Stam, R.W., Boer, M.L. Den, Meijerink, J.P., Ebus, M.E., Peters, G.J., Noordhuis, P., ...
Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of mixed lineage leukemia (MLL) gene rearrangements, a poor outcome, and resistance to chemotherapeutic drugs. One...
Prevention of lymphocyte cell death in sepsis improves survival in mice
Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., Chang, K. C., Cobb, J. P., Buchman, T. G., ...
Sepsis induces extensive lymphocyte apoptosis, a process which may be beneficial to host survival by down-regulating the inflammatory response or, alternatively, harmful by impairing host defenses....
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.
Linette, G P, Li, Y, Roth, K, Korsmeyer, S J
BCL-2-deficient T cells demonstrate accelerated cell cycle progression and increased apoptosis following activation. Increasing the levels of BCL-2 retarded the G0-->S transition, sustained the...
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
Sedlak, T W, Oltvai, Z N, Yang, E, Wang, K, Boise, L H, Thompson, C B, ...
A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to heterodimerize with Bax and to repress...
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
Domer, P H, Fakharzadeh, S S, Chen, C S, Jockel, J, Johansen, L, Silverman, G A, ...
A chromosomal translocation, t(4;11)-(q21;q23), is associated with an aggressive mixed-lineage leukemia. A yeast artificial chromosome was used to clone the chromosomal breakpoint of this...
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D M, Zutter, M, Hickey, W, Nahm, M, Korsmeyer, S J
The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from the chromosomal breakpoint of follicular B-cell lymphoma. Transgenic...
Zutter, M, Hockett, R D, Roberts, C W, McGuire, E A, Bloomstone, J, Morton, C C, ...
We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor...
Silverman, G A, Green, E D, Young, R L, Jockel, J I, Domer, P H, Korsmeyer, S J
The common translocation found in human follicular lymphoma, t(14;18)(q32;q21), results in deregulation of the BCL2 protoonocogene. The isolation of the intact gene would provide an essential...
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.
Kolesnitchenko, V, King, L, Riva, A, Tani, Y, Korsmeyer, S J, Cohen, D I
We have investigated the relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1...
Martin, J M, Veis, D, Korsmeyer, S J, Sugden, B
The stable expression of the Epstein-Barr virus (EBV) latent membrane protein (LMP) in certain EBV-negative Burkitt's lymphoma cell lines correlates with an increased expression of the oncogene Bcl-2...
Crescenzi, M, Seto, M, Herzig, G P, Weiss, P D, Griffith, R C, Korsmeyer, S J
Achieving the capacity to detect minimal numbers of neoplastic cells is a major cancer diagnostic challenge. Chromosomal translocations such as the t(14;18)(q32;q21) found in follicular and some...
Hockett, R D, De Villartay, J P, Pollock, K, Poplack, D G, Cohen, D I, Korsmeyer, S J
Individual T cells express the CD3 molecule in association with alternative gamma delta or alpha beta heterodimeric T-cell receptors (TCRs). T-cell precursors and occasional gamma delta-expressing T...
Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells.
Nunez, G, Seto, M, Seremetis, S, Ferrero, D, Grignani, F, Korsmeyer, S J, ...
Human follicular B-cell lymphomas possess a t(14;18) that translocates a putative protooncogene, BCL2, into the immunoglobulin heavy chain locus. The normal BCL2 gene is quiescent in resting B cells,...
Sorensen, P H, Chen, C S, Smith, F O, Arthur, D C, Domer, P H, Bernstein, I D, ...
Cytogenetic studies have previously identified abnormalities of chromosome band 11q23 in many cases of infant acute leukemia. Recent studies by ourselves and others have demonstrated breakpoint...
Hollis, G F, Evans, R J, Stafford-Hollis, J M, Korsmeyer, S J, McKearn, J P
Human pre-B cells, which produce immunoglobulin heavy chain but do not produce immunoglobulin light chain, are shown to contain a 1-kilobase transcript homologous to immunoglobulin lambda light-chain...
Silverman, G A, Ye, R D, Pollock, K M, Sadler, J E, Korsmeyer, S J
Well-characterized large genomic clones obtained from yeast artificial chromosome (YAC) libraries provide the framework to localize genes and approach genetic disease. We developed universally...
Deletional rearrangement in the human T-cell receptor alpha-chain locus.
De Villartay, J P, Lewis, D, Hockett, R, Waldmann, T A, Korsmeyer, S J, Cohen, D I
The antigen-specific receptor on the surface of mature T lymphocytes is a heterodimer consisting of polypeptides termed alpha and beta. In the course of characterizing human T-cell tumors with an...
Bakhshi, A, Wright, J J, Graninger, W, Seto, M, Owens, J, Cossman, J, ...
To elucidate the mechanism of the t(14;18)(q32;q21) chromosomal translocation found in follicular lymphoma, we examined the structure of both derivative (der) chromosomal breakpoints as well as their...
Bakhshi, A, Guglielmi, P, Siebenlist, U, Ravetch, J V, Jensen, J P, Korsmeyer, S J
The human heavy chain disease protein BW is an immunoglobulin mu-chain variant whose amino terminus is initiated at the fifth amino acid of the first constant region domain. We cloned and analyzed...
Benjamin, D, Magrath, I T, Triche, T J, Schroff, R W, Jensen, J P, Korsmeyer, S J
At nanomolar concentrations, phorbol 12-myristate 13-acetate induced differentiation in a human Epstein-Barr virus-negative B-cell line, JD 38, derived from an undifferentiated lymphoma and...
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
Korsmeyer, S J, Hieter, P A, Ravetch, J V, Poplack, D G, Waldmann, T A, Leder, P
We have used a special class of human acute lymphocytic leukemias, the common "non-T/non-B" cell type, to define a hierarchy of genetic rearrangements that occur during the earliest stages of B-cell...
bcl-2 mRNA is present at high levels in pre-B-cell lines but is down-regulated in most mature B-cell lines. To investigate the mechanisms responsible for its developmental control, we studied the...
Silverman, G A, Yang, E, Proffitt, J H, Zutter, M, Korsmeyer, S J
The goal of this study was to determine whether it will be feasible to study the expression of a large, human gene, such as the BCL2 proto-oncogene, by DNA transfection. The BCL2 proto-oncogene is...
McGuire, E A, Rintoul, C E, Sclar, G M, Korsmeyer, S J
T-cell translocation gene 1 (Ttg-1), also called rhombotin, is deregulated upon translocation into the alpha/delta T-cell receptor loci in acute lymphoblastic leukemias bearing the t(11;14)(p15;q11)....
McDonnell, T J, Nunez, G, Platt, F M, Hockenberry, D, London, L, McKearn, J P, ...
We characterized the basis for the follicular lymphoproliferation in transgenic mice bearing a Bcl-2-immunoglobulin (Bcl-2-Ig) minigene representing the t(14;18) of human follicular lymphoma....
McGuire, E A, Hockett, R D, Pollock, K M, Bartholdi, M F, O'Brien, S J, Korsmeyer, S J
Interchromosomal translocations within lymphoid neoplasms frequently involve the antigen receptor genes. We cloned the breakpoints of the t(11;14)(p15;q11) in a CD3-negative T-cell acute...
Nadler, L M, Korsmeyer, S J, Anderson, K C, Boyd, A W, Slaughenhoupt, B, Park, E, ...
The expression of B cell associated and restricted antigens on tumor cells isolated from 138 patients with non-T cell acute lymphoblastic leukemia (non-T cell ALL) was investigated by flow cytometric...
Korsmeyer, S J, Greene, W C, Cossman, J, Hsu, S M, Jensen, J P, Neckers, L M, ...
The origin and exact stage of differentiation of the neoplastic cells that comprise hairy cell leukemia have remained uncertain. As Ig heavy and light chain genes must both undergo a DNA...
Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.
Merino, R, Ding, L, Veis, D J, Korsmeyer, S J, Nuñez, G
Cell death is a prominent feature of B cell development. For example, a large population of B cells dies at the pre-B cell stage presumably due to the failure to express a functional immunoglobulin...
In vitro enhancement of immunoglobulin gene expression in chronic lymphocytic leukemia.
Cossman, J, Neckers, L M, Braziel, R M, Trepel, J B, Korsmeyer, S J, Bakhshi, A
B cell chronic lymphocytic leukemia (CLL) cells appear to be arrested in their differentiation so that little immunoglobulin is secreted in most cases. To determine their capacity for further...
Waldmann, T A, Broder, S, Goldman, C K, Frost, K, Korsmeyer, S J, Medici, M A
The pathogenesis of the immunoglobulin deficiency of 20 patients with ataxia telangiectasia was studied using an in vitro immunoglobulin biosynthesis system. 10 patients had no detectable IgA in...
Korsmeyer, S J, Arnold, A, Bakhshi, A, Ravetch, J V, Siebenlist, U, Hieter, P A, ...
We have explored the relationship among immunoglobulin gene rearrangement, cytoplasmic immunoglobulin production, and cell surface antigen expression within 37 cases of acute lymphocytic leukemia....
Felix, C A, Wright, J J, Poplack, D G, Reaman, G H, Cole, D, Goldman, P, ...
We examined alpha-, beta-, and gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell development. We wished to determine...
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.
Graninger, W B, Seto, M, Boutain, B, Goldman, P, Korsmeyer, S J
We examined the expression of the Bcl-2 gene at chromosome segment 18q21, that is translocated into the Ig heavy chain gene locus in t(14;18) bearing lymphomas. Bcl-2, while B cell associated, is...
Seto, M, Jaeger, U, Hockett, R D, Graninger, W, Bennett, S, Goldman, P, ...
The most common translocation in human lymphoma, the t(14;18)(q32;q21), generates heterogeneous 4.2-7.2 kb Bcl-2-immunoglobulin (Ig) chimeric mRNAs resulting from alternative Bcl-2 5' exons and...
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis.
Gross, A, Jockel, J, Wei, M C, Korsmeyer, S J
Expression of the pro-apoptotic molecule BAX has been shown to induce cell death. While BAX forms both homo- and heterodimers, questions remain concerning its native conformation in vivo and which...
Shibata, M A, Liu, M L, Knudson, M C, Shibata, E, Yoshidome, K, Bandey, T, ...
The dramatic increase in apoptosis observed during the development of preneoplastic mammary lesions is associated with a significant elevation in Bax expression in C3(1)/SV40 large T antigen (TAg)...
Prevention of lymphocyte cell death in sepsis improves survival in mice
Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., Chang, K. C., Cobb, J. P., Buchman, T. G., ...
Sepsis induces extensive lymphocyte apoptosis, a process which may be beneficial to host survival by down-regulating the inflammatory response or, alternatively, harmful by impairing host defenses....
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.
Linette, G P, Li, Y, Roth, K, Korsmeyer, S J
BCL-2-deficient T cells demonstrate accelerated cell cycle progression and increased apoptosis following activation. Increasing the levels of BCL-2 retarded the G0-->S transition, sustained the...
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
Sedlak, T W, Oltvai, Z N, Yang, E, Wang, K, Boise, L H, Thompson, C B, ...
A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to heterodimerize with Bax and to repress...
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
Domer, P H, Fakharzadeh, S S, Chen, C S, Jockel, J, Johansen, L, Silverman, G A, ...
A chromosomal translocation, t(4;11)-(q21;q23), is associated with an aggressive mixed-lineage leukemia. A yeast artificial chromosome was used to clone the chromosomal breakpoint of this...
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D M, Zutter, M, Hickey, W, Nahm, M, Korsmeyer, S J
The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from the chromosomal breakpoint of follicular B-cell lymphoma. Transgenic...
Zutter, M, Hockett, R D, Roberts, C W, McGuire, E A, Bloomstone, J, Morton, C C, ...
We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor...
Silverman, G A, Green, E D, Young, R L, Jockel, J I, Domer, P H, Korsmeyer, S J
The common translocation found in human follicular lymphoma, t(14;18)(q32;q21), results in deregulation of the BCL2 protoonocogene. The isolation of the intact gene would provide an essential...
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.
Kolesnitchenko, V, King, L, Riva, A, Tani, Y, Korsmeyer, S J, Cohen, D I
We have investigated the relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1...
Martin, J M, Veis, D, Korsmeyer, S J, Sugden, B
The stable expression of the Epstein-Barr virus (EBV) latent membrane protein (LMP) in certain EBV-negative Burkitt's lymphoma cell lines correlates with an increased expression of the oncogene Bcl-2...
Crescenzi, M, Seto, M, Herzig, G P, Weiss, P D, Griffith, R C, Korsmeyer, S J
Achieving the capacity to detect minimal numbers of neoplastic cells is a major cancer diagnostic challenge. Chromosomal translocations such as the t(14;18)(q32;q21) found in follicular and some...
Hockett, R D, De Villartay, J P, Pollock, K, Poplack, D G, Cohen, D I, Korsmeyer, S J
Individual T cells express the CD3 molecule in association with alternative gamma delta or alpha beta heterodimeric T-cell receptors (TCRs). T-cell precursors and occasional gamma delta-expressing T...
Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells.
Nunez, G, Seto, M, Seremetis, S, Ferrero, D, Grignani, F, Korsmeyer, S J, ...
Human follicular B-cell lymphomas possess a t(14;18) that translocates a putative protooncogene, BCL2, into the immunoglobulin heavy chain locus. The normal BCL2 gene is quiescent in resting B cells,...
Sorensen, P H, Chen, C S, Smith, F O, Arthur, D C, Domer, P H, Bernstein, I D, ...
Cytogenetic studies have previously identified abnormalities of chromosome band 11q23 in many cases of infant acute leukemia. Recent studies by ourselves and others have demonstrated breakpoint...
Hollis, G F, Evans, R J, Stafford-Hollis, J M, Korsmeyer, S J, McKearn, J P
Human pre-B cells, which produce immunoglobulin heavy chain but do not produce immunoglobulin light chain, are shown to contain a 1-kilobase transcript homologous to immunoglobulin lambda light-chain...
Silverman, G A, Ye, R D, Pollock, K M, Sadler, J E, Korsmeyer, S J
Well-characterized large genomic clones obtained from yeast artificial chromosome (YAC) libraries provide the framework to localize genes and approach genetic disease. We developed universally...
Deletional rearrangement in the human T-cell receptor alpha-chain locus.
De Villartay, J P, Lewis, D, Hockett, R, Waldmann, T A, Korsmeyer, S J, Cohen, D I
The antigen-specific receptor on the surface of mature T lymphocytes is a heterodimer consisting of polypeptides termed alpha and beta. In the course of characterizing human T-cell tumors with an...
Bakhshi, A, Wright, J J, Graninger, W, Seto, M, Owens, J, Cossman, J, ...
To elucidate the mechanism of the t(14;18)(q32;q21) chromosomal translocation found in follicular lymphoma, we examined the structure of both derivative (der) chromosomal breakpoints as well as their...
Bakhshi, A, Guglielmi, P, Siebenlist, U, Ravetch, J V, Jensen, J P, Korsmeyer, S J
The human heavy chain disease protein BW is an immunoglobulin mu-chain variant whose amino terminus is initiated at the fifth amino acid of the first constant region domain. We cloned and analyzed...
Benjamin, D, Magrath, I T, Triche, T J, Schroff, R W, Jensen, J P, Korsmeyer, S J
At nanomolar concentrations, phorbol 12-myristate 13-acetate induced differentiation in a human Epstein-Barr virus-negative B-cell line, JD 38, derived from an undifferentiated lymphoma and...
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
Korsmeyer, S J, Hieter, P A, Ravetch, J V, Poplack, D G, Waldmann, T A, Leder, P
We have used a special class of human acute lymphocytic leukemias, the common "non-T/non-B" cell type, to define a hierarchy of genetic rearrangements that occur during the earliest stages of B-cell...
bcl-2 mRNA is present at high levels in pre-B-cell lines but is down-regulated in most mature B-cell lines. To investigate the mechanisms responsible for its developmental control, we studied the...
Silverman, G A, Yang, E, Proffitt, J H, Zutter, M, Korsmeyer, S J
The goal of this study was to determine whether it will be feasible to study the expression of a large, human gene, such as the BCL2 proto-oncogene, by DNA transfection. The BCL2 proto-oncogene is...
McGuire, E A, Rintoul, C E, Sclar, G M, Korsmeyer, S J
T-cell translocation gene 1 (Ttg-1), also called rhombotin, is deregulated upon translocation into the alpha/delta T-cell receptor loci in acute lymphoblastic leukemias bearing the t(11;14)(p15;q11)....