Bartunek, J, Kong, SW, Vanderheyden, M, Brown, J, Riggy, L, Tack, W, ...
Tissue expression profiling in human pressure overload hypertrophy due to aortic stenosis (2002)
Bartunek, J, Kong, SW, Vanderheyden, M, Brown, J, Riggi, L, Chen, IB, ...
Malek, A M, Greene, A L, Izumo, S
Fluid shear stress induces a number of morphological and functional changes in vascular endothelium, including a rapid and significant down-regulation of endothelin 1 (ET-1) mRNA and peptide release...
Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
The molecular control of the differentiation process depends in part on lineage-restricted transcription factors that regulate expression of tissue-specific genes. Although significant progress has...
Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA.
Komuro, I, Wenninger, K E, Philipson, K D, Izumo, S
The Na+/Ca2+ exchanger plays important roles in Ca2+ handling in many excitable cells. In particular, the Na+/Ca2+ exchanger is expressed at high levels in the cardiac sarcolemma and is the dominant...
Sadoshima, J, Takahashi, T, Jahn, L, Izumo, S
Mechanical loading of cardiac and skeletal muscles in vivo and in vitro causes rapid activation of a number of immediate-early (IE) genes and hypertrophy of muscle cells. However, little is known as...
Schunkert, H, Jahn, L, Izumo, S, Apstein, C S, Lorell, B H
The effect of changes in left ventricular (LV) systolic force generation on cardiac c-fos and c-jun protooncogene expression was studied by using isolated beating hearts from male Wistar rats. An...
Lee, Y, Nadal-Ginard, B, Mahdavi, V, Izumo, S
The muscle-specific regulatory region of the alpha-cardiac myosin heavy-chain (MHC) gene contains the thyroid hormone response element (TRE) and two A/T-rich DNA sequences, designated A/T1 and A/T2,...
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.
Izumo, S, Nadal-Ginard, B, Mahdavi, V
Hypertrophy, an increase in cell size without cell division, is a fundamental adaptive process employed by postmitotic cardiac and skeletal muscle cells. Cardiac myosins undergo an adult-to-fetal...
Malek, A M, Gibbons, G H, Dzau, V J, Izumo, S
Fluid shear stress has been shown to be an important regulator of vascular structure and function through its effect on the endothelial cell. We have explored the effect of shear stress on the...
Shimizu, N, Smith, G, Izumo, S
The A element, a fourteen base pair sequence in the rabbit myosin heavy chain (HC) beta promoter (-276/-263), contains the M-CAT motif, a cis-acting element found in several muscle-specific genes....
Takahashi, T, Allen, P D, Lacro, R V, Marks, A R, Dennis, A R, Schoen, F J, ...
Cytoplasmic free calcium ions (Ca2+) play a central role in excitation-contraction coupling of cardiac muscle. Abnormal Ca2+ handling has been implicated in systolic and diastolic dysfunction in...
Erythrocyte Na,K pump in uremia. Acute correction of a transport defect by hemodialysis.
Izumo, H, Izumo, S, DeLuise, M, Flier, J S
We studied the erythrocyte Na,K-pump in chronically hemodialyzed uremic patients, immediately before and after a 4-h period of hemodialysis. Using [3H]ouabain as a probe, the number of Na,K-pump...
Komuro, I, Schalling, M, Jahn, L, Bodmer, R, Jenkins, N A, Copeland, N G, ...
Although it is likely that a highly complex network of transcription factors acts in concert during mammalian brain development, relatively few such genes have been characterized to date. We describe...
It is well known that external load plays a critical role in determining cardiac muscle mass and its phenotype, but little is known as to how mechanical load is transduced into intracellular signals...
Izumo, S, Lompré, A M, Matsuoka, R, Koren, G, Schwartz, K, Nadal-Ginard, B, ...
Expression of the cardiac myosin isozymes is regulated during development, by hormonal stimuli and hemodynamic load. In this study, the levels of expression of the two isoforms (alpha and beta) of...
Takahashi, T, Schunkert, H, Isoyama, S, Wei, J Y, Nadal-Ginard, B, Grossman, W, ...
Cardiac adaptation to hemodynamic stress involves both quantitative (hypertrophy) and qualitative (pattern of gene expression) changes. Our previous studies have shown that advancing age in the rat...
p21 ras plays as important role in cell proliferation, transformation and differentiation. Recently, the requirement of p21 ras has been suggested for cellular responses induced by stimulation of...
Sadoshima, J, Qiu, Z, Morgan, J P, Izumo, S
Hypotonic stress causes rapid cell swelling and initiates various cellular adaptive processes. However, it is unknown how cells initially sense low osmolarity and convert it into intracellular...
Aoki, H, Richmond, M, Izumo, S, Sadoshima, J
Although MAP (mitogen-activated protein) kinases are implicated in cell proliferation and differentiation in many cell types, the role of MAP kinases in cardiac hypertrophy remains unclear. We...
Malek, A M, Greene, A L, Izumo, S
Fluid shear stress induces a number of morphological and functional changes in vascular endothelium, including a rapid and significant down-regulation of endothelin 1 (ET-1) mRNA and peptide release...
Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
The molecular control of the differentiation process depends in part on lineage-restricted transcription factors that regulate expression of tissue-specific genes. Although significant progress has...
Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA.
Komuro, I, Wenninger, K E, Philipson, K D, Izumo, S
The Na+/Ca2+ exchanger plays important roles in Ca2+ handling in many excitable cells. In particular, the Na+/Ca2+ exchanger is expressed at high levels in the cardiac sarcolemma and is the dominant...
Sadoshima, J, Takahashi, T, Jahn, L, Izumo, S
Mechanical loading of cardiac and skeletal muscles in vivo and in vitro causes rapid activation of a number of immediate-early (IE) genes and hypertrophy of muscle cells. However, little is known as...
Schunkert, H, Jahn, L, Izumo, S, Apstein, C S, Lorell, B H
The effect of changes in left ventricular (LV) systolic force generation on cardiac c-fos and c-jun protooncogene expression was studied by using isolated beating hearts from male Wistar rats. An...
Lee, Y, Nadal-Ginard, B, Mahdavi, V, Izumo, S
The muscle-specific regulatory region of the alpha-cardiac myosin heavy-chain (MHC) gene contains the thyroid hormone response element (TRE) and two A/T-rich DNA sequences, designated A/T1 and A/T2,...
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.
Izumo, S, Nadal-Ginard, B, Mahdavi, V
Hypertrophy, an increase in cell size without cell division, is a fundamental adaptive process employed by postmitotic cardiac and skeletal muscle cells. Cardiac myosins undergo an adult-to-fetal...
Malek, A M, Gibbons, G H, Dzau, V J, Izumo, S
Fluid shear stress has been shown to be an important regulator of vascular structure and function through its effect on the endothelial cell. We have explored the effect of shear stress on the...
Shimizu, N, Smith, G, Izumo, S
The A element, a fourteen base pair sequence in the rabbit myosin heavy chain (HC) beta promoter (-276/-263), contains the M-CAT motif, a cis-acting element found in several muscle-specific genes....
Takahashi, T, Allen, P D, Lacro, R V, Marks, A R, Dennis, A R, Schoen, F J, ...
Cytoplasmic free calcium ions (Ca2+) play a central role in excitation-contraction coupling of cardiac muscle. Abnormal Ca2+ handling has been implicated in systolic and diastolic dysfunction in...
Erythrocyte Na,K pump in uremia. Acute correction of a transport defect by hemodialysis.
Izumo, H, Izumo, S, DeLuise, M, Flier, J S
We studied the erythrocyte Na,K-pump in chronically hemodialyzed uremic patients, immediately before and after a 4-h period of hemodialysis. Using [3H]ouabain as a probe, the number of Na,K-pump...
Komuro, I, Schalling, M, Jahn, L, Bodmer, R, Jenkins, N A, Copeland, N G, ...
Although it is likely that a highly complex network of transcription factors acts in concert during mammalian brain development, relatively few such genes have been characterized to date. We describe...
It is well known that external load plays a critical role in determining cardiac muscle mass and its phenotype, but little is known as to how mechanical load is transduced into intracellular signals...
Izumo, S, Lompré, A M, Matsuoka, R, Koren, G, Schwartz, K, Nadal-Ginard, B, ...
Expression of the cardiac myosin isozymes is regulated during development, by hormonal stimuli and hemodynamic load. In this study, the levels of expression of the two isoforms (alpha and beta) of...
Takahashi, T, Schunkert, H, Isoyama, S, Wei, J Y, Nadal-Ginard, B, Grossman, W, ...
Cardiac adaptation to hemodynamic stress involves both quantitative (hypertrophy) and qualitative (pattern of gene expression) changes. Our previous studies have shown that advancing age in the rat...
p21 ras plays as important role in cell proliferation, transformation and differentiation. Recently, the requirement of p21 ras has been suggested for cellular responses induced by stimulation of...
Sadoshima, J, Qiu, Z, Morgan, J P, Izumo, S
Hypotonic stress causes rapid cell swelling and initiates various cellular adaptive processes. However, it is unknown how cells initially sense low osmolarity and convert it into intracellular...
Aoki, H, Richmond, M, Izumo, S, Sadoshima, J
Although MAP (mitogen-activated protein) kinases are implicated in cell proliferation and differentiation in many cell types, the role of MAP kinases in cardiac hypertrophy remains unclear. We...
Kitze, B, Usuku, K, Yamano, Y, Yashiki, S, Nakamura, M, Fujiyoshi, T, ...
HTLV-1 causes two distinct human diseases, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukaemia/lymphoma (ATL). Persistently infected individuals carry a...
Turbay, D., Wechsler, S. B., Blanchard, K. M., Izumo, S.
BACKGROUND: Csx/Nkx2.5, a murine nonclustered homeobox gene expressed primarily in the heart, has significant sequence similarity to the Drosophila tinman gene. Tinman is essential for heart and gut...