S. J.

Escritos guaraníes como fuentes documentales de la historia paraguaya (2006)

La lengua guaraní, la lengua general hablada en el Paraguay colonial, tanto por la población española como por la indígena, la lengua en la que se vivía la historia de ese país llamado...

Escritos guaraníes como fuentes documentales de la historia paraguaya (2006)

La lengua guaraní, la lengua general hablada en el Paraguay colonial, tanto por la población española como por la indígena, la lengua en la que se vivía la historia...

USING VEGETATION TO CLEAN UP TNT-CONTAMINATED SITES. (R825513C013) (2005)

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the...

Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean stomatocytosis/macrothrombocytopenia) is the haematological presentation of phytosterolaemia (2005)

  • Rees,
  • D.C.,
  • Iolascon,
  • A.,
  • Carella,
  • M.,
  • ...

Phytosterolaemia (sitosterolaemia) is a recessively inherited metabolic condition in which the absorption of both cholesterol and plant-derived cholesterol-like molecules at the gut is unselective...

Transition from placental to air breathing stimulates haem-oxygenase-1 expression without functional consequence for pulmonary vascular adaptation in pigs and mice (2005)

  • Stanford,
  • S.J.,
  • Hislop,
  • A.A.,
  • Oltmanns,
  • U.,
  • ...

In systemic vessels, haem-oxygenase (HO) is induced during oxidative stress and known to modulate vasodilatation and vascular remodelling. At birth, with the transition from placental to air...

Induction of BCL-6 gene expression by interferon-gamma and identification of an IRE in exon I (2005)

  • Zhou,
  • G.,
  • Ono,
  • S.J.

BCL-6 is a POZ domain zinc-finger transcription factor that appears to play important roles in the development of the immune system and its regulation. Mutations within BCL-6 gene can therefore...

Maternal diet programs embryonic kidney gene expression (2005)

  • Welham,
  • S.J.,
  • Riley,
  • P.R.,
  • Wade,
  • A.,
  • ...

Human epidemiological data associating birth weight with adult disease suggests that organogenesis is 'programmed' by maternal diet. In rats, protein restriction in pregnancy produces offspring with...

Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response (2005)

  • Westerberg,
  • L.,
  • Larsson,
  • M.,
  • Hardy,
  • S.J.,
  • ...

The Wiskott-Aldrich syndrome protein (WASp) is mutated in the severe immunodeficiency disease Wiskott-Aldrich syndrome (WAS). The function of B cells and the physiologic alterations in WAS remain...

Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy (2005)

  • Taylor,
  • P.D.,
  • McConnell,
  • J.,
  • Khan,
  • I.Y.,
  • ...

We previously reported that prenatal and suckling exposure to a maternal diet rich in animal fat leads to cardiovascular dysfunction in young adult rat offspring with subsequent development of...

The MLC1v gene provides a transgenic marker of myocardium formation within developing chambers of the Xenopus heart (2005)

  • Smith,
  • S.J.,
  • Ataliotis,
  • P.,
  • Kotecha,
  • S.,
  • ...

Many details of cardiac chamber morphogenesis could be revealed if muscle fiber development could be visualized directly within the hearts of living vertebrate embryos. To achieve this end, we have...

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease (2005)

  • Roelfsema,
  • J.H.,
  • White,
  • S.J.,
  • Ariyurek,
  • Y.,
  • ...

CREB-binding protein and p300 function as transcriptional coactivators in the regulation of gene expression through various signal-transduction pathways. Both are potent histone acetyl transferases....

Calcium supplementation increases stature and bone mineral mass of 16- to 18-year-old boys (2005)

  • Prentice,
  • A.,
  • Ginty,
  • F.,
  • Stear,
  • S.J.,
  • ...

The effect of calcium carbonate supplementation on bone growth and mineral accretion was studied in 143 boys aged 16-18 yr, randomized to 1000 mg Ca/d or a matching placebo for 13 months....

High dose melphalan in the treatment of advanced neuroblastoma: results of a randomised trial (ENSG-1) by the European Neuroblastoma Study Group (2005)

  • Pritchard,
  • J.,
  • Cotterill,
  • S.J.,
  • Germond,
  • S.M.,
  • ...

BACKGROUND: High dose myeloablative chemotherapy ("megatherapy"), with haematopoietic stem cell support, is now widely used to consolidate response to induction chemotherapy in patients with advanced...

Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: a 22-year prospective, population-based, cohort study (2005)

  • Moore,
  • S.J.,
  • Green,
  • J.S.,
  • Fan,
  • Y.,
  • ...

Bardet-Biedl syndrome (BBS) and Laurence-Moon syndrome (LMS) have a similar phenotype, which includes retinal dystrophy, obesity, and hypogenitalism. They are differentiated by the presence of...

HIV-1 incorporates ABO histo-blood group antigens that sensitise virions to complement-mediated inactivation (2005)

  • Neil,
  • S.J.,
  • McKnight,
  • A.,
  • Gustafsson,
  • K.,
  • ...

ABO histo-blood group antigens have been postulated to modify pathogen spread through the action of natural antibodies and complement. The antigens are generated by a polymorphic glycosyltransferase...

Macrophage inflammatory protein-1 alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions (2005)

  • Miyazaki,
  • D.,
  • Nakamura,
  • T.,
  • Toda,
  • M.,
  • ...

Regulation of the immune response requires the cooperation of multiple signals in the activation of effector cells. For example, T cells require signals emanating from both the TCR for antigen (upon...

Continuous MLL-ENL Expression Is Necessary to Establish a "Hox Code" and Maintain Immortalization of Hematopoietic Progenitor Cells (2005)

The t[(11;19)(p22;q23)] translocation, which gives rise to the MLL-ENL fusion protein, is commonly found in infant acute leukemias of both the myeloid and lymphoid lineage. To investigate the...

Lack of serum oligoclonal antibody responses to Chlamydophila pneumoniae in multiple sclerosis (2005)

Chlamydophila pneumoniae has been proposed as an aetiological agent in MS via a mechanism involving molecular mimicry. We undertook to investigate whether the presence of CSF oligoclonal IgG OCB or...

Manual de Sa£de Bucal (2005)

  • Bedi,
  • R.,
  • Coventry,
  • J.F.,
  • Cunningham,
  • S.J.,
  • ...

Platelet hyper-function in acute coronary syndromes. (2005)

  • Harrison,
  • P.,
  • Mackie,
  • I.,
  • Mathur,
  • A.,
  • ...

Induction of BCL-6 gene expression by interferon-gamma and identification of an IRE in exon I (2005)

  • Zhou,
  • G.,
  • Ono,
  • S.J.

BCL-6 is a POZ domain zinc-finger transcription factor that appears to play important roles in the development of the immune system and its regulation. Mutations within BCL-6 gene can therefore...

Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions (2005)

  • Miyazaki,
  • D.,
  • Nakamura,
  • T.,
  • Toda,
  • M.,
  • ...

Regulation of the immune response requires the cooperation of multiple signals in the activation of effector cells. For example, T cells require signals emanating from both the TCR for antigen (upon...

Novel CHST6 nonsense and missense mutations responsible for macular corneal dystrophy (2005)

PURPOSE: To identify the underlying mutations in two unrelated British families with macular corneal dystrophy (MCD) by screening the carbohydrate sulfotransferase (CHST6) gene. DESIGN: Case reports...

A specific CCR3 chemokine receptor antagonist inhibits both early and late phase allergic inflammation in the conjunctiva (2005)

  • Nakamura,
  • T.,
  • Ohbayashi,
  • M.,
  • Toda,
  • M.,
  • ...

Allergic inflammation manifests as one of a number of diseases, including asthma, dermatitis, food allergy, vernal keratoconjunctivitis, and systemic anaphylaxis. Together these diseases affect...

Allergic conjunctivitis: update on pathophysiology and prospects for future treatment (2005)

Allergic conjunctivitis is in actuality a group of diseases affecting the ocular surface and is usually associated with type 1 hypersensitivity reactions. Two acute disorders, seasonal allergic...

Circulating anti-retinal antibodies as immune markers in age-related macular degeneration (2005)

  • Patel,
  • N.,
  • Ohbayashi,
  • M.,
  • Nugent,
  • A.K.,
  • ...

Age-related macular maculopathy (ARM) and age-related macular degeneration (AMD) are the leading causes of blindness in the Western world. Despite the magnitude of this clinical problem, very little...

Optic disk ovality as an index of tilt and its relationship to myopia and perimetry (2005)

PURPOSE: To examine the association of optic disk ovality with myopic refractive error, axial length, and the visual field. DESIGN: Prospective observational case series. METHODS: The study included...

Does the polymorphism of MHC class II promoters matter? (2005)

The promoters of genes of the major histocompatibility complex vary not only because of linkage disequilibrium with their coding sequences but also, we argue, because of natural selection that acts...

Functional observations in vitamin A deficiency: diagnosis and time course of recovery (2005)

AimsTo describe the effects of vitamin A deficiency (VAD) on retinal function and the subsequent recovery following treatment in three patients with systemic conditions (two with Crohn disease; one...

IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1 (2005)

  • Chau,
  • K.Y.,
  • Keane-Myers,
  • A.M.,
  • Fedele,
  • M.,
  • ...

We report for the first time that IFNG gene expression requires high mobility group (HMG)A1, the architectural transcription factor mediating enhanceosome formation. This finding is supported by our...

A nicotinic acetylcholine receptor mutation conferring target-site resistance to imidacloprid in Nilaparvata lugens (brown planthopper) (2005)

  • Liu,
  • Z.,
  • Williamson,
  • M.S.,
  • Lansdell,
  • S.J.,
  • ...

Neonicotinoids, such as imidacloprid, are nicotinic acetylcholine receptor (nAChR) agonists with potent insecticidal activity. Since its introduction in the early 1990s, imidacloprid has become one...

Molecular characterisation of nicotinic receptor subunits from the cat flea, Ctenocephalides felis (Siphonaptera: Pulicifae) (2005)

  • Bass,
  • C.,
  • Lansdell,
  • S.J.,
  • Millar,
  • N.S.,
  • ...

As part of a program to monitor the susceptibility of cat flea populations to the insecticide imidacloprid we have examined the cat flea nicotinic acetylcholine receptor, the target site protein of...

Diffusion MRI in multiple sclerosis (2005)

  • Rovaris,
  • M.,
  • Gass,
  • A.,
  • Bammer,
  • R.,
  • ...

Radiolabelling of glycosylated MFE-23 :: CPG2 fusion protein (MFECP1) with Tc-99m for quantitation of tumour antibody-enzyme localisation in antibody-directed enzyme pro-drug therapy (ADEPT) (2004)

  • Francis,
  • R.J.,
  • Mather,
  • S.J.,
  • Chester,
  • K.,
  • ...

MFECP1 is a glycosylated recombinant fusion protein composed of MFE-23, a high-affinity anti-carcinoembryonic antigen (CEA) single chain Fv (scFv), fused to the enzyme carboxypeptidase G2 (CPG2), and...

The gateway hypothesis of rostral PFC function (2004)

  • Burgess,
  • P.W.,
  • Simons,
  • J.S.,
  • Dumontheil,
  • I.,
  • ...

Immunocytochemical techniques for studying apoptosis in primary sympathetic neurons (2004)

  • Neame,
  • S.J.,
  • Whitfield,
  • J.,
  • Ham,
  • J.

Developing sympathetic neurons, which depend on nerve growth factor for survival, are one of the best studied in vitro models of neuronal apoptosis and have been extensively used for cellular and...

Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model (2004)

  • Ahmed,
  • F.,
  • Ings,
  • S.J.,
  • Pizzey,
  • A.R.,
  • ...

The reduced engraftment potential of hematopoietic stem/progenitor cells (HSPCs) after exposure to cytokines may be related to the impaired homing ability of actively cycling cells. We tested this...

Methods for culturing primary sympathetic neurons and for determining neuronal viability (2004)

  • Whitfield,
  • J.,
  • Neame,
  • S.J.,
  • Ham,
  • J.

Developing nerve growth factor (NGF)-dependent sympathetic neurons are one of the best-studied in vitro models of neuronal apoptosis and have been used to identify key components of the neuronal cell...

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 1: Cellular pharmacology, in vitro and initial in vivo antitumor activity (2004)

  • Hartley,
  • J.A.,
  • Spanswick,
  • V.J.,
  • Brooks,
  • N.,
  • ...

SJG-136 (NSC 694501) is a rationally designed pyrrolobenzodiazepine dimer that binds in the minor groove of DNA. It spans 6 bp with a preference for binding to purine- GATC-pyrimidine sequences. The...

A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine (2004)

Recombinant plant expression systems offer a means to produce large quantities of selected antigens for subunit vaccines. Cereals are particularly well-suited expression vehicles since the expressed...

A Test of the Boost explanation of Near Repeats. (2004)

Using techniques developed in the field of epidemiology, recent research conducted in both the UK (Johnson and Bowers, 2004) and Australia (Townsley et al., 2003) demonstrates that the risk of...

The Use of X-Ray Computerized Tomography to Measure the Accuracy of Total Knee Arthroplasty, (2003)

  • Henckel,
  • J.,
  • Richards,
  • R.,
  • Cobb,
  • J.P.,
  • ...

Third Annual Meeting of CAOS International, Marbella, Spain, 18-21 June,

An audit of antiretroviral treatment use in HIV-infected patients in a London clinic: the limitations of observational databases when auditing antiretroviral treatment use (2003)

  • Sabin,
  • C.A.,
  • Lampe,
  • F.C.,
  • Chaloner,
  • C.,
  • ...

OBJECTIVE: To audit the use of antiretroviral (ARV) treatment in a large treatment clinic in the UK against the British HIV Association (BHIVA) ARV treatment guidelines. METHODS: All patients under...

KCNQ/M currents in sensory neurons: significance for pain therapy (2003)

  • Passmore,
  • G.M.,
  • Selyanko,
  • A.A.,
  • Mistry,
  • M.,
  • ...

Neuronal hyperexcitability is a feature of epilepsy and both inflammatory and neuropathic pain. M currents [IK(M)] play a key role in regulating neuronal excitability, and mutations in neuronal...

Derepression of HMGA2 gene expression in retinoblastoma is associated with cell proliferation (2003)

  • Chau,
  • K.Y.,
  • Manfioletti,
  • G.,
  • Cheung-Chau,
  • K.W.,
  • ...

To assess whether retinoblastoma formation is associated with the expression of high mobility group (HMG) A2 protein, a transcription factor that is highly expressed during embryogenesis and...

Targeted retroviral infection of tumor cells by receptor cooperation (2003)

  • Martin,
  • F.,
  • Chowdhury,
  • S.,
  • Neil,
  • S.J.,
  • ...

Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223,...

Methylene blue and experimental gingivitis (2003)

  • Jackson,
  • R.J.,
  • Newman,
  • H.N.,
  • Strange,
  • J.,
  • ...

617

Retinal transplantation: progress and problems in clinical application (2003)

There is currently no real treatment for blinding disorders that stem from the degeneration of cells in the retina and affect at least 50 million individuals worldwide. The excitement that...

Benign asbestos pleural diseases (2003)

Photoperiodism: The coincidental perception of the season (2002)

Many plants use the seasonal change in daylength as a signal for flowering. Daylength sensing in Arabidopsis has now been shown to occur by an external coincidence mechanism, which operates by the...

Event-related brain dynamics (2002)

Advances in orthodontics (2002)

Performance of a new pubertal self-assessment questionnaire: a preliminary study (2001)

We describe the performance of a new, self-assessment questionnaire that aims to measure pubertal status by using gender-specific line drawings of the Tanner puberty stages. The study was carried out...

Features of carnitine palmitoyltransferase type I deficiency (2001)

  • Olpin,
  • S.E.,
  • Allen,
  • J.,
  • Bonham,
  • J.R.,
  • ...

Carnitine palmitoyltransferase type I (CPT I) is unique among long- chain fatty acid oxidation enzymes in that there are two tissue- specific isoforms, 'hepatic' and 'muscle', which are encoded by...

A variable inertial system for measuring the contractile properties of human muscle (2001)

PURPOSE: A flywheel system of variable inertia is described for inferring the mechanical properties of human muscle during a single explosive movement. METHODS: The system consists of a lightweight...

Synaptic P2X receptors (2001)

Over the past two years, ATP has clearly been shown to act as a co- transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X...

Synthesis and function of 3-phosphorylated inositol lipids (2001)

  • Vanhaesebroeck,
  • B.,
  • Leevers,
  • S.J.,
  • Ahmadi,
  • K.,
  • ...

Synthesis and Function of 3-Phosphorylated Inositol Lipids (2001)

  • Vanhaesebroeck,
  • B.,
  • Leevers,
  • S.J.,
  • Ahmadi,
  • K.,
  • ...

The 3-phosphorylated inositol lipids fulfill roles as second messengers by interacting with the lipid binding domains of a variety of cellular proteins. Such interactions can affect the subcellular...

Plant-based vaccines: unique advantages (2001)

Numerous studies have shown that viral epitopes and subunits of bacterial toxins can be expressed and correctly processed in transgenic plants. The recombinant proteins induce immune responses and...

Increased circulating platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis (2001)

  • Joseph,
  • J.E.,
  • Harrison,
  • P.,
  • MacKie,
  • I.J.,
  • ...

It is possible that platelet activation may play a pathogenic role in the increased risk of thrombosis associated with antiphospholipid antibodies (APA). In this study, levels of in vivo platelet...

c-Jun and the transcriptional control of neuronal apoptosis (2000)

  • Ham,
  • J.,
  • Eilers,
  • A.,
  • Whitfield,
  • J.,
  • ...

There has been considerable interest in the molecular mechanisms of apoptosis in mammalian neurons because this form of neuronal cell death is important for the normal development of the nervous...

Four-year PhDs in neuroscience: an assessment after four years (2000)

  • Rawlins,
  • N.,
  • Akerman,
  • C.J.,
  • Andolina,
  • I.,
  • ...

In 1996, as an innovation for the UK, the Wellcome Trust set up two 'American style' four-year PhD programmes in neuroscience, with an initial year of broad training followed by a three-year PhD....

Role of angiogenesis in benign, premalignant and malignant vulvar lesions (2000)

OBJECTIVE: To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions. STUDY DESIGN: Immunohistochemical demonstration of vascular endothelial growth...

Role of angiogenesis in benign, premalignant and malignant vulvar lesions (2000)

OBJECTIVE: To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions. STUDY DESIGN: Immunohistochemical demonstration of vascular endothelial growth...

GABAc receptor sensitivity is modulated by interaction with MAP1B (2000)

  • Billups,
  • D.,
  • Hanley,
  • J.G.,
  • Orme,
  • M.,
  • ...

GABA(C) receptors contain rho subunits and mediate feedback inhibition from retinal amacrine cells to bipolar cells. We previously identified the cytoskeletal protein MAP1B as a rho1 subunit...

Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF (1999)

  • Peppelenbosch,
  • M.,
  • Boone,
  • E.,
  • Jones,
  • G.E.,
  • ...

TNF is known to regulate macrophage (Mphi) migration, but the signaling pathways mediating this response have not been established. Here we report that stimulation of the 55-kDa TNF receptor (TNFR-1)...

Long term follow-up of orthognathic cases (1996)

 
Additional Information

Publishing period:

1875 - 2006 (276)

Co-authors: