Mookerjee, R.P., Stadlbauer, V., Lidder, S., Wright, G.A.K., Hodges, S.J., Davies, N.A., ...
Mortality in patients with alcoholic hepatitis (AH) remains high, and although corticosteroids are widely used for treatment, the results vary considerably. In AH, neutrophils are primed and...
Endotoxemia produces coma and brain swelling in bile duct ligated rats (2007)
Wright, G., Davies, N.A., Shawcross, D.L., Hodges, S.J., Zwingmann, C., Brooks, H.F., ...
This study explores the hypothesis that the inflammatory response induced by administration of lipopolysaccharide (LPS) exacerbates brain edema in cirrhotic rats; and if so whether this is associated...
Mookerjee, R.P., Wiesenthal, A., Icking, A., Hodges, S.J., Davies, N.A., Schilling, K., ...
Background & Aims: Increased intrahepatic resistance in cirrhosis is associated with reduced endothelial NO synthase (eNOS) activity and exacerbated by superimposed inflammation. NOSTRIN induces...
Mookerjee, R.P., Dalton, R.N., Davies, N.A., Hodges, S.J., Turner, C., Williams, R., ...
Acute liver failure (ALF) is characterized by rapid progressive organ failure and poor outcome. The pathophysiology of multiorgan dysfunction in ALF remains unclear but increased systemic...
Mookerjee, R.P., Malaki, M., Davies, N.A., Hodges, S.J., Dalton, R.N., Turner, C., ...
Previous studies suggest reduced hepatic endothelial nitric oxide synthase activity contributes to increased intrahepatic resistance. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide...
Davies, N.A., Hodges, S.J., Pitsillides, A.A., Mookerjee, R.P., Jalan, R., Mehdizadeh, S.
The production of nitric oxide (NO) in liver disease and its role in vascular control has been a subject of much interest in recent years. However, the activity of guanylate cyclase (GC), the enzyme...
Harrington, D.J., Soper, R., Edwards, C., Savidge, G.F., Hodges, S.J., Shearer, M.J.
We describe a method for the determination of the two major urinary metabolites of vitamin K as the methyl esters of their agyclone structures, 2-methyl-3-(3-3-carboxymethylpropyl)-1,4-naphthoquinone...
A carefully designed concurrent object-oriented language can provide a suitable target for a compositional design process that copes with the interference inherent with concurrency. The semantics of...
Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis (2003)
Tilg, H., Jalan, R., Kaser, A., Davies, N.A., Offner, F.A., Hodges, S.J., ...
Background/Aims: Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNF) has been demonstrated to play an important role in its pathophysiology. Methods:...
Remoting Peripherals using Memory-Mapped Networks (1998)
S. J. Hodges, S. L. Pope, D. E. Roberts
Memory-mapped networks such as Scalable Coherent Interconnect (SCI) [5] and Memory Channel [4] offer a new method for constructing network peripherals by remoting a host's IO bus. This paper details...
Enhancing Distributed Systems with Low-Latency Networking (1998)
Recently several network technologies which support user-level communication between processes using a shared-memory interface have become available [4, 7]. These technologies o#er very low latency,...
Remoting Peripherals using Memory-Mapped Networks (1998)
S. J. Hodges, S. L. Pope, D. E. Roberts
Memory-mapped networks such as Scalable Coherent Interconnect (SCI) [5] and Memory Channel [4] offer a new method for constructing network peripherals by remoting a host's IO bus. This paper details...
Mookerjee, R P, Sen, S, Davies, N A, Hodges, S J, Williams, R, Jalan, R
Background: The role of proinflammatory cytokines in the pathogenesis of portal hypertension is unclear.
Reduced bone formation in UK Gulf War veterans: a bone histomorphometric study
Compston, J E, Vedi, S, Stephen, A B, Bord, S, Lyons, A R, Hodges, S J, ...
Aims: Gulf War veterans report a high prevalence of musculoskeletal symptoms. The aim of this study was to establish whether there were abnormalities in bone turnover and remodelling in a group of...
Structure-activity studies of homologues of short chain neurotoxins from Elapid snake venoms.
Harvey, A. L., Hider, R. C., Hodges, S. J., Joubert, F. J.
Three neurotoxin homologues (CM10 and CM12 from Naja haje annulifera and S5C10 from Dendroaspis jamesoni kaimosae) and two short neurotoxins (CM14 from Naja haje annulifera and erabutoxin b from...