine adrenal chromaffin cells, prostaglandin E2 (PGE2) stimulates the formation of inositol phosphates and Ca2+ mobilization through its specific receptor [Yokohama, Tanaka, Ito, Negishi,...

Oxidation of tyrosine residues in proteins by tyrosinase. Formation of protein-bonded 3,4-dihydroxyphenylalanine and 5-S-cysteinyl-3,4-dihydroxyphenylalanine.

Ito, S, Kato, T, Shinpo, K, Fujita, K

A simple and rapid method was developed for the determination of 3,4-dihydroxyphenylalanine (dopa) and 5-S-cysteinyl-3,4-dihydroxyphenylalanine (5-S-cysteinyldopa) in proteins with the use of...

A new amino acid, 3-(2,5-SS-dicysteinyl-3,4-dihydroxyphenyl)alanine, from the tapetum lucidum of the gar (Lepisosteidae) and its enzymic synthesis.

Ito, S, Nicol, J A

The tapetum lucidum of the alligator gar Lepisosteus was shown by t.l.c. to contain a new phenolic amino acid, which is apparently a major constituent of the reflecting material. It was isolated in a...

Isolation of S-adenosyl-3-thiopropylamine from the eye of the sea catfish (Arius felis).

Ito, S, Nicol, J A

A method is reported for the separation of S-adenosyl-3-methylthiopropylamine and other basic compounds in the eye of the sea catfish (Arius felis) by ion-exchange chromatography on CM-Sephadex. One...

Cloning and functional expression of rat kidney dipeptidyl peptidase II.

Fukasawa, K M, Fukasawa, K, Higaki, K, Shiina, N, Ohno, M, Ito, S, ...

Dipeptidyl peptidase II (DPP II; EC 3.4.14.2) from rat kidney was purified to a specific activity of 65.4 micromol/min per mg of protein for Lys-Ala-beta-naphthylamide. The N-terminal and partial...

Cloning and rational mutagenesis of kexstatin I, a potent proteinaceous inhibitor of Kex2 proteinase.

Oda, K, Oyama, H, Ito, S, Fukiharu, M, Miyagawa, Y, Takahashi, S, ...

Kexstatin I is a potent proteinaceous inhibitor of Kex2 proteinase (EC 3.4.21.61). In the present study we show the molecular cloning, primary structure determination and expression of the gene...

Inward current activated by carbachol in rat intestinal smooth muscle cells.

Ito, S, Ohta, T, Nakazato, Y

1. Carbachol (0.1 mM or 10 microM)-evoked inward currents were studied with standard and perforated whole-cell patch clamp techniques in smooth muscle cells isolated from rat small intestine. The...

Chloride currents activated by caffeine in rat intestinal smooth muscle cells.

Ohta, T, Ito, S, Nakazato, Y

1. Current responses to caffeine in single smooth muscle cells isolated from rat intestine were studied with the whole-cell patch clamp technique. Intracellular calcium concentration, [Ca2+]i, was...

The inhibitory action of cyclic AMP on responses to carbachol dependent on calcium stores in rat gastric smooth muscle.

Ohta, T, Ito, S, Noto, T, Tachibana, R, Nakazato, Y, Ohga, A

1. The effects of cyclic AMP on contraction and Ca(2+)-activated K+ currents induced by carbachol (CCh), caffeine and inositol 1,4,5-trisphosphate (InsP3) were examined in intact and skinned smooth...

Membrane hyperpolarization inhibits agonist-induced synthesis of inositol 1,4,5-trisphosphate in rabbit mesenteric artery.

Itoh, T, Seki, N, Suzuki, S, Ito, S, Kajikuri, J, Kuriyama, H

1. Effects of membrane hyperpolarization induced by pinacidil on Ca2+ mobilization induced by noradrenaline (NA) were investigated by measuring intracellular Ca2+ concentration ([Ca2+]i), isometric...

Strychnine-sensitive glycine responses of neonatal rat hippocampal neurones.

Ito, S, Cherubini, E

1. Intracellular recordings employing current and voltage clamp techniques were used to study the effects of glycine on rat CA3 hippocampal neurones during the first 3 weeks of postnatal (P) life. 2....

Persistent pulsatile release of glutamate induced by N-methyl-D-aspartate in neonatal rat hippocampal neurones.

Cherubini, E, Ben-Ari, Y, Ito, S, Krnjević, K

1. Intracellular recordings were made from CA3 hippocampal neurones in vitro, during the first ten days of postnatal life and in adulthood. 2. Repeated (three to six) applications of...

Mechanical, electrical and cyclic nucleotide responses to peptide VIP and inhibitory nerve stimulation in rat stomach.

Ito, S, Kurokawa, A, Ohga, A, Ohta, T, Sawabe, K

1. Effects of apamin on electrical and mechanical activities and cyclic nucleotide accumulation in response to vasoactive intestinal peptide (VIP) and intramural nerve stimulation were investigated...

Gastric vasodilatation and vasoactive intestinal peptide output in response to vagal stimulation in the dog.

Ito, S, Ohga, A, Ohta, T

1. Gastric vasodilatation, relaxation, and vasoactive intestinal peptide (VIP) output in response to vagal stimulation were studied in anaesthetized dogs. 2. Stimulation of the peripheral end of the...

Gastric relaxation and vasoactive intestinal peptide output in response to reflex vagal stimulation in the dog.

Ito, S, Ohga, A, Ohta, T

1. Gastric relaxation, vasodilatation and vasoactive intestinal peptide (VIP) output from the stomach in response to stimulation of the central end of the cut vagus nerve were studied in...

Time course of release of catecholamine and other granular contents from perifused adrenal chromaffin cells of guinea-pig.

Ito, S

Experiments were carried out to investigate the time course of the release of catecholamine, dopamine-beta-hydroxylase (DBH) and adenine nucleotides from isolated chromaffin cells of guinea-pig...

Molecular and phenotypic analysis of Attractin mutant mice.

Gunn, T M, Inui, T, Kitada, K, Ito, S, Wakamatsu, K, He, L, ...

Mutations of the mouse Attractin (Atrn; formerly mahogany) gene were originally recognized because they suppress Agouti pigment type switching. More recently, effects independent of Agouti have been...

Changes in membrane surface areas in mouse parietal cells in relation to high levels of acid secretion.

Schofield, G C, Ito, S, Bolender, R P

Levels of gastric acid secretion which may be maximal for the mouse were recorded following treatment with histamine and carbachol. A 30-fold increase over control levels was obtained in perfused...

Loss of all ndh genes as determined by sequencing the entire chloroplast genome of the black pine Pinus thunbergii.

Wakasugi, T, Tsudzuki, J, Ito, S, Nakashima, K, Tsudzuki, T, Sugiura, M

The complete nucleotide sequence (119,707 bp) of the black pine (Pinus thunbergii) chloroplast genome has been determined. It contains 4 rRNA genes and 32 tRNA genes. To our knowledge, the tRNAPro...

Single type-2 astrocytes show multiple independent sites of Ca2+ signaling in response to histamine.

Inagaki, N, Fukui, H, Ito, S, Yamatodani, A, Wada, H

Intracellular Ca2+ plays an important role in signal transduction as a second messenger. In various types of cells, inositol 1,4,5-trisphosphate-induced elevations of intracellular free Ca2+...

Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

Yamashita, M, Fukui, H, Sugama, K, Horio, Y, Ito, S, Mizuguchi, H, ...

A functional cDNA clone for the histamine H1 receptor was isolated from a cDNA library of bovine adrenal medulla by a combination of molecular cloning in an expression vector and electrophysiological...

Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan.

Ito, Y, Azuma, T, Ito, S, Miyaji, H, Hirai, M, Yamazaki, Y, ...

Approximately 50% of Helicobacter pylori strains produce a cytotoxin that is encoded by vacA and that induces vacuolation of eukaryotic cells. Mosaicism in vacA alleles was reported, and there are...

Sophorolipids from Torulopsis bombicola: possible relation to alkane uptake.

Ito, S, Inoue, S

Torulopsis bombicola produces extracellular sophorolipids when it is grown on water-insoluble alkanes. Sophorolipids and related model compounds, which were not themselves used for growth, were found...

D-Alanine-requiring cell wall mutant of Escherichia coli.

Olden, K, Ito, S, Wilson, T H

A mutant of Escherichia coli is described whose cells show a spherical or irregular morphology, associated with leakage of beta-galactosidase and other intracellular proteins. The expression of the...

Bacteriocinlike killing action of a temperate bacteriophage phiBA1 of Bacillus aneurinolyticus.

Ito, S, Nishimune, T, Abe, M, Kimoto, M, Hayashi, R

A new temperate phage, phiBA1, was isolated from Bacillus aneurinolyticus, phiBA1 had an icosahedral head with a diameter of about 70 nm and a tail about 20 nm long and contained a circularly...

Comparison of three blood-clotting substances in Staphylococcus aureus strains.

Yoshida, K, Takahashi, M, Haga, K, Kono, E, Kushiro, H, Ito, S

Besides the two well-known blood-clotting substances, coagulase and clumping factor, a third one has been identified from the staphylococci which is a cell surface polysaccharide, is alkali stable,...

Vasodilator and constrictor actions of platelet-activating factor in the isolated microperfused afferent arteriole of the rabbit kidney. Role of endothelium-derived relaxing factor/nitric oxide and cyclooxygenase products.

Juncos, L A, Ren, Y L, Arima, S, Ito, S

It has been suggested that platelet-activating factor (PAF) plays a prominent role in the control of glomerular hemodynamics in various physiological and pathological conditions. We examined the...

Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.

Ito, S, Arima, S, Ren, Y L, Juncos, L A, Carretero, O A

It has been reported that sensitivity to angiotensin II (Ang II) is higher in efferent (Ef) than afferent (Af) arterioles (Arts). We tested the hypothesis that this is due to arteriolar differences...

Disparate effects of insulin on isolated rabbit afferent and efferent arterioles.

Juncos, L A, Ito, S

Despite evidence that insulin per se may be an important regulator of glomerular hemodynamics, little is known about its direct action on the glomerular afferent arterioles (Af-Art) and efferent...

Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.

Ito, S, Ren, Y

There is evidence that nitric oxide, an endothelium-derived relaxing factor, may be produced by the macula densa, as well as by blood vessels, within the kidney. To examine the role of nitric oxide...

Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.

Ito, S, Johnson, C S, Carretero, O A

Although endothelium-derived relaxing factor (EDRF) has been studied extensively in large vessels, little is known about its role in the preglomerular afferent arteriole (Af-Art). We tested the...

Diminished expression of CD40 ligand by activated neonatal T cells.

Nonoyama, S, Penix, L A, Edwards, C P, Lewis, D B, Ito, S, Aruffo, A, ...

CD40 and CD40 ligand (gp39) mediate contact-dependent T-B cell interaction. We determined the expression of CD40 ligand by activated neonatal T cells and the response of neonatal B cells when...

Flow modulates myogenic responses in isolated microperfused rabbit afferent arterioles via endothelium-derived nitric oxide.

Juncos, L A, Garvin, J, Carretero, O A, Ito, S

Flow may be a physiological stimulus of the endothelial release of nitric oxide (NO) and prostaglandins (PGs). We tested the hypothesis that pressure-induced constriction of the glomerular afferent...

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

Kinoshita, T, Shimoyama, M, Tobinai, K, Ito, M, Ito, S, Ikeda, S, ...

Expression of human T-cell leukemia virus type I (HTLV-I) is not detectable by immunofluorescence analysis or RNA blot analysis in most fresh peripheral blood mononuclear cells of patients with adult...

Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells.

Uzumaki, H, Okabe, T, Sasaki, N, Hagiwara, K, Takaku, F, Tobita, M, ...

Since radioiodination of human granulocyte colony-stimulating factor (G-CSF) is difficult, we synthesized a mutein of human G-CSF that retains full biological activity and receptor-binding capacity...

Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virus.

Ito, S, Richert, N, Pastan, I

The phosphorylation of vinculin by a highly purified tyrosine-specific protein kinase was enhanced more than 10-fold by anionic phospholipids: the phosphorylation of casein, actin, and alpha-actinin...

Entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes.

Rikihisa, Y, Ito, S

Factors involved in the phagocytosis and entry into polymorphonuclear leukocytes (PMNs) of Rickettsia tsutsugamushi were studied by electron microscopy. R. tsutsugamushi propagated in baby hamster...

Effect of antibody on entry of Rickettsia tsutsugamushi into polymorphonuclear leukocyte cytoplasm.

Rikihisa, Y, Ito, S

The effects of rickettsial antibodies on the entry of Rickettsia tsutsugamushi, Gilliam strain, into guinea pig polymorphonuclear leukocyte cytoplasm were studied by electron microscopy....

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

Xu, Y H, Richert, N, Ito, S, Merlino, G T, Pastan, I

To investigate the possibility that the epidermal growth factor (EGF) receptor functions as an oncogene product, we have determined the levels of EGF receptor protein and RNA in a variety of...

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

Beguinot, L, Hanover, J A, Ito, S, Richert, N D, Willingham, M C, Pastan, I

4 beta-Phorbol 12-myristate 13-acetate (PMA) treatment of KB cells at 37 degrees C rapidly induces a 50% reduction in epidermal growth factor (EGF) binding that is maximal by 30 min. EGF binding...

Cellular site of gastric acid secretion.

DiBona, D R, Ito, S, Berglindh, T, Sachs, G

Isolated gastric glands of the rabbit were examined both with differential interference-contrast microscopy and with electron microscopy to describe the morphologic correlates of acid secretion....

Changes in immunoferritin labeling of Rickettsia tsutsugamushi after serial cultivation in 60Co-irradiated BHK cells.

Rikihisa, Y, Rota, T, Lee, T H, MacDonald, A B, Ito, S

The immunolabeling characteristics of Rickettsia tsutsugamushi (Gilliam strain) were examined by using a purified immunoglobulin G fraction of antibody to R. tsutsugamushi raised in rabbits....

Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole.

Arima, S, Endo, Y, Yaoita, H, Omata, K, Ogawa, S, Tsunoda, K, ...

Although angiotensin II type 2 (AT2) receptor has recently been cloned, its functional role is not well understood. We tested the hypothesis that selective activation of AT2 receptor causes...

Localization of electron-dense tracers during entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes.

Rikihisa, Y, Ito, S

The invasion of Rickettsia tsutsugamushi, Gilliam strain, into guinea pig polymorphonuclear leukocytes (PMNs) and the localization and distribution of tracers were followed during the process by...

Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells.

Yokohama, H, Negishi, M, Sugama, K, Hayashi, H, Ito, S, Hayaishi, O

In bovine adrenal chromaffin cells, prostaglandin E2 (PGE2) stimulates the formation of inositol phosphates and Ca2+ mobilization through its specific receptor [Yokohama, Tanaka, Ito, Negishi,...

Inward current activated by carbachol in rat intestinal smooth muscle cells.

Ito, S, Ohta, T, Nakazato, Y

1. Carbachol (0.1 mM or 10 microM)-evoked inward currents were studied with standard and perforated whole-cell patch clamp techniques in smooth muscle cells isolated from rat small intestine. The...

Oxidation of tyrosine residues in proteins by tyrosinase. Formation of protein-bonded 3,4-dihydroxyphenylalanine and 5-S-cysteinyl-3,4-dihydroxyphenylalanine.

Ito, S, Kato, T, Shinpo, K, Fujita, K

A simple and rapid method was developed for the determination of 3,4-dihydroxyphenylalanine (dopa) and 5-S-cysteinyl-3,4-dihydroxyphenylalanine (5-S-cysteinyldopa) in proteins with the use of...

A new amino acid, 3-(2,5-SS-dicysteinyl-3,4-dihydroxyphenyl)alanine, from the tapetum lucidum of the gar (Lepisosteidae) and its enzymic synthesis.

Ito, S, Nicol, J A

The tapetum lucidum of the alligator gar Lepisosteus was shown by t.l.c. to contain a new phenolic amino acid, which is apparently a major constituent of the reflecting material. It was isolated in a...

Isolation of S-adenosyl-3-thiopropylamine from the eye of the sea catfish (Arius felis).

Ito, S, Nicol, J A

A method is reported for the separation of S-adenosyl-3-methylthiopropylamine and other basic compounds in the eye of the sea catfish (Arius felis) by ion-exchange chromatography on CM-Sephadex. One...

Chloride currents activated by caffeine in rat intestinal smooth muscle cells.

Ohta, T, Ito, S, Nakazato, Y

1. Current responses to caffeine in single smooth muscle cells isolated from rat intestine were studied with the whole-cell patch clamp technique. Intracellular calcium concentration, [Ca2+]i, was...

The inhibitory action of cyclic AMP on responses to carbachol dependent on calcium stores in rat gastric smooth muscle.

Ohta, T, Ito, S, Noto, T, Tachibana, R, Nakazato, Y, Ohga, A

1. The effects of cyclic AMP on contraction and Ca(2+)-activated K+ currents induced by carbachol (CCh), caffeine and inositol 1,4,5-trisphosphate (InsP3) were examined in intact and skinned smooth...

Membrane hyperpolarization inhibits agonist-induced synthesis of inositol 1,4,5-trisphosphate in rabbit mesenteric artery.

Itoh, T, Seki, N, Suzuki, S, Ito, S, Kajikuri, J, Kuriyama, H

1. Effects of membrane hyperpolarization induced by pinacidil on Ca2+ mobilization induced by noradrenaline (NA) were investigated by measuring intracellular Ca2+ concentration ([Ca2+]i), isometric...

Strychnine-sensitive glycine responses of neonatal rat hippocampal neurones.

Ito, S, Cherubini, E

1. Intracellular recordings employing current and voltage clamp techniques were used to study the effects of glycine on rat CA3 hippocampal neurones during the first 3 weeks of postnatal (P) life. 2....

Persistent pulsatile release of glutamate induced by N-methyl-D-aspartate in neonatal rat hippocampal neurones.

Cherubini, E, Ben-Ari, Y, Ito, S, Krnjević, K

1. Intracellular recordings were made from CA3 hippocampal neurones in vitro, during the first ten days of postnatal life and in adulthood. 2. Repeated (three to six) applications of...

Mechanical, electrical and cyclic nucleotide responses to peptide VIP and inhibitory nerve stimulation in rat stomach.

Ito, S, Kurokawa, A, Ohga, A, Ohta, T, Sawabe, K

1. Effects of apamin on electrical and mechanical activities and cyclic nucleotide accumulation in response to vasoactive intestinal peptide (VIP) and intramural nerve stimulation were investigated...

Gastric vasodilatation and vasoactive intestinal peptide output in response to vagal stimulation in the dog.

Ito, S, Ohga, A, Ohta, T

1. Gastric vasodilatation, relaxation, and vasoactive intestinal peptide (VIP) output in response to vagal stimulation were studied in anaesthetized dogs. 2. Stimulation of the peripheral end of the...

Gastric relaxation and vasoactive intestinal peptide output in response to reflex vagal stimulation in the dog.

Ito, S, Ohga, A, Ohta, T

1. Gastric relaxation, vasodilatation and vasoactive intestinal peptide (VIP) output from the stomach in response to stimulation of the central end of the cut vagus nerve were studied in...

Time course of release of catecholamine and other granular contents from perifused adrenal chromaffin cells of guinea-pig.

Ito, S

Experiments were carried out to investigate the time course of the release of catecholamine, dopamine-beta-hydroxylase (DBH) and adenine nucleotides from isolated chromaffin cells of guinea-pig...

Cloning and functional expression of rat kidney dipeptidyl peptidase II.

Fukasawa, K M, Fukasawa, K, Higaki, K, Shiina, N, Ohno, M, Ito, S, ...

Dipeptidyl peptidase II (DPP II; EC 3.4.14.2) from rat kidney was purified to a specific activity of 65.4 micromol/min per mg of protein for Lys-Ala-beta-naphthylamide. The N-terminal and partial...

Cloning and rational mutagenesis of kexstatin I, a potent proteinaceous inhibitor of Kex2 proteinase.

Oda, K, Oyama, H, Ito, S, Fukiharu, M, Miyagawa, Y, Takahashi, S, ...

Kexstatin I is a potent proteinaceous inhibitor of Kex2 proteinase (EC 3.4.21.61). In the present study we show the molecular cloning, primary structure determination and expression of the gene...

Changes in membrane surface areas in mouse parietal cells in relation to high levels of acid secretion.

Schofield, G C, Ito, S, Bolender, R P

Levels of gastric acid secretion which may be maximal for the mouse were recorded following treatment with histamine and carbachol. A 30-fold increase over control levels was obtained in perfused...

Molecular and phenotypic analysis of Attractin mutant mice.

Gunn, T M, Inui, T, Kitada, K, Ito, S, Wakamatsu, K, He, L, ...

Mutations of the mouse Attractin (Atrn; formerly mahogany) gene were originally recognized because they suppress Agouti pigment type switching. More recently, effects independent of Agouti have been...

Polymorphism of the A subunit of coagulation factor XIII: evidence for subtypes of the FXIIIA*1 and FXIIIA*2 alleles.

Suzuki, K, Matsui, K, Ito, S, Fujita, K, Matsumoto, H

Agarose gel isoelectric focusing (pH 5--6.5) in the study of plasma factor XIII (FXIII) polymorphism revealed heterogeneity characterized by a narrow or broad type of the electrophoretic band of the...

Effect of decay-accelerating factor on the assembly of the classical and alternative pathway C3 convertases in the presence of C4 or C3 nephritic factor.

Ito, S, Tamura, N, Fujita, T

Decay-accelerating factor (DAF) is a 70,000 MW membrane protein that regulates the complement system on the cell surface. In the present study, we found that DAF had no effect on the classical...

Inhibition of classical C5 convertase in the complement system by factor H.

Ito, S, Tamura, N

This paper described the influence of factor H on the haemolytic activity of the classical C5 convertase. Factor H showed little effect on the interaction of C5 with EAC1,4b,2a,3b cells bearing low...

CD27/CD70 interaction directly induces natural killer cell killing activity.

Yang, F C, Agematsu, K, Nakazawa, T, Mori, T, Ito, S, Kobata, T, ...

The CD27 molecule is expressed on a portion of natural killer (NK) cells as well as T and B cells. To provide the functional capacity of CD27 molecule on NK cells, we here highly purified CD3- CD56+...

High prevalence of arthropathy in HTLV-I carriers on a Japanese island.

Motokawa, S, Hasunuma, T, Tajima, K, Krieg, A M, Ito, S, Iwasaki, K, ...

OBJECTIVE: To determine the aetiological relationship between human T cell leukaemia virus type-I (HTLV-I) and arthritis, by performing an epidemiological study of the inhabitants of Tsushima, an...

Determination of IgA- and IgM-rheumatoid factors in patients with rheumatoid arthritis with and without nephropathy.

Nakano, M, Ueno, M, Nishi, S, Suzuki, S, Hasegawa, H, Watanabe, T, ...

OBJECTIVE: To clarify the characteristics and pathogenesis of renal disorders in patients with rheumatoid arthritis (RA). METHODS: In this study, 143 patients with RA were included, from whom 43 with...

Renal haemodynamic characteristics in patients with lupus nephritis

Nakano, M., Ueno, M., Hasegawa, H., Watanabe, T., Kuroda, T., Ito, S., ...

OBJECTIVE—To clarify the characteristics of renal haemodynamics in patients with lupus nephritis (LN).
METHODS—The glomerular filtration rate (GFR) and renal plasma flow (RPF) of 37 patients...

Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy.

Kohno, K., Palha, J. A., Miyakawa, K., Saraiva, M. J., Ito, S., Mabuchi, T., ...

Amyloid fibrils derived from the Japanese, Portuguese, and Swedish types of familial amyloidotic polyneuropathy all consist of a variant transthyretin (TTR) with a substitution of methionine for...

Effects of Helicobacter pylori eradication therapy on hyperammonaemia in patients with liver cirrhosis.

Miyaji, H, Ito, S, Azuma, T, Ito, Y, Yamazaki, Y, Ohtaki, Y, ...

BACKGROUND AND AIMS: Helicobacter pylori has strong urease activity. Ammonia produced by H pylori in the stomach can be a source of systemic ammonia in patients with hepatic dysfunction. The effect...

Profile of Helicobacter pylori cytotoxin derived from two areas of Japan with different prevalence of atrophic gastritis.

Ito, S, Azuma, T, Murakita, H, Hirai, M, Miyaji, H, Ito, Y, ...

BACKGROUND AND AIM: To clarify the roles of Helicobacter pylori cytotoxin in gastric atrophy, the cytotoxin positive rate and cytotoxin activity in Fukui and Okinawa, where the prevalence of atrophic...

Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats

Shimizu, I, Yasuda, M, Mizobuchi, Y, Ma, Y, Liu, F, Shiba, M, ...

Second Department of Internal Medicine, Tokushima University School of Medicine, Kuramoto-cho, Tokushima 770, Japan

Helicobacter pylori infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis

Suto, H, Azuma, T, Ito, S, Ohtani, M, Dojo, M, Ito, Y, ...

BACKGROUND AND AIMS—We previously reported the effect of Helicobacter pylori eradication on hyperammonaemia in patients with liver cirrhosis. However, the role of H pylori as a cause of...

Inhibitory effect of oestradiol on activation of rat hepatic stellate cells in vivo and in vitro

Shimizu, I, Mizobuchi, Y, Yasuda, M, Shiba, M, Ma, Y, Horie, T, ...

a Second Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima, Japan, b Department of Preclinical Medicine, Luzhou Medical College, Luzhou, China

Cross sectional echocardiographic demonstration of the mechanisms of abnormal interventricular septal motion in congenital total absence of the left pericardium.

Oki, T., Tabata, T., Yamada, H., Manabe, K., Fukuda, K., Abe, M., ...

OBJECTIVE: To investigate the influence of the absence of the pericardium on the left ventricular wall, particularly on interventricular septal motion, using M mode and cross sectional short axis...

Brugada syndrome associated with an autonomic disorder

Nomura, M, Nada, T, Endo, J, Kondo, Y, Yukinaka, M, Saito, K, ...

A 44 year old man with Brugada syndrome and ventricular fibrillation had an autonomic disorder, shown by spectral analysis of heart rate variability and 123I-MIBG myocardial scintigraphy. Periodic...

Enhancement of dedifferentiation and myoid differentiation of retinal pigment epithelial cells by platelet derived growth factor

Ando, A., Ueda, M., Uyama, M., Masu, Y., Ito, S.

AIMS—To clarify factor(s) involved in morphological dedifferentiation of retinal pigment epithelial (RPE) cells in vitro from mitotically quiescent hexagonal cells to flattened cells that lack...

Therapeutic effect of 15-deoxyspergualin on the progression of lupus nephritis in MRL mice. I. Immunopathological analyses.

Ito, S, Ueno, M, Arakawa, M, Saito, T, Aoyagi, T, Fujiwara, M

The effect of 15-deoxyspergualin (DSP), a newly developed immunosuppressive agent, on the development of spontaneously occurring lupus glomerulonephritis in MRL-lpr mice was examined. Administration...

Suppressive effect of IgE soluble immune complex on neutrophil chemotaxis.

Ito, S, Shinomiya, K, Mikawa, H

The effect of IgE soluble immune complex (SIC) and IgG SIC on neutrophil chemotaxis was investigated. Eight types of SIC were prepared from kappa type IgE myeloma protein and IgG myeloma protein:...

Suppressive effect of IgA soluble immune complexes on neutrophil chemotaxis.

Ito, S, Mikawa, H, Shinomiya, K, Yoshida, T

The effect of IgA and IgG soluble immune complexes (SIC) on neutrophil chemotaxis was investigated. Six types of SIC were prepared from kappa-type IgA and IgG myeloma proteins: IgA-anti-kappa chain...

Suppression of spontaneous murine lupus by inducing graft-versus-host reaction with CD8+ cells.

Ito, S, Ueno, M, Nishi, S, Arakawa, M, Fujiwara, M

Splenic CD8+ (Lyt-2+) cells of C57BL/6 mice were injected into semiallogeneic (NZB x BXSB)F1 mice, which spontaneously develop lupus nephritis, in order to examine whether the disease was somehow...

Anti-mannose binding lectin antibodies in sera of Japanese patients with systemic lupus erythematosus

TAKAHASHI, R, TSUTSUMI, A, OHTANI, K, GOTO, D, MATSUMOTO, I, ITO, S, ...

Mannose-binding lectin (MBL) is a key element in innate immunity with functions and structure similar to that of complement C1q. It has been reported that MBL deficiency is associated with occurrence...

Outbreak of Human Metapneumovirus Detected by Use of the Vero E6 Cell Line in Isolates Collected in Yamagata, Japan, in 2004 and 2005▿

Abiko, C., Mizuta, K., Itagaki, T., Katsushima, N., Ito, S., Matsuzaki, Y., ...

A number of epidemiological studies have shown human metapneumovirus (hMPV) to be one of the most important viral agents associated with acute respiratory infections in humans. However, due to the...

A novel index for expressing exposure of the infant to drugs in breast milk.

Ito, S, Koren, G

1. We present a novel index for expressing the exposure of the infant to drugs in breast milk, which unifies two independent factors: a pharmacokinetic parameter, drug clearance, and a physiochemical...

Ca2+ entry activated by emptying of intracellular Ca2+ stores in ileal smooth muscle of the rat.

Ohta, T, Kawai, K, Ito, S, Nakazato, Y

1. The effects of depletion of intracellular Ca2+ stores on muscle tension and the intracellular Ca2+ concentration ([Ca2+])i were studied in fura-2 loaded longitudinal smooth muscle cells of the rat...

The effect of the ionophores X-537A and A23187 on the noradrenaline output from peripheral adrenergic neurones in the presence of various divalent cations

Ito, S., Nakazato, Y., Ohga, A.

1 The effects of the ionophores, X-537A and A23187 on the noradrenaline output from peripheral adrenergic neurones of isolated vas deferens of the guinea-pig were investigated in the presence of...

Pharmacological evidence for the involvement of Na+ channels in the release of catecholamines from perfused adrenal glands.

Ito, S, Nakazato, Y, Ohga, A

Veratridine (0.1 mM) was found to be effective in producing an increase in the catecholamine output from perfused guinea-pig adrenal glands in the presence of high concentrations of hexamethonium...

The effect of veratridine on the release of catecholamines from the perfused adrenal gland.

Ito, S, Nakazato, Y, Ohga, A

1. Experiments on perfused adrenal glands of guinea-pigs were carried out to study the catecholamine output induced by veratridine in the presence of hexamethonium and atropine. 2. Veratridine (10...

Development of non-cholinergic, non-adrenergic excitatory and inhibitory responses to intramural nerve stimulation in rat stomach.

Ito, S., Kimura, A., Ohga, A.

1. The onset and development of functional innervation of intramural neurones were examined by transmural nerve stimulation in circular muscle strips isolated from the rat stomach during the period...

Alpha 1-adrenoceptor antagonist activity of novel pyrimidine derivatives (SHI437 and IK29) in rabbit aorta and trigone of the bladder.

Azuma, H., Sugimoto-Tokushima, M., Tanaka, K., Ikenoue, Y., Ito, S., Ishikawa, M.

1. In the rabbit isolated aorta and trigone of the bladder, noradrenaline, phenylephrine and clonidine elicited concentration-dependent contractions, which may be caused through activation of...

Effects of lemakalim on changes in Ca2+ concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery.

Ito, S., Kajikuri, J., Itoh, T., Kuriyama, H.

1. Effects of (-)-cromakalim (lemakalim) on tension and Ca2+ mobilization induced by noradrenaline (NA) were investigated by measuring intracellular Ca2+ concentration ([Ca2+]i) isometric tension and...

Blockade by ONO-NT-012, a unique prostanoid analogue, of prostaglandin E2-induced allodynia in conscious mice.

Minami, T., Nishihara, I., Sakamoto, K., Ito, S., Hyodo, M., Hayaishi, O.

1. Intrathecal (i.t.) administration of prostaglandin E2 (PGE2) to conscious mice was reported to induce allodynia, a state of discomfort and pain evoked by innocuous tactile stimuli through...

Effects of a newly synthesized K+ channel opener, Y-26763, on noradrenaline-induced Ca2+ mobilization in smooth muscle of the rabbit mesenteric artery.

Itoh, T., Ito, S., Shafiq, J., Suzuki, H.

1. The mechanisms underlying the vasodilatation induced by (-)-(3S,4R)-4-(N-acetyl-N-hydroxyamino)-6-cyano-3,4-dihydro-2, 2-dimethyl-2H-1-benzopyran-3-ol (Y-26763) were investigated by measuring...

Inhibitory effects of caffeine on secretagogue-induced catecholamine secretion from adrenal chromaffin cells of the guinea-pig.

Nakazato, Y., Tani, Y., Teraoka, H., Sugawara, T., Asano, T., Ohta, T., ...

1. The inhibitory action of caffeine on catecholamine secretion induced by secretagogues was investigated in perfused adrenal glands and dispersed chromaffin cells of the guinea-pig. 2. Caffeine (10...

All-or-nothing responses to carbachol in single intestinal smooth muscle cells of rat.

Ohta, T., Ito, S., Nakazato, Y.

1. Concentration-response relationships for carbachol (CCh)-induced increases in the cytosolic calcium concentration ([Ca2+]i) and membrane currents were studied by use of fura-2 microfluorimetry and...

Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice.

Minami, T., Nishihara, I., Uda, R., Ito, S., Hyodo, M., Hayaishi, O.

1. Intrathecal (i.t.) administration of prostaglandin E2 (PGE2) to conscious mice induced allodynia, a state of discomfort and pain evoked by innocuous tactile stimuli, and hyperalgesia as assessed...

Co-release of PHI and VIP in dog stomach by peripheral and central vagal stimulation.

Ohta, T., Ito, S., Ohga, A.

1. The purpose of this investigation was to examine the outputs of peptide histidine isoleucine (PHI) and vasoactive intestinal peptide (VIP) from the gastric corpus in response to stimulation of the...

Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea.

Ito, S., Okuda, E., Sugama, K., Negishi, M., Hayaishi, O.

ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, were evaluated with a fibroblastic cell line from bovine embryonic trachea (EBTr) which...

Effects of vasoactive intestinal peptide (VIP) on contractile responses of smooth muscle in rat stomach.

Ohta, T., Ito, S., Ohga, A.

1. The effects of vasoactive intestinal peptide (VIP) on contractile responses to carbachol (CCh), KCl and caffeine of the circular smooth muscle in rat stomach were examined by the isometric tension...

Exocytotic release of catecholamine from perfused adrenal gland of guinea-pig induced by veratridine.

Ito, S., Nakazato, Y., Ohga, A.

1 Experiments were carried out on perfused adrenal glands of guinea-pig to determine whether veratridine caused the exocytotic release of catecholamine by comparing its effect with that of splanchnic...

Further evidence for the involvement of Na+ channels in the release of adrenal catecholamine: the effect of scorpion venom and grayanotoxin I.

Ito, S., Nakazato, Y., Ohga, A.

1 The effects of venom from the scorpion, Leiurus quinquestriatus, and grayanotoxin I on catecholamine secretion were studied in the perfused adrenal glands of guinea-pig. 2 Scorpion venom (0.1 to 10...

Which drugs are contraindicated during breastfeeding? Practice guidelines.

Moretti, M. E., Lee, A., Ito, S.

QUESTION: Many breastfeeding mothers are concerned about taking medications that might affect their babies. Are there any guidelines on which drugs are safe? ANSWER: Only a few drugs pose a...

Effects of a water-soluble forskolin derivative (NKH477) and a membrane-permeable cyclic AMP analogue on noradrenaline-induced Ca2+ mobilization in smooth muscle of rabbit mesenteric artery.

Ito, S., Suzuki, S., Itoh, T.

1. Effects were studied of 6-(3-dimethylaminopropionyl) forskolin (NKH477), a water-soluble forskolin derivative and of dibutyryl-cyclic AMP, a membrane-permeable cyclic AMP analogue on noradrenaline...

Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk?

Oren, D., Nulman, I., Makhija, M., Ito, S., Koren, Gideon

QUESTION: I am concerned about use of corticosteroids during pregnancy. Some of my women patients of reproductive age are using topical, inhaled, or oral preparations, and I am not sure what to...

Do silicone breast implants affect breastfeeding?

Koren, G., Ito, S.

QUESTION: One of my patients has silicone breast implants. She gave birth to a healthy baby boy but is afraid to breastfeed because she read in a magazine that the baby might be affected by silicone...

Localisation of a 10q breakpoint within the PAX2 gene in a patient with a de novo t(10;13) translocation and optic nerve coloboma-renal disease.

Narahara, K, Baker, E, Ito, S, Yokoyama, Y, Yu, S, Hewitt, D, ...

We describe a 5 year old boy with a de novo t(10;13) translocation and optic nerve coloboma-renal disease (ONCR). On the basis of GTG banding analysis of prometaphase chromosomes, the patient's...

Postgastrectomy polyneuropathy with thiamine deficiency

Koike, H, Misu, K, Hattori, N, Ito, S, Ichimura, M, Ito, H, ...

OBJECTIVE—Polyneuropathy has been reported after gastrectomy performed to treat various lesions. Although thiamine deficiency is a possible cause of this neuropathy, the pathogenesis still remains...

Neonatal paroxetine withdrawal syndrome

Stiskal, J, Kulin, N, Koren, G, Ho, T, Ito, S

Four term neonates presented with symptoms such as jitteriness and necrotising enterocolitis after paroxetine exposure in utero.


Eight and 12 week courses of cyclophosphamide in nephrotic syndrome.

Ueda, N, Kuno, K, Ito, S

Seventy-three children with steroid dependent minimal change nephrotic syndrome were randomly allocated to receive treatment with cyclophosphamide (2 mg/kg/day) for either eight or 12 weeks, in...

In vivo muscle fibre behaviour during counter-movement exercise in humans reveals a significant role for tendon elasticity

Kawakami, Y, Muraoka, T, Ito, S, Kanehisa, H, Fukunaga, T

Six men performed a single ankle plantar flexion exercise in the supine position with the maximal effort with counter movement (CM, plantar flexion preceded by dorsiflexion) and without counter...

Continuing drug therapy while breastfeeding. Part 1. Common misconceptions of patients.

Ito, S., Lieu, M., Chan, W., Koren, G.

QUESTION: Some of my patients who need specific drugs during the postpartum period are hesitant to breastfeed even when I tell them that, according to available evidence, these drugs are safe. Am I...

Continuing drug therapy while breastfeeding. Part 2. Common misconceptions of physicians.

Koren, G., Moretti, M., Ito, S.

QUESTION: Is there any way to predict whether a drug taken by a mother is safe for a suckling baby, or is it just trial and error? One of my patients is receiving lithium for manic depression. She...

STUDIES ON THE DEPLETION AND ACCUMULATION OF MICROVILLI AND CHANGES IN THE TUBULOVESICULAR COMPARTMENT OF MOUSE PARIETAL CELLS IN RELATION TO GASTRIC ACID SECRETION

Ito, S., Schofield, G. C.

Gastric parietal cells in mice present a spectrum of microscopic appearances due mainly to variations in the abundance of the tubular and vesicular component of the cytoplasm and in the size and...

Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells

Itagaki, T, Shimizu, I, Cheng, X, Yuan, Y, Oshio, A, Tamaki, K, ...

Background: Oxidative stress, including the generation of reactive oxygen species (ROS), is involved in hepatofibrogenesis. The authors’ previous studies have shown that oestradiol suppresses...

The effect of L-dopa on the potentiation of radiation damage to human melanoma cells.

Yamada, I., Seki, S., Ito, S., Suzuki, S., Matsubara, O., Kasuga, T.

Since L-dopa (L-3,4-dihydroxyphenylalanine) has been shown to possess a selective toxicity for melanoma cells both in vitro and in vivo, we have examined the combined effect of L-dopa and radiation...

The killing effect of 4-S-cysteaminylphenol, a newly synthesised melanin precursor, on B16 melanoma cell lines.

Yamada, I., Seki, S., Ito, S., Suzuki, S., Matsubara, O., Kasuga, T.

We have examined the killing effect of 4-S-cysteaminylphenol (4-S-CAP), a newly synthesised melanin precursor, on B16 melanoma cell lines possessing different melanin-producing activities and found...

Detection of micrometastatic prostate cancer cells in the bone marrow of patients with prostate cancer.

Deguchi, T., Yang, M., Ehara, H., Ito, S., Nishino, Y., Takahashi, Y., ...

Thirty-five patients with prostate cancer were examined for micrometastases to the bone marrow using reverse transcription-polymerase chain reaction (RT-PCR) with primers specific for the...

Prospective validation of quantitative CEA mRNA detection in peritoneal washes in gastric carcinoma patients

Ito, S, Nakanishi, H, Kodera, Y, Mochizuki, Y, Tatematsu, M, Yamamura, Y

Prediction of peritoneal relapse is extremely important for gastric cancer patients after curative surgery. The present study prospectively validates the prognostic ability of quantifying...